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Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies
Abstract
Coffee consumption has been inconsistently associated with risk of stroke. The authors conducted a meta-analysis of prospective studies to quantitatively assess the association between coffee consumption and stroke risk. Pertinent studies were identified by searching PubMed and Embase from January 1966 through May 2011 and by reviewing the reference lists of retrieved articles. Prospective studies in which investigators reported relative risks of stroke for 3 or more categories of coffee consumption were eligible. Results from individual studies were pooled using a random-effects model. Eleven prospective studies, with 10,003 cases of stroke and 479,689 participants, met the inclusion criteria. There was some evidence of a nonlinear association between coffee consumption and risk of stroke (P for nonlinearity = 0.005). Compared with no coffee consumption, the relative risks of stroke were 0.86 (95% confidence interval (95% CI): 0.78, 0.94) for 2 cups of coffee per day, 0.83 (95% CI: 0.74, 0.92) for 3-4 cups/day, 0.87 (95% CI: 0.77, 0.97) for 6 cups/day, and 0.93 (95% CI: 0.79, 1.08) for 8 cups/day. There was marginal between-study heterogeneity among study-specific trends (I₂ = 12% and I₂ = 20% for the first and second spline transformations, respectively). Findings from this meta-analysis indicate that moderate coffee consumption may be weakly inversely associated with risk of stroke.
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“These meta-analyses did not support an association between coffee consumption and a higher CVD risk, but the shape of the association remains uncertain.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [15]
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- Heyden, 1978, Archives of Internal Medicine, 138, 1472, 10.1001/archinte.1978.03630350010006 · DOI
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Scientific Opinion on the safety of caffeine
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“Two meta-analyses of prospective cohort studies have specifically addressed the association between coffee consumption and the risk of stroke (Larsson and Orsini, 2011; Kim et al., 2012).”
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“…injury (Sachse et al. 2008) or attention deficit and hyperactivity disorder (ADHD) (Gross 1975; Garfinkel et al. 1981) and risk to develop brain stroke (Larsson and Orsini 2011; Larsson et al. 2011), depression (Smith 2009; Ruusunen et al. 2010; Lucas et al. 2011; Guo et al. 2014; Pham et al.…”
BackgroundAlcohol Consumption and Risk of Atrial Fibrillation
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“We conducted a doseresponse meta-analysis by using the same methods as described in previous meta-analyses (14,15).”
MethodSelf-citation
Metadata
- Authors
- Larsson, S. C., & Orsini, N.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Larsson, S. C.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-13
- Volume
- 174
- Issue
- 9
- Pages
- 993-1001
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2106703328
- Cited by
- 196
- References
- 38
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 15 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 15 · 2019: 4 · 2018: 11 · 2017: 13 · 2016: 21 · 2015: 25 · 2014: 23 · 2013: 20 · 2012: 11
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, stroke risk, dose-response relationship, nonlinear relationship, caffeine, cardiovascular disease, relative risk
- MeSH terms
- Coffee, Dose-Response Relationship, Drug, Female, Humans, Male, Prospective Studies, Risk, Risk Factors, Stroke
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