The DOI matches its Crossref record.
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
Open accessAbstract
Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and sporadic colon cancer, but the functions of the protein are not known. We show that APC protein localizes mainly to clusters of puncta near the ends of microtubules that extend into actively migrating regions of epithelial cell membranes. This subcellular distribution of APC protein requires microtubules, but not actin filaments. APC protein-containing membranes are actively involved in cell migration in response to wounding epithelial monolayers, addition of the motorgen hepatocyte growth factor, and during the formation of cell-cell contacts. In the intestine, APC protein levels increase at the crypt/villus boundary, where cell migration is crucial for enterocyte exit from the crypt and where cells accumulate during polyp formation that is linked to mutations in the microtubule-binding domain of APC protein. Together, these data indicate that APC protein has a role in directed cell migration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Epidermal growth factor receptor: Mechanisms of activation and signalling
Jorissen, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00098-8 · Cited by 1,565
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482
The -Catenin Destruction Complex
Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007898 · Cited by 1,062
APC, Signal transduction and genetic instability in colorectal cancer
Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937
Conserved microtubule–actin interactions in cell movement and morphogenesis
Rodriguez, O. C., Schaefer, A. W., Mandato, C. A., Forscher, P., Bement, W. M., & Waterman-Storer, C. M. (2003) · Nature Cell Biology · doi:10.1038/ncb0703-599 · Cited by 844
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656
Building epithelial architecture: insights from three-dimensional culture models
O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596
Watanabe, T., Wang, S., Noritake, J., Sato, K., Fukata, M., Takefuji, M., Nakagawa, M., Izumi, N., Akiyama, T., & Kaibuchi, K. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.017 · Cited by 480
Microtubules and signal transduction
Gundersen, G. G., & Cook, T. A. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80010-6 · Cited by 407
The APC tumour suppressor has a nuclear export function
Rosin-Arbesfeld, R., Townsley, F., & Bienz, M. (2000) · Nature · doi:10.1038/35023016 · Cited by 343
WNT as a Driver and Dependency in Cancer
Parsons, M. J., Tammela, T., & Dow, L. E. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0190 · Cited by 257
Targeting and transport: How microtubules control focal adhesion dynamics
Stehbens, S., & Wittmann, T. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201206050 · Cited by 244
van Horck, F. P. G., Ahmadian, M. R., Haeusler, L. C., Moolenaar, W. H., & Kranenburg, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003839200 · Cited by 174
Origin of the Precerebellar System
Rodriguez, C. I., & Dymecki, S. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00059-3 · Cited by 149
Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap
Infante, A. S., Stein, M. S., Zhai, Y., Borisy, G. G., & Gundersen, G. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3907 · Cited by 127
Modulation of the microtubule cytoskeleton: a role for a divergent canonical Wnt pathway
Salinas, P. C. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.003 · Cited by 100
Grohmann, A., Tanneberger, K., Alzner, A., Schneikert, J., & Behrens, J. (2007) · Journal of Cell Science · doi:10.1242/jcs.011320 · Cited by 85
Selective targeting of mutant adenomatous polyposis coli ( APC ) in colorectal cancer
Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y.-A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8127 · Cited by 88
Cunningham, C. C., Leclerc, N., Flanagan, L. A., Lu, M., Janmey, P. A., & Kosik, K. S. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.845 · Cited by 88
Natarajan, L., Witwer, N. E., & Eisenmann, D. M. (2001) · Genetics · doi:10.1093/genetics/159.1.159 · Cited by 75
Siesser, P. F., Motolese, M., Walker, M. P., Goldfarb, D., Gewain, K., Yan, F., Kulikauskas, R. M., Chien, A. J., Wordeman, L., & Major, M. B. (2012) · Science Signaling · doi:10.1126/scisignal.2002871 · Cited by 19
Metadata
- Authors
- Näthke, I. S., Adams, C. L., Polakis, P., Sellin, J. H., & Nelson, W. J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1996-07-01
- Volume
- 134
- Issue
- 1
- Pages
- 165-179
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1967921405
- Cited by
- 484
- References
- 0
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
