The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
Open accessAbstract
The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its relevance in the immune system is yet to be defined. Here, we investigated the importance of Gpx4 for physiological T cell responses by using T cell–specific Gpx4-deficient mice. Our results revealed that, despite normal thymic T cell development, CD8+ T cells from TΔGpx4/ΔGpx4 mice had an intrinsic defect in maintaining homeostatic balance in the periphery. Moreover, both antigen-specific CD8+ and CD4+ T cells lacking Gpx4 failed to expand and to protect from acute lymphocytic choriomeningitis virus and Leishmania major parasite infections, which were rescued with diet supplementation of high dosage of vitamin E. Notably, depletion of the Gpx4 gene in the memory phase of viral infection did not affect T cell recall responses upon secondary infection. Ex vivo, Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cell death driven by ferroptosis but not necroptosis. These studies unveil an essential role of Gpx4 for T cell immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the inducible or tissue-specific ablation of Gpx4 in mice provokes a variety of pathological conditions, including acute renal or hepatic injury [547, 563, 589], neurodegeneration [550, 590, 591], and defective immunity to infection [567], all of which can be prevented or mitigated by ferroptosis-inhibiting strategies.”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [567]
In the citing paper
“GPX4 is essential for the survival and expansion of recently activated T cells, indicating the importance of preventing lipid peroxidation and of iron dysregulation resulting in ferroptosis, in T cell proliferation (Matsushita et al., 2015).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Matsushita et al., 2015
In the citing paper
“GPX4 is essential for the survival and expansion of recently activated T cells, indicating the importance of preventing lipid peroxidation and of iron dysregulation resulting in ferroptosis, in T cell proliferation (Matsushita et al., 2015).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Matsushita et al., 2015
In the citing paper
“Gpx4 exerts important effects on the immune system as it is crucial for the survival of CD8+ T cells and for the expansion of both CD4+ and CD8+ T cells upon T cell receptor triggering in response to infection by preventing membrane lipid peroxidation and ferroptosis”
From Iron in immune cell function and host defense (2021) · cites this paper as [112]
In the citing paper
“and high levels of reactive oxygen species in T cells impair cytotoxicity, perhaps mediated by T cell lipid peroxidation, resulting in failure to control viruses (Henson et al. 2014; Matsushita et al. 2015).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Matsushita et al. 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · cited 1×
“Cystine in the extracellular space is transported exclusively by the xc and converted to cysteine, which facilitates the synthesis of intracellular glutathione (GSH), a major cellular antioxidant (Fahey and Sundquist, 1991).”
BackgroundBiochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · cited 1×
“The central importance for cellular physiology and normal development of the cytosolic form is highlighted by the embryonic lethality observed in mice with a homozygous Gpx4 deletion (Yant et al., 2003).”
BackgroundMitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · cited 1×
“After immune responses to infections, T cell populations are controlled and maintained by programmed cell death, one of which is initiated by the death receptor ligation, involving Fas-associated death domain protein (FADD) and caspase 8 (Ashkenazi and Dixit, 1998).”
BackgroundReactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · cited 1×
“Concurrently, it is well appreciated that ROS are at the interface of several cell signaling pathways that regulate cell proliferation, differentiation, and death (D’Autréaux and Toledano, 2007; Finkel, 2011; Ray et al., 2012).”
BackgroundROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642 · cited 1×
“Although apoptosis has long been considered the primary form of programmed cell death, recent studies have identified that necroptosis can also occur by inactivation of caspase 8 and complex formation of RIP kinase 1 and 3 (Cho et al., 2009; Declercq et al., 2009).”
BackgroundChemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068 · cited 1×
“ERK1/2 phosphorylation upon TCR triggering depends on the generation of hydrogen peroxide and stimulates glutamine uptake (Devadas et al., 2002; Carr et al., 2010).”
BackgroundReconciling the chemistry and biology of reactive oxygen species
Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · cited 2×
“Indeed, RAS–RAF–MEK signaling has been shown to be required for erastin-induced ferroptosis of tumor cells (Yagoda et al., 2007).”
BackgroundCho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · cited 1×
“Although apoptosis has long been considered the primary form of programmed cell death, recent studies have identified that necroptosis can also occur by inactivation of caspase 8 and complex formation of RIP kinase 1 and 3 (Cho et al., 2009; Declercq et al., 2009).”
Background
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–677 of 677
Reactive Oxygen Species in Glioma
Deshpande, R. P., & Babu, P. P. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_145 · Cited by 1
Bajor, M., Kłopotowska, M., Baranowska, I., Hajduk, S., Leśniowska, N., Jurga, A., Granica, M., Łaźniewski, M., Krawczyk, M., Dziewicka, M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5280443/v1 · Cited by 1
The critical role of cysteine import and metabolism in pancreatic cancer
Badgley, M. A. (2017) · doi:10.7916/d8db8dhx
Spatiotemporal Regulation of T Cell Activation
Yokosuka, T., Wakamatsu, E., Yanase, N., Hata, K., & Machiyama, H. (2018) · Seibutsu Butsuri · doi:10.2142/biophys.58.005
Blankstein, A. R. (2017) · Mspace (University of Manitoba)
Modernized Divination into Ferroptosis
Jain, R. R. (2020) · International Journal for Research in Applied Science and Engineering Technology · doi:10.22214/ijraset.2020.30622
Recapitulating Parkinson’s disease pathology in a three-dimensional neural cell culture model
Taylor-Whiteley, T. R. (2019) · Sheffield Hallam University · doi:10.7190/shu-thesis-00321
Zhu, L., Chen, M., Huang, B., Liu, M., Zhong, C., & Li, Q. (2021) · Research Square · doi:10.21203/rs.3.rs-333081/v1
Luo, D., Tao, Q., Jiang, H., Junling, Z., Zhang, N., Zhu, Y., Wang, G., Li, Y., & Huang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-761186/v1
Inhibiting ACSL1 related ferroptosis restrains MHV-A59 infectionPreprint
Xia, H., Zhang, Z., & You, F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.14.464337
“For example, ferroptosis in T 240 cells suppressed T cell expansion and prevented viral clearance (59).”
BackgroundReactive Oxygen Species in Glioma
Deshpande, R. P., & Babu, P. P. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_145-1
Fan, X., Zhong, Y., Fan, Y., Zhang, L., Xie, F., & Zhang, Z. (2022) · Research Square · doi:10.21203/rs.3.rs-1464127/v1
Ferroptoz ve erkek infertilitesi
Ergün, S., Hekim, G. N. T., & Gunes, S. O. (2022) · Androloji Bülteni · doi:10.24898/tandro.2022.21549
Lopez-Escamez, J. A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727964907.793549280
Suppressing Ferroptosis Decreases the Multiplication of Mycobacterium Marinum in Human MacrophagesPreprint
Ji, G., Chen, R., Feng, S., Cheng, W., & Ren, H. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4352898
Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Drijvers, J. M., Gillis, J. E., Muijlwijk, T., Nguyen, T. H. P., Gaudiano, E. F., Harris, I. S., LaFleur, M. W., Ringel, A. E., Yao, C.-H., Kurmi, K., et al. (2023) · doi:10.1158/2326-6066.c.6550425.v1
Jiang, S., & Xie, Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_7
Ferroptosis and Infectious Diseases
Zhang, Y., & Chi, J. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_16
Shen, Y., Zheng, Q., Che, G., & Chen, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3553140/v1
Chen, W., Su, X., Pan, Y., Xue, Y., Zeng, L., Xu, Q., Yu, X., Yin, X., Zhou, H., Feng, Z., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572489
The Tangential Dialogue Between Science and Medicine: A Case in Point
Schor, N. F. (2024) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2024.01.017
Zhu, L., Yang, F., Wang, L., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059396
Zhu, L., Yang, F., Wang, L., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059387
Zhu, L., Yang, F., Wang, L., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059399
Zhu, L., Yang, F., Wang, L., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059375
Li, H., Yang, S., Zhao, H., Zhang, J., Guo, W., Shen, T., & Han, Q. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178108
Zhu, L., Yang, F., Lingwei, W., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059405
Zhu, L., Yang, F., Lingwei, W., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059381
Chen, Y., Guo, L., Zhou, Z., An, R., & Wang, J. (2022) · Figshare · doi:10.6084/m9.figshare.19470295
Zhu, L., Yang, F., Lingwei, W., Dong, L., Huang, Z., Wang, G., Chen, G., & Li, Q. (2021) · Figshare · doi:10.6084/m9.figshare.14059369
Chen, Y., Guo, L., Zhou, Z., An, R., & Wang, J. (2022) · Figshare · doi:10.6084/m9.figshare.19470292
Su, X., Wang, Z., Li, J., Gao, S., Fan, Y., & Wang, K. (2024) · Figshare · doi:10.6084/m9.figshare.25459610
Wu, J., Wang, C., Wang, Y., Xue, C., Wang, Y., Zhang, L., Abdelnaby, T., El-Waseif, M., & Zhang, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108174
The Impact of Selenium Exposure During Pregnancy on Risk for Miscarriage: A Systematic Review
Kyriakou, S.-I., Tsarna, E., Stachika, N., Dalla, C., Potiris, A., Stavros, S., & Christopoulos, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020968
“Specifically, Se is notable for the activity of ebselen, a synthetic organoselenium compound, which can inhibit ferroptosis induced by erastin exposure or GPx4 deletion [45,46], highlighting selenium’s antioxidative and anti-ferroptotic properties.”
Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential
Mitre, A. O., Neag, M. A., Bâldea, I., Filip, G. A., Mitre, B., & Pârvu, A. E. (2026) · Inflammation · doi:10.1007/s10753-025-02356-8
“GPX4 is required for the expansion phase of T cells and survival, thus playing an important role in cell-mediated immunity [53 ].”
‘DieT’ control: how dietary fats make T cells die
Lee, Y., Koh, C., Jeon, Y., & Chung, Y. (2026) · Vita · doi:10.15302/vita.2026.03.0019
Sipieter, F. (2015) · theses.fr (ABES) · doi:10.70675/d530ded3z94aez4864z858azb556e4d75412
Deciphering ferroptosis in gene-edited mouse models
Yu, Y., Lu, Y., & Fang, X. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.02.010
Hajj, S. E. (2022) · theses.fr (ABES) · doi:10.70675/5b42e204z603bz415fz8150z7f6a62958c77
Characterising the role of alpha synuclein in Ferroptosis, in the context of Parkinson's Disease
Mahoney‐Sanchez, L. (2022) · theses.fr (ABES) · doi:10.70675/a7f080d0z9ffaz4e1ez9550z0e29c4958e66
Oxidative and nitrosative damage in multiple sclerosis
Prozorovski, T., Meuth, S. G., Hartung, H. ‐., & Berndt, C. (2026) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001482
Diet sets the ferroptosis threshold of T cells
Liu, Y.-B., Xu, D., & Deng, J. (2026) · LabMed discovery. · doi:10.1016/j.lmd.2026.100128
Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage
Hayward, M.-K., Northey, J. J., Opazo-Mellado, V., Stashko, C., Maller, O., Ironside, A. J., Que, X., Lakins, J. N., Hwang, E. S., Witztum, J. L., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.03.022
HIF ‐1α/ HMOX1 ‐Mediated Ferroptosis in Macrophages Exacerbates Malaria Progression
Liang, G., Li, J., Xie, X., Yuan, H., Xiao, W., Chen, M., Lu, K., Xu, L., Pan, L., Wei, H., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202504265rr
Friend or Foe? The Dual Role of Ferroptosis in Tumor Immunity and Immunotherapy
Liu, F., Halimulati, M., Luo, J., Jia, L., & Tao, Q. (2026) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.70009
“Inhibition of DHODH has been shown to sensitize cancer cells to ferroptosis and modulate immune evasion (Mao et al. 2021; Matsushita et al. 2015).”
Li, Z., & 蔡建庭 (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02192-6
Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy
Li, S., & Gajewski, T. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-014762 · Cited by 2
“53 In the lipid-rich TME, CD8 + T cells were shown to be vulnerable to ferro-ptotic cell death.”
Lipid ROS measurement by spectral flow cytometry based on the ratiometric dye BODIPY™ C11 581/591
Butcher, D., Wang, N., Nettelfield, S., & Yu, D. (2026) · Methods in cell biology · doi:10.1016/bs.mcb.2026.05.017
Guo, F., Deng, T., Yan, J., Mo, Y., Huang, Q., Jiang, Q., Mo, L., Ning, S., & Li, C. (2026) · Functional & Integrative Genomics · doi:10.1007/s10142-026-01918-9
“Matsushita et al. reveal a dual regulatory role of ferroptosis in immune cells: GPX4 deficiency induces ferroptosis in regulatory T cells (Tregs), enhancing antitumor immunity, whereas Xu et al. indicate GPX4 loss in CD8 + T cells impairs proliferation and effector functions (Matsushita et al. 2015,…”
Reactive species as regulators of immune cell metabolism, tolerance, and autoimmunity
Kobayashi, T., & Brenner, D. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.002
Fueling Death: The Metabolic Control of Ferroptosis
Carrà, G., Scalera, A., Barbieri, I., Menga, A., & Porporato, P. E. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_16
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
Wang, Z., Fu, X., Bai, J., Liu, Y., & Huang, K. (2026) · MedComm · doi:10.1002/mco2.70886
“…composition matters: ferroptosis is defined as an iron-dependent, lipid-peroxidation-driven regulated death, and T cells themselves require antioxidant protection to avoid ferroptotic collapse, as GPX4 loss drives lipid peroxidation and ferroptosis in T cells, limiting immune protection [ 107 ].”
Metabolic control of ferroptosis in cancer: lipid dependencies as therapeutic vulnerabilities
Dio, A. D., Smaldone, G., Napolitano, V., Bertamino, A., & Gomez-Monterrey, I. M. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1872103
Iron-ing out ferroptosis-mediated T cell dysfunction in cancer
Derrick, E. B., & Beavis, P. A. (2026) · Nature Cancer · doi:10.1038/s43018-026-01204-4
Zhang, C., & 许发明 (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.115148
Repression of ferroptotic cell death mediated antitumor immunity by mitochondrial calcium signaling
Chen, J., Zhao, B. L., Dong, H., Liao, Z., Wang, S., Ma, A., Sun, Y., Cheng, X., Lin, S., Li, X., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2606216123
Ferroptosis and Alzheimer’s disease: Neuroimmune crosstalk and pharmacological opportunities
Marakhovskaya, Y. A., Churov, A. V., Arbatsky, M. S., & Sergeeva, S. P. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150514
Liu, X.-L., & Ma, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1907693
“Nevertheless, the prevailing view remains that ferroptosis-induced inflammatory dysregulation is a major driver of septic organ injury (Amaral et al., 2019; Matsushita et al., 2015).”
CRISPR screens for the discovery of novel ferroptosis targets: progress and perspectives
Yu, W., Cui, Y., Zhao, Q., & Luo, L. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118410
Deferiprone Modulates Ferroptosis to Protect Macrophages and Liver during Neospora caninum Infection
Zhu, Z., Jiang, X., Huang, R., Guo, X., Wang, Y., Liu, T., Wang, J., Huang, J., Huang, W., Zhang, D., et al. (2026) · Acta Parasitologica · doi:10.1007/s11686-026-01343-9
“GPX4-deficient T cells exhibit impaired proliferation and reduced anti-Leishmania activity [27], while Nrf2-mediated mac - rophage polarization promotes parasite survival [28 ].”
Ferroptosis-driven immune output: metal modulation of an iron-centered redox network
Liu, L., Zheng, Y., & Mao, Z. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.09.025
Chen, H., Wang, Y., Yao, Z., Li, J., Li, P., & Diao, L. (2026) · Toxics · doi:10.3390/toxics14090814
“The lipid peroxidation products and the release of DAMPs from damaged mitochondria during ferroptosis can directly activate pattern recognition receptors [43].”
Ferroptosis in metabolic dysfunction-associated steatotic liver disease
Kotlyarov, S. N., Iskrina, A., & Котлярова, А. А. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1912709
“Moreover, this defect is corrected by vitamin E (238).”
Xia, S., Shen, X., Chen, G., Liu, R., & Yang, X. P. (2026) · Viruses · doi:10.3390/v18101075
“Conversely, CD4 + T cells lacking murine Gpx4 fail to expand and to protect the host from acute virus or parasite infections, while the AKT-GSK3 β axis can promote the longevity of virus-specific memory CD4 + T cells by preventing ferroptosis [131,132].”
Khan, M. Z., Li, M., Qadeer, A., Ullah, A., Liu, J., Ma, Q., Liu, W., & 王长法 (2026) · Antioxidants · doi:10.3390/antiox15101271
“…and supports the survival and metabolic fitness of memory lymphocytes [88], while ferrop-tosis and iron flux influence dendritic-cell function, the polarization and persistence of effector cells [89], and the release of damage-associated molecular patterns that act as endogenous adjuvants [90].”
A non-canonical function of glutathione to suppress ferroptosis via FSP1
Han, J., Zhang, Y.-D., Liu, S., Yang, L., Sun, S.-L., Zhang, B., Liu, A.-K., Zhu, L.-F., Wang, R., Song, D., et al. (2026) · Cell · doi:10.1016/j.cell.2026.09.024
Cao, Z., & Ao, X. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1954104
CRISPR-Cas9 screen identifies eIF4G2 as a regulator of CD8+ T cell dysfunction
Holcomb, E. A., Jiang, L., Pearson, A. N., James, J., Tate, A., Wang, Z., Dasgupta, A., Clauwaert, J., Armas, N. D., Elaimy, A. L., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag187
毕妍娜, Zhao, Y., Ge, Y., 陳, 哲., Zhao, L., & Sun, G. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218859
Oxidized phospholipids: evolution, signaling, cell death, and human diseases
Ouyang, S., Sun, W., Duan, W., Wu, Y.-P., Lin, X., Gong, H.-B., Sun, J., Luo, X., Niu, J., Li, K., et al. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.10.026
Metabolic hallmarks of regulated cell death
Kang, R., Chen, X., Kroemer, G., & Tang, D. (2026) · Cell Research · doi:10.1038/s41422-026-01306-9
Ferroptosis in skin diseases and cutaneous immunology
Cheng, Y., Lei, H., Deng, G., Li, D., Meng, Y., Guo, Z., Zhou, Q., & Zeng, F. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102069
Metadata
- Authors
- Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M.
- Affiliations
- ETH Zurich (CH)
- Helmholtz Munich (DE)
- Molecular Biomedicine, Institute of Molecular Health Science, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland 1
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2015-03-30
- Volume
- 212
- Issue
- 4
- Pages
- 555-568
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC4387287
- OpenAlex
- W2065934830
- Cited by
- 672
- References
- 57
- Citations by year
- 2026: 65 · 2025: 77 · 2024: 90 · 2023: 90 · 2022: 95 · 2021: 92 · 2020: 56 · 2019: 28 · 2018: 25 · 2017: 22 · 2016: 24 · 2015: 8
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (publishedVersion, cc-by-nc-sa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-sa)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- ETH Zürich Research Collection
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (141175, 310030B_141175/1)
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Keywords
- GPX4, ferroptosis, lipid peroxidation, T cell immunity, CD8+ T cells, CD4+ T cells, phospholipid hydroperoxides, vitamin E, lymphocytic choriomeningitis virus, Leishmania major, antiviral immunity, antiparasitic immunity, T cell homeostasis, T cell-specific knockout mice
- MeSH terms
- Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Cell Membrane, Glutathione Peroxidase, Immunologic Memory, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Thymus Gland, Vitamin E, Vitamins, Lipid Peroxidation, CD4-Positive T-Lymphocytes, Leishmaniasis, Cutaneous, Cell Death, Leishmania major, Mice, Knockout, CD8-Positive T-Lymphocytes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
