Prospects for epigenetic epidemiology
Open accessAbstract
Epigenetic modification can mediate environmental influences on gene expression and can modulate the disease risk associated with genetic variation. Epigenetic analysis therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. The spatial and temporal variance in epigenetic profile is of particular relevance for developmental epidemiology and the study of aging, including the variable age at onset for many common diseases. This review serves as a general introduction to the topic by describing epigenetic mechanisms, with a focus on DNA methylation; genetic and environmental factors that influence DNA methylation; epigenetic influences on development, aging, and disease; and current methodology for measuring epigenetic profile. Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studying the epigenome in well-characterized samples may enable discovery of novel genes and pathways through which genetic factors and environmental exposures influence disease initiation and development, providing new targets for prevention and treatment.
“Studying the epigenome in the well-characterized samples may enable us to discover novel genes and pathways through which genetic factors and environmental exposures influence disease initiation and development, and thereby provide new targets for prevention and treatment”
From Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases (2016) · cites this paper as Foley et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
1 retracted
Chang, H., Anway, M. D., Rekow, S. S., & Skinner, M. K. (2006) · Endocrinology · doi:10.1210/en.2006-0987 · Cited by 148 · see citing works
RetractedStatistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882 · see citing works
Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,681 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
CpG islands in vertebrate genomes.
Gardiner-Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,462 · see citing works
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238 · see citing works
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011 · see citing works
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · see citing works
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563 · see citing works
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works
Genomic DNA methylation: the mark and its mediators.
Klose, R. J., & Bird, A. P. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.008 · Cited by 2,501 · see citing works
International Journal of Oncology
(2026) · International Journal of Oncology · doi:10.3892/ijo · Cited by 2,332 · see citing works
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086 · see citing works
Cytosine methylation and the ecology of intragenomic parasites
Yoder, J. A., Walsh, C. P., & Bestor, T. H. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01181-5 · Cited by 1,941 · see citing works
The epigenetic progenitor origin of human cancer
Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works
ALSPAC–The Avon Longitudinal Study of Parents and Children
Golding, Pembrey, Jones, & The Alspac Study Team (2001) · Paediatric and Perinatal Epidemiology · doi:10.1046/j.1365-3016.2001.00325.x · Cited by 1,549 · see citing works
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523 · see citing works
Dolinoy, D. C., Huang, D., & Jirtle, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703739104 · Cited by 1,369 · see citing works
Amos, C. I., Wu, X., Broderick, P., Gorlov, I. P., Gu, J., Eisen, T., Dong, Q., Zhang, Q., Gu, X., Vijayakrishnan, J., et al. (2008) · Nature Genetics · doi:10.1038/ng.109 · Cited by 1,310 · see citing works
Hung, R. J., McKay, J. D., Gaborieau, V., Boffetta, P., Hashibe, M., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., et al. (2008) · Nature · doi:10.1038/nature06885 · Cited by 1,275 · see citing works
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,191 · see citing works
Sex-specific, male-line transgenerational responses in humans
The ALSPAC Study Team, Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., & Golding, J. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201538 · Cited by 1,150 · see citing works
Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139 · see citing works
4 Histology and Histopathology
(2015) · Thieme eBooks · doi:10.1055/b-0035-108581 · Cited by 1,052 · see citing works
Cyclical DNA methylation of a transcriptionally active promoter
Métivier, R., Gallais, R., Tiffoche, C., Péron, C. L., Jurkowska, R., Carmouche, R. P., Ibberson, D., Baráth, P., Demay, F., Reid, G., et al. (2008) · Nature · doi:10.1038/nature06544 · Cited by 942 · see citing works
Dolinoy, D. C., Weidman, J. R., Waterland, R. A., & Jirtle, R. L. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8700 · Cited by 932 · see citing works
Friso, S., Choi, S., Girelli, D., Mason, J. B., Dolnikowski, G. G., Bagley, P. J., Olivieri, O., Jacques, P. F., Rosenberg, I. H., Corrocher, R., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062066299 · Cited by 932 · see citing works
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905 · see citing works
Kaati, G., Bygren, L., & Edvinsson, S. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200859 · Cited by 896 · see citing works
The 5-methylcytosine content of DNA from human tumors
Gama-Sosa, M. A., Kickhoefer, V. A., Trewyn, R. W., Oxenhandler, R. W., Kuo, K. C., Gehrke, C. W., & Ehrlich, M. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.19.6883 · Cited by 846 · see citing works
DNA hypomethylation and human diseases
Wilson, A. S., Power, B. E., & Molloy, P. L. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.007 · Cited by 804 · see citing works
Ho, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
5-Methylcytosine in Eukaryotic DNA
Ehrlich, M., & Wang, R. Y. ‐. (1981) · Science · doi:10.1126/science.6262918 · Cited by 745 · see citing works
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
Hansen, R. S., Wijmenga, C., Luo, P., Stanek, A. M., Canfield, T. K., Weemaes, C. M. R., & Gartler, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14412 · Cited by 734 · see citing works
Epigenetic gene silencing in cancer: the DNA hypermethylome
Esteller, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm018 · Cited by 725 · see citing works
Analysis of repetitive element DNA methylation by MethyLight
Weisenberger, D. J. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki987 · Cited by 716 · see citing works
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702 · see citing works
Epigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · cited 1× · see citing works
“The epigenotype, in contrast, is tissue and cell-type specific and may vary over time as a function of environmental exposure, aging, and random processes (48, 60, 172, 173).”
Transient cyclical methylation of promoter DNA
Kangaspeska, S., Stride, B. D., Métivier, R., Polycarpou-Schwarz, M., Ibberson, D., Carmouche, R. P., Beneš, V., Gannon, F., & Reid, G. (2008) · Nature · doi:10.1038/nature06640 · Cited by 682 · see citing works
Champagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675 · see citing works
DNA Methylation Decreases in Aging But Not in Immortal Cells
Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 649 · see citing works
Rakyan, V. K., Chong, S., Blewitt, M. E., Cuthbert, P. C., Morgan, H. D., Luu, K. V. K., & Whitelaw, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436776100 · Cited by 642 · see citing works
Yi, P., Melnyk, S., Pogribna, M., Pogribny, I. P., Hine, R. J., & James, S. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002725200 · Cited by 640 · see citing works
Alberg, A. J., Ford, J. G., & Samet, J. M. (2007) · CHEST Journal · doi:10.1378/chest.07-1347 · Cited by 625 · see citing works
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521 · see citing works
Transgenerational response to nutrition, early life circumstances and longevity
Kaati, G., Bygren, L. O., Pembrey, M., & Sjöström, M. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201832 · Cited by 500 · see citing works
Germline epimutation of MLH1 in individuals with multiple cancers
Suter, C. M., Martin, D. I. K., & Ward, R. L. (2004) · Nature Genetics · doi:10.1038/ng1342 · Cited by 475 · see citing works
Regression models for twin studies: a critical review
Carlin, J. B., Gurrin, L. C., Sterne, J. A. C., Morley, R., & Dwyer, T. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi153 · Cited by 472 · see citing works
Self-citationBoyes, J., & Bird, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05055.x · Cited by 471 · cited 1× · see citing works
“However, for some genes, evidence exists that a small change in the level of DNA methylation, especially in the lower range, can dramatically alter gene expression (87, 88).”
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Abdolmaleky, H. M., Cheng, K.-H., Faraone, S. V., Wilcox, M., Glatt, S. J., Gao, F., Smith, C. L., Shafa, R., Aeali, B., Carnevale, J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl253 · Cited by 462 · see citing works
An integrated epigenetic and genetic approach to common human disease
BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448 · see citing works
(2002) · PubMed · Cited by 440 · see citing works
Comprehensive high-throughput arrays for relative methylation (CHARM)Preprint
Irizarry, R. A., Ladd‐Acosta, C., Carvalho, B. S., Wu, H., Brandenburg, S. A., Jeddeloh, J. A., Wen, B., & Feinberg, A. P. (2008) · Genome Research · doi:10.1101/gr.7301508 · Cited by 433 · see citing works
Stress as a trigger of autoimmune disease
Stojanovich, L., & Marisavljević, D. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.11.007 · Cited by 423 · see citing works
Impact of aging on DNA methylation
Richardson, B. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00010-2 · Cited by 420 · see citing works
Burdge, G. C., Slater-Jefferies, J. L., Torrens, C., Phillips, E. S., Hanson, M. A., & Lillycrop, K. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507352392 · Cited by 418 · see citing works
Epigenetics at the Epicenter of Modern Medicine
Feinberg, A. P. (2008) · JAMA · doi:10.1001/jama.299.11.1345 · Cited by 414 · see citing works
Ebrahim, S., & Davey Smith, G. (2008) · Human Genetics · doi:10.1007/s00439-007-0448-6 · Cited by 410 · see citing works
Biochimica et biophysica acta. Protein structure and molecular enzymology
ScienceDirect (2002) · Cited by 395 · see citing works
DNA Methylation, Cancer Susceptibility, and Nutrient Interactions
Davis, C. D., & Uthus, E. O. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901002 · Cited by 390 · see citing works
Abdolmaleky, H. M., Cheng, K., Russo, A. L., Smith, C. L., Faraone, S. V., Wilcox, M., Shafa, R., Glatt, S. J., Nguyen, G. H., Ponte, J. F., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30140 · Cited by 390 · see citing works
Rakyan, V. K., Down, T. A., Thorne, N., Flicek, P., Kulesha, E., Gräf, S., Tomazou, E. M., Bäckdahl, L., Johnson, N., Herberth, M., et al. (2008) · Genome Research · doi:10.1101/gr.077479.108 · Cited by 379 · see citing works
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors
Herceg, Z. (2007) · Mutagenesis · doi:10.1093/mutage/gel068 · Cited by 371 · see citing works
Epigenetics of autism spectrum disorders
Schanen, N. C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl213 · Cited by 341 · see citing works
Epigenetics and Assisted Reproductive Technology: A Call for Investigation
Niemitz, E. L., & Feinberg, A. P. (2004) · The American Journal of Human Genetics · doi:10.1086/382897 · Cited by 325 · see citing works
Longevity Determined by Paternal Ancestors' Nutrition during Their Slow Growth Period
Bygren, L. O., Kaati, G., & Edvinsson, S. (2001) · Acta Biotheoretica · doi:10.1023/a:1010241825519 · Cited by 315 · see citing works
Environmental Epigenetics and Asthma
Miller, R. L., & Ho, S. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200710-1511pp · Cited by 304 · see citing works
CpG-Island Methylation in Aging and Cancer
Issa, J. J. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59696-4_7 · Cited by 301 · see citing works
Dependence of Transcriptional Repression on CpG Methylation Density
Hsieh, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5487 · Cited by 300 · see citing works
van Engeland, M., Weijenberg, M. P., Roemen, G. M. J. M., Brink, M., A, A. P. D. B., Goldbohm, R. A., van den Brandt, P. A., Baylin, S. B., de Goeij, A. F. P. M., & Herman, J. G. (2003) · PubMed · Cited by 297 · see citing works
Microarray-based DNA methylation profiling: technology and applications
Schumacher, A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj461 · Cited by 295 · see citing works
The methylome: approaches for global DNA methylation profiling
Beck, S., & Rakyan, V. K. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.006 · Cited by 277 · see citing works
Holloway, J. W., Yang, I. A., & Holgate, S. T. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.071 · Cited by 271 · see citing works
Castro, R., Rivera, I. A., Ravasco, P., Camilo, M., Jakobs, C., Blom, H. J., & de Almeida, I. T. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.017244 · Cited by 265 · see citing works
Maternal care, the epigenome and phenotypic differences in behavior
Moshe Szyf, A., Weaver, I. C. G., & Meaney, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.001 · Cited by 263 · see citing works
Li, S., Washburn, K. A., Moore, R., Uno, T., Teng, C. T., Newbold, R. R., McLachlan, J. A., & Negishi, M. (1997) · PubMed · Cited by 260 · see citing works
Taylor, K. H., Kramer, R. S., Davis, J. W., Guo, J., Duff, D. J., Xu, D. H., Caldwell, C. W., & Shi, H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1016 · Cited by 258 · see citing works
Gene-Nutrient Interactions and DNA Methylation
Friso, S., & Choi, S. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2382s · Cited by 257 · see citing works
Cross‐Talk between Aging and Cancer: The Epigenetic Language
FRAGA, M. F., AGRELO, R., & ESTELLER, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.005 · Cited by 251 · see citing works
The Cell-specific Expression of Endothelial Nitric-oxide Synthase
Chan, Y., Fish, J. E., D'Abreo, C., Lin, S., Robb, G. B., Teichert, A.-M., Karantzoulis-Fegaras, F., Keightley, A. M., Steer, B. M., & Marsden, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405063200 · Cited by 243 · see citing works
Epigenetic germline inheritance
Chong, S., & Whitelaw, E. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.09.001 · Cited by 239 · see citing works
Heijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm010 · Cited by 238 · see citing works
Cadieux, B., Ching, T., VandenBerg, S. R., & Costello, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1547 · Cited by 235 · see citing works
Intra- and Interindividual Epigenetic Variation in Human Germ Cells
Flanagan, J. M., Popendikytė, V., Pozdniakovaite, N., Sobolev, M., Assadzadeh, A., Schumacher, A., Zangeneh, M., Lau, L. Y. S., Virtanen, C., Wang, S.-C., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504729 · Cited by 233 · see citing works
Developmental estrogen exposures predispose to prostate carcinogenesis with aging
Prins, G. S., Birch, L. A., Tang, W., & Ho, S. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.10.001 · Cited by 227 · see citing works
Methylation of Endogenous Human Retroelements in Health and Disease
Schulz, W. A., Steinhoff, C., & Florl, A. R. (2006) · Springer eBooks · doi:10.1007/3-540-31181-5_11 · Cited by 222 · see citing works
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
Goyal, R. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl002 · Cited by 220 · see citing works
Abdolmaleky, H. M., Smith, C. L., Faraone, S. V., Shafa, R., Stone, W., Glatt, S. J., & Tsuang, M. T. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20142 · Cited by 216 · see citing works
Aging, methylation and cancer.
Ahuja, N., & Issa, J. J. (2000) · PubMed · doi:10.14670/hh-15.835 · Cited by 205 · see citing works
Genistein Alters Methylation Patterns in Mice
Day, J. K., Bauer, A. M., desBordes, C., Zhuang, Y., Kim, B.-E., Newton, L. G., Nehra, V., Forsee, K. M., MacDonald, R. S., Besch-Williford, C. L., et al. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2419s · Cited by 204 · see citing works
Role of DNA Methylation in the Regulation of Cell Function: Autoimmunity, Aging and Cancer
Richardson, B. C. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2401s · Cited by 204 · see citing works
Epigenetic Remodeling of the IL-2 and IFN -γ Loci in Memory CD8 T Cells Is Influenced by CD4 T Cells
Northrop, J. K., Thomas, R. M., Wells, A. D., & Shen, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1062 · Cited by 203 · see citing works
Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker
Wu, L. L., & Wu, J. T. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00174-2 · Cited by 200 · see citing works
Age-Associated Activation of Epigenetically Repressed Genes in the Mouse
Bennett‐Baker, P. E., Wilkowski, J. M., & Burke, D. (2003) · Genetics · doi:10.1093/genetics/165.4.2055 · Cited by 198 · see citing works
Effects of alcohol on folate metabolism: implications for carcinogenesis
Mason, J. B., & Choi, S. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.03.012 · Cited by 198 · see citing works
Perri, F., Cotugno, R., Piepoli, A., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01284.x · Cited by 193 · see citing works
Cho, N.-Y., Kim, B. S., Choi, M., Yoo, E., Moon, K., Cho, Y. H., Kim, D., & Kang, G. H. (2006) · The Journal of Pathology · doi:10.1002/path.2106 · Cited by 192 · see citing works
Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island
Philibert, R. A., Madan, A., Andersen, A. M., Cadoret, R. J., Packer, H., & Sandhu, H. K. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30414 · Cited by 191 · see citing works
Li, S., Hansman, R. L., Newbold, R. R., Davis, B. J., McLachlan, J. A., & Barrett, J. C. (2003) · Molecular Carcinogenesis · doi:10.1002/mc.10147 · Cited by 190 · see citing works
Cystic Fibrosis: A Review of Epidemiology and Pathobiology
Strausbaugh, S. D., & Davis, P. B. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.02.011 · Cited by 184 · see citing works
Epigenetic mechanisms in the context of complex diseases
van Vliet, J., Oates, N., & Whitelaw, E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6526-z · Cited by 171 · see citing works
Using LUMA: a Luminometric-Based Assay for Global DNA-Methylation
Mohsen, K., Johansson, S., & Ekström, T. J. (2006) · Epigenetics · doi:10.4161/epi.1.1.2587 · Cited by 168 · see citing works
Epigenetics and Complex Disease: From Etiology to New Therapeutics
Ptak, C., & Petronis, A. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094731 · Cited by 167 · see citing works
Aging, cancer and nutrition: the DNA methylation connection
Liu, L., Wylie, R. C., Andrews, L. G., & Tollefsbol, T. O. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.08.001 · Cited by 165 · see citing works
DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
nsch, D. B., Lenz, B., Kornhuber, J., & Bleich, S. (2005) · Neuroreport · doi:10.1097/00001756-200502080-00020 · Cited by 163 · see citing works
Drago, A., & Ronchi, D. D. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707781368450 · Cited by 162 · see citing works
Bleich, S., Lenz, B., Ziegenbein, M., Beutler, S., Frieling, H., Kornhuber, J., & Bönsch, D. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00068.x · Cited by 162 · see citing works
Bönsch, D., Lenz, B., Fiszer, R., Frieling, H., Kornhuber, J., & Bleich, S. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0413-2 · Cited by 160 · see citing works
Mikovits, J. A., Young, H. A., Vertino, P. M., Issa, J. J., Pitha, P. M., Turcovski‐Corrales, S. M., Taub, D. D., Petrow‐Sadowski, C., Baylin, S. B., & Ruscetti, F. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5166 · Cited by 160 · see citing works
MGMT hypermethylation: A prognostic foe, a predictive friend
Jacinto, F. V., & Esteller, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.03.013 · Cited by 158 · see citing works
Fenech, M. F. (2005) · Mutagenesis · doi:10.1093/mutage/gei040 · Cited by 158 · see citing works
DNA methylation in aging of mice
Singhal, R. P., Mays-Hoopes, L. L., & Eichhorn, G. L. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90040-6 · Cited by 156 · see citing works
Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism
nsch, D. B., Lenz, B., Reulbach, U., Kornhuber, J., & Bleich, S. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0232-x · Cited by 155 · see citing works
Bacterial Infection Promotes DNA Hypermethylation
Bobetsis, Y. A., Barros, S. P., Lin, D. M., Weidman, J. R., Dolinoy, D. C., Jirtle, R. L., Boggess, K., Beck, J. D., & Offenbacher, S. (2007) · Journal of Dental Research · doi:10.1177/154405910708600212 · Cited by 144 · see citing works
The Importance of Hyperhomocysteinemia as a Risk Factor for Diseases: An Overview
Herrmann, W. A. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.110 · Cited by 143 · see citing works
Gene-Nutrient Interactions in One-Carbon Metabolism
Friso, S., & Choi, S. (2005) · Current Drug Metabolism · doi:10.2174/1389200052997339 · Cited by 141 · see citing works
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Bock, C., Walter, J., Paulsen, M., & Lengauer, T. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn122 · Cited by 139 · see citing works
DNMT3B polymorphisms and risk of primary lung cancer
Lee, S. J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh307 · Cited by 138 · see citing works
Oates, N., van Vliet, J., Duffy, D. L., Kroes, H. Y., Martin, N. G., Boomsma, D. I., Campbell, M., Coulthard, M. G., Whitelaw, E., & Chong, S. (2006) · The American Journal of Human Genetics · doi:10.1086/505031 · Cited by 135 · see citing works
Thrall, G., Lane, D. A., Carroll, D., & Lip, G. Y. H. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.01.004 · Cited by 135 · see citing works
Lahiri, D. K., Maloney, B., Basha, R. M., Ge, Y. W., & Zawia, N. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362164 · Cited by 134 · see citing works
The 5-Methylcytosine content of highly repeated sequences in human DNA
Gama-Sosa, M. A., Wang, R. Y. ‐., Kuo, K. C., Gehrke, C. W., & Ehrlich, M. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.10.3087 · Cited by 133 · see citing works
Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status
Cravo, M. L., & Camilo, M. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00297-x · Cited by 133 · see citing works
Genetics and Epigenetics in Major Psychiatric Disorders
Abdolmaleky, H. M., Thiagalingam, S., & Wilcox, M. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505030-00002 · Cited by 132 · see citing works
Cancer-Linked DNA Hypomethylation and Its Relationship to Hypermethylation
Ehrlich, M. (2006) · Springer eBooks · doi:10.1007/3-540-31181-5_12 · Cited by 131 · see citing works
Post, R. M., & Leverich, G. S. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060573 · Cited by 126 · see citing works
Sætrom, P., Snøve, O., & Rossi, J. J. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e318045760e · Cited by 125 · see citing works
Epigenomics: Mapping the Methylome
Wilson, I. M., Davies, J. J., Weber, M., Brown, C. J., Alvarez, C. E., MacAulay, C. E., Schübeler, D., & Lam, W. L. (2005) · Cell Cycle · doi:10.4161/cc.5.2.2367 · Cited by 122 · see citing works
Khoury, M. J., Little, J., & Burke, W. (2003) · Cited by 116 · see citing works
Polesskaya, O. O., Aston, C., & Sokolov, B. P. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20732 · Cited by 116 · see citing works
Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter
Zhang, Z., Deng, C., Lu, Q., & Richardson, B. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00014-3 · Cited by 115 · see citing works
Mohr, D. C., & Pelletier, D. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.03.011 · Cited by 110 · see citing works
DNA damage in mice treated with sulfur dioxide by inhalation
Meng, Z., Qin, G., & Zhang, B. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20142 · Cited by 108 · see citing works
Liu, H., Zhou, Y., Boggs, S. E., Belinsky, S. A., & Liu, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210400 · Cited by 108 · see citing works
Frieling, H., Gozner, A., Römer, K. D., Lenz, B., Bönsch, D., Wilhelm, J., Hillemacher, T., de Zwaan, M., Kornhuber, J., & Bleich, S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001931 · Cited by 107 · see citing works
Pulling, L. C., Vuillemenot, B. R., Hutt, J. A., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2119 · Cited by 107 · see citing works
The potential role of epigenomic dysregulation in complex human disease
Hatchwell, E., & Greally, J. M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.08.010 · Cited by 106 · see citing works
Chapter 9 Epigenetic Gene Regulation in Cancer
Ballestar, E., & Esteller, M. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00009-0 · Cited by 97 · see citing works
Genetic variants in epigenetic genes and breast cancer risk
Cebrián, A., Pharoah, P. D. P., Ahmed, S., Ropero, S., Fraga, M. F., Smith, P. L., Conroy, D. M., Luben, R., Perkins, B., Easton, D. F., et al. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi375 · Cited by 96 · see citing works
Ogino, S., Hazra, A., Tranah, G. J., Kirkner, G. J., Kawasaki, T., Nosho, K., Ohnishi, M., Suemoto, Y., Meyerhardt, J. A., Hunter, D. J., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm160 · Cited by 96 · see citing works
Dietary Components Impact Histone Modifications and Cancer Risk
Davis, C. D., & Ross, S. A. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00285.x · Cited by 94 · see citing works
Fang, J., Mikovits, J. A., Bagni, R., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.20.9753-9761.2001 · Cited by 89 · see citing works
Genetic Variation in the One-Carbon Transfer Pathway and Ovarian Cancer Risk
Kelemen, L. E., Sellers, T. A., Schildkraut, J. M., Cunningham, J. M., Vierkant, R. A., Pankratz, V. S., Fredericksen, Z. S., Gadre, M. K., Rider, D. N., Liebow, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5165 · Cited by 88 · see citing works
Montgomery, K. G., Liu, M. C. P., Eccles, D., et al. (2004) · Breast Cancer Research · doi:10.1186/bcr807 · Cited by 86 · see citing works
Variations in DNA Methylation Patterns During the Cell Cycle of HeLa Cells
Brown, S. E., Fraga, M. F., Weaver, I. C. G., et al. (2007) · Epigenetics · doi:10.4161/epi.2.1.3880 · Cited by 79 · see citing works
CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer
Gutiérrez, M. I., Siraj, A. K., Khaled, H. M., Koon, N., El-Rifai, W. M., & Bhatia, K. G. (2004) · Modern Pathology · doi:10.1038/modpathol.3800177 · Cited by 79 · see citing works
Epigenetic and gene expression changes related to transgenerational carcinogenesis
Cheng, R. Y. S., Hockman, T. M., Crawford, E. B., Anderson, L. M., & Shiao, Y. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.20022 · Cited by 79 · see citing works
Kitazawa, R., & Kitazawa, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0205 · Cited by 78 · see citing works
Frieling, H., Bleich, S., Otten, J., Römer, K. D., Kornhuber, J., de Zwaan, M., Jacoby, G. E., Wilhelm, J., & Hillemacher, T. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301662 · Cited by 75 · see citing works
DNA Methyltransferases: Facts, Clues, Mysteries
Brenner, C., & Fuks, F. (2006) · Springer eBooks · doi:10.1007/3-540-31390-7_3 · Cited by 75 · see citing works
Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders
Abdolmaleky, H. M., Smith, C. L., Zhou, J., & Thiagalingam, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_9 · Cited by 74 · see citing works
Fang, M., Jin, Z. H., Wang, Y., Liao, J., Yang, G., Wang, L., & Yang, C. S. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.3.615 · Cited by 74 · see citing works
Genetic Epidemiology and the Future of Disease Prevention and Public Health
Khoury, M. J. (1997) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017940 · Cited by 70 · see citing works
DNA Global Hypomethylation in EBV-Transformed Interphase Nuclei
Habib, M., Fares, F., Bourgeois, C. A., Bella, C., Bernardino-Sgherri, J., Hernandez‐Blazquez, F. J., de Capoa, A., & Niveleau, A. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4434 · Cited by 69 · see citing works
Sato, K., Fukata, H., Kogo, Y., Ohgane, J., Shiota, K., & Mori, C. (2006) · Endocrine Journal · doi:10.1507/endocrj.k06-009 · Cited by 67 · see citing works
Antenatal Exposure to DES: Lessons Learned … Future Concerns
Rubin, M. M. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000271138.31234.d7 · Cited by 63 · see citing works
Jones, I. M., Galick, H. A., Kato, P., et al. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0424:tsgbac]2.0.co;2 · Cited by 63 · see citing works
Pang, Y., Norihisa, Y., Benjamin, D., et al. (1992) · Blood · doi:10.1182/blood.v80.3.724.bloodjournal803724 · Cited by 61 · see citing works
Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer
Kitajima, Y., Ohtaka, K., Mitsuno, M., et al. (2008) · Oncology Reports · doi:10.3892/or.19.1.197 · Cited by 60 · see citing works
Yu, W., Sipowicz, M. A., Haines, D. C., et al. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8692 · Cited by 56 · see citing works
Molecular Epidemiology of p53 Protein Mutations in Workers Exposed to Vinyl Chloride
Smith, S. J., Li, Y., Whitley, R. J., et al. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009450 · Cited by 54 · see citing works
Leopardi, P. (2006) · Mutagenesis · doi:10.1093/mutage/gel031 · Cited by 53 · see citing works
Fetal Origins of Adult Disease Fetal Origins Of Adult Disease?
Morley, R., & Dwyer, T. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03557.x · Cited by 52 · see citing works
Self-citationArchived Guthrie Blood Spots as a Novel Source for Quantitative DNA Methylation Analysis
Wong, N. C., Morley, R., Saffery, R., & Craig, J. M. (2008) · BioTechniques · doi:10.2144/000112945 · Cited by 50 · see citing works
Self-citationEpigenetics of Complex Diseases: From General Theory to Laboratory Experiments
Schumacher, A., & Petronis, A. (2006) · Springer eBooks · doi:10.1007/3-540-31181-5_6 · Cited by 50 · see citing works
5. Genetics of allergic disease
Steinke, J. W., Rich, S. S., & Borish, L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.07.029 · Cited by 48 · see citing works
Zhu, R., Li, B., Li, H., et al. (2007) · Pathology International · doi:10.1111/j.1440-1827.2007.02104.x · Cited by 44 · see citing works
Limpaiboon, T., Khaenam, P., Chinnasri, P., et al. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.020 · Cited by 42 · see citing works
E‐cadherin Gene Promoter Hypermethylation in H. pylori‐Induced Enlarged Fold Gastritis
Miyazaki, T., Murayama, Y., Shinomura, Y., Yamamoto, T., Watabe, K., Tsutsui, S., Kiyohara, T., Tamura, S., & Hayashi, N. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00519.x · Cited by 41 · see citing works
Genomic Imprinting – Roles and Regulation in Development
Kelsey, G. (2007) · KARGER eBooks · doi:10.1159/000109637 · Cited by 40 · see citing works
Hyperhomocysteinemia: an additional cardiovascular risk factor.
Fanapour, P. C., Yug, B., & Kochar, M. S. (1999) · PubMed · Cited by 33 · see citing works
Park, B. L., Kim, L. H., Shin, H. D., et al. (2004) · Journal of Human Genetics · doi:10.1007/s10038-004-0192-x · Cited by 32 · see citing works
The importance of (early) folate status to primary and secondary coronary artery disease prevention
Muskiet, F. A. J. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.03.013 · Cited by 30 · see citing works
Genetics as a tool to improve cancer outcomes: ethics and policy
Burke, W., & Press, N. (2006) · Nature Reviews. Cancer · doi:10.1038/nrc1890 · Cited by 23 · see citing works
Cobiac, L. (2007) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000107065 · Cited by 22 · see citing works
Huntriss, J., Lorenzi, R., Purewal, A., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6876 · Cited by 20 · see citing works
Promoter Hypermethylation for Molecular Nodal Staging in Non–Small Cell Lung Cancer
Safar, A. M., Spencer, H. J., Su, X., Cooney, C. A., Shwaiki, A., & Fan, C. (2007) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2007-131-936-phfmns · Cited by 20 · see citing works
Glycophorin A mutant frequency in radiation workers at the nuclear power plants and a hospital
Ha, M., Yoo, K., & Cho, S.-H. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00009-x · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Ballestar E, Esteller M. epigenetic gene regulation in cancer. Adv Genet. 2008;61:247-267.
Cited by
Sorted by citations
Epigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518 · see citing works
Sun, Y. V., & Hu, Y.-J. (2016) · Advances in Genetics · doi:10.1016/bs.adgen.2015.11.004 · Cited by 459 · see citing works
Epigenetic regulation in the pathophysiology of Alzheimer's disease
Chouliaras, L., Rutten, B. P. F., Kenis, G., Peerbooms, O., Visser, P. J., Verhey, F., van Os, J., Steinbusch, H. W. M., & van den Hove, D. L. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.002 · Cited by 262 · see citing works
Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression
Kang, H.-J., Kim, J.-M., Stewart, R., Kim, S.-Y., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Shin, M.-G., & Yoon, J.-S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.01.006 · Cited by 254 · see citing works
Maud, C., Ryan, J., McIntosh, J. E., & Olsson, C. A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1740-9 · Cited by 151 · see citing works
Olsson, C. A., Foley, D. L., Parkinson-Bates, M., Byrnes, G., McKenzie, M., Patton, G. C., Morley, R., Anney, R. J. L., Craig, J. M., & Saffery, R. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2009.12.003 · Cited by 137 · see citing works
Self-citationNovakovic, B., Ryan, J., Pereira, N., Boughton, B., Craig, J. M., & Saffery, R. (2014) · Epigenetics · doi:10.4161/epi.27248 · Cited by 131 · see citing works
Self-citationAlexander, N., Wankerl, M., Hennig, J., Miller, R., Zänkert, S., Steudte-Schmiedgen, S., Stalder, T., & Kirschbaum, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.88 · Cited by 95 · see citing works
Itoh, H., Iwasaki, M., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R., Yoshida, T., Yokoyama, K., & Tsugane, S. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.05.035 · Cited by 53 · see citing works
Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry
Archer, T., & Blum, K. (2012) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000115 · Cited by 54 · see citing works
Sun, Y. V. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0058-2 · Cited by 27 · see citing works
- Authors
- Foley, D. L., Craig, J. M., Morley, R., Olsson, C. J., Dwyer, T., Smith, K., & Saffery, R.
- Affiliations
- The University of Melbourne (AU)
- Royal Children's Hospital (AU)
- Corresponding author
- Saffery, R.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-13
- Volume
- 169
- Issue
- 4
- Pages
- 389-400
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC3290967
- OpenAlex
- W2142396486
- Cited by
- 244
- References
- 182
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 23 · 2013: 19 · 2012: 32
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- epigenetic epidemiology, DNA methylation, gene-environment interaction, gene expression regulation, developmental epidemiology, aging, age of onset, disease risk
- MeSH terms
- Aging, Animals, Environment, Environmental Exposure, Humans, Neoplasms, Risk Factors, Gene Expression, Molecular Epidemiology, DNA Methylation, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review