The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Open accessAbstract
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which fatty acids mediate this effect, rats were infused with either a lipid emulsion (consisting mostly of 18:2 fatty acids) or glycerol. Intracellular C18:2 CoA increased in a time-dependent fashion, reaching an approximately 6-fold elevation by 5 h, whereas there was no change in the concentration of any other fatty acyl-CoAs. Diacylglycerol (DAG) also increased transiently after 3-4 h of lipid infusion. In contrast there was no increase in intracellular ceramide or triglyceride concentrations during the lipid infusion. Increases in intracellular C18:2 CoA and DAG concentration were associated with protein kinase C (PKC)-theta activation and a reduction in both insulin-stimulated IRS-1 tyrosine phosphorylation and IRS-1 associated PI3-kinase activity, which were associated with an increase in IRS-1 Ser(307) phosphorylation. These data support the hypothesis that an increase in plasma fatty acid concentration results in an increase in intracellular fatty acyl-CoA and DAG concentrations, which results in activation of PKC-theta leading to increased IRS-1 Ser(307) phosphorylation. This in turn leads to decreased IRS-1 tyrosine phosphorylation and decreased activation of IRS-1-associated PI3-kinase activity resulting in decreased insulin-stimulated glucose transport activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Lipid accumulation in skeletal muscle (7) or metabolic overload in mitochondria (8) have also been shown to occur with IR”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as [7]
In the citing paper
“Both acute (4 hours) and chronic (4 days) physiologic elevation of plasma FFA concentration in insulin sensitive individuals impairs insulin signaling and causes insulin resistance in skeletal muscle [28, 62–68].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [64]
In the citing paper
“It is well established that chronically elevated plasma FFA levels cause insulin resistance in skeletal muscle [1, 12, 14, 62–65].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [64]
In the citing paper
“Rodent and human studies have suggested increased serine phosphorylation of IRS-1 in insulin resistant states [111, 171–173].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [173]
In the citing paper
“GLUT4, the insulin regulatable transporter, is found in skeletal muscle, has a Km of approximately 5 mmol/L, which is close to that of the plasma glucose concentration, and is associated with HK-II [173, 174].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [173]
In the citing paper
“While increased levels of fatty acyl-CoA in general are associated with IR and in C18:2-CoA accumulation is a potential indicator of IR [115,117].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [117]
In the citing paper
“In particular, an overabundance of SFA (e.g., Palmitate) can induce IR through the accumulation of lipid derivatives including DAGs, ceramides and long chain acyl-CoAs in the cytosol, which in turn can interfere with IRS1-PKB signalling [113,114,115,116,117,118].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [117]
In the citing paper
“In contrast, decreasing fatty acid flux in humans via pharmacological inhibition of lipolysis (49) or by discontinuing a lipid-plus-heparin infusion in rats (58) decreases IMTG concentration and/or the accumulation of fatty acid intermediates.”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [58]
In the citing paper
“Accordingly, increasing fatty acid flux via a lipid-plus-heparin infusion in humans (23,46) or rodents (58) results in a corresponding increase in the concentration of IMTG and/or fatty acid intermediates.”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [58]
In the citing paper
“Adipose tissue in obese people is insulin resistant, which raises nonesterified fatty acid levels, worsening insulin resistance in muscle 29,33 and altering hepatic metabolism 31 ;”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [33]
In the citing paper
“This disconnection between intramyocellular triglyceride and peripheral insulin action confirms that intra myocellular triglyceride is only a crude marker for the active metabolite (putatively diacylglycerol) that causes fat-induced insulin resistance.38”
From Lipid-induced insulin resistance: unravelling the mechanism (2010) · cites this paper as [38]
In the citing paper
“Increased tissue lipid load, as with obesity, and/or sustained inactivity, may lead to the accumulation of fatty acyl coenzyme A (CoA), diacylglycerols, ceramides, products of incomplete oxidation, and ROS, all of which have been linked experimentally to reduced insulin signaling and action (96 -102).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Self-citationAguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487
Self-citationDresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
Self-citationGriffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267
Self-citationKrssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264
Self-citationSkeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Laybutt, 1999, Am. J. Physiol., 277, E1070
Cited by
Sorted by citations
Items 301–400 of 1,002
Therapeutic approaches for muscle wasting disorders
Lynch, G. S., Schertzer, J. D., & Ryall, J. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.004 · Cited by 155
Resistin: molecular history and prognosis
Banerjee, R. R., & Lazar, M. A. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0428-9 · Cited by 151
How the association between obesity and inflammation may lead to insulin resistance and cancer
Amin, M. N., Hussain, M. S., Sarwar, M. S., Moghal, M. M. R., Das, A., Hossain, M. Z., Chowdhury, J. A., Millat, M. S., & Islam, M. S. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.01.041 · Cited by 157
Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice
Li, X., Zhang, D., Vatner, D. F., Goedeke, L., Hirabara, S. M., Zhang, Y., Perry, R. J., & Shulman, G. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922169117 · Cited by 154
Self-citationLavoie, J.-M., & Gauthier, M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6600-y · Cited by 152
Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity
Petersen, M. C., Smith, G. I., Palacios, H. H., Farabi, S. S., Yoshino, M., Yoshino, J., Cho, K., Davila-Roman, V. G., Shankaran, M., Barve, R. A., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.002 · Cited by 149
Self-citationShulman, G. I. (2004) · Physiology · doi:10.1152/physiol.00007.2004 · Cited by 152
Self-citationMitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus
Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0030-1 · Cited by 146
Age-related inflammation and insulin resistance: a review of their intricate interdependency
Park, M. H., Kim, D. H., Lee, E. K., Kim, N. D., Im, D., Lee, J., Yu, B. P., & Chung, H. Y. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0474-6 · Cited by 152
Obesity and cancer, a case for insulin signaling
Poloz, Y., & Stambolic, V. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.381 · Cited by 154
Johannsen, D. L., Tchoukalova, Y. D., Tam, C. S., Covington, J. D., Xie, W., Schwarz, J., Bajpeyi, S., & Ravussin, É. (2014) · Diabetes Care · doi:10.2337/dc14-0761 · Cited by 151
Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet
Tan, C. K., Leuenberger, N., Tan, M., Yan, Y. W., Chen, Y., Kambadur, R., Wahli, W., & Tan, N. S. (2011) · Diabetes · doi:10.2337/db10-0801 · Cited by 150
Self-citationLipid Mediators of Insulin Resistance
Holland, W. L., Knotts, T. A., Chavez, J. A., Wang, L.-P., Hoehn, K. L., & Summers, S. A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00327.x · Cited by 149
Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes
Appari, M., Channon, K. M., & McNeill, E. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7060 · Cited by 154
Watt, M. J., & Hoy, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2011 · Cited by 142
Chan, S. M. H., Sun, R., Zeng, X., Choong, Z.-H., Wang, H., Watt, M. J., & Ye, J. (2013) · Diabetes · doi:10.2337/db12-1397 · Cited by 149
Zhou, Q. G., Hou, F. F., Guo, Z. J., Liang, M., Wang, G. B., & Zhang, X. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.873 · Cited by 145
Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging
Gong, Z., Tas, E., Yakar, S., & Muzumdar, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.022 · Cited by 153
Gual, P., Grémeaux, T., Gonzalez, T., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2003) · Diabetologia · doi:10.1007/s00125-003-1223-4 · Cited by 144
Jurczak, M. J., Lee, A., Jornayvaz, F. R., Lee, H., Birkenfeld, A. L., Guigni, B. A., Kahn, M., Samuel, V. T., Glimcher, L. H., & Shulman, G. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316760 · Cited by 143
Self-citationHigh intensity interval training improves liver and adipose tissue insulin sensitivity
Marcinko, K., Sikkema, S. R., Samaan, M. C., Kemp, B. E., Fullerton, M. D., & Steinberg, G. R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.006 · Cited by 146
Network distribution of mitochondria and lipid droplets in human muscle fibres
Shaw, C. S., Jones, D. A., & Wagenmakers, A. J. M. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0349-8 · Cited by 140
Freda, P. U., Shen, W., Heymsfield, S. B., Reyes-Vidal, C. M., Geer, E. B., Bruce, J. N., & Gallagher, D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2780 · Cited by 141
Lanza, I. R., Blachnio-Zabielska, A., Johnson, M. L., Schimke, J. M., Jakaitis, D. R., Lebrasseur, N. K., Jensen, M. D., Sreekumaran Nair, K., & Zabielski, P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00584.2012 · Cited by 135
Hong, L., Rabaglia, M. E., Stoehr, J. P., Nadler, S. T., Schueler, K. L., Zou, F., Yandell, B. S., & Attie, A. (2003) · Diabetes · doi:10.2337/diabetes.52.3.688 · Cited by 141
Abdul-Ghani, M. A., Muller, F. L., Liu, Y., Chavez, A. O., Balas, B., Zuo, P., Chang, Z., Tripathy, D., Jani, R., Molina-Carrion, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90287.2008 · Cited by 140
Richards, O. C., Raines, S. M., & Attie, A. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0035 · Cited by 150
Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus
Venables, M. C., & Jeukendrup, A. E. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.983 · Cited by 137
Qi, Q., Bray, G. A., Smith, S. R., Hu, F. B., Sacks, F. M., & Qi, L. (2011) · Circulation · doi:10.1161/circulationaha.111.025767 · Cited by 147
Free Fatty Acids and Skeletal Muscle Insulin Resistance
Rachek, L. I. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00008-9 · Cited by 141
Uncoupling protein‐3: clues in an ongoing mitochondrial mystery
Bézaire, V., Seifert, E. L., & Harper, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-6966rev · Cited by 144
Henriksen, E. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.002 · Cited by 136
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140
Bonen, A., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., & Heigenhauser, G. J. F. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803212 · Cited by 146
Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, T. E., Frøsig, C., Birk, J. B., Bisiani, B., Hiscock, N., Pilegaard, H., Wojtaszewski, J. F. P., et al. (2011) · Diabetes · doi:10.2337/db10-0698 · Cited by 136
Lipid metabolism in sarcopenia
Al Saedi, A., Debruin, D. A., Hayes, A., & Hamrick, M. (2022) · Bone · doi:10.1016/j.bone.2022.116539 · Cited by 140
Dyck, D. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-037 · Cited by 136
Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically Ill
Langouche, L., Perre, S. V., Wouters, P. J., D’Hoore, A. J. L., Hansen, T. K., & den Berghe, G. V. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0813 · Cited by 136
Bosma, M., Kersten, S., Hesselink, M. K. C., & Schrauwen, P. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.003 · Cited by 135
Nagle, C. A., An, J., Shiota, M., Torres, T. P., Cline, G. W., Liu, Z., Wang, S., Catlin, R. L., Shulman, G. I., Newgard, C. B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611550200 · Cited by 136
Self-citationLysophosphatidylcholine as an effector of fatty acid-induced insulin resistance
Han, M. S., Lim, Y.-M., Quan, W., Kim, J. R., Chung, K. W., Kang, M., Kim, S., Park, S. Y., Han, J., Park, S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014787 · Cited by 136
Self-citationLee, H., Birkenfeld, A. L., Jornayvaz, F. R., Jurczak, M. J., Kanda, S., Popov, V., Frederick, D. W., Zhang, D., Guigni, B. A., Bharadwaj, K. G., et al. (2011) · Hepatology · doi:10.1002/hep.24571 · Cited by 135
Self-citationA high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
Musselman, L. P., Fink, J. L., Narzinski, K., Ramachandran, P. V., Hathiramani, S. S., Cagan, R. L., & Baranski, T. (2011) · Journal of Cell Science · doi:10.1242/jcs.102947 · Cited by 134
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
Aryal, B., Singh, A. K., Zhang, X., Varela, L., Rotllan, N., Goedeke, L., Chaube, B., Camporez, J.-P., Vatner, D. F., Horvath, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 127
Self-citationMetabolic Stress Signaling Mediated by Mixed-Lineage Kinases
Jaeschke, A., & Davis, R. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.008 · Cited by 137
Hulston, C. J., Churnside, A. A., & Venables, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004097 · Cited by 140
Metabolism, hypoxia and the diabetic heart
Heather, L. C., & Clarke, K. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.01.007 · Cited by 132
Papaetis, G. S., Papakyriakou, P., & Panagiotou, T. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.52350 · Cited by 143
Mechanisms regulating phosphoinositide 3‐kinase signalling in insulin‐sensitive tissues
Shepherd, P. R. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01382.x · Cited by 132
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults
Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I., & Nair, K. S. (2016) · Diabetes · doi:10.2337/db15-0675 · Cited by 129
Self-citationMuoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-083 · Cited by 129
Zhang, L., Ussher, J. R., Oka, T., Cadete, V. J. J., Wagg, C. S., & Lopaschuk, G. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq266 · Cited by 130
Molecular mechanisms of lipid‐induced insulin resistance in muscle, liver and vasculature
Krebs, M., & Roden, M. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00439.x · Cited by 130
Keung, W., Ussher, J. R., Jaswal, J. S., Raubenheimer, M., Lam, V. H., Wagg, C. S., & Lopaschuk, G. D. (2012) · Diabetes · doi:10.2337/db12-0259 · Cited by 129
The Effect of Exercise and Nutrition on Intramuscular Fat Metabolism and Insulin Sensitivity
Shaw, C. S., Clark, J., & Wagenmakers, A. J. M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104817 · Cited by 128
Insulin action and signalling in fat and muscle from dexamethasone-treated rats
Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W., & Jensen, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.034 · Cited by 125
The Role of Chronic Inflammation in Obesity-Associated Cancers
Ramos‐Niño, M. E. (2013) · ISRN Oncology · doi:10.1155/2013/697521 · Cited by 137
An Immune Response Network Associated with Blood Lipid Levels
Inouye, M., Silander, K., Hämäläinen, E., Salomaa, V. V., Harald, K., Jousilahti, P., Männistö, S., Eriksson, J. G., Saarela, J., Ripatti, S., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001113 · Cited by 128
Fridlyand, L. E., & Philipson, L. H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1363.019 · Cited by 122
Lombardo, Y. B., Hein, G. J., & Chicco, A. G. (2007) · Lipids · doi:10.1007/s11745-007-3039-3 · Cited by 126
Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance
Duan, C., Yang, H., White, M. F., & Rui, L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7435-7443.2004 · Cited by 127
Self-citationJornayvaz, F. R., Samuel, V. T., & Shulman, G. I. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104726 · Cited by 132
Self-citationMorino, K., Neschen, S., Bilz, S., Sono, S., Tsirigotis, D., Reznick, R. M., Moore, I., Nagai, Y., Samuel, V., Sebastian, D., et al. (2008) · Diabetes · doi:10.2337/db06-0454 · Cited by 125
Self-citationUpdate on the molecular biology of dyslipidemias
Ramasamy, I. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.10.033 · Cited by 131
Miyamoto, H., Moriishi, K., Moriya, K., Murata, S., Tanaka, K., Suzuki, T., Miyamura, T., Koike, K., & Matsuura, Y. (2006) · Journal of Virology · doi:10.1128/jvi.01683-06 · Cited by 124
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Bandet, C. L., Tan, S., Bourron, O., Stunff, H. L., & Hajduch, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030479 · Cited by 127
Kraegen, E. W., Saha, A. K., Preston, E., Wilks, D. L., Hoy, A. J., Cooney, G. J., & Ruderman, N. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00316.2005 · Cited by 126
Self-citationLiu, Y., Herschkovitz, A., Boura‐Halfon, S., Ronen, D., Paz, K., LeRoith, D., & Zick, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9668-9681.2004 · Cited by 127
Exercise, heat shock proteins and insulin resistance
Archer, A. E., Von Schulze, A. T., & Geiger, P. C. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0529 · Cited by 122
Improvement of insulin sensitivity by antagonism of the renin-angiotensin system
Henriksen, E. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00147.2007 · Cited by 127
Clamp, L. D., Hume, D. J., Lambert, E. V., & Kroff, J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.31 · Cited by 124
Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination
Papaconstantinou, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.025 · Cited by 127
Insulin Signaling in Type 2 Diabetes
Brännmark, C., Nyman, E., Fagerholm, S., Bergenholm, L., Ekstrand, E.-M., Cedersund, G., & Strålfors, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.432062 · Cited by 122
Radin, M. S., Sinha, S., Bhatt, B. A., Dedousis, N. L., & O'Doherty, R. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0861-3 · Cited by 125
Yan, X., Zhu, M. J., Xu, W., Tong, J. F., Ford, S. P., Nathanielsz, P. W., & Du, . (2009) · Endocrinology · doi:10.1210/en.2009-0849 · Cited by 133
The Role of Catechins in Regulating Diabetes: An Update Review
Wen, L., Wu, D., Tan, X., Zhong, M., Xing, J., Li, W., Li, D., & Cao, F. (2022) · Nutrients · doi:10.3390/nu14214681 · Cited by 132
Glycosphingolipids and insulin resistance
Langeveld, M., & Aerts, J. M. F. G. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.03.002 · Cited by 127
Ringvold, H. C., & Khalil, R. A. (2016) · Advances in Pharmacology · doi:10.1016/bs.apha.2016.06.002 · Cited by 99
Natalicchio, A., Marrano, N., Biondi, G., Spagnuolo, R., Labarbuta, R., Porreca, I., Cignarelli, A., Bugliani, M., Marchetti, P., Perrini, S., et al. (2017) · Diabetes · doi:10.2337/db17-0002 · Cited by 122
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview
Holloway, G. P., Luiken, J. J. F. P., Glatz, J. F. C., Spriet, L. L., & Bonen, A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01878.x · Cited by 127
Laplante, M., Festuccia, W. T., Soucy, G., Gélinas, Y., Lalonde, J., Berger, J. P., & Deshaies, Y. (2006) · Diabetes · doi:10.2337/db06-0551 · Cited by 119
Lee, S., Hong, I., Kim, B., Shim, S., Lee, J., Lee, H., Choi, C. S., Kim, B., & Park, T. (2015) · Hepatology · doi:10.1002/hep.27804 · Cited by 121
Maternal obesity, lipotoxicity and cardiovascular diseases in offspring
Dong, M., Zheng, Q., Ford, S. P., Nathanielsz, P. W., & Ren, J. T. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.08.023 · Cited by 122
García‐Ruiz, C., Baulies, A., Marí, M., García-Rovés, P. M., & Fernández-Checa, J. C. (2013) · Free Radical Research · doi:10.3109/10715762.2013.830717 · Cited by 119
Park, S., Cho, Y.-R., Finck, B. N., Kim, H.-J., Higashimori, T., Hong, E., Lee, M., Danton, C., Deshmukh, S. D., Cline, G. W., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2514 · Cited by 122
Self-citationGrahn, T. H. M., Kaur, R., Yin, J., Schweiger, M., Sharma, V. M., Lee, M., Ido, Y., Smas, C. M., Zechner, R., Lass, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.539890 · Cited by 117
Tai, C. C., & Ding, S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.09.010 · Cited by 123
da Silva Rosa, S. C., Martens, M. D., Field, J. T., Nguyen, L., Kereliuk, S. M., Hai, Y., Chapman, D., Diehl-Jones, W., Aliani, M., West, A. R., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1821548 · Cited by 117
Guo, L., & Tabrizchi, R. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.009 · Cited by 117
Molecular mechanism of insulin resistance
Bhattacharya, S., Dey, D., & Roy, S. S. (2007) · Journal of Biosciences · doi:10.1007/s12038-007-0038-8 · Cited by 119
Turban, S., & Hajduch, É. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.022 · Cited by 124
Yang, M. J., Wei, D., Mo, C., Zhang, J., Wang, X., Han, X., Wang, Z., & Xiao, H. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-104 · Cited by 122
Zammit, V. A. (2013) · Biochemical Journal · doi:10.1042/bj20121689 · Cited by 115
Zick, Y. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320812 · Cited by 116
An Unsuspected Metabolic Role for Atrial Natriuretic Peptides
Lafontan, M., Moro, C., Sengenès, C., Galitzky, J., Crampes, F., & Berlan, M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000183728.14712.d8 · Cited by 114
Wang, H., Knaub, L. A., Jensen, D. R., Young Jung, D., Hong, E.-G., Ko, H.-J., Coates, A. M., Goldberg, I. J., de la Houssaye, B. A., Janssen, R. C., et al. (2009) · Diabetes · doi:10.2337/db07-1839 · Cited by 91
Self-citationInducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice
Charbonneau, A., & Marette, A. (2010) · Diabetes · doi:10.2337/db09-1238 · Cited by 116
Selathurai, A., Kowalski, G. M., Burch, M. L., Sepulveda, P. V., Risis, S., Lee, R. S., Lamon, S., Meikle, P. J., Genders, A. J., McGee, S. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.001 · Cited by 109
Inhibition of ADRP prevents diet-induced insulin resistance
Varela, G. M., Antwi, D. A., Dhir, R. N., Yin, X., Singhal, N. S., Graham, M. J., Crooke, R. M., & Ahima, R. S. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90204.2008 · Cited by 113
Fullerton, M. D., Hakimuddin, F., Bonen, A., & Bakovic, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023846 · Cited by 112
Metadata
- Authors
- Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., Atcheson, B., White, M. F., Kraegen, E. W., & Shulman, G. I.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Garvan Institute of Medical Research (AU)
- Joslin Diabetes Center (US)
- Corresponding author
- Shulman, Gerald I.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 52
- Pages
- 50230-50236
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2130850001
- Cited by
- 1,561
- References
- 21
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 36 · 2023: 27 · 2022: 26 · 2021: 47 · 2020: 55 · 2019: 52 · 2018: 56 · 2017: 71 · 2016: 65 · 2015: 65 · 2014: 77 · 2013: 97 · 2012: 101
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P30 DK, DK-45735)
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01-DK40936, R01DK040936, P30DK045735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- fatty acids, insulin resistance, skeletal muscle, IRS-1, phosphatidylinositol 3-kinase, protein kinase C theta, diacylglycerol, fatty acyl-CoA, IRS-1 serine phosphorylation, IRS-1 tyrosine phosphorylation, glucose transport, lipid emulsions
- MeSH terms
- Animals, Diglycerides, Fat Emulsions, Intravenous, Fatty Acids, Nonesterified, Insulin, Kinetics, Male, Phosphoproteins, Phosphorylation, Rats, Wistar, Muscle, Skeletal, Phosphotyrosine, Phosphatidylinositol 3-Kinases, Rats, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
