Cannabinoids and appetite: food craving and food pleasure

Kirkham, Tim C.

doi:10.1080/09540260902782810

Cited by 189Cannabis and Cannabinoid ResearchRegulation of Appetite and ObesityEating Disorders and Behaviors

Cannabinoids and appetite: food craving and food pleasure

Kirkham, Tim C.·2009·International Review of Psychiatry

DOI 10.1080/09540260902782810

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Abstract

The ability of Cannabis sativa to promote eating has been documented for many centuries, with the drug reported by its users to promote strong cravings for, and an intensification of the sensory and hedonic properties of food. These effects are now known to result from the actions of cannabinoid molecules at specific cannabinoid receptor sites within the brain, and to reflect the physiological role of their natural ligands, the endocannabinoids, in the control of appetite. Recent developments in the biochemistry and pharmacology of endocannabinoid systems have generated convincing evidence from animal models for a normal role of endocannabinoids in the control of eating motivation. The availability of specific cannabinoid receptor agonists and antagonists raises the possibility of improved therapies for disorders of eating and body weight: not only in the suppression of appetite to counter our susceptibility to the over-consumption of highly pleasurable and energy-dense foods; but also in the treatment of conditions that involve reduced appetite and weight loss. Here, we outline some of the findings of the past decade that link endocannabinoid function appetite control, and the possible clinical applications of that knowledge.

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Cannabinoids increase food craving and calorie intake.
“A well-known effect of cannabinoids is increased food craving and calorie intake (Kirkham, 2009).”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Kirkham, 2009

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
Cota, D., Marsicano, G., Tschöp, M. H., Grübler, Y., Flachskamm, C., Schubert, M. I., Auer, D. P., Yassouridis, A., Thöne‐Reineke, C., Ortmann, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17725 · Cited by 1,168 · see citing works
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
Osei‐Hyiaman, D., DePetrillo, M. A., Pacher, P., Liu, J., Radaeva, S., Bátkai, S., Harvey-White, J. D., Mackie, K., Offertáler, L., Wang, L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23057 · Cited by 1,103 · see citing works
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Christensen, R., Kristensen, P. K., Bartels, E. M., Bliddal, H., & Astrup, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61721-8 · Cited by 1,097 · see citing works
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol
Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works
Self-citation
Endocannabinoid control of food intake and energy balance
Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 746 · see citing works
An anorexic lipid mediator regulated by feeding
de Fonseca, F. R., Navarro, M. A., de Heras, R. G., Escuredo, L., Nava, F. A., Fu, J., Murillo‐Rodríguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., et al. (2001) · Nature · doi:10.1038/35102582 · Cited by 695 · see citing works
Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors
Arnone, M., Maruani, J., Chaperon, F., Thiébot, M.-H., Poncelet, M., Soubrié, P., & Fur, G. L. (1997) · Psychopharmacology · doi:10.1007/s002130050326 · Cited by 593 · see citing works
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
Ravinet‐Trillou, C., Arnone, M., Delgorge, C., Gonalons, N., Keane, P., Maffrand, J., & Soubrié, P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00545.2002 · Cited by 565 · see citing works
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
Williams, C. M., & Kirkham, F. J. (1999) · Psychopharmacology · doi:10.1007/s002130050953 · Cited by 508 · see citing works
Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
Beal, J. E., Olson, R., Laubenstein, L., Morales, J. O., Bellman, P., Yangco, B., Lefkowitz, L., Plasse, T. F., & Shepard, K. V. (1995) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(94)00117-4 · Cited by 504 · see citing works
Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
Colombo, G., Agabio, R., Diaz, G., Lobina, C., Reali, R., & Gessa, G. L. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00322-1 · Cited by 486 · see citing works
A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding
Gómez, R., Navarro, M., Ferrer, B., Trigo, J. M., Bilbao, A., del Arco, I., Cippitelli, A., Nava, F. A., Piomelli, D., & de Fonseca, F. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09612.2002 · Cited by 486 · see citing works
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
Jamshidi, N., & Taylor, D. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704379 · Cited by 466 · see citing works
Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes
Peciña, S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02102-8 · Cited by 405 · see citing works
Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · cited 4× · see citing works
“That accumbens endocannabinoids can enhance the hedonic impact of sweet taste is directly supported by the finding that intra-AcbSh administration of anandamide specifically increases the number of positive ingestive responses to intra-oral infusions of sweet solutions in taste reactivity tests (Mahler et al., 2007).”
BackgroundInfluential
The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish.
Gaoni, Y., & Mechoulam, R. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00730a036 · Cited by 364 · see citing works
Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
Artmann, A., Petersen, G. L., Hellgren, L. I., Boberg, J., Skonberg, C., Nellemann, C., Hansen, S. H., & Hansen, H. S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.01.006 · Cited by 323 · see citing works
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
van der Stelt, M., & Marzo, V. D. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.101 · Cited by 286 · see citing works
Taste responses and preferences for sweet high-fat foods: Evidence for opioid involvement☆
Drewnowski, A., Krahn, D. D., Demitrack, M. A., NAIRN, K., & Gosnell, B. A. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90155-u · Cited by 286 · see citing works
The endocannabinoid system in obesity and type 2 diabetes
Marzo, V. D. (2008) · Diabetologia · doi:10.1007/s00125-008-1048-2 · Cited by 280 · see citing works
Blood Levels of the Endocannabinoid Anandamide are Increased in Anorexia Nervosa and in Binge-Eating Disorder, but not in Bulimia Nervosa
Monteleone, P., Matias, I., Martiadis, V., PETROCELLIS, L. D., Maj, M., & Marzo, V. D. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300695 · Cited by 272 · see citing works
Handbook of experimental pharmacology
DIX, C. J. (1984) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(84)90179-5 · Cited by 268 · see citing works
SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset.
Simiand, J., Keane, M., Keane, P. E., & Soubrié, P. (1998) · PubMed · Cited by 264 · see citing works
Hyperphagia in pre-fed rats following oral δ9-THC
Williams, C. M., Rogers, P. J., & Kirkham, T. C. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00170-x · Cited by 258 · see citing works
Self-citation
Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
Sipe, J. C., Waalen, J., Gerber, A., & Beutler, E. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802954 · Cited by 257 · see citing works
Marijuana Intoxication : Common Experiences
TART, C. T. (1970) · Nature · doi:10.1038/226701a0 · Cited by 252 · see citing works
Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N -acylethanolamines in piglets
Berger, A., Crozier, G. L., Bisogno, T., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101119098 · Cited by 247 · see citing works
The endocannabinoid system in brain reward processes
Solinas, M., Goldberg, S. R., & Piomelli, D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.130 · Cited by 243 · see citing works
Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist
Gallate, J. E., Saharov, T., Mallet, P. E., & McGregor, I. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00170-3 · Cited by 235 · see citing works
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
Solinas, M., Justinová, Z., Goldberg, S. R., & Tanda, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03880.x · Cited by 229 · see citing works
Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice
Hao, S., Avraham, Y., Mechoulam, R., & Berry, E. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00059-5 · Cited by 229 · see citing works
Recent clinical experience with dronabinol
Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., & Wadleigh, R. G. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90385-f · Cited by 225 · see citing works
Endocannabinoids in the regulation of appetite and body weight
Kirkham, T. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00004 · Cited by 220 · see citing works
Self-citation
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
Vickers, S. P., Webster, L. J., Wyatt, A. C., Dourish, C. T., & Kennett, G. A. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1384-8 · Cited by 207 · see citing works
The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716
Gallate, J. E., & McGregor, I. S. (1999) · Psychopharmacology · doi:10.1007/s002130050893 · Cited by 199 · see citing works
Efficacy and Safety of Rimonabant for Improvement of Multiple Cardiometabolic Risk Factors in Overweight/Obese Patients
Gaal, L. V., Pi‐Sunyer, X., Després, J., McCarthy, C., & Scheen, A. J. (2008) · Diabetes Care · doi:10.2337/dc08-s258 · Cited by 198 · see citing works
Observational analysis of feeding induced by Δ9-THC and anandamide
Williams, C. M., & Kirkham, T. C. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00725-4 · Cited by 194 · see citing works
Self-citation
The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin
Tucci, S. A., Rogers, E. K., Korbonits, M., & Kirkham, T. C. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705968 · Cited by 183 · see citing works
Self-citation
Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice
Hildebrandt, A. L., Kelly-Sullivan, D., & Black, S. C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01343-8 · Cited by 181 · see citing works
Motivational Effects of Cannabinoids and Opioids on Food Reinforcement Depend on Simultaneous Activation of Cannabinoid and Opioid Systems
Solinas, M., & Goldberg, S. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300720 · Cited by 174 · see citing works
Endogenous opioids and feeding behavior: a 30-year historical perspective
Bodnar, R. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.01.006 · Cited by 170 · see citing works
Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice
Poncelet, M., Maruani, J., Calassi, R., & Soubrié, P. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00397-5 · Cited by 159 · see citing works
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c‐Fos expression in the hypothalamus
Gómez, E. S., Matias, I., Rueda‐Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L., Marzo, V. D., & Prospero-Garcia, O. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707313 · Cited by 158 · see citing works
Reduced sensitivity to reward in CB1 knockout mice
Sanchis‐Segura, C., Cline, B. H., Marsicano, G., Lutz, B., & Spanagel, R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1877-8 · Cited by 158 · see citing works
Reversal of Δ9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine
Williams, C. M., & Kirkham, T. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00694-3 · Cited by 158 · see citing works
Self-citation
Synergistic efects of opioid and cannabinoid antagonists on food intake
Kirkham, T. C., & Williams, C. M. (2001) · Psychopharmacology · doi:10.1007/s002130000596 · Cited by 156 · see citing works
Self-citation
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after Δ9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716
Higgs, S., Williams, C. M., & Kirkham, T. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1263-3 · Cited by 154 · see citing works
Self-citation
The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food
Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A., & Melis, M. R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.012 · Cited by 138 · see citing works
A Double-Blind Trial of ??9-Tetrahydrocannabinol in Primary Anorexia Nervosa
Gross, H. A., Ebert, M. H., Faden, V. B., Goldberg, S. C., Kaye, W. H., Caine, E. D., Hawks, R. L., & Zinberg, N. E. (1983) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198306000-00004 · Cited by 133 · see citing works
Selective effects of naltrexone on food pleasantness and intake
Yeomans, M. R., & Gray, R. W. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80017-5 · Cited by 133 · see citing works
Trick or treat from food endocannabinoids?
Marzo, V. D., Sepe, N., PETROCELLIS, L. D., et al. (1998) · Nature · doi:10.1038/25267 · Cited by 132 · see citing works
Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
Harrold, J. A., Elliott, J. C., King, P., Widdowson, P. S., & Williams, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03245-6 · Cited by 130 · see citing works
Dronabinol and marijuana in HIV+ marijuana smokers: acute effects on caloric intake and mood
Haney, M., Rabkin, J., Gunderson, E., & Foltin, R. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2242-2 · Cited by 126 · see citing works
Naloxone attenuation of sham feeding is modified by manipulation of sucrose concentration
Kirkham, T. C., & Cooper, S. J. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90310-1 · Cited by 125 · see citing works
Self-citation
Activating Parabrachial Cannabinoid CB 1 Receptors Selectively Stimulates Feeding of Palatable Foods in Rats
DiPatrizio, N. V., & Simansky, K. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1171-08.2008 · Cited by 124 · see citing works
Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre‐ and Postnatal Development
Fride, E. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01670.x · Cited by 121 · see citing works
Endocannabinoids and Food Intake: Newborn Suckling and Appetite Regulation in Adulthood
Fride, E., Bregman, T., & Kirkham, T. C. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000401 · Cited by 111 · see citing works
Self-citation
Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men
Russo, P., Strazzullo, P., Cappuccio, F. P., Trégouët, D., Lauria, F., Loguercio, M., Barba, G., Versiero, M., & Siani, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2523 · Cited by 105 · see citing works
Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and bingeing/purging subtypes
Siegfried, Z., Kanyas, K., Latzer, Y., Karni, O., Bloch, M., Lerer, B., & Berry, E. M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20089 · Cited by 100 · see citing works
β‐Endorphin elevations in the ventral tegmental area regulate the discriminative effects of Δ‐9‐tetrahydrocannabinol
Solinas, M., Zangen, A., Thiriet, N., & Goldberg, S. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03420.x · Cited by 83 · see citing works
Effect of Δ9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test
Jarrett, M. M., Limebeer, C. L., & PARKER, L. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.033 · Cited by 81 · see citing works
Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population
Gazzerro, P., Caruso, M. G., Notarnicola, M., Misciagna, G., Guerra, V., Laezza, C., & Bifulco, M. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803510 · Cited by 76 · see citing works
Cannabinoid agonist, CP 55,940, facilitates intake of palatable foods when injected into the hindbrain
Miller, C. C., Murray, T. F., Freeman, K. G., & Edwards, G. L. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.10.019 · Cited by 74 · see citing works
Opioid Mechanisms in the Control of Food Consumption and Taste Preferences
Cooper, S. J., & Kirkham, T. C. (1993) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-77540-6_10 · Cited by 69 · see citing works
Self-citation
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats
Werner, N. A., & Koch, J. E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04274-9 · Cited by 61 · see citing works
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice
Chen, R. Z., Huang, R. R., Shen, C.-P., MacNeil, D. J., & Fong, T. M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.004 · Cited by 60 · see citing works
Food Cravings and Addiction
Shepherd, R. (2002) · Appetite · doi:10.1006/appe.2002.0491 · Cited by 58 · see citing works
Grooming, scratching and feeding: role of response competition in acute anorectic response to rimonabant in male rats
Tallett, A. J., Blundell, J. E., & Rodgers, R. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0880-2 · Cited by 53 · see citing works
Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders
Berridge, K. C. (2007) · Elsevier eBooks · doi:10.1016/b978-012370633-1/50008-6 · Cited by 48 · see citing works
Effect of Δ9-tetrahydrocannabinol on quinine palatability and AM251 on sucrose and quinine palatability using the taste reactivity test
Jarrett, M. M., Scantlebury, J., & Parker, L. A. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.10.003 · Cited by 46 · see citing works
Cannabinoid Type‐1 Receptor Gene Polymorphisms Are Associated with Central Obesity in a Southern Brazilian Population
Jaeger, J. P., Mattevi, V. S., Callegari-Jacques, S. M., & Hutz, M. H. (2008) · Disease Markers · doi:10.1155/2008/841490 · Cited by 45 · see citing works
Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs
Bessesen, D. H. (2007) · Obesity Management · doi:10.1089/obe.2007.0072 · Cited by 44 · see citing works
Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation
Bivens, C. L. M., Thomas, W. J., & Stanley, B. G. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01289-4 · Cited by 44 · see citing works
Enhanced anorectic potency of naloxone in rats sham feeding 30% sucrose: Reversal by repeated naloxone administration
Kirkham, T. C. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90103-b · Cited by 40 · see citing works
Self-citation
Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice
Avraham, Y., Menachem, A. B., Okun, A., Zlotarav, O., Abel, N., Mechoulam, R., & Berry, E. M. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.12.002 · Cited by 40 · see citing works
Endocannabinoids: Some Like it Fat (and Sweet Too)
Matias, I., Cristino, L., & Marzo, V. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01678.x · Cited by 40 · see citing works
Appetite and body weight : integrative systems and the development of anti-obesity drugs
Kirkham, T. C., & Cooper, S. J. (2007) · Cited by 37 · see citing works
Self-citation
Acute anorectic response to cannabinoid CB1 receptor antagonist/inverse agonist AM 251 in rats: indirect behavioural mediation
Tallett, A. J., Blundell, J. E., & Rodgers, J. R. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282eff0a9 · Cited by 32 · see citing works
Activity of SH141716 on post-reinforcement pauses in operant responding for sucrose reward in rats
Perio, A., Barnouin, M. C., Poncelet, M., & Soubrié, P. (2001) · Behavioural Pharmacology · doi:10.1097/00008877-200112000-00009 · Cited by 29 · see citing works
Behavioural pharmacology
Doble, A., Martin, I. L., & Nutt, D. (2020) · CRC Press eBooks · doi:10.4324/9781003076407-6 · Cited by 28 · see citing works
[Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: overview of RIO studies].
Scheen, A. J., Gaal, L. G. V., Després, J., Pi-Sunyer, X., Golay, A., & Hanotin, C. (2006) · PubMed · Cited by 21 · see citing works
The Role of Palatability in Control of Human Appetite
Yeomans, M. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012370633-1/50010-4 · Cited by 16 · see citing works
The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems Regulating Food Intake
Stratford, T. R. (2007) · Elsevier eBooks · doi:10.1016/b978-012370633-1/50003-7 · Cited by 12 · see citing works
Le rimonabant améliore le profil de risque cardio-métabolique chez le sujet obèse ou en surpoids: synthèse des études «RIO»
Scheen, A. J., Gall, L. G. V., Després, J., et al. (2006) · Revue Médicale Suisse · doi:10.53738/revmed.2006.2.76.1916 · Cited by 5 · see citing works
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Authors: Kirkham, T. C.
Affiliations: University of Liverpool (GB)
Corresponding author: Kirkham, Tim C.
Venue: International Review of Psychiatry
Publisher: Informa UK Limited
Published: 2009-01
Volume: 21
Issue: 2
Pages: 163-171
ISSN: 0954-0261 (ISSN-L)
1369-1627
DOI: 10.1080/09540260902782810
OpenAlex: W2149074955
Cited by: 189
References: 85
Citations by year: 2026: 4 · 2025: 11 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 33 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 12 · 2015: 6 · 2014: 12 · 2013: 4 · 2012: 11
FWCI: 8.38
Type: journal article
Language: en
Open access: closed
Locations: International Review of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: cannabinoids, appetite regulation, food cravings, food enjoyment, endocannabinoid system, cannabinoid receptors, eating motivation, Cannabis sativa, eating disorders, obesity, weight loss, appetite suppressants, energy-dense foods
MeSH terms: Animals, Appetite, Brain, Cannabinoids, Feeding Behavior, Humans, Motivation, Receptors, Cannabinoid, Cannabinoid Receptor Modulators

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Cannabinoids and appetite: food craving and food pleasure

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