Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review
Open accessAbstract
Background and objectives Per- and polyfluoroalkyl substances (PFASs) are a large group of manufactured nonbiodegradable compounds. Despite increasing awareness as global pollutants, the impact of PFAS exposure on human health is not well understood, and there are growing concerns for adverse effects on kidney function. Therefore, we conducted a scoping review to summarize and identify gaps in the understanding between PFAS exposure and kidney health. Design, setting, participants, & measurements We systematically searched PubMed, EMBASE, EBSCO Global Health, World Health Organization Global Index, and Web of Science for studies published from 1990 to 2018. We included studies on the epidemiology, pharmacokinetics, or toxicology of PFAS exposure and kidney-related health, including clinical, histologic, molecular, and metabolic outcomes related to kidney disease, or outcomes related to the pharmacokinetic role of the kidneys. Results We identified 74 studies, including 21 epidemiologic, 13 pharmacokinetic, and 40 toxicological studies. Three population-based epidemiologic studies demonstrated associations between PFAS exposure and lower kidney function. Along with toxicology studies ( n =10) showing tubular histologic and cellular changes from PFAS exposure, pharmacokinetic studies ( n =5) demonstrated the kidneys were major routes of elimination, with active proximal tubule transport. In several studies ( n =17), PFAS exposure altered several pathways linked to kidney disease, including oxidative stress pathways, peroxisome proliferators-activated receptor pathways, NF-E2–related factor 2 pathways, partial epithelial mesenchymal transition, and enhanced endothelial permeability through actin filament modeling. Conclusions A growing body of evidence portends PFASs are emerging environmental threats to kidney health; yet several important gaps in our understanding still exist.
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PFAS exposure has been associated with dysfunction and genesis of kidney and liver disease, including increased risk for carcinogenesis in these tissues.
“PFAS exposure has been associated with dysfunction and genesis of kidney and liver disease, including increased risk for carcinogenesis in these tissues”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Stanifer et al., 2018
Toxicology studies have identified histological and cellular outcomes indicative of PFAS-induced nephrotoxicity, including oxidative stress, apoptosis, and enhanced microvascular endothelial permeability.
“Toxicology studies, including in vivo and in vitro experiments, have identified histological and cellular outcomes indicative of PFAS-induced nephrotoxicity (Shankar et al., 2011; Stanifer et al., 2018). Such findings include oxidative stress, apoptosis, and enhanced microvascular endothelial permeability.”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Stanifer et al., 2018
Cites
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641 · see citing works
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
Hu, X. C., Andrews, D. Q., Lindstrom, A. B., Bruton, T. A., Schaider, L. A., Grandjean, P., Lohmann, R., Carignan, C. C., Blum, A., Balan, S. A., et al. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00260 · Cited by 1,333 · see citing works
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247 · see citing works
Wang, Z., Cousins, I. T., Scheringer, M., & Hungerbühler, K. (2013) · Environment International · doi:10.1016/j.envint.2013.08.021 · Cited by 924 · see citing works
Barry, V., Winquist, A. G., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306615 · Cited by 781 · see citing works
Accumulation of perfluoroalkyl substances in human tissues
Pérez, F., Nadal, M., Navarro-Ortega, A., Fàbrega, F., Domingo, J. L., Barceló, D., & Farré, M. (2013) · Environment International · doi:10.1016/j.envint.2013.06.004 · Cited by 730 · see citing works
Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)
Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660 · see citing works
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530 · see citing works
The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
Nigám, S. K., Bush, K. T., Martovetsky, G., Ahn, S.-Y., Liu, H. C., Richard, E., Bhatnagar, V., & Wu, W. (2014) · Physiological Reviews · doi:10.1152/physrev.00025.2013 · Cited by 505 · see citing works
Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
Seacat, A. M., Thomford, P. J., Hansen, K. J., Clemen, L. A., Eldridge, S. R., Elcombe, C. R., & Butenhoff, J. L. (2003) · Toxicology · doi:10.1016/s0300-483x(02)00511-5 · Cited by 399 · see citing works
Cui, L., Zhou, Q.-F., Liao, C.-Y., Fu, J.-J., & Jiang, G.-B. (2009) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-008-9194-6 · Cited by 368 · see citing works
Olsen, G. W., Burris, J. M., Burlew, M., & Mandel, J. H. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000052958.59271.10 · Cited by 362 · see citing works
Shi, Y., Vestergren, R., Xu, L., Zhou, Z., Li, C., Liang, Y., & Cai, Y. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05849 · Cited by 361 · see citing works
Vieira, V. M., Hoffman, K., Shin, H., Weinberg, J., Webster, T. F., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205829 · Cited by 355 · see citing works
Chronic kidney disease in low- and middle-income countries
Stanifer, J. W., Muiru, A. N., Jafar, T. H., & Patel, U. D. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv466 · Cited by 344 · see citing works
Self-citationThe Role of Nrf2 and MAPK Pathways in PFOS-Induced Oxidative Stress in Zebrafish Embryos
Shi, X., & Zhou, B. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq066 · Cited by 307 · see citing works
Harada, K. H., Inoue, K., Morikawa, A., Yoshinaga, T., Saito, N., & Koizumi, A. (2005) · Environmental Research · doi:10.1016/j.envres.2004.12.003 · Cited by 286 · see citing works
Pan, Y., Zhu, Y., Zheng, T., Cui, Q., Buka, S. L., Zhang, B., Guo, Y., Xia, W., Yeung, L. W. Y., Li, Y., et al. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b04590 · Cited by 259 · see citing works
Hu, W. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.2.429 · Cited by 245 · see citing works
Thirty years of medical surveillance in perfluooctanoic acid production workers
Costa, G., Sartori, S., & Consonni, D. (2009) · Journal of Occupational & Environmental Medicine · doi:10.1097/jom.0b013e3181965d80 · Cited by 238 · see citing works
Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks.
Li, K., Gao, P., Xiang, P., Zhang, X.-X., Cui, X.-Y., & Ma, L. (2017) · Environment International · doi:10.1016/j.envint.2016.11.014 · Cited by 231 · see citing works
Mastrantonio, M., Bai, E., Uccelli, R., Cordiano, V., Screpanti, A., & Crosignani, P. (2018) · European Journal of Public Health · doi:10.1093/eurpub/ckx066 · Cited by 228 · see citing works
Steenland, K., Tinker, S., Shankar, A., & Ducatman, A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0900940 · Cited by 224 · see citing works
Beesoon, S., & Martin, J. W. (2015) · Environmental Science & Technology · doi:10.1021/es505399w · Cited by 223 · see citing works
Zhou, Z., Shi, Y., Vestergren, R., Wang, T., Liang, Y., & Cai, Y. (2014) · Environmental Science & Technology · doi:10.1021/es4057467 · Cited by 205 · see citing works
Emmett, E. A., Zhang, H., Shofer, F. S., Freeman, D. W., Rodway, N. V., Desai, C. S., & Shaw, L. M. J. (2006) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000233380.13087.37 · Cited by 197 · see citing works
Yang, C.-H., Glover, K. P., & Han, X. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq219 · Cited by 197 · see citing works
Perfluorinated Compounds in Umbilical Cord Blood and Adverse Birth Outcomes
Chen, M.-H., Ha, E., Wen, T.-W., Su, Y.-D., Lien, G., Chen, C.-Y., Chen, P.-C., & Hsieh, W. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042474 · Cited by 191 · see citing works
Qian, Y., Ducatman, A., Ward, R., Leonard, S., Bukowski, V., Lan Guo, N., Shi, X., Vallyathan, V., & Castranova, V. (2010) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287391003689317 · Cited by 191 · see citing works
The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat
Butenhoff, J. L., Kennedy, G. L., Frame, S. R., O’Connor, J. C., & York, R. G. (2004) · Toxicology · doi:10.1016/j.tox.2003.11.005 · Cited by 188 · see citing works
Fu, J., Gao, Y., Cui, L., Wang, T., Liang, Y., Qu, G., Yuan, B., Wang, Y., Zhang, A., & Jiang, G. (2016) · Scientific Reports · doi:10.1038/srep38039 · Cited by 184 · see citing works
Cohort Mortality Study of Workers Exposed to Perfluorooctanoic Acid
Steenland, K., & Woskie, S. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws171 · Cited by 181 · see citing works
King, S. C., Pollack, L. A., Li, J., King, J., & Master, V. A. (2014) · The Journal of Urology · doi:10.1016/j.juro.2013.12.046 · Cited by 179 · see citing works
Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
Alexander, B. H., Olsen, G. W., Burris, J. M., Mandel, J. H., & Mandel, J. S. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.10.722 · Cited by 179 · see citing works
Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults
Shankar, A., Xiao, J., & Ducatman, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr171 · Cited by 166 · see citing works
Watkins, D. J., Josson, J., Elston, B., Bartell, S. M., Shin, H.-M., Vieira, V. M., Savitz, D. A., Fletcher, T., & Wellenius, G. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205838 · Cited by 158 · see citing works
Leonard, R. C., Kreckmann, K. H., Sakr, C. J., & Symons, J. M. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.06.011 · Cited by 147 · see citing works
Butenhoff, J. L., Chang, S., Olsen, G. W., & Thomford, P. J. (2012) · Toxicology · doi:10.1016/j.tox.2012.01.003 · Cited by 144 · see citing works
Yu, N., Wei, S., Li, M., Yang, J., Li, K., Jin, L. N., Xie, Y., Giesy, J. P., Zhang, X., & Yu, H. (2016) · Scientific Reports · doi:10.1038/srep23963 · Cited by 137 · see citing works
Kataria, A., Trachtman, H., Málaga-Diéguez, L., & Trasande, L. (2015) · Environmental Health · doi:10.1186/s12940-015-0077-9 · Cited by 130 · see citing works
Ingelido, A. M., Abballe, A., Gemma, S., Dellatte, E., Iacovella, N., Angelis, G. D., Zampaglioni, F., Marra, V., Miniero, R., Valentini, S., et al. (2017) · Environment International · doi:10.1016/j.envint.2017.10.026 · Cited by 127 · see citing works
Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity
Hagos, Y., & Wolff, N. A. (2010) · Toxins · doi:10.3390/toxins2082055 · Cited by 126 · see citing works
Perfluorinated compounds in relation to birth weight in the Norwegian Mother and Child Cohort Study.
Whitworth, K. W., Haug, L., Baird, D., Becher, G., Hoppin, J., Skjærven, R., Thomsen, C., Eggesbø, M., Travlos, G., Wilson, R., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr459 · Cited by 112 · see citing works
Curran, I. H., Hierlihy, S. L., Liston, V., Pantazopoulos, P., Nunnikhoven, A., Tittlemier, S. A., Barker, M., Trick, K. D., & Bondy, G. S. (2008) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390802361763 · Cited by 110 · see citing works
Kishi, R., Nakajima, T., Goudarzi, H., Kobayashi, S., Sasaki, S., Okada, E., Miyashita, C., Itoh, S., Araki, A., Ikeno, T., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408834 · Cited by 104 · see citing works
Dhingra, R., Winquist, A. G., Darrow, L. A., Klein, M., & Steenland, K. (2016) · Environmental Health Perspectives · doi:10.1289/ehp273 · Cited by 103 · see citing works
Caverly Rae, J. M., Craig, L., Slone, T. W., Frame, S. R., Buxton, L. W., & Kennedy, G. L. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.06.001 · Cited by 102 · see citing works
Arukwe, A., & Mortensen, A. S. (2011) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2011.06.012 · Cited by 102 · see citing works
Lin, C., Lin, L., Wen, T.-W., Lien, G., Chien, K., Hsu, S. H.-J., Liao, C., Sung, F.-C., Chen, P., & Su, T. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.04.042 · Cited by 101 · see citing works
PBPK modeling for PFOS and PFOA: Validation with human experimental data
Fàbrega, F., Kumar, V., Schuhmacher, M., Domingo, J. L., & Nadal, M. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.007 · Cited by 100 · see citing works
Ding, L., Hao, F., Shi, Z., Wang, Y., Zhang, H., Tang, H., & Dai, J. (2009) · Journal of Proteome Research · doi:10.1021/pr9000256 · Cited by 98 · see citing works
Mortality and cancer incidence in ammonium perfluorooctanoate production workers
Raleigh, K. K., Alexander, B. H., Olsen, G. W., Ramachandran, G., Morey, S. Z., Church, T. R., Logan, P. W., Scott, P., & Allen, E. M. (2014) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102109 · Cited by 97 · see citing works
Abbott, B. D., Wood, C. R., Watkins, A. M., Tatum-Gibbs, K. R., Das, K. P., & Lau, C. S. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.11.005 · Cited by 94 · see citing works
Tan, X., Xie, G., Sun, X., Li, Q., Zhong, W. H., Qiao, P. L., Sun, X., Jia, W. P., & Zhou, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061409 · Cited by 92 · see citing works
Fair, P. A., Romano, T. A., Schaefer, A. M., Reif, J. S., Bossart, G. D., Houde, M., Muir, D. C. G., Adams, J., Rice, C. D., Hulsey, T. C., et al. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2122 · Cited by 92 · see citing works
Newsted, J. L., Beach, S. A., Gallagher, S. P., & Giesy, J. P. (2007) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-007-9039-8 · Cited by 89 · see citing works
Klaunig, J. E., Shinohara, M., Iwai, H., Chengelis, C. P., Kirkpatrick, J. B., Wang, Z., & Bruner, R. H. (2014) · Toxicologic Pathology · doi:10.1177/0192623314530532 · Cited by 87 · see citing works
Wang, X., Liu, L., Zhang, W., Zhang, J., Du, X., Huang, Q., Tian, M., & Shen, H. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.04.086 · Cited by 82 · see citing works
Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes
Conway, B., Badders, A., Costacou, T., Arthur, J., & Innes, K. (2018) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s173809 · Cited by 80 · see citing works
Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice
Son, H., Kim, S.-H., Shin, H., Bae, H. I., & Yang, J. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0246-x · Cited by 79 · see citing works
Lieder, P. H., Chang, S.-C., York, R. G., & Butenhoff, J. L. (2009) · Toxicology · doi:10.1016/j.tox.2008.10.002 · Cited by 76 · see citing works
Peng, S., Yan, L., Zhang, J., Wang, Z., Tian, M., & Shen, H. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.07.014 · Cited by 74 · see citing works
Elevated Blood Pressure in Offspring of Rats Exposed to Diverse Chemicals During Pregnancy
Rogers, J. M., Ellis‐Hutchings, R. G., Grey, B. E., Zucker, R. M., Norwood, J., Grace, C. E., Gordon, C. J., & Lau, C. S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft248 · Cited by 74 · see citing works
Xing, J., Wang, G., Zhao, J., Wang, E., Yin, B., Fang, D., Zhao, J., Zhang, H., Chen, Y. Q., & Chen, W. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2015.12.008 · Cited by 73 · see citing works
Takagi, A., Sai, K., Umemura, T., Hasegawa, R., & Kurokawa, Y. (1991) · Cancer Letters · doi:10.1016/0304-3835(91)90063-n · Cited by 72 · see citing works
Chou, H., Wen, L.-L., Chang, C.-C., Lin, C., Lu, J., & Juan, S. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx183 · Cited by 70 · see citing works
Kariuki, M., Nagato, E. G., Lankadurai, B. P., Simpson, A. J., & Simpson, M. J. (2017) · Metabolites · doi:10.3390/metabo7020015 · Cited by 63 · see citing works
Kim, H.-S., Jun Kwack, S., Sik Han, E., Seok Kang, T., Hee Kim, S., & Young Han, S. (2011) · The Journal of Toxicological Sciences · doi:10.2131/jts.36.201 · Cited by 62 · see citing works
Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation
Wen, L.-L., Lin, C., Chou, H., Chang, C., Lo, H.-Y., & Juan, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155190 · Cited by 62 · see citing works
Qin, X.-D., Qian, Z. M., Vaughn, M. G., Huang, J., Ward, P., Zeng, X., Zhou, Y., Zhu, Y., Yuan, P., Li, M., et al. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.02.050 · Cited by 57 · see citing works
Metabolomic responses to sublethal contaminant exposure in neonate and adultDaphnia magna
Wagner, N. D., Simpson, A. J., & Simpson, M. J. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3604 · Cited by 54 · see citing works
Russell, M. H., Waterland, R. L., & Wong, F. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2014.07.061 · Cited by 53 · cited 1× · see citing works
“Unlike other species, although men demonstrate longer t1/2 compared with women, it remains unclear the extent to which the proximal tubule handling of PFASs is regulated through sex hormones (32,36).”
BackgroundWorley, R., Yang, X.-X., & Fisher, J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.07.001 · Cited by 51 · see citing works
Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats
Takahashi, M., Ishida, S., Hirata‐Koizumi, M., Ono, A., & Hirose, A. (2014) · The Journal of Toxicological Sciences · doi:10.2131/jts.39.97 · Cited by 49 · see citing works
Cancer Risk Among Tetrafluoroethylene Synthesis and Polymerization Workers
Consonni, D., Straíf, K., Symons, J. M., Tomenson, J. A., van Amelsvoort, L. G. P. M., Sleeuwenhoek, A., Cherrie, J. W., Bonetti, P., Colombo, I., Farrar, D. G., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws588 · Cited by 46 · see citing works
Zhang, H., Ding, L., Fang, X., Shi, Z., Zhang, Y., Chen, H., Yan, X., & Dai, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020862 · Cited by 44 · see citing works
Toxicological evaluation of 6:2 fluorotelomer alcohol
Serex, T. L., Anand, S., Munley, S. M., Donner, E. M., Frame, S. R., Buck, R. C., & Loveless, S. E. (2014) · Toxicology · doi:10.1016/j.tox.2014.01.009 · Cited by 34 · see citing works
Gorrochategui, E., Lacorte, S., Tauler, R., & Martin, F. L. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00076 · Cited by 34 · see citing works
Chang, S., Allen, B. C., Andres, K. L., Ehresman, D. J., Falvo, R., Provencher, A., Olsen, G. W., & Butenhoff, J. L. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfw267 · Cited by 32 · see citing works
Lankadurai, B. P., Simpson, A. J., & Simpson, M. J. (2012) · Environmental Chemistry · doi:10.1071/en12112 · Cited by 30 · see citing works
Subchronic Toxicity of a Fluoroalkylethanol Mixture in Rats
Ladics, G. S., Stadler, J. C., MAKOVEC, G. T., Everds, N. E., & Buck, R. C. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-52506 · Cited by 30 · see citing works
Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid
Eldasher, L. M., Wen, X., Little, M. S., Bircsak, K. M., Yacovino, L. L., & Aleksunes, L. M. (2013) · Toxicology · doi:10.1016/j.tox.2013.02.009 · Cited by 29 · see citing works
Induction of cytochrome P4504A by the peroxisome proliferator perfluoro-n-octanoic acid
Díaz, M. J. V., Chinje, E. C., Kentish, P., Jarnot, B. M., George, M., & Gibson, G. (1994) · Toxicology · doi:10.1016/0300-483x(94)90056-6 · Cited by 28 · see citing works
Witzmann, F. A., Fultz, C. D., & Lipscomb, J. C. (1996) · Electrophoresis · doi:10.1002/elps.1150170132 · Cited by 23 · see citing works
Dhingra, R., Lally, C. A., Darrow, L. A., Klein, M., Winquist, A. G., & Steenland, K. (2015) · Environmental Research · doi:10.1016/j.envres.2015.11.018 · Cited by 23 · see citing works
Skov, K., Kongsbak, K., Hadrup, N., Frandsen, H. L., Svingen, T., Smedsgaard, J., Audouze, K., Eklund, A. C., & Vinggaard, A. M. (2015) · Metabolomics · doi:10.1007/s11306-015-0802-y · Cited by 5 · see citing works
Perfluorooctane Sulfonate (PFOS) Promotes Renal Injury Under Diabetic Condition In Vitro
Chung, A. C. K. (2015) · Hong Kong Journal of Nephrology · doi:10.1016/j.hkjn.2015.08.014 · Cited by 3 · see citing works
Olsen, G. W., Butenhoff, J. L., & Zobel, L. R. (2012) · Epidemiology · doi:10.1097/01.ede.0000417208.38915.26 · Cited by 2 · see citing works
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Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445 · see citing works
Epidemiology of Renal Cell Carcinoma: 2022 Update
Bukavina, L., Bensalah, K., Bray, F., Carlo, M. I., Challacombe, B. J., Karam, J. A., Kassouf, W., Mitchell, T. J., Montironi, R., O’Brien, T., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.08.019 · Cited by 805 · see citing works
Brunn, H., Arnold, G., Körner, W., Rippen, G., Steinhäuser, K. G., & Valentin, I. (2023) · Environmental Sciences Europe · doi:10.1186/s12302-023-00721-8 · Cited by 504 · see citing works
Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499 · see citing works
Brase, R. A., Mullin, E. J., & Spink, D. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030995 · Cited by 374 · see citing works
Espartero, L. J. L., Yamada, M., Ford, J., Owens, G., Prow, T. W., & Juhasz, A. L. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113431 · Cited by 282 · see citing works
Schulz, K., Silva, M. R., & Klaper, R. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139186 · Cited by 259 · see citing works
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243 · see citing works
Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma
Shearer, J. J., Callahan, C. L., Calafat, A. M., Huang, W., Jones, R. R., Sabbisetti, V. S., Freedman, N. D., Sampson, J. N., Silverman, D. T., Purdue, M. P., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa143 · Cited by 236 · see citing works
Sustainable Development Goals relevant to kidney health: an update on progress
Luyckx, V. A., Al‐Aly, Z., Bello, A. K., Bellorín-Font, E., Carlini, R. G., Fabian, J., García-García, G., Iyengar, A. A., Sekkarie, M., Biesen, W. V., et al. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00363-6 · Cited by 228 · see citing works
Self-citationChang, C.-J., Barr, D., Ryan, P., Panuwet, P., Smarr, M., Liu, K. H., Kannan, K., Yakimavets, V., Tan, Y.-R., Ly, V., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106964 · Cited by 154 · see citing works
Starnes, H. M., Rock, K. D., Jackson, T. W., & Belcher, S. M. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.881584 · Cited by 166 · see citing works
“Multiple studies have reported significant associations between PFAS exposure with lower eGFR and increased odds of CKD (Shankar et al., 2011; Vearrier et al., 2013; Watkins et al., 2013; Kataria et al., 2015; Dhingra et al., 2017; Blake et al., 2018; Stanifer et al., 2018).”
BackgroundInfluentialJha, G., Kankarla, V., Mclennon, E., Pal, S., Sihi, D., Dari, B., Diaz, D., & Nocco, M. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312550 · Cited by 160 · see citing works
Jeong, N., Chung, T.-H., & Tong, T. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c04041 · Cited by 156 · see citing works
Yang, Z., Liu, X., & Tian, Y. (2018) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2018.10.024 · Cited by 155 · see citing works
Epigenetic changes by per- and polyfluoroalkyl substances (PFAS)
Kim, S., Thapar, I. K., & Brooks, B. W. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116929 · Cited by 157 · see citing works
Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances
Temkin, A. M., Hocevar, B. A., Andrews, D. Q., Naidenko, O. V., & Kamendulis, L. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17051668 · Cited by 153 · see citing works
Guo, P., Furnary, T., Vasiliou, V., Yan, Q., Nyhan, K., Jones, D. P., Johnson, C. H., & Liew, Z. (2022) · Environment International · doi:10.1016/j.envint.2022.107159 · Cited by 145 · see citing works
Kang, H., Lee, J. P., & Choi, K. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148343 · Cited by 146 · see citing works
Addressing health inequalities in diverse, rural communities: An unmet need
Richman, L. S., Pearson, J. A., Beasley, C. M., & Stanifer, J. W. (2019) · SSM - Population Health · doi:10.1016/j.ssmph.2019.100398 · Cited by 143 · see citing works
Self-citationRemoving PFAS from aquatic systems using natural and renewable material-based adsorbents: A review
Militao, I. M., Roddick, F., Bergamasco, R., & Fan, L. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2021.105271 · Cited by 144 · see citing works
Lü, Y., Gao, K., Li, X., Tang, Z., Xiang, L., Zhao, H., Fu, J., Wang, L., Zhu, N., Cai, Z., et al. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b01608 · Cited by 134 · see citing works
Treatment technologies for removal of per- and polyfluoroalkyl substances (PFAS) in biosolids
Garg, A., Shetti, N. P., Basu, S., Nadagouda, M. N., & Aminabhavi, T. M. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139964 · Cited by 127 · see citing works
DeLuca, N. M., Angrish, M., Wilkins, A., Thayer, K., & Cohen Hubal, E. A. (2021) · Environment International · doi:10.1016/j.envint.2020.106308 · Cited by 122 · see citing works
Endocrine-disrupting chemicals and child health
Ghassabian, A., Vandenberg, L., Kannan, K., & Trasande, L. (2022) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-021921-093352 · Cited by 112 · see citing works
Habib, Z., Song, M., Ikram, S., & Zahra, Z. (2024) · Pollutants · doi:10.3390/pollutants4010009 · Cited by 121 · see citing works
Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer
Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Madak‐Erdogan, Z., Irudayaraj, J., & Spinella, M. J. (2022) · Cancers · doi:10.3390/cancers14122919 · Cited by 112 · see citing works
Decomposition kinetics of perfluorinated sulfonic acids
Khan, M. Y., So, S., & da Silva, G. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2019.124615 · Cited by 101 · see citing works
Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust
Young, A. S., Sparer, E. H., Pickard, H. M., Sunderland, E. M., Peaslee, G. F., & Allen, J. G. (2021) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-021-00288-7 · Cited by 96 · see citing works
Li, S., Oliva, P., Zhang, L., Goodrich, J. A., McConnell, R., Conti, D. V., Chatzi, L., & Aung, M. (2025) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-024-00742-2 · Cited by 101 · see citing works
Jain, R. B., & DUCATMAN, A. M. (2019) · Environmental Research · doi:10.1016/j.envres.2019.04.034 · Cited by 89 · see citing works
Kang, H., Lee, J., Lee, J. P., & Choi, K. (2019) · Environment International · doi:10.1016/j.envint.2019.105034 · Cited by 89 · see citing works
Cárdenas, A., Hivert, M., Gold, D. R., Hauser, R. B., KLEINMAN, K. P., Lin, P. D., Fleisch, A. F., Calafat, A. M., Ye, X., Webster, T. F., et al. (2019) · Diabetes Care · doi:10.2337/dc18-2254 · Cited by 87 · see citing works
Hsu, C., & Tain, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745716 · Cited by 88 · see citing works
Catalytic Hydrogenolysis of Aryl C–F Bonds Using a Bimetallic Rhodium–Indium Complex
Moore, J. T., & Lu, C. C. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c04937 · Cited by 87 · see citing works
Niu, Z., Duan, Z., He, W., Chen, T., Tang, H., Du, S., Sun, J., Chen, H., Hu, Y., Iijima, Y., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134312 · Cited by 88 · see citing works
Larcher, A., Campi, R., Bex, A., Bray, F., Bukavina, L., Jonasch, E., Jemal, A., Linehan, W. M., Marandino, L., Mir, M. C., et al. (2025) · European Urology · doi:10.1016/j.eururo.2025.06.005 · Cited by 83 · see citing works
Borghese, M. M., WALKER, M. C., Helewa, M. E., Fraser, W. D., & Arbuckle, T. E. (2020) · Environment International · doi:10.1016/j.envint.2020.105789 · Cited by 85 · see citing works
Seyyedsalehi, M. S., & Boffetta, P. (2023) · La Medicina del Lavoro · doi:10.23749/mdl.v114i5.15065 · Cited by 77 · see citing works
Remediation of perfluorooctanoic acid (PFOA) polluted soil using pulsed corona discharge plasma
Zhan, J., Ai, Z., Héroux, P., Guo, Y., Sun, Z., Li, Z., Zhao, J., & Liu, Y. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121688 · Cited by 75 · see citing works
Jain, R. B., & DUCATMAN, A. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.11.033 · Cited by 73 · see citing works
Li, H., Dong, Q., Zhang, M., Gong, T., Zan, R., & Wang, W. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121579 · Cited by 80 · see citing works
Zeng, X., Lodge, C., Dharmage, S. C., Bloom, M. S., Yu, Y., Yang, M., Chu, C., Li, Q., Hu, L., Liu, K., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.105160 · Cited by 72 · see citing works
Environment-Wide Association Study of CKD
Lee, J., Oh, S., Kang, H., Kim, S., Lee, G., Li, L., Kim, C. T., An, J. N., Oh, Y. K., Lim, C. S., et al. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06780619 · Cited by 69 · see citing works
Lin, P. D., Cárdenas, A., Hauser, R. B., Gold, D. R., KLEINMAN, K. P., Hivert, M., Calafat, A. M., Webster, T. F., Horton, E. S., & Oken, E. (2021) · Environment International · doi:10.1016/j.envint.2020.106375 · Cited by 66 · see citing works
Haimbaugh, A. S., Wu, C., Akemann, C., Meyer, D. N., Connell, M. L., Abdi, M., Khalaf, A., Johnson, D., & Baker, T. R. (2022) · Toxics · doi:10.3390/toxics10060334 · Cited by 66 · see citing works
Wang, J., Pan, Y., Wei, X., & Dai, J. (2020) · Environmental Science and Technology · doi:10.1021/acs.est.0c01877 · Cited by 61 · see citing works
He, A., Li, J., Zhao, L., Lu, Y., Liang, Y., Zhou, Z., Man, Z., Lv, J., Wang, Y., & Jiang, G. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c06480 · Cited by 65 · see citing works
Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines
Solan, M. E., Senthilkumar, S., Aquino, G. V., Bruce, E. D., & Lavado, R. (2022) · Toxicology · doi:10.1016/j.tox.2022.153281 · Cited by 64 · see citing works
Zhang, T., Zhang, B., Bai, X., Yao, Y., Wang, L., Shu, Y., Kannan, K., Huang, X., & Sun, H. (2019) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.9b00085 · Cited by 63 · see citing works
The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
Zhang, X., Flaws, J. A., Spinella, M. J., & Irudayaraj, J. (2022) · Toxics · doi:10.3390/toxics11010032 · Cited by 63 · see citing works
Global Biogeochemical Cycle of Fluorine
Schlesinger, W. H., Klein, E. M., & Vengosh, A. (2020) · Global Biogeochemical Cycles · doi:10.1029/2020gb006722 · Cited by 62 · see citing works
Liu, Y., Li, N., Papandonatos, G., Calafat, A., Eaton, C., Kelsey, K., Chen, A.-M., Lanphear, B., Cecil, K., Kalkwarf, H., et al. (2020) · Environmental Science and Technology · doi:10.1021/acs.est.0c06088 · Cited by 44 · see citing works
Rhee, J., Chang, V. C., Cheng, I. C., Calafat, A. M., Botelho, J. C., Shearer, J. J., Sampson, J. N., Setiawan, V. W., Wilkens, L. R., Silverman, D. T., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108197 · Cited by 62 · see citing works
Domingo, J. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121181 · Cited by 62 · see citing works
You, L., Zheng, F., Su, C., Wang, L., Li, X., Chen, Q., Kou, J., Wang, X., Wang, Y., Wang, Y., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.106919 · Cited by 60 · see citing works
Cakmak, S., Lukina, A. O., Karthikeyan, S., Atlas, E., & Dales, R. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153900 · Cited by 58 · see citing works
Liu, D., Yan, S., Wang, P., Chen, Q., Liu, Y., Cui, J., Liang, Y., Ren, S., & Gao, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1103141 · Cited by 61 · see citing works
Banwell, C. L., Housen, T., Smurthwaite, K. S., Trevenar, S. M., Walker, L., Todd, K., Rosas, M., & Kirk, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245141 · Cited by 54 · see citing works
Imir, O. B., Kaminsky, A. Z., Zuo, Q., Liu, Y.-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W., Prins, G. S., & Madak‐Erdogan, Z. (2021) · Nutrients · doi:10.3390/nu13113902 · Cited by 53 · see citing works
Wang, J., Zeng, X., Bloom, M. S., Qian, Z. M., Hinyard, L., BeLue, R., Lin, S., Wang, S.-Q., Tian, Y.-P., Yang, M., et al. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.11.191 · Cited by 52 · see citing works
Chen, H., Cao, Y., Wang, C., Tie, F., Dong, W., Camaiti, M., & Baglioni, P. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103343 · Cited by 49 · see citing works
Firouzjaei, M. D., Zolghadr, E., Ahmadalipour, S., Taghvaei, N., Afkhami, F. A., Nejati, S., & Ellıott, M. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01340-6 · Cited by 48 · see citing works
Environmental Exposures and Kidney Disease
Kshirsagar, A. V., Zeitler, E. M., Weaver, A. M., Franceschini, N., & Engel, L. S. (2022) · Kidney360 · doi:10.34067/kid.0007962021 · Cited by 51 · see citing works
Racism and Kidney Health: Turning Equity Into a Reality
Mohottige, D., Diamantidis, C. J., Norris, K. C., & Boulware, L. E. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2021.01.010 · Cited by 46 · see citing works
Self-citationMoon, J. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117707 · Cited by 45 · see citing works
Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors
Wen, Y., Rashid, F., Fazal, Z., Singh, R., Spinella, M. J., & Irudayaraj, J. (2022) · Current Zoology · doi:10.1093/eep/dvac010 · Cited by 42 · see citing works
Clark, K. L., Shukla, M., George, J. W., Gustin, S. L. F., Rowley, M. J., & Davis, J. S. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae049 · Cited by 44 · see citing works
Elucidating Degradation Mechanisms for a Range of Pfas Via Controlled Irradiation Studies
Patch, D. J., O'Connor, N., Koch, I., Cresswell, T., Hughes, C. E., Davies, J. B., Scott, J. L., O’Carroll, D. M., & Weber, K. P. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154941 · Cited by 43 · see citing works
Sun, Y., Li, G., Wang, W., Gu, W., Wong, P. K., & An, T. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2019.04.012 · Cited by 43 · see citing works
Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A population-based study
Mao, W., Hu, Q., Chen, S., Chen, Y., Luo, M., Zhang, Z., Geng, J., Wu, J., Xu, B., & Chen, M. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111497 · Cited by 43 · see citing works
Baumert, B. O., Fischer, F. C., Nielsen, F., Grandjean, P., Bartell, S. M., Stratakis, N., Walker, D. I., Valvi, D., Kohli, R., Inge, T. H., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c02765 · Cited by 42 · see citing works
Per- and polyfluoroalkyl substances target and alter human prostate stem-progenitor cells
Hu, W., Lu, R., Hu, D., Imir, O. B., Zuo, Q., Moline, D., Afradiasbagharani, P., Liu, L., Lowe, S., Birch, L. A., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114902 · Cited by 42 · see citing works
Su, F., Zeeshan, M., Xiong, L., Lv, J., Yan, W. S., Tang, X., Zhou, Y., Ou, Y., Huang, W., Feng, W., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156299 · Cited by 40 · see citing works
Li, X., Hou, M., Zhang, F., Ji, Z., Cai, Y., & Shi, Y. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.4c08701 · Cited by 42 · see citing works
Involvement of per-and polyfluoroalkyl compounds in tumor development
Pesonen, M., & Vähäkangas, K. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03685-7 · Cited by 40 · see citing works
Lin, T.-W., Chen, M., Lin, C., Chen, M., Tsai, M., Chan, D., Hung, K., & Chen, P. (2020) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2020.113607 · Cited by 40 · see citing works
Crute, C., Hall, S., Landon, C. D., Garner, A., Everitt, J. I., Zhang, S., Blake, B. E., Olofsson, D., Chen, H., Murphy, S. K., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156499 · Cited by 40 · see citing works
Self-citationYoung, A. S., Zoeller, T. R., Hauser, R. B., James-Todd, T. M., Coull, B. A., Behnisch, P., Brouwer, A., Zhu, H., Kannan, K., & Allen, J. G. (2021) · Environmental Health Perspectives · doi:10.1289/ehp8054 · Cited by 38 · see citing works
Wise, L. A., Wesselink, A. K., Schildroth, S., Calafat, A. M., Bethea, T. N., Geller, R. J., Coleman, C. M., Fruh, V., Henn, B. C., Botelho, J. C., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111860 · Cited by 39 · see citing works
Cogorno, J., & Rolle, M. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c09501 · Cited by 38 · see citing works
Young, A. S., Hauser, R. B., James-Todd, T. M., Coull, B. A., Zhu, H., Kannan, K., Specht, A. J., Bliss, M., & Allen, J. G. (2020) · Environment International · doi:10.1016/j.envint.2020.106151 · Cited by 37 · see citing works
Xie, L.-N., Wang, X.-C., Su, L., Ji, S., Dong, X.-J., Zhu, H., Hou, S.-S., Wang, C., Li, Z.-H., Dong, B., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119020 · Cited by 37 · see citing works
Li, H., Yang, M., Yang, J. G., Seery, S., Ma, C., Liu, Y., Zhang, X., Li, A., & Guo, H. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139411 · Cited by 38 · see citing works
Young, A. S., Pickard, H. M., Sunderland, E. M., & Allen, J. G. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05198 · Cited by 36 · see citing works
A genetically-encoded biosensor for direct detection of perfluorooctanoic acid
Mann, M. M., & Berger, B. W. (2023) · Scientific Reports · doi:10.1038/s41598-023-41953-1 · Cited by 36 · see citing works
Liang, L.-X., Dong, P., Zhou, Y., Zhang, L., Qian, Z. M., Geiger, S. D., Bingheim, E., Tang, X., Yan, W. S., Lv, J., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.115057 · Cited by 34 · see citing works
Bailey, J. M., Wang, L., McDonald, J. M., Gray, J. S., Petrie, J. G., Martin, E. T., Savitz, D. A., Karrer, T. A., Fisher, K. A., Geiger, M. J., et al. (2023) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-023-00564-8 · Cited by 34 · see citing works
Persistent pollutants: focus on perfluorinated compounds and kidney
Ferrari, F., Orlando, A., Ricci, Z., & Ronco, C. (2019) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000658 · Cited by 34 · see citing works
Oxidative stress and Cx43-mediated apoptosis are involved in PFOS-induced nephrotoxicity
Tang, L., Yu, J., Zhuge, S., Chen, H., Zhang, L., & Jiang, G. (2022) · Toxicology · doi:10.1016/j.tox.2022.153283 · Cited by 33 · see citing works
Sun, R., Babalol, S., Ni, R., Dolatabad, A. A., Cao, J., & Xiao, F. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132660 · Cited by 32 · see citing works
Mann, M. M., Tang, J. D., & Berger, B. W. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27981 · Cited by 29 · see citing works
Official health communications are failing PFAS-contaminated communities
DUCATMAN, A. M., LaPier, J., Fuoco, R. E., & DeWitt, J. C. (2022) · Environmental Health · doi:10.1186/s12940-022-00857-9 · Cited by 29 · see citing works
Zhou, J., Shu, R., Yu, C., Xiong, Z., Xiao, Q., Li, Z., Xie, X., & Fu, Z. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127255 · Cited by 28 · see citing works
Yun, J., Jang, E.-C., Kwon, S.-C., Min, Y., & Lee, Y.-J. (2023) · Annals of Occupational and Environmental Medicine · doi:10.35371/aoem.2023.35.e5 · Cited by 26 · see citing works
Pálešová, N., Maître, L., Stratakis, N., Řiháčková, K., Pindur, A., Kohoutek, J., Šenk, P., Polcrova, A. B., Gregor, P., Vrijheid, M., et al. (2023) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2023.114215 · Cited by 27 · see citing works
Sands, M., Zhang, X., Gal, A., Laws, M. J., Spinella, M. J., Erdogan, Z. M., & Irudayaraj, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108556 · Cited by 28 · see citing works
Zheng, X., Pan, Y., Qu, Y., Ji, S., Wang, J., Li, Z., Zhao, F., Wu, B., Xie, L., Li, Y., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c11095 · Cited by 29 · see citing works
Li, Z., Zhang, Y., Wang, F., Wang, R., Zhang, S., Zhang, Z., Li, P., Yao, J., Bi, J., He, J., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113060 · Cited by 27 · see citing works
Elgarahy, A. M., Eloffy, M. G., Saber, A. N., Abouzid, M., Rashad, E., Ghorab, M. A., El‐Sherif, D. M., & Elwakeel, K. Z. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-13334-2 · Cited by 27 · see citing works
- Authors
- Stanifer, J. W., Stapleton, H. M., Souma, T., Wittmer, A., Zhao, X., & Boulware, L. E.
- Affiliations
- Duke University (US)
- Nicholas School of the Environment, and
- Corresponding author
- Stanifer, John W.
- Venue
- Clinical Journal of the American Society of Nephrology
- Published
- 2018-09-13
- Volume
- 13
- Issue
- 10
- Pages
- 1479-1492
- ISSN
- 1555-9041 (ISSN-L)
- 1555-905X
- PMC
- PMC6218824
- OpenAlex
- W2891379353
- Cited by
- 233
- References
- 89
- Citations by year
- 2026: 25 · 2025: 33 · 2024: 40 · 2023: 33 · 2022: 32 · 2021: 30 · 2020: 23 · 2019: 14 · 2018: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Journal of the American Society of Nephrology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- per- and polyfluoroalkyl substances, PFAS exposure, kidney health, renal function, kidney disease, nephrotoxicity, pharmacokinetics, oxidative stress, peroxisome proliferator-activated receptors, NF-E2-related factor 2, epithelial-mesenchymal transition, endothelial permeability, actin cytoskeleton, environmental pollutants
- MeSH terms
- Environmental Exposure, Environmental Pollutants, Fluorocarbon Polymers, Humans, Kidney Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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