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PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
Open accessAbstract
Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly found that elimination of the gene in adult mice allowed disturbed hematopoiesis, dominated by granulocyte production. Impaired production of lymphocytes was evident in PU.1-deficient bone marrow (BM), but myelocytes and clonogenic granulocytic progenitors that are responsive to granulocyte colony-stimulating factor or interleukin-3 increased dramatically. No identifiable common lymphoid or myeloid progenitor populations were discernable by flow cytometry; however, clonogenic assays suggested an overall increased frequency of blast colony-forming cells and BM chimeras revealed existence of long-term self-renewing PU.1-deficient cells that required PU.1 for lymphoid, but not granulocyte, generation. PU.1 deletion in granulocyte-macrophage progenitors, but not in common myeloid progenitors, resulted in excess granulocyte production; this suggested specific roles of PU.1 at different stages of myeloid development. These findings emphasize the distinct nature of adult hematopoiesis and reveal that PU.1 regulates the specification of the multipotent lymphoid and myeloid compartments and restrains, rather than promotes, granulopoiesis.
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“Ets family transcription factor PU.1 is pivotal for normal hematopoiesis as it directs differentiation of hematopoietic progenitors to different cell lineages such as macrophage, granulocyte or B cell (1).”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“In preleukemic states (e.g., MDS), where PU.1 downregulation permits clonal expansion 33-35”
From USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization (2026) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“One such master regulator is the Ets-family transcription factor PU.1, which is indispensable for HSC function and the differentiation of cells within the myeloid as well as lymphoid lineages3–5.”
From Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (2015) · cites this paper as [4]
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In the citing paper
“its action is also important or indispensable for sustained generation of all known hematopoietic precursors that have lymphoid developmental potentials (1–9).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“All the hematopoietic progenitors that generate either B or T cells appear to originate from PU.1-expressing, PU.1-dependent prethymic cells (2, 27)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
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“It probably extends for over 10 days for the thymocytes in young adult mice (153), where it is crucial for successful T-cell generation (2, 147).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
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In the citing paper
“Dysregulation of the PU.1 transcriptional network is a common phenotype associated with hematological malignancy, particularly diseases of the myeloid lineage (Cook et al., 2004; Dakic et al., 2005; Koschmieder et al., 2005; Will et al., 2015; Sive et al., 2016; Aivalioti et al., 2022).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Dakic et al., 2005
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“PU.1 is a hematopoietic-specific and ETS family transcription factor that is essential for lymphoid and myeloid development25–28.”
From HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages (2024) · cites this paper as [27]
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“in postnatal mice, although T cell development is much more severely affected by PU.1 deletion than neutrophil development (2)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
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“These findings are consistent with prior work indicating PU.1 can constrain myelopoietic activity (DeKoter et al., 1998; Dakic et al., 2005)”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Dakic et al., 2005
In the citing paper
“PU.1 binds to purine-rich sequence (PU-box) and activates gene expression during immune cell development [24, 25].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [25]
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Metadata
- Authors
- Dakic, A., Metcalf, D., Di Rago, L., Mifsud, S., Wu, L., & Nutt, S. L.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-05-02
- Volume
- 201
- Issue
- 9
- Pages
- 1487-1502
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2213186
- OpenAlex
- W2136610354
- Cited by
- 297
- References
- 51
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 15 · 2023: 13 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 9 · 2015: 18 · 2014: 15 · 2013: 26 · 2012: 21
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (CA22556)
- Medical Research Council
- National Health and Medical Research Council
- Cancer Council Victoria
- National Cancer Institute (R37CA022556, CA22556, R01CA022556)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- PU.1, granulopoiesis, hematopoietic progenitor cells, CFU-GM, common myeloid progenitors, lymphocyte production, granulocyte colony-stimulating factor, interleukin-3, bone marrow chimeras, transcription factors, adult hematopoiesis
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Antibodies, Monoclonal, Blood Cell Count, Cell Differentiation, Cells, Cultured, Colony-Forming Units Assay, Flow Cytometry, Genetic Vectors, Genotype, Granulocytes, Hematopoietic Stem Cells, Mice, Inbred C57BL, Mice, Transgenic, Proto-Oncogene Proteins, Blotting, Western, Trans-Activators, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Myeloid Cells, Green Fluorescent Proteins, Mice
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