Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans

Tricon, Sabine; Burdge, Graham C; Kew, Samantha; Banerjee, Tapati; Russell, Jennifer J; Jones, Emma L; Grimble, Robert F; Williams, Christine M; Yaqoob, Parveen; Calder, Philip C

doi:10.1093/ajcn/80.3.614

Cited by 294Fatty Acid Research and HealthLipid metabolism and biosynthesisCholesterol and Lipid Metabolism

Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans

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Tricon, Sabine, Burdge, Graham C, Kew, Samantha, Banerjee, Tapati, Russell, Jennifer J, Jones, Emma L, Grimble, Robert F, Williams, Christine M +2 more·2004·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/80.3.614

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Abstract

Background Conjugated linoleic acid (CLA) is reported to have weight-reducing and antiatherogenic properties when fed to laboratory animals. However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear. Objective This study investigated the effects of 3 doses of highly enriched cis-9,trans-11 (0.59, 1.19, and 2.38 g/d) or trans-10,cis-12 (0.63, 1.26, and 2.52 g/d) CLA preparations on body composition, blood lipid profile, and markers of insulin resistance in healthy men. Design Healthy men consumed 1, 2, and 4 capsules sequentially, containing either 80% cis-9,trans-11 CLA or 80% trans-10,cis-12 CLA for consecutive 8-wk periods. This phase was followed by a 6-wk washout and a crossover to the other isomer. Results Body composition was not significantly affected by either isomer of CLA. Mean plasma triacylglycerol concentration was higher during supplementation with trans-10,cis-12 CLA than during that with cis-9,trans-11 CLA, although there was no influence of dose. There were significant effects of both isomer and dose on plasma total cholesterol and LDL-cholesterol concentrations but not on HDL-cholesterol concentration. The ratios of LDL to HDL cholesterol and of total to HDL cholesterol were higher during supplementation with trans-10,cis-12 CLA than during that with cis-9,trans-11 CLA. CLA supplementation had no significant effect on plasma insulin concentration, homeostasis model for insulin resistance, or revised qua…

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The beneficial clinical responses linked with cLA consumption are due in part to the formation and signaling actions of NO2-cLA.
“The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity, all of which we propose are due in part to the formation and signaling actions of NO2-cLA [29–32].”
From Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes (2015) · cites this paper as [30]
The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity.
“The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity, all of which we propose are due in part to the formation and signaling actions of NO2-cLA [29–32].”
From Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes (2015) · cites this paper as [30]

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Authors: Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., & Calder, P. C.
Affiliations: University of Reading (GB)
University of Southampton (GB)
Corresponding author: Yaqoob, Parveen
ORCID: Burdge, Graham C
Yaqoob, Parveen
Calder, Philip C
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2004-11
Volume: 80
Issue: 3
Pages: 614-620
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/80.3.614
OpenAlex: W2124658854
Cited by: 294
References: 37
Citations by year: 2026: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 15 · 2014: 14 · 2013: 14 · 2012: 17
FWCI: 23.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6680 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: conjugated linoleic acid, cis-9,trans-11 CLA, trans-10, cis-12 CLA, CLA isomers, lipid profile, LDL cholesterol, HDL cholesterol, LDL/HDL ratio, triglycerides, body composition, insulin resistance, dietary supplementation, dose-response relationship
MeSH terms: Adipose Tissue, Adult, Blood Glucose, Body Composition, Cholesterol, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Insulin, Insulin Resistance, Isomerism, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Cross-Over Studies, Dietary Supplements, Linoleic Acids, Conjugated

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Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans

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