Cited by 571Alzheimer's disease research and treatmentsMitochondrial Function and PathologyAutophagy in Disease and Therapy

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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Anandatheerthavarada, Hindupur K., Biswas, Gopa, Robin, Marie-Anne, Avadhani, Narayan G.·2003·The Journal of Cell Biology

DOI 10.1083/jcb.200207030PMC PMC2172865

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Abstract

Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is known to be the source of the toxic amyloid beta (Abeta) peptide associated with the pathogenesis of Alzheimer's disease (AD). Here we demonstrate that by virtue of its chimeric NH2-terminal signal, APP is also targeted to mitochondria of cortical neuronal cells and select regions of the brain of a transgenic mouse model for AD. The positively charged residues at 40, 44, and 51 of APP are critical components of the mitochondrial-targeting signal. Chemical cross-linking together with immunoelectron microscopy show that the mitochondrial APP exists in NH2-terminal inside transmembrane orientation and in contact with mitochondrial translocase proteins. Mutational studies show that the acidic domain, which spans sequence 220-290 of APP, causes the transmembrane arrest with the COOH-terminal 73-kD portion of the protein facing the cytoplasmic side. Accumulation of full-length APP in the mitochondrial compartment in a transmembrane-arrested form, but not lacking the acidic domain, caused mitochondrial dysfunction and impaired energy metabolism. These results show, for the first time, that APP is targeted to neuronal mitochondria under some physiological and pathological conditions.

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“…$8.00 The Journal of Cell Biology, Volume 161, Number 1, April 14, 2003 41–54 http://www.jcb.org/cgi/doi/10.1083/jcb.200207030 JCB Article 41 Mitochondrial targeting and a novel transmembrane arrest of Alzheimer’s amyloid precursor protein impairs mitochondrial function in neuronal cells”
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Authors: Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G.
Affiliations: University of Pennsylvania (US)
ORCID: Avadhani, Narayan G.
Venue: The Journal of Cell Biology
Publisher: Rockefeller University Press
Published: 2003-04-14
Volume: 161
Issue: 1
Pages: 41-54
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.200207030
PMC: PMC2172865
OpenAlex: W2132988134
Cited by: 571
References: 47
Citations by year: 2026: 11 · 2025: 12 · 2024: 18 · 2023: 22 · 2022: 16 · 2021: 24 · 2020: 23 · 2019: 18 · 2018: 35 · 2017: 14 · 2016: 27 · 2015: 24 · 2014: 17 · 2013: 24 · 2012: 31
FWCI: 13.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01gm034483-01a3)
National Institute of General Medical Sciences (GM34483)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: amyloid precursor protein, APP695, mitochondrial targeting, mitochondrial dysfunction, energy metabolism, Alzheimer's disease, amyloid-beta, mitochondrial translocase, acidic domain, cortical neurons, transgenic mouse model, crosslinking, immunoelectron microscopy
MeSH terms: Alzheimer Disease, Amino Acid Sequence, Animals, Brain, Cell Compartmentation, Cells, Cultured, Disease Models, Animal, Energy Metabolism, Humans, Immunohistochemistry, Intracellular Membranes, Mice, Transgenic, Microscopy, Electron, Mitochondria, Molecular Conformation, Neurons, Recombinant Fusion Proteins, Amyloid beta-Protein Precursor, Protein Structure, Tertiary, Protein Transport, Cytochrome-c Oxidase Deficiency, Mice

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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