The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
Abstract
The last decade has seen tremendous progress in our understanding of the organization and function of the circadian clock. A number of so-called clock genes were discovered, and these genes and their protein products were shown to organize into feedback loops to give a near 24 h rhythmicity. However, the mechanism is much more complicated. First, many new clock components have been identified, increasing both our understanding and the overall complexity of the mechanism. Second, there is now evidence that transcription may not play a central role in determining the functioning of the clock: the identification of post-translational modifications of the clock proteins has revealed new levels of control. Finally, chromatin remodeling seems to be crucial in the regulation of the expression of major clock components. This review describes the recent advances in our knowledge of the molecular clockwork in mammals; in particular, the contribution of new clock components and of post-transcriptional and post-translational events to circadian timekeeping are discussed.
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Citations
Cites
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Cited by
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
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“In turn, REVERBs and RORs inhibit and activate, respectively, the rhythmic transcription ofBmal1 andClock (54, 56).”
The circadian clock and pathology of the ageing brain
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Health Consequences of Circadian Disruption in Humans and Animal Models
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Metadata
- Authors
- Dardente, H., Dardente, H., & Cermakian, N.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 24
- Issue
- 2
- Pages
- 195-213
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2136645014
- Cited by
- 289
- References
- 15
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
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