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Cited by 15Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?

MORRIS, R. G. M., DAVIS, S., BUTCHER, S. P.·1991·Behavioural and Neural Aspects of Learning and Memory
DOI 10.1093/acprof:oso/9780198521983.003.0011
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Abstract

One way of investigating the functional significance of long-term potentiation (LTP) is to use selective antagonists of those excitatory amino acid receptors whose activation is essential for its induction. This chapter discusses various design requirements for such experiments and reviews work indicating that the N-methyl-d-aspartate (NMDA) receptor antagonist AP5 causes a behaviourally selective learning impairment having certain common features to the behavioural profile seen after hippocampal lesions. Two new studies are described whose results show that AP5 has no effect upon the retrieval of previously established memories, and that the dose–response profile of the impairment of spatial learning occurs across a range of extracellular concentrations in hippocampus for which receptor selectivity exists. These experiments show that activation of NMDA receptors is essential for certain kinds of learning.

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Citations

Cites

Research works printed but not linked: 28

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Metadata

Authors
MORRIS, R. G. M., DAVIS, S., & BUTCHER, S. P.
Affiliations
University of Edinburgh (GB)
ORCID
Venue
Behavioural and Neural Aspects of Learning and Memory
Publisher
Oxford University PressOxford
Published
1991-06-20
Pages
89-106
DOI
10.1093/acprof:oso/9780198521983.003.0011
OpenAlex
W4244379074
Cited by
15
References
88
Citations by year
2020: 1 · 2018: 1 · 2014: 1
FWCI
1.03
Type
book chapter
Language
en
Open access
closed
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
hippocampal synaptic plasticity, NMDA receptor, long-term potentiation, AP5, NMDA receptor antagonists, spatial learning, memory retrieval, learning disabilities, hippocampal lesions, glutamate receptors, information storage

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