Redox Control of Inflammation in Macrophages

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

Protective and pathogenic functions of macrophage subsets

Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181

Nitric oxide synthase in innate and adaptive immunity: an update

Bogdan, C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.01.003 · Cited by 862

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 948

Macrophage activation and its role in repair and pathology after spinal cord injury

Gensel, J. C., & Zhang, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.12.045 · Cited by 792

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Steven, S., Frenis, K., Oelze, M. W., Kalinovic, S., Kuntić, M., Jiménez, M. T. B., Vujačić-Mirski, K., Helmstädter, J., Kröller‐Schön, S., Münzel, T. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 756

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Kapralov, A. A., Yang, Q., Dar, H. H., Tyurina, Y. Y., Anthonymuthu, T. S., Kim, R., Croix, C. M. S., Mikulska‐Ruminska, K., Liu, B., Shrivastava, I. H., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0462-8 · Cited by 667

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632

Mammalian lipoxygenases and their biological relevance

Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 644

Reactive Oxygen Species in Macrophages: Sources and Targets

Canton, M., Sánchez‐Rodríguez, R., Spera, I., Venegas, F. C., Favia, M., Viola, A., & Castegna, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734229 · Cited by 490

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

Genard, G., Lucas, S., & Michiels, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00828 · Cited by 423

Macrophage polarization and meta-inflammation

Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 376

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms

Gallo, J., Goodman, S. B., Konttinen, Y. T., Wimmer, M. A., & Holinka, M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.05.005 · Cited by 354

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 373

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

Kumar, A., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4268 · Cited by 339

Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

Wang, L., & He, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967193 · Cited by 334

Redox regulation in metabolic programming and inflammation

Griffiths, H. R., Gao, D., & Pararasa, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.023 · Cited by 287

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

Daiber, A., Lisa, F. D., Oelze, M. W., Kröller‐Schön, S., Steven, S., Schulz, E., & Münzel, T. F. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13403 · Cited by 274

Cancer cell and macrophage cross-talk in the tumor microenvironment

Dehne, N., Mora, J., Namgaladze, D., Weigert, A., & Brüne, B. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.04.007 · Cited by 270

Oxidative Stress in Pulmonary Fibrosis

Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 312

Can Activation of NRF2 Be a Strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., García‐Yagüe, Á. J., Lastra, D., Manda, G., Rojo, A. I., et al. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.07.003 · Cited by 240

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

Ivanov, I., Kühn, H., & Heydeck, D. (2015) · Gene · doi:10.1016/j.gene.2015.07.073 · Cited by 228

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

Kumar, A., Barrett, J. P., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.158 · Cited by 213

Redox Regulation of Inflammation: Old Elements, a New Story

Lei, Y., Wang, K., Deng, L., Chen, Y., Nice, E. C., & Huang, C. (2014) · Medicinal Research Reviews · doi:10.1002/med.21330 · Cited by 210

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

Wang, Y., Huang, Y., Xu, Y., Ruan, W., Wang, H., Zhang, Y., Saavedra, J. M., Zhang, L., Huang, Z., & Pang, T. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7003 · Cited by 203

Redox Control of Skeletal Muscle Regeneration

Moal, E. L., Pialoux, V., Juban, G., Groussard, C., Zouhal, H., Chazaud, B., & Mounier, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6782 · Cited by 206

Medical gas plasma-stimulated wound healing: Evidence and mechanisms

Bekeschus, S., von Woedtke, T., Emmert, S., & Schmidt, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102116 · Cited by 200

Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 171

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 180

Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

Namgaladze, D., & Brüne, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.002 · Cited by 169

Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development

Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 168

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

Wenzel, P., Kossmann, S., Münzel, T. F., & Daiber, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.027 · Cited by 161

Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages

Yu, W., Wang, X., Zhao, J., Liu, R., Liu, J., Wang, Z., Peng, J., Wu, H., Zhang, X., Long, Z., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101761 · Cited by 158

The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 157

Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes

Appari, M., Channon, K. M., & McNeill, E. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7060 · Cited by 154

Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

Cárdeno, A., Aparicio‐Soto, M., la Paz, S. M., Bermúdez, B., Muriana, F. J. G., & Alarcón‐de‐la‐Lastra, C. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.009 · Cited by 148

Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration

Tauzin, S., Starnes, T. W., Barros-Becker, F., Lam, P., & Anna Huttenlocher, A. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201408090 · Cited by 137

STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

Zhang, Q., Wei, J., Liu, Z., Huang, X., Sun, M., Lai, W., Chen, Z., Wu, J., Chen, Y., Guo, X., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102367 · Cited by 138

Monocyte differentiation and macrophage polarization

Orekhov, A. N., Orekhova, V. A., Nikiforov, N. G., Myasoedova, V. A., Grechko, A. V., Romanenko, E. B., Zhang, D., & Chistiakov, D. A. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.04 · Cited by 144

Redox regulation of NF ‐κB p50 and M1 polarization in microglia

Taetzsch, T., Levesque, S., McGraw, C., Brookins, S., Luqa, R., Bonini, M. G., Mason, R. P., Oh, U., & Block, M. L. (2014) · Glia · doi:10.1002/glia.22762 · Cited by 139

The Muscle Stem Cell Niche in Health and Disease

Mashinchian, O., Pisconti, A., Moal, E. L., & Bentzinger, C. F. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.003 · Cited by 140

Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater

Weigert, A., Olesch, C., & Brüne, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01706 · Cited by 130

Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners

Farruggia, C., Kim, M., Bae, M., Lee, Y., Pham, T. X., Yang, Y. J., Han, M. J., Park, Y., & Lee, J. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.005 · Cited by 131

Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases

Daiber, A., Kröller‐Schön, S., Oelze, M. W., Hahad, O., Li, H., Schulz, R., Steven, S., & Münzel, T. F. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101506 · Cited by 136

Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

Jeong, J., Cha, H., Han, M. H., Hwang, S. J., Lee, D.-S., Yoo, J. S., Choi, I., Kim, S., Kim, H., Kim, G., et al. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.272 · Cited by 125

The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways

Xu, W., Lu, H., Yuan, Y., Deng, Z., Zheng, L., & Li, H. (2022) · Foods · doi:10.3390/foods11162439 · Cited by 127

Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications

Vlasova, I. I., Kapralov, A. A., Michael, Z. P., Burkert, S. C., Shurin, M. R., Star, A., Shvedova, A. A., & Kagan, V. E. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.01.002 · Cited by 120

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO

Herb, M., Gluschko, A., Wiegmann, K., Farid, A., Wolf, A., Utermöhlen, O., Krut, O., Krönke, M., & Schramm, M. (2019) · Science Signaling · doi:10.1126/scisignal.aar5926 · Cited by 119

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

Zhao, J., Huang, F., He, F., Gao, C.-C., Liang, S.-Q., Ma, P., Dong, G., Han, H., & Qin, H. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2019 · Cited by 115

Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity

Mury, P., Chirico, E. N., Mura, M., Millon, A., Canet‐Soulas, E., & Pialoux, V. (2018) · Sports Medicine · doi:10.1007/s40279-018-0996-z · Cited by 112

Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation

Ondua, M., Njoya, E. M., Abdalla, M. A., & McGaw, L. J. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.12.030 · Cited by 113

Human Classical Monocytes Control the Intracellular Stage of Leishmania braziliensis by Reactive Oxygen Species

Novais, F. O., Nguyen, B. T., Beiting, D. P., Carvalho, L. P., Glennie, N. D., Passos, S., Carvalho, E. M., & Scott, P. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu013 · Cited by 109

Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease

Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021) · Cells · doi:10.3390/cells10081884 · Cited by 112

5-Hydroxymethylfurfural Mitigates Lipopolysaccharide-Stimulated Inflammation via Suppression of MAPK, NF-κB and mTOR Activation in RAW 264.7 Cells

Kong, F., Lee, B. H., & Wei, K. (2019) · Molecules · doi:10.3390/molecules24020275 · Cited by 107

Selenium inhibits Staphylococcus aureus-induced inflammation by suppressing the activation of the NF-κB and MAPK signalling pathways in RAW264.7 macrophages

Bi, C., Wang, H., Wang, Y., Sun, J., Dong, J., Meng, X., & Li, J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.044 · Cited by 108

Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species

Komatsu, W., Kishi, H., Yagasaki, K., & Ohhira, S. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.023 · Cited by 105

Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells

Ke, X., Chen, C., Song, Y., Cai, Q., Li, J., Tang, Y., Han, X., Qu, W., Chen, A., Wang, H., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10956 · Cited by 105

IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages

Scott, T., Lewis, C., Zhu, M., Wang, C., Samuel, C. S., Drummond, G. R., & Kemp‐Harper, B. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-46237-2 · Cited by 109

Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2

Xu, H., Hertzel, A. V., Steen, K. A., Wang, Q., Suttles, J., & Bernlohr, D. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01122-14 · Cited by 104

Macrophage iron homeostasis and polarization in the context of cancer

Jung, M., Mertens, C., & Brüne, B. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.011 · Cited by 105

Role of Nrf2 and Autophagy in Acute Lung Injury

de la Vega, M. R., Dodson, M. B., Groß, C., Mansour, H. M., Lantz, R. C., Chapman, E., Wang, T., Black, S. M., Garcia, J. G. N., & Zhang, D. D. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0053-2 · Cited by 104

FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2

Steen, K. A., Xu, H., & Bernlohr, D. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00282-16 · Cited by 97

Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury

Zhang, B., Bailey, W. M., McVicar, A. L., & Gensel, J. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.029 · Cited by 100

Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury

Haber, M., Abdel Baki, S. G., Grin'kina, N. M., Irizarry, R., Ershova, A., Orsi, S., Grill, R. J., Dash, P., & Bergold, P. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.002 · Cited by 95

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

Barrett, J. P., Henry, R. J., Villapol, S., Stoica, B. A., Kumar, A., Burns, M. P., Faden, A. I., & Loane, D. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0843-4 · Cited by 94

M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis

Mukhopadhyay, D., Mukherjee, S., Roy, S., Dalton, J. E., Kundu, S., Sarkar, A., Das, N. K., Kaye, P. M., & Chatterjee, M. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004145 · Cited by 91

Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling

Tu, Y., Liu, J., Kong, D., Guo, X., Li, J., Long, Z., Peng, J., Wang, Z., Wu, H., Liu, P., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.014 · Cited by 89

Reactive Oxygen Species‐Scavenging Nanomedicines for the Treatment of Oxidative Stress Injuries

Yoshitomi, T., & Nagasaki, Y. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300576 · Cited by 88

Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases

Cuadrado, A. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-103416 · Cited by 88

Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling

Gopallawa, I., Freund, J. R., & Lee, R. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03494-y · Cited by 85

Cu,Zn–Superoxide Dismutase–Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis

He, C., Larson‐Casey, J. L., Gu, L., Ryan, A. J., Murthy, S., & Carter, A. B. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0183oc · Cited by 84

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80

Plant-derived extracellular vesicles -a novel clinical anti-inflammatory drug carrier worthy of investigation

Shao, M., Jin, X., Chen, S., Yang, N., & Feng, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115904 · Cited by 84

Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis

Wang, X., Hausding, M., Weng, S., Kim, Y. O., Steven, S., Klein, T., Daiber, A., & Schuppan, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6953 · Cited by 83

Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia

Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.017 · Cited by 81

Fucoidan inhibits lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and zebrafish larvae

Jeong, J.-W., Hwang, S. J., Han, M. H., Lee, D.-S., Yoo, J. S., Choi, I., Cha, H., Kim, S., Kim, H., Kim, G., et al. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0045-2 · Cited by 76

Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure

Badary, O. A., Hamza, M. S., & Tikamdas, R. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s308863 · Cited by 76

Immunotoxicity of ochratoxin A and aflatoxin B1 in combination is associated with the nuclear factor kappa B signaling pathway in 3D4/21 cells

Hou, L., Gan, F., Zhou, X., Zhou, Y., Qian, G., Liu, Z., & Huang, K. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.02.009 · Cited by 76

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

Lewis, B. W., Ford, M. L., Rogers, L. K., & Britt, R. D. (2021) · Antioxidants · doi:10.3390/antiox10091335 · Cited by 78

A redox-based electrogenetic CRISPR system to connect with and control biological information networks

Bhokisham, N., VanArsdale, E. S., Stephens, K., Hauk, P., Payne, G. F., & Bentley, W. E. (2020) · Nature Communications · doi:10.1038/s41467-020-16249-x · Cited by 74

Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

Bi, Z., Cai, Y., Shi, X., Chen, J., Li, D., Zhang, P., & Liu, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150631 · Cited by 76

25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages

Shibata, N., Carlin, A. F., Spann, N. J., Saijo, K., Morello, C. S., McDonald, J. G., Romanoski, C. E., Maurya, M. R., Kaikkonen, M. U., Lam, M. T. Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.519637 · Cited by 72

Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse

Yin, G. N., Choi, M. J., Kim, W. J., Kwon, M., Song, K., Park, J., Das, N. D., Kwon, K., Batbold, D., Oh, G. T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403471111 · Cited by 72

Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage

Coelho, I., Duarte, N., Barros, A., Macedo, M. P., & Penha-Gonçalves, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616044 · Cited by 70

Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia

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Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

Wei, K.-H., Lin, I.-T., Chowdhury, K., Lim, K. L., Liu, K., Ko, T., Chang, Y., Yang, K., & Lai, S.-L. (2023) · eLife · doi:10.7554/elife.84679 · Cited by 73

Decipher the Glioblastoma Microenvironment: The First Milestone for New Groundbreaking Therapeutic Strategies

Fanelli, G. N., Grassini, D., Ortenzi, V., Pasqualetti, F., Montemurro, N., Perrini, P., Naccarato, A. G., & Scatena, C. (2021) · Genes · doi:10.3390/genes12030445 · Cited by 72

Targeting ROS production through inhibition of NADPH oxidases

Reis, J., Gorgulla, C., Massari, M., Marchese, S., Valente, S., Noce, B., Basile, L., Törner, R., Cox, H., Viennet, T., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01457-5 · Cited by 70

Effect of micro- and nanoplastic particles on human macrophages

Adler, M. Y., Issoual, I., Rückert, M., Deloch, L., Meier, C., Tschernig, T., Alexiou, C., Pfister, F., Ramsperger, A. F. R. M., Laforsch, C., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134253 · Cited by 74

Apoptotic cells enhance sphingosine‐1‐phosphate receptor 1 dependent macrophage migration

Weichand, B., Weis, N., Weigert, A., Grossmann, N., Levkau, B., & Brüne, B. (2013) · European Journal of Immunology · doi:10.1002/eji.201343441 · Cited by 68

Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1

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Redox Regulation of Inflammatory Processes Is Enzymatically Controlled

Lorenzen, I., Mullen, L., Bekeschus, S., & Hanschmann, E.-M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8459402 · Cited by 70

Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice

Håversen, L., Sundelin, J. P., Mardinoğlu, A., Rutberg, M., Ståhlman, M., Wilhelmsson, U., Hultén, L. M., Pekny, M., Fogelstrand, P., Bentzon, J. F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34659-2 · Cited by 64

Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages

Liu, Q., Zhuang, Y., Song, X., Niu, Q., Sun, Q., Li, X., Li, N., Liu, B., Huang, F., & Qiu, Z. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00535-x · Cited by 67

How the redox state regulates immunity

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Activity of antibacterial, antiviral, anti-inflammatory in compounds andrographolide salt

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Modulatory role of dietary polyunsaturated fatty acids in Nrf2-mediated redox homeostasis

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In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway

Xu, H., Hao, S., Gan, F., Wang, H., Xu, J., Liu, D., & Huang, K. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.05.016 · Cited by 62

Naturally Occurring Hydroxytyrosol Derivatives: Hydroxytyrosyl Acetate and 3,4-Dihydroxyphenylglycol Modulate Inflammatory Response in Murine Peritoneal Macrophages. Potential Utility as New Dietary Supplements

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Recent advances in understanding hematopoiesis in Fanconi Anemia

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A review on redox mediated regulation of macrophage function and polarization in human diseases

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Redox-signals and macrophage biology

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The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases

Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657

Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective

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Redox signaling in macrophages

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