Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability

Qian, Yong; Ducatman, Alan; Ward, Rebecca; Leonard, Steve; Bukowski, Valerie; Lan Guo, Nancy; Shi, Xianglin; Vallyathan, Val; Castranova, Vincent

doi:10.1080/15287391003689317

Cited by 193Per- and polyfluoroalkyl substances researchFluorine in Organic ChemistryPeroxisome Proliferator-Activated Receptors

Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability

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Qian, Yong, Ducatman, Alan, Ward, Rebecca, Leonard, Steve, Bukowski, Valerie, Lan Guo, Nancy, Shi, Xianglin, Vallyathan, Val +1 more·2010·Journal of Toxicology and Environmental Health, Part A

DOI 10.1080/15287391003689317PMC PMC3107001

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Abstract

Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment. In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level.

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Another mechanism by which PFAS disrupt the endothelial barrier of the blood-brain barrier is through generation of reactive oxygen species that induce remodeling of actin filaments.
“Another mechanism by which PFAS disrupt the endothelial barrier of the BBB is through generation of reactive oxygen species (ROS), that are ultimately able to induce remodeling of actin filaments (Qian et al., 2010).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Qian et al., 2010
The Results section reports that PFOS-induced ROS production contributed to actin filament remodeling in human microvascular endothelial cells, and the Discussion links this process to increased endothelial permeability. The paper does not establish the mechanism in the blood-brain barrier or for PFAS generally beyond PFOS. (LLM, conf=0.88)
Experimental — accuracy not yet measured
In vivo and in vitro experiments have demonstrated that PFAS exposure can lead to severe inflammation in organs, including the liver, kidneys, and nervous system.
“in vivo and in vitro experiments have demonstrated that PFAS exposure can lead to severe inflammation in organs, including the liver, kidneys, and nervous system”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Qian et al., 2010
The Discussion (page unavailable) reports PFOS-induced oxidative stress and endothelial permeability changes, and notes that permeability abnormalities can contribute to inflammation. The Abstract (page unavailable) mentions hepatic oxidative damage in fish and neurotoxicity in neuronal cells, but no passage establishes severe inflammation in the liver, kidneys, or nervous system. I searched the copy for inflammation and kidney-related findings. (LLM, conf=0.76)
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Perfluoroctanoic acid (PFOA) enhances NOTCH-signaling in an angiogenesis model of placental trophoblast cells
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Authors: Qian, Y., Ducatman, A., Ward, R., Leonard, S., Bukowski, V., Lan Guo, N., Shi, X., Vallyathan, V., & Castranova, V.
Affiliations: National Institute for Occupational Safety and Health (US)
West Virginia University (US)
University of Kentucky (US)
Corresponding author: Qian, Yong
ORCID: Qian, Yong
Ducatman, Alan
Ward, Rebecca
Shi, Xianglin
Venue: Journal of Toxicology and Environmental Health, Part A
Publisher: Informa UK Limited
Published: 2010-04-14
Volume: 73
Issue: 12
Pages: 819-836
ISSN: 0098-4108 (ISSN-L)
1528-7394
1087-2620
DOI: 10.1080/15287391003689317
PMC: PMC3107001
OpenAlex: W2089669600
Cited by: 191
References: 69
Citations by year: 2026: 20 · 2025: 19 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 6.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. National Library of Medicine (R01LM009500)
National Center for Research Resources (P20 RR16440, P20RR016440)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: PFOS, perfluoroalkyl acids, reactive oxygen species, endothelial permeability, human microvascular endothelial cells, actin filament remodeling, endothelial barrier dysfunction, PFOS toxicity, environmental exposure
MeSH terms: Animals, Capillary Permeability, Cell Line, Cell Membrane Permeability, Electron Spin Resonance Spectroscopy, Endothelium, Vascular, Environmental Pollutants, Fluorocarbons, Humans, Macrophages, Actin Cytoskeleton, Regeneration, Electric Impedance, Reactive Oxygen Species, Alkanesulfonic Acids, Microscopy, Confocal, Mice, Microvessels

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Perfluorooctane Sulfonate (PFOS) Induces Reactive Oxygen Species (ROS) Production in Human Microvascular Endothelial Cells: Role in Endothelial Permeability

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