Cited by 142Probiotics and Fermented FoodsGut microbiota and healthTryptophan and brain disorders

Psychobiotics: A new approach for treating mental illness?

Misra, Snigdha, Mohanty, Debapriya·2019·Critical Reviews in Food Science and Nutrition

Abstract

Gut microbiomes may have a significant impact on mood and cognition, which is leading experts towards a new frontier in neuroscience. Studies have shown that increase in the amount of good bacteria in the gut can curb inflammation and cortisol level, reduces symptoms of depression and anxiety, lowers stress reactivity, improves memory and even lessens neuroticism and social anxiety. This shows that, probably the beneficial gut bacteria or probiotics function mechanistically as delivery vehicles for neuroactive compounds. Thus, a psychobiotic is a live organism, when ingested in adequate amounts, produces a health benefit in patients suffering from psychiatric illness. Study of these novel class of probiotics may open up the possibility of rearrangement of intestinal microbiota for effective management of various psychiatric disorders.

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Registry

Crossref · 10.1080/10408398.2017.1399860

Cites

49 of 49 references verified0 citation errors · 0 not checkable

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  • The gut microbiota is involved in modulating the expression of neurochemical receptors and modulating the brain-gut axis, leading to psychotropic, antidepressant, and anxiolytic effects.

    “The gut microbiota is also involved in modulating the expression of neurochemical receptors and modulating the brain-gut axis, leading to psychotropic, antidepressant, and anxiolytic effects [236].”
  • Psychobiotics exert antidepressant effects by altering emotional, cognitive, and neuronal indices.

    “These act through the brain-gut axis, and exert antidepressant effects by altering emotional, cognitive, and neuronal indices [236,239].”

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Authors
Misra, S., & Mohanty, D.
Affiliations
  • IMU University (MY)
  • Odisha University of Agriculture and Technology (IN)
Corresponding author
Misra, Snigdha
Venue
Critical Reviews in Food Science and Nutrition
Published
2017-11-30
Volume
59
Issue
8
Pages
1230-1236
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2771183037
Cited by
142
References
49
Citations by year
2026: 15 · 2025: 16 · 2024: 19 · 2023: 24 · 2022: 21 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 11
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
psychobiotics, gut microbiota, probiotics, mental illness, depression, anxiety, stress reactivity, neuroinflammation, cortisol, neuroactive compounds, memory, social anxiety, neuroticism
MeSH terms
Gastrointestinal Microbiome, Animals, Bacteria, Mental Disorders, Brain, Cognition, Depression, Humans, Neuropsychology, Bacterial Physiological Phenomena, Probiotics

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