Abnormalities of connected speech in semantic dementia vs Alzheimer's disease
Abstract
Background: Neurodegenerative syndromes are associated with varying degrees of language impairment. Connected speech analysis provides the most realistic measure of language function but its use has been restricted by operational constraints. Aims: In this prospective study we assessed the relative utility of a picture description task and a semi-structured interview in exposing the language decline in semantic dementia (SD) and typical mild Alzheimer's disease (AD), compared to each other and to healthy volunteers. Methods & Procedures: Our cohort comprised 16 patients with a clinical diagnosis of SD, 20 with mild typical AD, and 30 healthy participants. All speech samples were recorded during a face-to-face interview and were subjected to a well-controlled quantitative analysis. Outcomes & Results: Our results suggest that (a) the picture description task is more sensitive to abnormalities in the semantic measures, whereas the interviews are better at exposing morpho-syntactic deficits; (b) circumlocution is not, as has sometimes been claimed, a salient feature of speech in SD; (c) increases in the frequency of hesitation markers and of phonological and syntactic errors are prominent features of language decline in mild AD; and (d) a 150-word interview sample is adequate to provide a realistic reflection of language impairment. Conclusions: This study compared, for the first time, the two most commonly used methods of eliciting connected speech and documented many similarities in results from the two but also some salient differences in their sensitivity to specific aspects of language deficit. In addition, although replicating some aspects such as anomia, of what is already known about the language impairments in these two conditions, the study provides novel findings for both that could help clinicians in syndromic classification of anomic speech.
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Patients with amnestic or non-amnestic AD presentations produced more inflectional errors and fewer tense-inflected verbs than HC.
“We and others have observed a similar finding in previous studies, 11 , 50 , 51 in which patients with amnestic or non‐amnestic AD presentations produced more inflectional errors (e.g., “She run” instead of “She runs”) and fewer tense‐inflected verbs than HC.”
From Automatic classification of AD pathology in FTD phenotypes using natural speech (2024) · cites this paper as [51]
Participants with the amnestic AD presentation produced more frequent inflectional errors than HC, whereas individuals with svPPA did not differ from HC.
“Other reports 51 have also found that participants with the amnestic AD presentation produced more frequent inflectional errors than HC, whereas individuals with svPPA did not differ from HC.”
From Automatic classification of AD pathology in FTD phenotypes using natural speech (2024) · cites this paper as [51]
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- Authors
- Sajjadi, S. A., Patterson, K., Tomek, M., & Nestor, P. J.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Nestor, Peter J.
- Venue
- Aphasiology
- Publisher
- Informa UK Limited
- Published
- 2012-02-07
- Volume
- 26
- Issue
- 6
- Pages
- 847-866
- ISSN
- 0268-7038 (ISSN-L)
- 1464-5041
- OpenAlex
- W2085275087
- Cited by
- 142
- References
- 61
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 21 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aphasiology (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- semantic dementia, Alzheimer's disease, connected speech, picture description task, semi-structured interviews, language loss, periphrasis, hesitation markers, phonological errors, syntactic errors, anomia
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