Cited by 251Monoclonal and Polyclonal Antibodies ResearchCellular transport and secretionPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

Open access

Mellman, I, Plutner, H·1984·The Journal of cell biology

DOI 10.1083/jcb.98.4.1170PMC PMC2113248

Open this paper in CoChat — free account

Abstract

We have studied the Fc receptor-mediated pinocytosis of immunoglobulin G (IgG)-containing immune complexes by mouse macrophages. IgG complexes were formed from affinity-purified rabbit dinitrophenyl IgG and dinitrophenyl modified BSA at molar ratios of 2.5-10:1. Both the specificity of binding and the fate of internalized receptors were analyzed using monoclonal and polyclonal anti-Fc receptor antibodies. Based on the susceptibility of surface-bound ligand to release by proteolysis, we have found that at 37 degrees C, 125I-labeled IgG complexes were rapidly internalized (t1/2 less than 2 min) and delivered to lysosomes; acid-soluble 125I was detectable in the growth medium within 5-10 min of uptake. However, kinetic evidence indicated that Fc receptors were not efficiently re-used for multiple rounds of ligand uptake. Instead, macrophages that were exposed continuously to saturating concentrations of IgG complexes exhibited a selective and largely irreversible removal of Fc receptors from the plasma membrane. This loss of surface receptors correlated with an increased rate of receptor turnover, determined by immune precipitation of Fc receptors from 125I-labeled macrophages. Thus, in contrast to the results obtained in the accompanying paper (I. Mellman, H. Plutner, and P. Ukkonen, 1984, J. Cell Biol. 98:1163-1169) using a monovalent ligand, these data indicate that the interaction of Fc receptors with polyvalent complexes leads to the degradation of both ligand and receptor following their delivery to lysosomes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1083/jcb.98.4.1170

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril
Fraker, P. J., & Speck, J. C. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91322-0 · Cited by 4,553
Coated pits, coated vesicles, and receptor-mediated endocytosis
Goldstein, J. L., Anderson, R. G. W., & Brown, M. S. (1979) · Nature · doi:10.1038/279679a0 · Cited by 1,532
Endocytosis and the recycling of plasma membrane.
Steinman, R. M., Mellman, I., Müller, W. A., & Cohn, Z. A. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.1 · Cited by 1,459
Self-citation
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
Carpenter, G., & Cohen, S. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.71.1.159 · Cited by 1,291
Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.
Unkeless, J. C. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.150.3.580 · Cited by 1,271
Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts
Goldstein, J. L., & Brown, M. S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42341-7 · Cited by 1,123
Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
Gavin, J. R., Roth, J., Neville, D. M., MEYTS, P. D., & Buell, D. N. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.84 · Cited by 1,040
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.
González‐Noriega, A., Grubb, J. H., Talkad, V. D., & Sly, W. S. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.839 · Cited by 736
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES
Cohn, Z. A., & Benson, B. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.121.1.153 · Cited by 691
Rapid acidification of endocytic vesicles containing α2-macroglobulin
Tycko, B., & Maxfield, F. R. (1982) · Cell · doi:10.1016/0092-8674(82)90219-7 · Cited by 673

Show all 34 references

Sorted by citations

ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,552
Self-citation
CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES
Watts, C. K. W. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.821 · Cited by 754
Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies
Keizer, R. J., Huitema, A. D. R., Schellens, J. H. M., & Beijnen, J. H. (2010) · Clinical Pharmacokinetics · doi:10.2165/11531280-000000000-00000 · Cited by 725
Membrane transport in the endocytic pathway
Grüenberg, J., & Maxfield, F. R. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80013-1 · Cited by 645
Receptor-mediated endocytosis
Wileman, T. E., Harding, C., & Stahl, P. D. (1985) · Biochemical Journal · doi:10.1042/bj2320001 · Cited by 566
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
Mayor, S., Presley, J. F., & Maxfield, F. R. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.6.1257 · Cited by 436
Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes
Amigorena, S., Bonnerot, C., Drake, J. R., Choquet, D., Hunziker, W., Guillet, J., Webster, P. C., Sautès‐Fridman, C., Mellman, I., & Fridman, W. H. (1992) · Science · doi:10.1126/science.1535455 · Cited by 450
Self-citation
The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.
Rothberg, K. G., Ying, Y. S., Kolhouse, J. F., Kamen, B. A., & Anderson, R. G. W. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.3.637 · Cited by 441
Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells.
Gottlieb, T. A., Ivanov, I. E., Adesnik, M., & Sabatini, D. D. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.3.695 · Cited by 439
Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes
Schmid, S. L. (1988) · Cell · doi:10.1016/0092-8674(88)90532-6 · Cited by 377
Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
Matteoli, M., Takei, K., Perin, M., Südhof, T., & Camilli, P. D. (1992) · Journal of Cell Biology · doi:10.1083/jcb.117.4.849 · Cited by 326
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome
Dunn, K. W., McGraw, T. E., & Maxfield, F. R. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.6.3303 · Cited by 275
Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA
Mostov, K. E., & Deitcher, D. L. (1986) · Cell · doi:10.1016/0092-8674(86)90887-1 · Cited by 319
Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINS
Raghavan, M., & Björkman, P. J. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.181 · Cited by 312
Glycoproteins of the lysosomal membrane.
Lewis, V., Green, S. A., Marsh, M., Vihko, P., Helenius, A., & Mellman, I. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.6.1839 · Cited by 309
Self-citation
Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development
Ovacik, M., & Lin, K. (2018) · Clinical and Translational Science · doi:10.1111/cts.12567 · Cited by 299
Delivery into cells: lessons learned from plant and bacterial toxins
Sandvig, K., & van Deurs, B. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302525 · Cited by 273
Phagocytosis of polymer microspheres by macrophages
Tabata, Y., & Ikada, Y. (2006) · Springer eBooks · doi:10.1007/bfb0043062 · Cited by 271
Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity
Miettinen, H. M., Rose, J. K., & Mellman, I. (1989) · Cell · doi:10.1016/0092-8674(89)90846-5 · Cited by 257
Self-citation
A dynamical model for receptor-mediated cell adhesion to surfaces
Hammer, D. A., & Lauffenburger, D. A. (1987) · Biophysical Journal · doi:10.1016/s0006-3495(87)83236-8 · Cited by 258
Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction
French, A. R., Tadaki, D. K., Niyogi, S. K., & Lauffenburger, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4334 · Cited by 249
The Ways of Endocytosis
van Deurs, B., PETERSEN, O. W., Olsnes, S., & Sandvig, K. (1989) · International review of cytology · doi:10.1016/s0074-7696(08)61336-4 · Cited by 236
Routing of internalized ricin and ricin conjugates to the Golgi complex.
van Deurs, B., Tønnessen, T. I., PETERSEN, O. W., Sandvig, K., & Olsnes, S. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.1.37 · Cited by 234
Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.
Bonifacino, J. S., Suzuki, C. K., Lippincott‐Schwartz, J., Weissman, A. M., & Klausner, R. D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.73 · Cited by 226
A di‐leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells.
Hunziker, W., & Fumey, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06594.x · Cited by 252
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Junker, F., Gordon, J., & Qureshi, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01393 · Cited by 219
Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis
Marsh, M., Schmid, S. L., Kern, H., Harms, E., Male, P., Mellman, I., & Helenius, A. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.4.875 · Cited by 209
Self-citation
Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif.
Johnson, L. S., Dunn, K. W., Pytowski, B., & McGraw, T. E. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1251 · Cited by 207
The Transferrin Receptor: A Potential Molecular Imaging Marker for Human Cancer
Högemann, D., Bos, E., Blondet, C., Sato, F., Abé, T., Josephson, L., Weissleder, R., Gaudet, J., Sgroi, D. C., Peters, P. J., et al. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80034-9 · Cited by 201
Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.
Green, S. A., Zimmer, K. ‐., Griffiths, G. W., & Mellman, I. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.3.1227 · Cited by 200
Self-citation
Tyrosine phosphorylation is required for Fc receptor–mediated phagocytosis in mouse macrophages
Greenberg, S., Chang, P., & Silverstein, S. C. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.2.529 · Cited by 198
A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein.
Stanton, L. W., White, R. T., Bryant, C. M., Protter, A. A., & Endemann, G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41692-4 · Cited by 192
The importance of being acid: the role of acidification in intracellular membrane traffic
Mellman, I. (1992) · Journal of Experimental Biology · doi:10.1242/jeb.172.1.39 · Cited by 188
Self-citation
Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
Chatterjee, B., Smed‐Sörensen, A., Cohn, L. B., Chalouni, C. M., Vandlen, R. A., Lee, B.-C., Widger, J., Keler, T., Delamarre, L., & Mellman, I. (2012) · Blood · doi:10.1182/blood-2012-01-402370 · Cited by 195
Self-citation
Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation
Vidal, M., Mangeat, P. H., & Hoekstra, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.16.1867 · Cited by 184
Internalization and rapid recycling of macrophage Fc receptors tagged with monovalent antireceptor antibody: possible role of a prelysosomal compartment.
Mellman, I., Plutner, H., & Ukkonen, P. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.4.1163 · Cited by 184
Self-citation
Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
Wang, J., Lozier, J. N., Johnson, G. R., Kirshner, S., Verthelyi, D. I., Pariser, A., Shores, E. W., & Rosenberg, A. S. (2008) · Nature Biotechnology · doi:10.1038/nbt.1484 · Cited by 172
Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cells
Matter, K., Whitney, J. A., Yamamoto, E. M., & Mellman, I. (1993) · Cell · doi:10.1016/0092-8674(93)90727-8 · Cited by 134
Self-citation
A complementary DNA clone for a macrophage-lymphocyte Fc receptor
Lewis, V. A., Koch, T., Plutner, H., & Mellman, I. (1986) · Nature · doi:10.1038/324372a0 · Cited by 165
Self-citation
Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
Martin-Alonso, C., Tabrizi, S., Xiong, K., Blewett, T., Sridhar, S., Crnjac, A., Patel, S., An, Z., Bekdemir, A., Shea, D., et al. (2024) · Science · doi:10.1126/science.adf2341 · Cited by 158
Exosome Secretion: The Art of Reutilizing Nonrecycled Proteins?
Gassart, A. D., Géminard, C., Hoekstra, D., & Vidal, M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00223.x · Cited by 157
Biogenesis of epithelial cell polarity: Intracellular sorting and vectorial exocytosis of an apical plasma membrane glycoprotein
Misek, D. E., Bard, E., & Rodriguez-Boulan, E. J. (1984) · Cell · doi:10.1016/0092-8674(84)90460-4 · Cited by 156
Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.
Marsh, E. W., Leopold, P. L., Jones, N. L., & Maxfield, F. R. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.6.1509 · Cited by 155
Exosomes: Revisiting their role as “garbage bags”
Vidal, M. (2019) · Traffic · doi:10.1111/tra.12687 · Cited by 155
Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).
Stuart, S. G., Trounstine, M. L., Vaux, D. J., Koch, T., Martens, C. L., Mellman, I., & Moore, K. W. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.6.1668 · Cited by 151
Self-citation
Liver immunobiology.
Parker, G. A., & Picut, C. (2005) · Toxicologic pathology (Print) · doi:10.1080/01926230590522365 · Cited by 117
Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cells
Green, S., & Kelly, R. B. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.1.47 · Cited by 145
Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes.
Ukkonen, P., Lewis, V., Marsh, M., Helenius, A., & Mellman, I. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.4.952 · Cited by 145
Self-citation
Expression of macrophage-lymphocyte Fc receptors in Madin-Darby canine kidney cells: polarity and transcytosis differ for isoforms with or without coated pit localization domains.
Hunziker, W., & Mellman, I. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3291 · Cited by 141
Self-citation
The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes
Green, S., Setiadi, H., McEver, R., & Kelly, R. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.4.435 · Cited by 112
Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.
Miettinen, H. M., Matter, K., Hunziker, W., Rose, J. K., & Mellman, I. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.4.875 · Cited by 137
Self-citation
Rab17 Regulates Membrane Trafficking through Apical Recycling Endosomes in Polarized Epithelial Cells
Zacchi, P., Stenmark, H., Parton, R. G., Orioli, D., Lim, F., Giner, A., Mellman, I., Zerial, M., & Murphy, C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.5.1039 · Cited by 140
Self-citation
Receptor-mediated endocytosis.
Stahl, P. D., & Schwartz, A. L. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112359 · Cited by 134
Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.
Minami, Y., Samelson, L. E., & Klausner, R. D. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45206-4 · Cited by 132
Endocytosis of glycophospholipid‐anchored and transmembrane forms of CD4 by different endocytic pathways.
Keller, G. A., Siegel, M. W., & Caras, I. W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05124.x · Cited by 126
Differential Role of Actin, Clathrin, and Dynamin in Fcγ Receptor-mediated Endocytosis and Phagocytosis
Tse, S. M. L., Furuya, W., Gold, E., Schreiber, A. D., Sandvig, K., Inman, R. D., & Grinstein, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207966200 · Cited by 124
Antigen‐Presenting Function of B Lymphocytes
Pierce, S. K., Morris, J. F., Grusby, M. J., Kaumaya, P. T. P., Buskirk, A. M. V., Srinivasan, M., Crump, B. L., & Smolenski, L. A. (1988) · Immunological Reviews · doi:10.1111/j.1600-065x.1988.tb00778.x · Cited by 122
The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.
Joiner, K. A., Ganz, T., Albert, J. P., & Rotrosen, D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.2771 · Cited by 117
Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcγRIIb2
Mousavi, S. A., Sporstφl, M., Fladeby, C., Kjeken, R., Barois, N., & Berg, T. (2007) · Hepatology · doi:10.1002/hep.21748 · Cited by 113
Apical Plasma Membrane Proteins and Endolyn-78 Travel through a Subapical Compartment in Polarized WIF-B Hepatocytes
Ihrke, G., Martin, G. V., Shanks, M. R., Schrader, M., Schroer, T. A., & Hubbard, A. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.115 · Cited by 112
The uptake of LDL-IC by human macrophages: predominant involvement of the FcγRI receptor
Lopes-Virella, M. F., Binzafar, N., Rackley, S., Takei, A., Via, M. L., & Virella, G. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00157-3 · Cited by 112
Binding of monomeric immunoglobulin G triggers Fc gamma RI-mediated endocytosis.
Harrison, P. T., Davis, W., Norman, J. C., Hockaday, A. R., & Allen, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51097-3 · Cited by 104
Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells
Wiewrodt, R. G., Thomas, A., Cipelletti, L., Christofidou‐Solomidou, M., Weitz, D. A., Feinstein, S. I., Schaffer, D., Albelda, S. Μ., Koval, M. H., & Muzykantov, V. R. (2002) · Blood · doi:10.1182/blood.v99.3.912 · Cited by 104
Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules
Weflen, A. W., Baier, N., Tang, Q.-J., Van den Hof, M., Blumberg, R. S., Lencer, W. I., & Massol, R. H. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-04-0174 · Cited by 101
Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.
Weissman, A. M., Klausner, R. D., Rao, K., & Harford, J. B. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.3.951 · Cited by 96
Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.
Breitfeld, P. P., Casanova, J. E., McKinnon, W. C., & Mostov, K. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77413-9 · Cited by 96
Sorting and traffic in the central vacuolar system
Klausner, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90783-6 · Cited by 95
Fc receptor mediated endocytosis of small soluble immunoglobulin G immune complexes in Kupffer and endothelial cells from rat liver
Løvdal, T., Andersen, E., Brech, A., & Berg, T. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.18.3255 · Cited by 93
Proteolytic cleavage of ricin A chain in endosomal vesicles. Evidence for the action of endosomal proteases at both neutral and acidic pH.
Blum, J. S., Fiani, M. L., & Stahl, P. D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54537-3 · Cited by 92
The FcγRIa (CD64) Ligand Binding Chain Triggers Major Histocompatibility Complex Class II Antigen Presentation Independently of Its Associated FcR γ-Chain
van Vugt, M. J., Kleijmeer, M. J., Keler, T., Zeelenberg, I. S., van Dijk, M. A., Leusen, J. H. W., Geuze, H. J., & van de Winkel, J. G. J. (1999) · Blood · doi:10.1182/blood.v94.2.808 · Cited by 91
Integrin alpha 3 beta 1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells.
Coopman, P. J. P., Thomas, D. M., Gehlsen, K. R., & Mueller, S. C. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.11.1789 · Cited by 91
Receptor-mediated targeted drug or toxin delivery
Řı́hová, B. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00084-7 · Cited by 90
Type II and III Receptors for Immunoglobulin G (IgG) Control the Presentation of Different T Cell Epitopes from Single IgG-complexed Antigens
Amigorena, S., Lankar, D., Briken, V., Gapin, L., Viguier, M., & Bonnerot, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.505 · Cited by 87
Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.
Riedel, H., Dull, T. J., Honegger, A., Schlessinger, J., & Ullrich, A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08444.x · Cited by 87
Transferrin receptors recycle to cis and middle as well as trans Golgi cisternae in Ig-secreting myeloma cells.
Woods, J. W., Doriaux, M., & Farquhar, M. G. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.1.277 · Cited by 84
Binding of nucleosomes to a cell surface receptor: Redistribution and endocytosis in the presence of lupus antibodies
Kontouzov, S., Cabrespines, A., Amoura, Z., Chabre, H., Lotton, C., & Bach, J. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260230 · Cited by 81
Modulation of transferrin receptor expression and function by anti-transferrin receptor antibodies and antibody fragments
Lesley, J., Schulte, R. J., & Woods, J. W. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90293-0 · Cited by 77
Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis.
Neutra, M. R., Ciechanover, A. J., Owen, L. S., & Lodish, H. F. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.11.2997327 · Cited by 77
The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages.
Tabas, I. A., Myers, J. N., Innerarity, T. L., Xu, X. X., Arnold, K. S., Boyles, J. K., & Maxfield, F. R. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.6.1547 · Cited by 77
Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages
Tyteca, D. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5613 · Cited by 75
Dimerization of internalized epidermal growth factor receptors.
Sorkin, A. D., & Carpenter, G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54518-x · Cited by 75
Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers
Raub, T. J., & Audus, K. L. (1990) · Journal of Cell Science · doi:10.1242/jcs.97.1.127 · Cited by 74
Quantification of endocytosis-derived membrane traffic
Thilo, L. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90010-3 · Cited by 74
Mechanisms of growth inhibition by anti-transferrin receptor monoclonal antibodies.
Taetle, R., Castagnola, J., & Mendelsohn, J. M. (1986) · PubMed · Cited by 71
Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors
Ortiz, D. F., Lansing, J. C., Rutitzky, L. I., Kurtagic, E., Prod’homme, T., Choudhury, A., Washburn, N., Bhatnagar, N., Beneduce, C., Holte, K., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9418 · Cited by 71
Fusion between vesicles from the pathway of receptor‐mediated endocytosis in a cell‐free system
Woodman, P. G., & WARREN, G. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb13972.x · Cited by 69
Internalization of blocking antibodies against mannose‐6‐phosphate specific receptors.
Gartung, C., Braulke, T., Hasilík, A., & FIGURA, K. V. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03842.x · Cited by 68
Structure and function of Fc receptors on macrophages and lymphocytes
Mellman, I., Koch, T., Healey, G. A., Hunziker, W., Lewis, V., Plutner, H., Miettinen, H. M., Vaux, D. J., Moore, K. W., & Stuart, S. G. (1988) · Journal of Cell Science · doi:10.1242/jcs.1988.supplement_9.3 · Cited by 67
Self-citation
Therapeutic Drug Monitoring of Anti-tumor Necrosis Factor Agents in Patients with Inflammatory Bowel Diseases
Yarur, A. J., & Rubin, D. T. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000380 · Cited by 66
Liver Cell Uptake and Degradation of Soluble Immunoglobulin G Immune Complexes In Vivo And In Vitro In Rats
Johansson, A. G., Løvdal, T., Magnusson, K., Berg, T., & Skogh, T. (1996) · Hepatology · doi:10.1002/hep.510240128 · Cited by 66
An internalized transmembrane protein resides in a fusion-competent endosome for less than 5 minutes.
Gruenberg, J. E., & Howell, K. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5758 · Cited by 66
Feto-maternal microchimerism in connective tissue diseases
Gannag�, M., Amoura, Z., Lantz, O. J., Pietté, J. C., & Caillat‐Zucman, S. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002012)32:12 · Cited by 61
Molecular and Cellular Mechanisms of Receptor-Mediated Endocytosis
Brown, V. I., & Greene, M. I. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.399 · Cited by 62
Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor γ-chain signaling
Shen, L., van Egmond, M., Siemasko, K. F., Gao, H. Q., Wade, T. K., Lang, M. L., Clark, M. R., van de Winkel, J. G. J., & Wade, W. F. (2001) · Blood · doi:10.1182/blood.v97.1.205 · Cited by 60
Role of COPI in Phagosome Maturation
Botelho, R. J., Hackam, D. J., Schreiber, A. D., & Grinstein, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910068199 · Cited by 57
The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis.
Pfeffer, S. R. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.229 · Cited by 59
Analysis of intracellular receptor/ligand sorting in endosomes
Linderman, J. J., & Lauffenburger, D. A. (1988) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(88)80157-7 · Cited by 57
Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis.
Takemura, R., Stenberg, P. E., Bainton, D. F., & Werb, Z. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.1.55 · Cited by 56
(C) Means to enhance penetration
Shen, W., Wan, J., & Ekrami, H. (1992) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(92)90016-j · Cited by 58
Role of Ubiquitin and Proteasomes in Phagosome Maturation
Lee, W. L., Kim, M.-K., Schreiber, A. D., & Grinstein, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-06-0464 · Cited by 53

Authors: Mellman, I., & Plutner, H.
ORCID: Mellman, I
Venue: The Journal of cell biology
Publisher: Rockefeller University Press
Published: 1984-04-01
Volume: 98
Issue: 4
Pages: 1170-1177
ISSN: 0021-9525 (ISSN-L)
1540-8140
DOI: 10.1083/jcb.98.4.1170
PMC: PMC2113248
OpenAlex: W2075507579
Cited by: 251
References: 34
Citations by year: 2026: 3 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 4
FWCI: 21.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: The Journal of Cell Biology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: Fc receptors, macrophages, immune complexes, receptor internalization, receptor degradation, pinocytosis, lysosomes, receptor turnover, IgG, ligand uptake, receptor recycling
MeSH terms: Animals, Antibodies, Monoclonal, Antigen-Antibody Complex, Cell Line, Immunoglobulin G, Kinetics, Macrophages, Microscopy, Fluorescence, Pinocytosis, Receptors, Fc, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks