CoChat
Sign Up
Cited by 351Genetic Associations and EpidemiologyForensic and Genetic ResearchLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 215 of the 217 references it cites were found in a registry or an index.

APOE distribution in world populations with new data from India and the UK

Singh, P. P., Singh, M., Mastana, S. S.·2006·Annals of Human Biology
DOI 10.1080/03014460600594513
Open this paper in CoChat — free account

Abstract

Background The APOE gene and its protein product is associated with a number of plasma proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) chylomicrons, chylomicron remnants, and plays a crucial role in lipid metabolism. The APOE gene is polymorphic and common alleles (*E2, *E3 and *E4) have been associated with a number of common and complex diseases in different populations. Due to their crucial role in metabolism and clinical significance, it is imperative that allelic variation in different populations is analysed to evaluate the usage of APOE in an evolutionary and clinical context. Aim We report allelic variation at the APOE locus in three European and four Indian populations and evaluate global patterns of genetic variation at this locus. The large, intricate and unexpected heterogeneity of this locus in its global perspective may have insightful consequences, which we have explored in this paper. Subject and methods Apolipoprotein E genotypes were determined in four population groups (Punjabi Sikhs, Punjabi Hindus, Maria Gonds and Koch, total individuals = 497) of India and three regionally sub-divided British populations (Nottinghamshire, East Midlands and West Midlands, total individuals = 621). The extent and distribution of APOE allele frequencies were compared with 292 populations of the world using a variety of multivariate methods. Results Three alleles, APOE*E2, APOE*E3 and APOE*E4, were observed with contrasting variation, althou…

Overview

Integrity signals

Registry

Crossref · 10.1080/03014460600594513

Cites

215 of 215 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 217 references

Research works printed but not linked: 56

  1. Corbo RM, 1999, Is APOE*4 a ‘thrifty allele? Ann Hum Genet, 63, 301
  2. Dhawan J, 1998, Curr Sci, 74, 1060
  3. Mastana SS, 2000, Hum Biol, 72, 499
  4. Seixas S, 1999, Hum Biol, 71, 1001
  5. Vardan S, 1995, Indian Heart J, 47, 399
  6. Bercedo-Sanz A, 1998, An Esp Pediatr, 49, 120
  7. Boerwinkle E, 1988, Am J Hum Genet, 42, 104
  8. Boerwinkle E, 1991, Am J Hum Genet, 49, 1145
  9. Brega A, 1998, Hum Biol, 70, 715
  10. Chanprasertyothin S, 2000, J Med Assoc Thai, 83, 1233
  11. Chen BS, 1990, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 12, 223
  12. Corbo RM, 1995, Ann Hum Genet, 59, 197, 10.1111/j.1469-1809.1995.tb00741.x · DOI
  13. Crews DE, 1993, Hum Biol, 65, 211
  14. Csaszar A, 1995, Acta Biomed Ateneo Parmense, 66, 169
  15. Deka R, 1994, Hum Biol, 66, 805
  16. Fiol C, 1991, Clin Invest Arterioscler, 3, 130
  17. Gamboa R, 2000, Hum Biol, 72, 975
  18. Gerdes LU, 1996, Hum Genet, 98, 546, 10.1007/s004390050257 · DOI
  19. Gueguen R, 1989, Am J Hum Genet, 45, 793
  20. Hagve TA, 1993, Tidsskr Nor Laegeforen, 113, 853
  21. Hallman DM, 1991, Am J Hum Genet, 49, 338
  22. James RW, 1987, Schweiz Med Wochenschr, 117, 2021
  23. Kamboh MI, 1989, Dis Markers, 7, 49
  24. Kamboh MI, 1991, Hum Biol, 63, 179
  25. Kamboh MI, 1996, Hum Biol, 68, 231
  26. Kamboh MI, 1999, Genet Epidemiol, 16, 205, 10.1002/(SICI)1098-2272(1999)16:2<205::AID-GEPI7>3.0.CO;2-P · DOI
  27. Kim HS, 1998, Hum Hered, 48, 315
  28. Kowalska A, 1998, Hum Biol, 70, 1093
  29. Lahlali-Kacemi N, 2002, Ann Biol Clin (Paris), 60, 73
  30. Lai S, 2001, Zhonghua Liu Xing Bing Xue Za Zhi, 22, 202
  31. Lee DM, 2002, Taehan Kan Hakhoe Chi, 8, 355
  32. Liu HC, 2000, Neurology, 54, 2356
  33. Lucotte G, 1995, Alzheimer Res, 1, 145
  34. Mastana SS, 1998, Ann Hum Biol, 25, 137, 10.1080/03014469800005512 · DOI
  35. Pedersen JC, 1990, Clin Genet, 38, 227
  36. Petrovic D, 2000, Folia Biol (Krakow), 46, 131
  37. Robitaille N, 1996, Hum Biol, 68, 357
  38. Ruiu G, 1995, Aging, 7, 185
  39. Sayi JG, 1997, East Afr Med J, 74, 668
  40. Scacchi R, 1997, Hum Biol, 69, 375
  41. Schachter F, 1994, Nat Genet, 6, 29, 10.1038/ng0194-29 · DOI · Paper page
  42. Seixas S, 1999, Hum Biol, 71, 1001
  43. Senanarong V, 2001, J Med Assoc Thai, 84, 182
  44. Sepehrnia B, 1988, Am J Hum Genet, 43, 847
  45. Singh PP, 2001, Anthropol Anz, 59, 27, 10.1127/anthranz/59/2001/27 · DOI
  46. Singh PP, 2002, Hum Biol, 74, 673, 10.1353/hub.2002.0057 · DOI
  47. Tai DY, 1999, Zhonghua Yi Xue Za Zhi, 62, 133
  48. Tsukamoto K, 1993, J Lab Clin Med, 121, 598
  49. Vickers JC, 2002, Mol Vis, 8, 389
  50. Willis F, 2003, J Natl Med Assoc, 95, 71
  51. Wu YN, 2001, Zhongua Yi Xue Ki Xue YuanXue Bao, 23, 450
  52. Zajickova K, 2003, J Endocrinol Res, 26, 312
  53. Zannis VI, 1984, Adv Hum Genet, 14, 125
  54. Zekraoui L, 1997, Hum Biol, 69, 575
  55. Zhang JG, 1999, Zhongguo Yao Li Xue Bao, 20, 218
  56. Zhu W, 2001, ZhonghuaYu Fang Yi Xue Za Zhi, 35, 297

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Singh, P. P., Singh, M., & Mastana, S. S.
Affiliations
  • Punjabi University (IN)
  • Loughborough University (GB)
Corresponding author
Mastana, S. S.
ORCID
Venue
Annals of Human Biology
Publisher
Informa UK Limited
Published
2006-01
Volume
33
Issue
3
Pages
279-308
ISSN
  • 0301-4460 (ISSN-L)
  • 1464-5033
DOI
10.1080/03014460600594513
OpenAlex
W2065859331
Cited by
351
References
217
Citations by year
2026: 13 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 21 · 2021: 23 · 2020: 24 · 2019: 24 · 2018: 21 · 2017: 14 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 13 · 2012: 16
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Human Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Loughborough University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
apolipoprotein E, APOE alleles, allele frequency, genetic variation, population genetics, APOE ε4, heterozygosity, Punjabi Sikhs, British population, gene differentiation, lipid metabolism
MeSH terms
Apolipoproteins E, Gene Frequency, Genetics, Population, Genotype, United Kingdom, Humans, India, Genetic Variation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review