The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
Open accessAbstract
Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly found that elimination of the gene in adult mice allowed disturbed hematopoiesis, dominated by granulocyte production. Impaired production of lymphocytes was evident in PU.1-deficient bone marrow (BM), but myelocytes and clonogenic granulocytic progenitors that are responsive to granulocyte colony-stimulating factor or interleukin-3 increased dramatically. No identifiable common lymphoid or myeloid progenitor populations were discernable by flow cytometry; however, clonogenic assays suggested an overall increased frequency of blast colony-forming cells and BM chimeras revealed existence of long-term self-renewing PU.1-deficient cells that required PU.1 for lymphoid, but not granulocyte, generation. PU.1 deletion in granulocyte-macrophage progenitors, but not in common myeloid progenitors, resulted in excess granulocyte production; this suggested specific roles of PU.1 at different stages of myeloid development. These findings emphasize the distinct nature of adult hematopoiesis and reveal that PU.1 regulates the specification of the multipotent lymphoid and myeloid compartments and restrains, rather than promotes, granulopoiesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Ets family transcription factor PU.1 is pivotal for normal hematopoiesis as it directs differentiation of hematopoietic progenitors to different cell lineages such as macrophage, granulocyte or B cell (1).”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In preleukemic states (e.g., MDS), where PU.1 downregulation permits clonal expansion 33-35”
From USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization (2026) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“One such master regulator is the Ets-family transcription factor PU.1, which is indispensable for HSC function and the differentiation of cells within the myeloid as well as lymphoid lineages3–5.”
From Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (2015) · cites this paper as [4]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“its action is also important or indispensable for sustained generation of all known hematopoietic precursors that have lymphoid developmental potentials (1–9).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“All the hematopoietic progenitors that generate either B or T cells appear to originate from PU.1-expressing, PU.1-dependent prethymic cells (2, 27)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It probably extends for over 10 days for the thymocytes in young adult mice (153), where it is crucial for successful T-cell generation (2, 147).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Dysregulation of the PU.1 transcriptional network is a common phenotype associated with hematological malignancy, particularly diseases of the myeloid lineage (Cook et al., 2004; Dakic et al., 2005; Koschmieder et al., 2005; Will et al., 2015; Sive et al., 2016; Aivalioti et al., 2022).”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Dakic et al., 2005
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“PU.1 is a hematopoietic-specific and ETS family transcription factor that is essential for lymphoid and myeloid development25–28.”
From HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages (2024) · cites this paper as [27]
The cited source says what the claim attributes to it.
In the citing paper
“in postnatal mice, although T cell development is much more severely affected by PU.1 deletion than neutrophil development (2)”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“These findings are consistent with prior work indicating PU.1 can constrain myelopoietic activity (DeKoter et al., 1998; Dakic et al., 2005)”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as Dakic et al., 2005
In the citing paper
“PU.1 binds to purine-rich sequence (PU-box) and activates gene expression during immune cell development [24, 25].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 1,025
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
DeKoter, R. P., & Singh, H. (2000) · Science · doi:10.1126/science.288.5470.1439 · Cited by 749
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644
Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602
Flagged first, then by citations
Research works printed but not linked: 5
- 2004, Blood., 104, 3437
- 1996, Curr. Top. Microbiol. Immunol., 211, 137
- 1995, Oncogene., 11, 1549
- 1995, Leukemia., 9, 1556
- 1992, Exp. Hematol., 20, 600
Cited by
Sorted by citations
Items 101–200 of 298
Transcriptional regulation in early B cell development
Fuxa, M., & Skok, J. A. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.02.002 · Cited by 62
Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development
Li, H., Ji, M. H., Klarmann, K. D., & Keller, J. R. (2010) · Blood · doi:10.1182/blood-2009-11-255075 · Cited by 66
Won, H., Nandakumar, V., Yates, P., Sanchez, S., Jones, L. E., Huang, X. F., & Chen, S. (2014) · Blood · doi:10.1182/blood-2013-10-534313 · Cited by 62
Advances in the molecular pathobiology of B-lymphoblastic leukemia
Zhou, Y., You, M. J., Young, K. H., Lin, P., Lu, G. G., Medeiros, L. J., & Bueso-Ramos, C. (2012) · Human Pathology · doi:10.1016/j.humpath.2012.02.004 · Cited by 62
Huber, R., Pietsch, D., Günther, J., Welz, B., Vogt, N., & Brand, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1322-4 · Cited by 62
Pang, S. H. M., de Graaf, C. A., Hilton, D. J., Huntington, N. D., Carotta, S., Wu, L., & Nutt, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01264 · Cited by 60
“The increased Lin− compartment in Spi1fl/−MxCre+Rag1gfp/+ mice was due to an increase in the proportion of Sca-1−c-Kit+ myeloid progenitors as we have previously shown [Figures 1C,D (35)].”
BackgroundResultInfluentialSelf-citationProgression of regulatory gene expression states in fetal and adult pro-T-cell development
David‐Fung, E., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., & Rothenberg, E. V. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00355.x · Cited by 60
Su, T.-Y., Hauenstein, J., Somuncular, E., Dumral, Ö., Leonard, E., Gustafsson, C., Tzortzis, E., Forlani, A., Johansson, A., Qian, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52318-1 · Cited by 66
Hikami, K., Kawasaki, A., Ito, I., Koga, M., Ito, S., Hayashi, T., Matsumoto, I., Tsutsumi, A., Kusaoi, M., Takasaki, Y., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30188 · Cited by 58
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils
Fischer, J., Walter, C., Tönges, A., Aleth, H., Jordão, M. J. C., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0343-z · Cited by 56
Jack, G. D., Zhang, L., & Friedman, A. D. (2009) · Blood · doi:10.1182/blood-2008-11-191536 · Cited by 56
Shin, D., Lee, C., & Morse, H. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027384 · Cited by 59
Transcriptional Control of Macrophage Identity, Self-Renewal, and Function
Molawi, K., & Sieweke, M. H. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00010-7 · Cited by 58
The role of transcription factors in the guidance of granulopoiesis.
Fiedler, K., & Brunner, C. (2012) · PubMed Central · Cited by 56
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis
Karmaus, P. W. F., Herrada, A. A., Guy, C. S., Neale, G. A. M., Dhungana, Y., Long, L., Vogel, P., Ávila-Pacheco, J., Clish, C. B., & Chi, H. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161855 · Cited by 58
Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models
DeKoter, R. P., Kamath, M. B., & Houston, I. B. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.06.004 · Cited by 54
Ma, O., Hong, S., Guo, H. W., Ghiaur, G., & Friedman, A. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095784 · Cited by 56
Tatetsu, H., Ueno, S., Hata, H., Yamada, Y., Takeya, M., Mitsuya, H., Tenen, D. G., & Okuno, Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4265 · Cited by 55
Houston, I. B., Kamath, M. B., Schweitzer, B. L., Chlon, T. M., & DeKoter, R. P. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.04.005 · Cited by 49
Koh, B., Hufford, M. M., Pham, D., Olson, M. R., Wu, T., Jabeen, R., Sun, X., & Kaplan, M. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502383 · Cited by 52
Verbiest, T., Bouffler, S., Nutt, S. L., & Badie, C. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv016 · Cited by 46
Self-citationAdult Hematopoiesis is Regulated by TIF1γ, a Repressor of TAL1 and PU.1 Transcriptional Activity
Kusy, S., Gault, N., Ferri, F., Lewandowski, D., Barroca, V., Jaracz-Ros, A., Losson, R., & Romeo, P.-H. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.005 · Cited by 47
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
Weng, H., Huang, H., & Chen, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7342-8_4 · Cited by 45
The molecular determinants of microglial developmental dynamics
Barry-Carroll, L., & Gómez‐Nicola, D. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00813-1 · Cited by 49
Simmons, S., Knoll, M., Drewell, C., Wolf, I., Mollenkopf, H., Bouquet, C., & Melchers, F. (2012) · Blood · doi:10.1182/blood-2012-03-414821 · Cited by 47
Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination
Rothenberg, E. V., & Scripture-Adams, D. D. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.07.006 · Cited by 43
Role of MicroRNAs in the development and function of innate immune cells
Kingsley, S. M. K., & Bhat, B. V. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1284212 · Cited by 43
Concise Review: Erythroid Versus Myeloid Lineage Commitment: Regulating the Master Regulators
Wolff, L., & Humeniuk, R. (2013) · Stem Cells · doi:10.1002/stem.1379 · Cited by 47
Li, K., Wu, Y., Li, Y., Yu, Q., Zhigang, T., Wei, H., & Qu, K. (2020) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.12.003 · Cited by 38
Arnold, T., & Betsholtz, C. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-12 · Cited by 42
Ye, B., Liu, B., Yang, L., Huang, G., Hao, L., Xia, P., Wang, S., Du, Y., Qin, X. S., Zhu, P., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01788-7 · Cited by 40
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity
Bellavance, M., Gosselin, D., Yong, V. W., Stys, P. K., & Rivest, S. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0759-z · Cited by 39
Mechanisms of self-renewal in hematopoietic stem cells
Wang, Z., & Ema, H. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1919-5 · Cited by 40
Siwaponanan, P., Siegers, J. Y., Ghazali, R., Ng, T., McColl, B., Ng, G. Z., SUTTON, P. R. N., Wang, N., Ooi, I., Thiengtavor, C., et al. (2017) · Blood · doi:10.1182/blood-2016-07-730135 · Cited by 37
Hematopoietic stem cells and retroviral infection
Banerjee, P., Crawford, L. B., Samuelson, E., & Feuer, G. (2010) · Retrovirology · doi:10.1186/1742-4690-7-8 · Cited by 42
Hematopoiesis and T‐cell specification as a model developmental system
Rothenberg, E. V., Kueh, H. Y., Yui, M. A., & Zhang, J. A. (2016) · Immunological Reviews · doi:10.1111/imr.12417 · Cited by 36
T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1
Zhu, H., Zhang, L., Wu, Y., Dong, B., Guo, W., Wang, M., Yang, L., Fan, X., Tang, Y., Liu, N., et al. (2018) · eLife · doi:10.7554/elife.38314 · Cited by 38
Rimmelé, P., Kosmider, O., Mayeux, P., Moreau-Gachelin, F., & Guillouf, C. (2007) · Blood · doi:10.1182/blood-2006-03-006718 · Cited by 35
The Er71 Is an Important Regulator of Hematopoietic Stem Cells in Adult Mice
Lee, D., Kim, T., & Lim, D. (2011) · Stem Cells · doi:10.1002/stem.597 · Cited by 34
Kim, S.-S., Romero, R. J., Kim, J.-S., Abbas, A., Espinoza, J., Kusanovic, J. P., Hassan, S. S., Yoon, B. H., & Kim, C. J. (2008) · Laboratory Investigation · doi:10.1038/labinvest.3700749 · Cited by 35
Yu, S., Jing, X., Colgan, J. D., Zhao, D., & Xue, H. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.021 · Cited by 34
Perivascular macrophages in the CNS : From health to neurovascular diseases
Li, Z., Guo, Y., Zhai, X., Zhang, Y., Chen, W., Zhu, Z., Xuan, W., & Li, P. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13954 · Cited by 36
Mast cell transcriptional networks
Takemoto, C. M., Lee, Y.-N., Jegga, A. G., Zablocki, D., Brandal, S., Shahlaee, A. H., Huang, S., Ye, Y., Gowrisankar, S., Huynh, J. L., et al. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.02.005 · Cited by 33
Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation
Moreau-Gachelin, F. (2008) · Retrovirology · doi:10.1186/1742-4690-5-99 · Cited by 34
Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood
Zhao, Y., Li, X., Zhao, W., Wang, J., Yu, J., Wan, Z., Gao, K., Yi, G., Xie, W., Fan, B., et al. (2019) · GigaScience · doi:10.1093/gigascience/giz047 · Cited by 28
Mishra, M., Thacker, G., Sharma, A., Singh, A. K., Upadhyay, V., Sanyal, S., Verma, S. P., Tripathi, A. K., Bhatt, M. L. B., & Trivedi, A. K. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0268 · Cited by 30
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia
Aue, G., Du, Y., Cleveland, S. M., Smith, S. B., Davé, U. P., Liu, D., Weniger, M. A., Metais, J. Y., Jenkins, N. A., Copeland, N. G., et al. (2011) · Blood · doi:10.1182/blood-2011-04-351528 · Cited by 33
Sadoun, H. A., Burgess, M. O., Hentges, K. E., & Mace, K. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501944 · Cited by 30
Patrick, D. M., de la Visitación, N., Krishnan, J., Chen, W., Ormseth, M. J., Stein, C., Davies, S. S., Amarnath, V., Crofford, L. J., Williams, J. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.136678 · Cited by 30
Huang, K., Du, J., Ma, N., Liu, J., Wu, P., Dong, X., Meng, M., Wang, W., Chen, X., Shi, X., et al. (2015) · Cell Regeneration · doi:10.1186/s13619-015-0018-7 · Cited by 32
Zhou, W., Li, S., Wang, H., Zhou, J., Li, S., Chen, G., Guan, W. P., Fu, X., Nervi, C., Yu, L., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00480-z · Cited by 29
IMiD compounds affect CD34+ cell fate and maturation via CRBN-induced IKZF1 degradation
Li, S., Fu, J., Wang, H., Ma, H., Xu, X., Yang, Y., Deng, S., Mapara, M. Y., & Lentzsch, S. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017010348 · Cited by 30
Salerno, L., Cosentino, C., Morrone, G., & Amato, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132208 · Cited by 28
Tosun, B., Wolff, L. I., Houben, A., Nutt, S. L., & Hartmann, C. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4629 · Cited by 27
Self-citationAwe, O., Hufford, M. M., Wu, H., Pham, D., Chang, H.-C., Jabeen, R., Dent, A. L., & Kaplan, M. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500780 · Cited by 27
Yang, H., Liang, H., Yan, J.-S., Tao, R., Hao, S., & Ma, L. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1106-x · Cited by 26
HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1
Wang, H., Bei, L., Shah, C. A., Hu, L., & Eklund, E. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401909 · Cited by 25
Transcriptional Control of Pre-B Cell Development and Leukemia Prevention
Pang, S. H. M., Carotta, S., & Nutt, S. L. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_377 · Cited by 28
Self-citationMartin-Estebane, M., & Gomez-Nicola, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00149 · Cited by 25
Transcriptional Control of NK Cells
Sun, J. C.-Y. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_452 · Cited by 24
Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia
Monni, R., Haddaoui, L., Naba, A., Gallais, I., Arpin, M., Mayeux, P., & Moreau-Gachelin, F. (2008) · Blood · doi:10.1182/blood-2007-09-110510 · Cited by 25
Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish
Sun, J., Liu, W., Li, L., Chen, J., Wu, M., Zhang, Y., Leung, A. Y. H., Zhang, W., Wen, Z., & Liao, W. (2013) · Leukemia · doi:10.1038/leu.2013.67 · Cited by 24
Zhang, L., & Friedman, A. D. (2011) · Blood · doi:10.1182/blood-2011-01-331157 · Cited by 23
Lasitschka, F., Giese, T., Paparella, M., Kurzhals, S. R., Wabnitz, G. H., Jacob, K., Gras, J., Bode, K. A., Heninger, A., Sziskzai, T., et al. (2017) · Immunity Inflammation and Disease · doi:10.1002/iid3.184 · Cited by 24
GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes
Sadeghi, K., Wisgrill, L., Wessely, I., Diesner, S. C., Schüller, S. S., Duerr, C., Heinle, A., Sachet, M., Pollak, A. J., Förster‐Waldl, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162667 · Cited by 23
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells
Hosokawa, H., Koizumi, M., Masuhara, K., Romero-Wolf, M., Tanaka, T., Nakayama, T., & Rothenberg, E. V. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202648 · Cited by 23
Multi‐scale modeling of GMP differentiation based on single‐cell genealogies
Marr, C., Strasser, M. K., Schwarzfischer, M., Schroeder, T., & Theis, F. J. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08664.x · Cited by 21
Fuchs, O. (2007) · Folia Biologica · doi:10.14712/fb2007053030097 · Cited by 33
Bruno, L., Ramlall, V., Studer, R., Sauer, S., Bradley, D., Dharmalingam, G., Carroll, T. L., Ghoneim, M., Chopin, M., Nutt, S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0471-5 · Cited by 20
Self-citationAlzheimer’s Disease Genetics: A Dampened Microglial Response?
Chatila, Z. K., & Bradshaw, E. M. (2021) · The Neuroscientist · doi:10.1177/10738584211024531 · Cited by 20
Fukuchi, Y., Ito, M., Shibata, F., Kitamura, T., & Nakajima, H. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0320 · Cited by 20
Pharmacogenetics of Alkylator-Associated Acute Myeloid Leukemia
Knoche, E., McLeod, H. L., & Graubert, T. A. (2006) · Pharmacogenomics · doi:10.2217/14622416.7.5.719 · Cited by 19
Dendritic cell functions in vivo: A user's guide to current and next‐ generation mutant mouse models
Dalod, M., & Scheu, S. (2022) · European Journal of Immunology · doi:10.1002/eji.202149513 · Cited by 19
Coppin, E., Zhang, X., Ohayon-Steckel, L., Johny, E., Dasari, A., Zheng, K. H., Stiekema, L. C. A., Cifuentes-Pagano, E., Pagano, P. J., Chaparala, S., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318956 · Cited by 18
The Role of the Tec Kinase Bruton's Tyrosine Kinase (Btk) in Leukocyte Recruitment
Block, H., & Zarbock, A. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2012.668982 · Cited by 20
Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105186 · Cited by 20
Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment
Rothenberg, E. V. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.04.002 · Cited by 17
Gao, D., Pinello, N., Nguyen, T. V., Thoeng, A., Nagarajah, R., Holst, J., Rasko, J. E. J., & Wong, J. J. L. (2018) · Epigenomics · doi:10.2217/epi-2018-0050 · Cited by 17
Kosmider, O., Selimoglu‐Buet, D., Gallais, I., Denis, N., & Moreau-Gachelin, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005721 · Cited by 17
A lineage-specific requirement for YY1 Polycomb Group protein function in early T cell development
Assumpção, A. L. F. V., Fu, G., Singh, D. K., Lu, Z., Kuehnl, A. M., Welch, R., Ong, I. M., Wen, R., & Pan, X. (2021) · Development · doi:10.1242/dev.197319 · Cited by 16
Zhang, Y., Kang, Z., Liu, M., Wang, L., & Liu, F. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.02.010 · Cited by 15
Harnessing the potential of monocytes/macrophages to regenerate tissue-engineered vascular grafts
Das, A., Smith, R. J., & Andreadis, S. T. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae106 · Cited by 17
Barbara, A., Katakura, F., & Belosevic, M. (2012) · InTech eBooks · doi:10.5772/53589 · Cited by 16
Guidi, R., Wedeles, C. J., & Wilson, M. S. (2020) · Non-Coding RNA · doi:10.3390/ncrna6010010 · Cited by 17
The role of monocytes in models of infection by protozoan parasites
Hu, S., Wei, W., & Körner, H. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.06.020 · Cited by 17
Regulatory factors for initial T lymphocyte lineage specification
Rothenberg, E. V. (2007) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3281de72a8 · Cited by 16
Chromatin Dynamics during Differentiation of Myeloid Cells
Schönheit, J., Leutz, A., & Rosenbauer, F. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.08.015 · Cited by 15
PU.1 promotes cell cycle exit in the murine myeloid lineage associated with downregulation of E2F1
Ziliotto, R. G., Gruca, M. R., Podder, S., Noel, G., Ogle, C. K., Hess, D. A., & DeKoter, R. P. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.11.011 · Cited by 16
Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1
Fraszczak, J., Helness, A., Chen, R., Vadnais, C., Robert, F., Khandanpour, C., & Möröy, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160344 · Cited by 15
Young, P. P., Ardestani, S., & Li, B. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0045-4 · Cited by 15
Olme, C.-H., Brown, N., Finnon, R., Bouffler, S. D., & Badie, C. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.04.018 · Cited by 16
Olme, C.-H., Finnon, R., Brown, N., Kabacik, S., Bouffler, S. D., & Badie, C. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.05.019 · Cited by 16
E2a/Pbx1 oncogene inhibits terminal differentiation but not myeloid potential of pro-T cells
Bourette, R. P., Grasset, M.-F., & Mouchiroud, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209777 · Cited by 15
PU.1 immortalizes hematopoietic progenitors in a GM-CSF-dependent manner
Houston, I. B., Huang, K. J., Jennings, S. R., & DeKoter, R. P. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2006.11.003 · Cited by 15
PU.1 is required to restrain myelopoiesis during chronic inflammatory stress
Chavez, J. S., Rabe, J. L., Niño, K. E., Wells, H. H., Gessner, R. L., Mills, T. S., Hernandez, G., & Pietras, E. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1204160 · Cited by 14
Regulation of pDC fate determination by histone deacetylase 3
Zhang, Y., Wu, T., He, Z., Lai, W., Shen, X., Lv, J., Wang, Y., & Wu, L. (2023) · eLife · doi:10.7554/elife.80477 · Cited by 14
Self-citationBarakat, D. J., Suresh, R., Barberi, T. J., Pienta, K. J., Simons, B. W., & Friedman, A. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191188 · Cited by 16
Rothenberg, E. V., Champhekar, A. S., Damle, S. S., Real, M. M. D., Kueh, H. Y., Li, L., & Yui, M. A. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020271 · Cited by 13
Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*
Tuong, Z. K., Stewart, B. J., Guo, S. A., & Clatworthy, M. R. (2021) · Immunological Reviews · doi:10.1111/imr.13036 · Cited by 13
Epigenetic Code and Self-Identity
Calvanese, V., Lara, E., & Fraga, M. F. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1680-7_14 · Cited by 13
Metadata
- Authors
- Dakic, A., Metcalf, D., Di Rago, L., Mifsud, S., Wu, L., & Nutt, S. L.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-05-02
- Volume
- 201
- Issue
- 9
- Pages
- 1487-1502
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2213186
- OpenAlex
- W2136610354
- Cited by
- 297
- References
- 51
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 15 · 2023: 13 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 17 · 2016: 9 · 2015: 18 · 2014: 15 · 2013: 26 · 2012: 21
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health (CA22556)
- Medical Research Council
- National Health and Medical Research Council
- Cancer Council Victoria
- National Cancer Institute (R37CA022556, CA22556, R01CA022556)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- PU.1, granulopoiesis, hematopoietic progenitor cells, CFU-GM, common myeloid progenitors, lymphocyte production, granulocyte colony-stimulating factor, interleukin-3, bone marrow chimeras, transcription factors, adult hematopoiesis
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Antibodies, Monoclonal, Blood Cell Count, Cell Differentiation, Cells, Cultured, Colony-Forming Units Assay, Flow Cytometry, Genetic Vectors, Genotype, Granulocytes, Hematopoietic Stem Cells, Mice, Inbred C57BL, Mice, Transgenic, Proto-Oncogene Proteins, Blotting, Western, Trans-Activators, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Myeloid Cells, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
