Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes

Peciña, Susana; Berridge, Kent C

doi:10.1016/s0006-8993(00)02102-8

Cited by 405Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes

Peciña, Susana, Berridge, Kent C·2000·Brain Research

DOI 10.1016/s0006-8993(00)02102-8

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Abstract

Microinjection of opioid agonists, such as morphine, into the nucleus accumbens shell produces increases in eating behavior (i.e. 'wanting' for food). This study (1) reports direct evidence that activation of accumbens opioid receptors in rats also augments food 'liking', or the hedonic impact of taste, and (2) identified a neural site that definitely contains receptors capable of increasing food intake. Morphine microinjections (0.5 microgram) into accumbens shell, which caused rats to increase eating, were found also to cause selective increases in positive hedonic patterns of behavioral affective reaction elicited by oral sucrose, using the 'taste reactivity' test of hedonic palatability. This positive shift indicated that morphine microinjections enhanced the hedonic impact of food palatability. The accumbens site mediating morphine-induced increases in food 'wanting' and 'liking' was identified using a novel method based on local expression of Fos induced directly by drug microinjections. The plume-shaped region of drug-induced increase in Fos immunoreactivity immediately surrounding a morphine microinjection site (Fos plume) was objectively mapped. A point-sampling procedure was used to measure the shape and size of 'positive' plumes of Fos expression triggered by microinjections of morphine at locations that caused increases in eating behavior. This revealed a functionally 'positive' neural region, containing receptors directly activated by behaviorally-effective drug microinjections. A subtraction mapping procedure was then used to eliminate all surrounding regions containing any 'negative' Fos plumes that failed to increase food intake. The subtraction produced a conservative map of the positive site, by eliminating regions that gave mixed effects, and leaving only a positive region that must contain receptors capable of mediating increases in food intake. The resulting mapped 'opioid eating site' was contained primarily within the medial caudal subregion of the nucleus accumbens shell, and did not substantially penetrate either into the accumbens core or into other subregions of the shell. Several other structures outside the nucleus accumbens (such as rostral ventral pallidum), immediately medial and adjacent to the shell, also appeared to be included in the functional site. Opioid receptors within this site thus are capable of mediating morphine-induced increases in eating, in part by enhancing the hedonic reward properties of food.

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Pharmacological control of the output from the NAc shell can have profound effects on food consumption, as does surgical or chemical lesion of the nigrostriatal or mesolimbic DA pathways.
“Pharmacological control of the output from the NAc shell can also have profound effects on food consumption [312,313], as does surgical or chemical lesion of the nigrostriatal or mesolimbic DA pathways.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [312]
MOR and DOR mediate generally positive motivation and affect, while KOR mediates generally negative motivation and aversion.
“Nonetheless, the three receptor types have different behavioral domains, with MOR and DOR mediating generally positive motivation and affect, while KOR mediates generally negative motivation and aversion (Pfeiffer et al 1986; Shippenberg et al 1987; Pecina and Berridge 2000; McLaughlin et al 2003; for reviews see Van Ree et al 2000; Le Merrer et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Pecina and Berridge 2000
Microinjections of opiate into the nucleus accumbens increased food intake and the reward value of food.
“Furthermore, microinjections of opiate into the nucleus accumbens increased food intake and the reward value of food (5).”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [5]

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Untitled work
(1996) · doi:10.1002/(sici)1096-9861(19960219)365:4

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Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates.
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Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
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The Brain, Appetite, and Obesity
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The neurobiology of positive emotions
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Nucleus Accumbens Neurons Are Innately Tuned for Rewarding and Aversive Taste Stimuli, Encode Their Predictors, and Are Linked to Motor Output
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Hedonic Hot Spots in the Brain
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Dopamine modulates the reward experiences elicited by music
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The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
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Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
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“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
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Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
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Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue
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D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
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Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue‐triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for <scp>PIT</scp> enhancement
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High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating
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Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?
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Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens
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Cannabinoids and appetite: food craving and food pleasure
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Optogenetic Excitation of Central Amygdala Amplifies and Narrows Incentive Motivation to Pursue One Reward Above Another
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Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley
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Affective Influence on Judgments and Decisions: Moving towards Core Mechanisms
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Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration
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Appetite and reward
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Special Review: Decision Utility, The Brain, and Pursuit of Hedonic Goals
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Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
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The hedonic impact and intake of food are increased by midazolam microinjection in the parabrachial nucleus
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Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
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Increased food intake after opioid microinjections into nucleus accumbens and ventral tegmental area of rat
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Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting”
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Self-citation

Authors: Peciña, S., & Berridge, K. C.
Affiliations: University of Michigan (US)
Corresponding author: Berridge, Kent C
ORCID: Berridge, Kent C
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-04
Volume: 863
Issue: 1-2
Pages: 71-86
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(00)02102-8
OpenAlex: W2053400076
Cited by: 405
References: 94
Citations by year: 2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 55 · 2019: 16 · 2018: 17 · 2017: 13 · 2016: 10 · 2015: 18 · 2014: 19 · 2013: 17 · 2012: 20
FWCI: 4.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: nucleus accumbens shell, opioid receptors, morphine, dietary intake, food liking, desire to eat, taste reactivity, functional mapping, reward, dietary habits
MeSH terms: Animals, Brain Mapping, Drug Interactions, Eating, Male, Microinjections, Morphine, Narcotics, Nucleus Accumbens, Receptors, Opioid, Reward, Sucrose, Taste, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Rats

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Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes

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