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Cited by 1,540

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics

Open access
Uhlén, Mathias, Björling, Erik, Agaton, Charlotta, Szigyarto, Cristina Al-Khalili, Amini, Bahram, Andersen, Elisabet, Andersson, Ann-Catrin, Angelidou, Pia, Asplund, Anna, Asplund, Caroline, Berglund, Lisa, Bergström, Kristina, Brumer, Harry, Cerjan, Dijana, Ekström, Marica, Elobeid, Adila, Eriksson, Cecilia, Fagerberg, Linn, Falk, Ronny, Fall, Jenny, Forsberg, Mattias, Björklund, Marcus Gry, Gumbel, Kristoffer, Halimi, Asif, Hallin, Inga, Hamsten, Carl, Hansson, Marianne, Hedhammar, My, Hercules, Görel, Kampf, Caroline, Larsson, Karin, Lindskog, Mats, Lodewyckx, Wald, Lund, Jan, Lundeberg, Joakim, Magnusson, Kristina, Malm, Erik, Nilsson, Peter, Ödling, Jenny, Oksvold, Per, Olsson, Ingmarie, Öster, Emma, Ottosson, Jenny, Paavilainen, Linda, Persson, Anja, Rimini, Rebecca, Rockberg, Johan, Runeson, Marcus, Sivertsson, Åsa, Sköllermo, Anna, Steen, Johanna, Stenvall, Maria, Sterky, Fredrik, Strömberg, Sara, Sundberg, Mårten, Tegel, Hanna, Tourle, Samuel, Wahlund, Eva, Waldén, Annelie, Wan, Jinghong, Wernérus, Henrik, Westberg, Joakim, Wester, Kenneth, Wrethagen, Ulla, Xu, Lan Lan, Hober, Sophia, Pontén, Fredrik·2005·Molecular & Cellular Proteomics
DOI 10.1074/mcp.m500279-mcp200
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Abstract

Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, approximately 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.

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Authors
Uhlén, M., Björling, E., Agaton, C., Szigyarto, C. A.-K., Amini, B., Andersen, E., Andersson, A.-C., Angelidou, P., Asplund, A., Asplund, C., Berglund, L., Bergström, K., Brumer, H., Cerjan, D., Ekström, M., Elobeid, A., Eriksson, C., Fagerberg, L., Falk, R., Fall, J., Forsberg, M., Björklund, M. G., Gumbel, K., Halimi, A., Hallin, I., Hamsten, C., Hansson, M., Hedhammar, M., Hercules, G., Kampf, C., Larsson, K., Lindskog, M., Lodewyckx, W., Lund, J., Lundeberg, J., Magnusson, K., Malm, E., Nilsson, P., Ödling, J., Oksvold, P., Olsson, I., Öster, E., Ottosson, J., Paavilainen, L., Persson, A., Rimini, R., Rockberg, J., Runeson, M., Sivertsson, Å., Sköllermo, A., Steen, J., Stenvall, M., Sterky, F., Strömberg, S., Sundberg, M., Tegel, H., Tourle, S., Wahlund, E., Waldén, A., Wan, J., Wernérus, H., Westberg, J., Wester, K., Wrethagen, U., Xu, L. L., Hober, S., & Pontén, F.
Venue
Molecular & Cellular Proteomics
Publisher
Elsevier BV
Published
2005-12
Volume
4
Issue
12
Pages
1920-1932
ISSN
1535-9476 (ISSN-L)
DOI
10.1074/mcp.m500279-mcp200
OpenAlex
W2106876831
Cited by
1,540
References
2
FWCI
19.13
Type
journal article
Language
en
Open access
hybrid

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