Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model
Open accessAbstract
Myocardial infarction (MI) in rats is accompanied by apoptosis in the limbic system and a behavioural syndrome similar to models of depression. We have already shown that probiotics can reduce post-MI apoptosis and designed the present study to determine if probiotics can also prevent post-MI depressive behaviour. We also tested the hypothesis that probiotics achieve their central effects through changes in the intestinal barrier. MI was induced in anaesthetised rats via 40-min transient occlusion of the left anterior coronary artery. Sham rats underwent the same surgical procedure without actual coronary occlusion. For 7 d before MI and between the seventh post-MI day and euthanasia, half the MI and sham rats were given one billion live bacterial cells of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 per d dissolved in water, while the remaining animals received only the vehicle (maltodextrin). Depressive behaviour was evaluated 2 weeks post-MI in social interaction, forced swimming and passive avoidance step-down tests. Intestinal permeability was evaluated by oral administration with fluorescein isothiocyanate–dextran, 4 h before euthanasia. MI rats displayed less social interaction and impaired performance in the forced swimming and passive avoidance step-down tests compared to the sham controls ( P < 0·05). Probiotics reversed the behavioural effects of MI ( P < 0·05), but did not alter the behaviour of sham rats. Intestinal permeability was increased in MI rats and reversed by probiotics. In conclusion, L. helveticus R0052 and B. longum R0175 combination interferes with the development of post-MI depressive behaviour and restores intestinal barrier integrity in MI rats.
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In laboratory rats subjected to experimental myocardial infarction, the same probiotic combination reduced the increase in intestinal permeability and stress-induced cerebral apoptosis.
“When administered to laboratory rats subjected to experimental myocardial infarction, the same probiotic combination reduced the increase in intestinal permeability127 and stress-induced cerebral apoptosis128 found in animals that underwent infarction without probiotic pretreatment.”
From The Gut Microbiome and the Brain (2014) · cites this paper as [127]
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- Authors
- Arseneault-Bréard, J., Rondeau, I., Gilbert, K., Girard, S.-A., Tompkins, T. A., Godbout, R., & Rousseau, G.
- Affiliations
- Hôpital du Sacré-Cœur de Montréal (CA)
- Lallemand (Canada) (CA)
- Corresponding author
- Rousseau, Guy
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-09-21
- Volume
- 107
- Issue
- 12
- Pages
- 1793-1799
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2163151823
- Cited by
- 205
- References
- 46
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 15 · 2023: 17 · 2022: 30 · 2021: 19 · 2020: 18 · 2019: 12 · 2018: 19 · 2017: 15 · 2016: 14 · 2015: 13 · 2014: 10 · 2013: 3 · 2012: 3
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada (250234-07)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, Lactobacillus helveticus R0052, myocardial infarction, post-myocardial infarction depression, intestinal permeability, intestinal barrier integrity, gut-brain axis, social interaction, forced swim test, passive avoidance, apoptosis, coronary artery occlusion
- MeSH terms
- Animals, Avoidance Learning, Behavior, Animal, Bifidobacterium, Depression, Dextrans, Disease Models, Animal, Interpersonal Relations, Intestinal Diseases, Intestines, Myocardial Infarction, Permeability, Swimming, Fluorescein-5-isothiocyanate, Rats, Sprague-Dawley, Probiotics, Rats, Lactobacillus helveticus, Coronary Occlusion
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