Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome
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Illness severity in COVID-19 correlates with specificity of serological responses, but antibody levels decrease in most patients.
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Serological neutralizing antibody responses peak within 3-5 weeks after infection, and the peak magnitude correlates with clinical illness severity.
“Studies suggest that serological neutralizing antibody responses peak within 3–5 weeks after infection, with the magnitude of the peak being correlated with the severity of clinical illness13.”
From Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection (2021) · cites this paper as [13]
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Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Self-citationZhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works
Self-citationChen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016 · see citing works
Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., and the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., et al. (2020) · JAMA · doi:10.1001/jama.2020.6775 · Cited by 9,254 · see citing works
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897 · see citing works
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,436 · see citing works
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
Corman, V. M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D. K. W., Bleicker, T., Brünink, S., Schneider, J. A., Schmidt, M. L., et al. (2020) · Eurosurveillance · doi:10.2807/1560-7917.es.2020.25.3.2000045 · Cited by 7,266 · see citing works
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
Chen, T., Wu, D., Chen, H., Yan, W., Yang, D., Chen, G., Ma, K., Xu, D., Yu, H., Wang, H., et al. (2020) · BMJ · doi:10.1136/bmj.m1091 · Cited by 3,903 · see citing works
Self-citationAn mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Jackson, L. A., Anderson, E. J., Rouphael, N. G., Roberts, P. C., Makhene, M., Coler, R. N., McCullough, M. P., Chappell, J. D., Denison, M. R., Stevens, L. J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2022483 · Cited by 3,237 · see citing works
Antibody responses to SARS-CoV-2 in patients with COVID-19
Long, Q.-X., Liu, B.-Z., Deng, H.-J., Wu, G.-C., Deng, K., Chen, Y.-K., Liao, P., Qiu, J.-F., Lin, Y., Cai, X.-F., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0897-1 · Cited by 2,876 · see citing works
Structure, Function, and Evolution of Coronavirus Spike Proteins
Li, F. (2016) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042301 · Cited by 2,740 · see citing works
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0965-6 · Cited by 2,686 · see citing works
Folegatti, P. M., Ewer, K. J., Aley, P. K., Angus, B., Becker, S., Belij-Rammerstorfer, S., Bellamy, D., Bibi, S., Bittaye, M., Clutterbuck, E. A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31604-4 · Cited by 2,419 · see citing works
Prevalence of Asymptomatic SARS-CoV-2 Infection
Oran, D. P., & Topol, E. J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-3012 · Cited by 2,280 · see citing works
Human neutralizing antibodies elicited by SARS-CoV-2 infection
Ju, B., Zhang, Q., Ge, J., Wang, R., Sun, J., Ge, X., Yu, J., Shan, S., Zhou, B., Song, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2380-z · Cited by 1,667 · see citing works
Self-citationTai, W., He, L., Zhang, X., Pu, J., Voronin, D., Jiang, S., Zhou, Y., & Du, L. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0400-4 · Cited by 1,654 · see citing works
Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., et al. (2020) · doi:10.1101/2020.06.30.20142570 · Cited by 1,569 · see citing works
Tian, X., Li, C., Huang, A., Xia, S., Lu, S., Shi, Z., Lu, L., Jiang, S., Yang, Z., Wu, Y., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1729069 · Cited by 1,239 · see citing works
Rogers, T. F., Zhao, F., Huang, D., Beutler, N., Burns, A., He, W.-T., Limbo, O., Smith, C., Song, G., Woehl, J., et al. (2020) · Science · doi:10.1126/science.abc7520 · Cited by 1,230 · see citing works
Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
Keech, C., Albert, G., Cho, I., Robertson, A., Reed, P., Neal, S., Plested, J. S., Zhu, M., Cloney-Clark, S., Zhou, H., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2026920 · Cited by 1,156 · see citing works
Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19
Ibarrondo, F. J., Fulcher, J. A., Goodman-Meza, D., Elliott, J., Hofmann, C., Hausner, M. A., Ferbas, K. G., Tobin, N. H., Aldrovandi, G. M., & Yang, O. O. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2025179 · Cited by 1,021 · see citing works
DNA vaccine protection against SARS-CoV-2 in rhesus macaques
Yu, J., Tostanoski, L. H., Peter, L., Mercado, N. B., McMahan, K., Mahrokhian, S. H., Nkolola, J. P., Liu, J., Li, Z., Chandrashekar, A., et al. (2020) · Science · doi:10.1126/science.abc6284 · Cited by 997 · see citing works
The convalescent sera option for containing COVID-19
Casadevall, A., & Pirofski, L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138003 · Cited by 904 · see citing works
Humoral Immune Response to SARS-CoV-2 in Iceland
Gudbjartsson, D. F., Norddahl, G. L., Melsted, P., Gunnarsdottir, K., Holm, H., Eythorsson, E., Arnthorsson, A. O., Helgason, D., Bjarnadottir, K., Ingvarsson, R. F., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2026116 · Cited by 903 · see citing works
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Isho, B., Abe, K. T., Zuo, M., Jamal, A. J., Rathod, B., Wang, J. H., Li, Z., Chao, G., Rojas, O. L., Bang, Y. M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abe5511 · Cited by 822 · see citing works
Seasonal coronavirus protective immunity is short-lasting
Edridge, A. W. D., Kaczorowska, J., Hoste, A. C. R., Bakker, M., Klein, M., Loens, K., Jebbink, M. F., Matser, A., Kinsella, C. M., Rueda, P., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1083-1 · Cited by 767 · see citing works
To, K. K.-W., Hung, I. F.-N., Ip, J. D., Chu, A. W.-H., Chan, W.-M., Tam, A. R., Fong, C. H.-Y., Yuan, S., Tsoi, H.-W., Ng, A. C.-K., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1275 · Cited by 746 · see citing works
Crawford, K. H. D., Eguia, R. T., Dingens, A. S., Loes, A. N., Malone, K. D., Wolf, C. R., Chu, H. Y., Tortorici, M. A., Veesler, D., Murphy, M., et al. (2020) · Viruses · doi:10.3390/v12050513 · Cited by 727 · see citing works
Stadlbauer, D., Amanat, F., Chromikova, V., Jiang, K., Strohmeier, S., Arunkumar, G. A., Tan, J., Bhavsar, D., Capuano, C., Roubidoux, E. K., et al. (2020) · Current Protocols in Microbiology · doi:10.1002/cpmc.100 · Cited by 623 · see citing works
Iyer, A., Jones, F. K., Nodoushani, A., Kelly, M., Becker, M. V., Slater, D., Mills, R., Teng, E., Kamruzzaman, M., Garcia-Beltran, W., et al. (2020) · Science immunology · doi:10.1126/sciimmunol.abe0367 · Cited by 612 · see citing works
The time course of the immune response to experimental coronavirus infection of man
Callow, K. A., Parry, H. F., Sergeant, M., & Tyrrell, D. A. J. (1990) · Epidemiology and Infection · doi:10.1017/s0950268800048019 · Cited by 598 · see citing works
Kinetics of viral load and antibody response in relation to COVID-19 severity
Wang, Y., Zhang, L., Sang, L., Feng, Y., Ruan, S., Zhong, B., Song, T., Alshukairi, A. N., Chen, R., Zhang, Z., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138759 · Cited by 534 · see citing works
Magleby, R., Westblade, L. F., Trzebucki, A. M., Simon, M. S., Rajan, M., Park, J. C., Goyal, P., Safford, M. M., & Satlin, M. J. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa851 · Cited by 412 · see citing works
Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19
Cervia, C., Nilsson, J., Zurbuchen, Y., Valaperti, A., Schreiner, J., Wolfensberger, A., Raeber, M. E., Adamo, S., Weigang, S., Emmenegger, M., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.040 · Cited by 402 · see citing works
Transmission of MERS-Coronavirus in Household Contacts
Drosten, C., Meyer, B., Müller, M. A., Corman, V. M., Almasri, M. M., Hossain, R., Madani, H. H., Sieberg, A., Bosch, B., Lattwein, E., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1405858 · Cited by 393 · see citing works
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival
Atyeo, C., Fischinger, S., Zohar, T., Slein, M. D., Burke, J., Loos, C., McCulloch, D. J., Newman, K. L., Wolf, C., Yu, J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.020 · Cited by 349 · see citing works
Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2
Hogan, C. A., Sahoo, M. K., & Pinsky, B. A. (2020) · JAMA · doi:10.1001/jama.2020.5445 · Cited by 317 · see citing works
Self-citationPrevalence of Asymptomatic SARS-CoV-2 Infection
Oran, D. P., & Topol, E. J. (2021) · Annals of Internal Medicine · doi:10.7326/l20-1285 · Cited by 241 · see citing works
Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2
Nielsen, S. C. A., Yang, F., Jackson, K., Hoh, R. A., Röltgen, K., Jean, G. H., Stevens, B., Lee, J.-Y., Rustagi, A., Rogers, A. J., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.09.002 · Cited by 236 · see citing works
Self-citationDisease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
Chen, X., Pan, Z., Yue, S., Yu, F., Zhang, J., Yang, Y., Li, R., Liu, B., Yang, X., Gao, L., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00301-9 · Cited by 234 · see citing works
Westblade, L. F., Brar, G. S., Pinheiro, L. C., Paidoussis, D., Rajan, M., Martin, P., Goyal, P., Sepulveda, J. L., Zhang, L., George, G., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.09.007 · Cited by 217 · see citing works
Powell, A. E., Zhang, K., Sanyal, M., Tang, S., Weidenbacher, P. A. B., Li, S., Pham, T. D., Pak, J. E., Chiu, W., & Kim, P. S. (2021) · ACS Central Science · doi:10.1021/acscentsci.0c01405 · Cited by 174 · see citing works
Self-citationSerology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland
Perez‐Saez, J., Lauer, S. A., Kaiser, L., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30584-3 · Cited by 167 · see citing works
Antibody Response and Disease Severity in Healthcare Worker MERS Survivors
Alshukairi, A. N., Khalid, I., Ahmed, W., Dada, A. M., Bayumi, D. T., Malic, L. S., Althawadi, S., Ignacio, K. H., Alsalmi, H., Al-Abdely, H. M., et al. (2016) · Emerging infectious diseases · doi:10.3201/eid2206.160010 · Cited by 139 · see citing works
High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease
Hogan, C. A., Stevens, B., Sahoo, M. K., Huang, C., Garamani, N., Gombar, S., Yamamoto, F. F., Murugesan, K., Kurzer, J. H., Zehnder, J. L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1054 · Cited by 132 · see citing works
Self-citationReinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report
Goldman, J. D., Wang, K., Röltgen, K., Nielsen, S. C. A., Roach, J. C., Naccache, S. N., Yang, F., Wirz, O. F., Yost, K. E., Lee, J.-Y., et al. (2022) · Vaccines · doi:10.3390/vaccines11010005 · Cited by 95 · see citing works
Self-citationReinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case reportPreprint
Goldman, J. D., Wang, K., Röltgen, K., Nielsen, S. C. A., Roach, J. C., Naccache, S. N., Yang, F., Wirz, O. F., Yost, K. E., Lee, J.-Y., et al. (2020) · medRxiv · doi:10.1101/2020.09.22.20192443 · Cited by 93 · see citing works
Self-citationOkba, N. M. A., Raj, V. S., Widjaja, I., GeurtsvanKessel, C. H., de Bruin, E., Chandler, F. D., Park, W. B., Kim, N. J., Farag, E., Al-Hajri, M., et al. (2019) · Emerging infectious diseases · doi:10.3201/eid2510.190051 · Cited by 79 · see citing works
Perspectives on the development of neutralizing antibodies against SARS-CoV-2
Ho, M. (2020) · Antibody Therapeutics · doi:10.1093/abt/tbaa009 · Cited by 43 · see citing works
Powell, A. E., Zhang, K., Sanyal, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.28.272518 · Cited by 31 · see citing works
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- Authors
- Röltgen, K., Powell, A. E., Wirz, O. F., Stevens, B. A., Hogan, C. A., Najeeb, J., Hunter, M., Wang, H., Sahoo, M. K., Huang, C., Yamamoto, F., Manohar, M., Manalac, J., Otrelo-Cardoso, A. R., Pham, T. D., Rustagi, A., Rogers, A. J., Shah, N. H., Blish, C. A., Cochran, J. R., Jardetzky, T. S., Zehnder, J. L., Wang, T. T., Narasimhan, B., Gombar, S., Tibshirani, R., Nadeau, K. C., Kim, P. S., Pinsky, B. A., & Boyd, S. D.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- ATUM (United States) (US)
- Stanford Blood Center (US)
- Chan Zuckerberg Biohub San Francisco (US)
- Corresponding author
- Röltgen, Katharina
- Powell, Abigail E.
- Wirz, Oliver F.
- Stevens, Bryan A.
- Kim, Peter S.
- Pinsky, Benjamin A.
- Boyd, Scott D.
- ORCID
- Röltgen, Katharina
- Powell, Abigail E.
- Wirz, Oliver F.
- Stevens, Bryan A.
- Hogan, Catherine A.
- Najeeb, Javaria
- Wang, Hannah
- Sahoo, Malaya K.
- Huang, ChunHong
- Manohar, Monali
- Otrelo-Cardoso, Ana R.
- Pham, Tho D.
- Rustagi, Arjun
- Rogers, Angela J.
- Shah, Nigam H.
- Blish, Catherine A.
- Cochran, Jennifer R.
- Jardetzky, Theodore S.
- Zehnder, James L.
- Wang, Taia T.
- Narasimhan, Balasubramanian
- Gombar, Saurabh
- Tibshirani, Robert
- Nadeau, Kari C.
- Kim, Peter S.
- Pinsky, Benjamin A.
- Boyd, Scott D.
- Venue
- Science Immunology
- Published
- 2020-12-18
- Volume
- 5
- Issue
- 54
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC7857392
- OpenAlex
- W3111459703
- Cited by
- 452
- References
- 53
- Citations by year
- 2026: 6 · 2025: 31 · 2024: 33 · 2023: 62 · 2022: 136 · 2021: 180 · 2020: 3 · 2014: 1
- FWCI
- 12.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Science Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ImmPort
- Funders
- National Institutes of Health (1U54CA260517)
- National Institute of Allergy and Infectious Diseases (T32 AI007502-23)
- Stanford Maternal and Child Health Research Institute (Postdoctoral Fellowship)
- Swiss National Science Foundation (Early Postdoc.Mobility Fellowship)
- NIH/NIAID (R01AI127877, R01AI130398)
- Crown Family Foundation (endowment)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, COVID-19 pandemic, antibody response, neutralizing antibodies, spike protein receptor-binding domain, ACE2 receptor, IgG antibody titers, disease severity, prognostic factors, pseudovirus neutralization assay, nucleocapsid antigen, antibody waning, asymptomatic infection, hospitalized patients
- MeSH terms
- Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Severity of Illness Index, Antibodies, Neutralizing, Real-Time Polymerase Chain Reaction, Spike Glycoprotein, Coronavirus
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