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α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells
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“α-Synuclein can decrease p53 expression and transcriptional activity to protect neuronal cells from proapoptotic effectors, in contrast to the A53T mutant form of the protein, which is correlated with PD.222”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [222]
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β-Synuclein Inhibits α-Synuclein Aggregation
Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., & Masliah, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00462-7 · Cited by 398
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Cited by
Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L., & Lee, M. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4308-05.2006 · Cited by 684
Rego, A. C., & Oliveira, C. R. (2003) · Neurochemical Research · doi:10.1023/a:1025682611389 · Cited by 472
Zhou, W., & Freed, C. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507124200 · Cited by 346
Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps
Levy, O. A., Malagelada, C., & Greene, L. A. (2009) · Apoptosis · doi:10.1007/s10495-008-0309-3 · Cited by 287
Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease
Dev, K. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00140-0 · Cited by 263
Metadata
- Authors
- Alves da Costa, C., Paitel, E., Vincent, B., & Checler, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 52
- Pages
- 50980-50984
- ISSN
- 0021-9258
- Cited by
- 122
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 6528 d)
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- CoChat. (2026). Citation check: α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells. https://app.cochat.ai/papers/10.1074/jbc.m207825200
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- Alves da Costa, C., Paitel, E., Vincent, B., & Checler, F. (2002). α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m207825200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
