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Cited by 351Genetic Associations and EpidemiologyForensic and Genetic ResearchLipoproteins and Cardiovascular Health

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APOE distribution in world populations with new data from India and the UK

Singh, P. P., Singh, M., Mastana, S. S.·2006·Annals of Human Biology
DOI 10.1080/03014460600594513
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Abstract

Background The APOE gene and its protein product is associated with a number of plasma proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) chylomicrons, chylomicron remnants, and plays a crucial role in lipid metabolism. The APOE gene is polymorphic and common alleles (*E2, *E3 and *E4) have been associated with a number of common and complex diseases in different populations. Due to their crucial role in metabolism and clinical significance, it is imperative that allelic variation in different populations is analysed to evaluate the usage of APOE in an evolutionary and clinical context. Aim We report allelic variation at the APOE locus in three European and four Indian populations and evaluate global patterns of genetic variation at this locus. The large, intricate and unexpected heterogeneity of this locus in its global perspective may have insightful consequences, which we have explored in this paper. Subject and methods Apolipoprotein E genotypes were determined in four population groups (Punjabi Sikhs, Punjabi Hindus, Maria Gonds and Koch, total individuals = 497) of India and three regionally sub-divided British populations (Nottinghamshire, East Midlands and West Midlands, total individuals = 621). The extent and distribution of APOE allele frequencies were compared with 292 populations of the world using a variety of multivariate methods. Results Three alleles, APOE*E2, APOE*E3 and APOE*E4, were observed with contrasting variation, althou…

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Metadata

Authors
Singh, P. P., Singh, M., & Mastana, S. S.
Affiliations
  • Punjabi University (IN)
  • Loughborough University (GB)
Corresponding author
Mastana, S. S.
ORCID
Venue
Annals of Human Biology
Publisher
Informa UK Limited
Published
2006-01
Volume
33
Issue
3
Pages
279-308
ISSN
  • 0301-4460 (ISSN-L)
  • 1464-5033
DOI
10.1080/03014460600594513
OpenAlex
W2065859331
Cited by
351
References
217
Citations by year
2026: 13 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 21 · 2021: 23 · 2020: 24 · 2019: 24 · 2018: 21 · 2017: 14 · 2016: 22 · 2015: 16 · 2014: 19 · 2013: 13 · 2012: 16
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Human Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Loughborough University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
apolipoprotein E, APOE alleles, allele frequency, genetic variation, population genetics, APOE ε4, heterozygosity, Punjabi Sikhs, British population, gene differentiation, lipid metabolism
MeSH terms
Apolipoproteins E, Gene Frequency, Genetics, Population, Genotype, United Kingdom, Humans, India, Genetic Variation

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