Cited by 56Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchPain Mechanisms and Treatments

Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord

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Cantaut-Belarif, Yasmine, Antri, Myriam, Pizzarelli, Rocco, Colasse, Sabrina, Vaccari, Ilaria, Soares, Sylvia, Renner, Marianne, Dallel, Radhouane +2 more·2017·Journal of Cell Biology

Abstract

Microglia control excitatory synapses, but their role in inhibitory neurotransmission has been less well characterized. Herein, we show that microglia control the strength of glycinergic but not GABAergic synapses via modulation of the diffusion dynamics and synaptic trapping of glycine (GlyR) but not GABAA receptors. We further demonstrate that microglia regulate the activity-dependent plasticity of glycinergic synapses by tuning the GlyR diffusion trap. This microglia–synapse cross talk requires production of prostaglandin E2 by microglia, leading to the activation of neuronal EP2 receptors and cyclic adenosine monophosphate–dependent protein kinase. Thus, we now provide a link between microglial activation and synaptic dysfunctions, which are common early features of many brain diseases.

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Authors
Cantaut-Belarif, Y., Antri, M., Pizzarelli, R., Colasse, S., Vaccari, I., Soares, S., Renner, M., Dallel, R., Triller, A., & Bessis, A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Inserm (FR)
Corresponding author
Bessis, Alain
Venue
Journal of Cell Biology
Published
2017-07-17
Volume
216
Issue
9
Pages
2979-2989
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W2736215336
Cited by
56
References
64
Citations by year
2026: 2 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 2
FWCI
3.66
Type
journal article
Language
en
Open access
Locations
  • The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche
  • H2020 European Research Council
  • Investissements d’Avenir (ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-0001-02 PSL Research University)
  • Fondation pour la Recherche Médicale (FDT20130928360, DGE20111123023)
  • Région Ile-de-France (NERF 2009-44, NERF 2011-45)
  • Fédération pour la Recherche sur le Cerveau (2011)
  • France BioImaging (ANR-10-INSB-04-01)
  • Institut national de la santé et de la recherche médicale
  • Clermont Université
  • Région Auvergne
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
microglia, glycinergic synapses, GABAergic synapses, prostaglandin E2, glycine receptor, GABAA receptor, activity-dependent synaptic plasticity, EP2 receptor, protein kinase A, inhibitory neurotransmission, spinal cord
MeSH terms
Animals, Carrier Proteins, Cells, Cultured, Diffusion, Female, gamma-Aminobutyric Acid, Glycine, Male, Membrane Potentials, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Synaptic Transmission, Receptors, GABA-A, Spinal Cord, Synaptic Membranes, Time Factors, Dinoprostone, Microglia, Cyclic AMP-Dependent Protein Kinases, Receptors, Glycine, Protein Transport, Tissue Culture Techniques, Electrical Synapses, Receptors, Prostaglandin E, EP2 Subtype

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