SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease
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Abstract
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
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Eighteen mutant pseudoviruses were made as previously described, and each had a robust titre adequate for neutralization studies.
“A total of 18 mutant pseudoviruses were made as previously described 20,21 , and each was found to have a robust titre (Extended Data Fig. 1c) that was adequate for neutralization studies.”
From Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 (2021) · cites this paper as [21]
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- Authors
- Wang, P., Liu, L., Nair, M. S., Yin, M. T., Luo, Y., Wang, Q., Yuan, T., Mori, K., Solis, A. G., Yamashita, M., Garg, A., Purpura, L. J., Laracy, J. C., Yu, J., Joshua-Tor, L., Sodroski, J., Huang, Y., & Ho, D. D.
- Affiliations
- Aaron Diamond AIDS Research Center (US)
- Columbia University (US)
- Harvard University (US)
- Columbia University Vagelos College of Physicians and Surgeons
- Cold Spring Harbor Laboratory (US)
- Cold Spring Harbor Laboratory
- Corresponding author
- Ho, David D.
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2020-01
- Volume
- 9
- Issue
- 1
- Pages
- 2091-2093
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC7534308
- OpenAlex
- W3085665862
- Cited by
- 122
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 15 · 2022: 22 · 2021: 51 · 2020: 24
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- The JBP Foundation
- Wu Family China Center
- Jack Ma Foundation
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (T32AI114398)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, neutralizing antibodies, antibody response, severe COVID-19, nucleocapsid protein, spike protein, antibody titers, pseudovirus neutralization, plasma therapy, monoclonal antibodies, humoral immunity
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Antigens, Viral, Female, Humans, Male, Middle Aged, Neutralization Tests, Pneumonia, Viral, Severity of Illness Index, Viral Envelope Proteins, Coronavirus Infections, Nucleocapsid, Antibodies, Neutralizing, Pandemics, Spike Glycoprotein, Coronavirus
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