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A role for Dicer in immune regulation
Open accessAbstract
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor β. These results suggest that T reg cell development involves Dicer-generated RNAs.
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Metadata
- Authors
- Cobb, B. S., Hertweck, A., Smith, J., O'Connor, E., Graf, D., Cook, T., Smale, S. T., Sakaguchi, S., Livesey, F. J., Fisher, A. G., & Merkenschlager, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2006-10-23
- Volume
- 203
- Issue
- 11
- Pages
- 2519-2527
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2118694755
- Cited by
- 522
- References
- 11
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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