Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes
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Aims/hypothesis Higher habitual coffee drinking has been associated with a lower risk of developing type 2 diabetes. The relation between coffee consumption and risk of cardiovascular disease (CVD) has been examined in many studies, but the issue remains controversial. This study was designed to assess the association between coffee consumption and CVD mortality among patients with type 2 diabetes.Methods We prospectively followed 3,837 randomly ascertained Finnish patients with type 2 diabetes aged 25 to 74 years. Coffee consumption and other study parameters were determined at baseline. The International Classification of Diseases was used to identify CHD, CVD and stroke cases using computerised record linkage to the national Death Registry. The associations between coffee consumption at baseline and risk of total, CVD, CHD, and stroke mortality were analysed by using Cox proportional hazards models.Results During the average follow-up of 20.8 years, 1,471 deaths were recorded, of which 909 were coded as CVD, 598 as CHD and 210 as stroke. The respective multivariate-adjusted hazard ratios in participants who drank 0-2, 3-4, 5-6, and > or =7 cups of coffee daily were 1.00, 0.77, 0.68 and 0.70 for total mortality (P<0.001 for trend), 1.00, 0.79, 0.70 and 0.71 for CVD mortality (P=0.006 for trend), 1.00, 0.78, 0.70 and 0.63 for CHD mortality (p=0.01 for trend), and 1.00, 0.77, 0.64 and 0.90 for stroke mortality (p=0.12 for trend).Conclusions/interpretation In this large prospective study we found that in type 2 diabetic patients coffee drinking is associated with reduced total, CVD and CHD mortality.
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Among four studies providing age-stratified results, comparing highest with lowest coffee intake, the RR of CVD was 0.91 (95% CI 0.59 to 1.40) for age ≥ 65 years.
“the RR was 0.91 (95% CI, 0.59 to 1.40) for age ≥ 65 years.”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [29]
Among four studies providing age-stratified results, comparing highest with lowest coffee intake, the RR of CVD was 0.96 (95% CI 0.65 to 1.42) for age < 65 years.
“the RR of CVD was 0.96 (95% CI, 0.65 to 1.42) for age < 65 years”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [29]
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Stamler, J., Vaccaro, O., Neaton, J. D., Wentworth, D., & The Multiple Risk Factor Intervention Trial Research Group (1993) · Diabetes Care · doi:10.2337/diacare.16.2.434 · Cited by 4,063 · see citing works
WHO MONICA Project Principal Invest (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90084-4 · Cited by 1,798 · see citing works
Long-Term Complications of Diabetes Mellitus
Nathan, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306103282306 · Cited by 1,495 · see citing works
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Glucose Tolerance and Cardiovascular Mortality: Comparison of Fasting and 2-Hour Diagnostic Criteria
(2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.3.397 · Cited by 1,371 · see citing works
Kornitzer, M., Berghmans, L., Wilmet, M. D., Darquennes, H., Lagasse, R., & Payen, R. (1988) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 1,270 · see citing works
Diabetes Mellitus: Report of a WHO Study Group.
(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-4-597_2 · Cited by 1,030 · see citing works
R�sen, P., Nawroth, P., King, G. L., M�ller, W., Tritschler, H., & Packer, L. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.196 · Cited by 881 · see citing works
Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review
van Dam, R. M., & Hu, F. B. (2005) · JAMA · doi:10.1001/jama.294.1.97 · Cited by 662 · see citing works
Fuller, J., Shipley, M. J., Rose, G., Jarrett, R. J., & KEEN, H. (1983) · BMJ · doi:10.1136/bmj.287.6396.867 · Cited by 632 · see citing works
Wei, M., Gaskill, S. P., Haffner, S., & Stern, M. (1998) · Diabetes Care · doi:10.2337/diacare.21.7.1167 · Cited by 515 · see citing works
Coffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490 · see citing works
Coffee consumption and risk for type 2 diabetes mellitus
Salazar-Martinez, E., Willett, W. C., Ascherio, A., Manson, J. E., Leitzmann, M. F., Stampfer, M. J., & Hu, F. B. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-1-200401060-00005 · Cited by 462 · see citing works
Coffee consumption and risk of type 2 diabetes mellitus
van Dam, R. M., & Feskens, E. J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11436-x · Cited by 444 · see citing works
Should minimal blood glucose variability become the gold standard of glycemic control?
Hirsch, I. B., & Brownlee, M. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2004.10.001 · Cited by 405 · see citing works
Cardiovascular risk factor changes in Finland, 1972–1997
Vartiainen, E. A., Jousilahti, P., Alfthan, G., Sundvall, J., Pietinen, P., & Puska, P. (2000) · International Journal of Epidemiology · doi:10.1093/ije/29.1.49 · Cited by 401 · see citing works
Self-citationFree radicals in diabetic endothelial cell dysfunction
Tesfamariam, B. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90040-x · Cited by 398 · see citing works
Tesfamariam, B., Brown, M. L., Deykin, D., & Cohen, R. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114521 · Cited by 363 · see citing works
Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women
Tuomilehto, J. O. (2004) · JAMA · doi:10.1001/jama.291.10.1213 · Cited by 281 · see citing works
Self-citationHabitual caffeine intake and the risk of hypertension in women
Winkelmayer, W. C. (2005) · JAMA · doi:10.1001/jama.294.18.2330 · Cited by 274 · see citing works
Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes
Hu, G., Jousilahti, P., Barengo, N. C., Qiao, Q., Lakka, T. A., & Tuomilehto, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.799 · Cited by 265 · see citing works
Self-citationAndersen, L. F., Jacobs, D. R., Carlsen, M. H., & Blomhoff, R. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.1039 · Cited by 262 · see citing works
Hu, G., Eriksson, J. G., Barengo, N. C., Lakka, T. A., Valle, T. T., Nissinen, A. M., Jousilahti, P., & Tuomilehto, J. O. (2004) · Circulation · doi:10.1161/01.cir.0000138102.23783.94 · Cited by 252 · see citing works
Self-citationPredictors of Stroke in Middle-Aged Patients With Non–Insulin-Dependent Diabetes
Lehto, S., Rönnemaa, T., Pyörälà, K., & Laakso, M. (1996) · Stroke · doi:10.1161/01.str.27.1.63 · Cited by 227 · see citing works
Coffee Consumption and Coronary Heart Disease in Men and Women: A Prospective Cohort Study
Lopez-Garcia, E., van Dam, R. M., Willett, W. C., Rimm, E. B., Manson, J. E., Stampfer, M. J., Rexrode, K. M., & Hu, F. B. (2006) · Circulation · doi:10.1161/circulationaha.105.598664 · Cited by 215 · see citing works
Age, body mass index and Type 2 diabetes?associations modified by ethnicity
Group, T. D.-D. S. (2003) · Diabetologia · doi:10.1007/s00125-003-1158-9 · Cited by 215 · see citing works
Wouw, M. P. M. E. W.-V. D., Katan, M., Viani, R., Huggett, A. C., Liardon, R., Liardon, R., Lund‐Larsen, P. G., Thelle, D. S., Ahola, I., & Aro, A. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41169-1 · Cited by 200 · see citing works
Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals
Diederich, D. A., Skopec, J., Diederich, A., & Dai, F. X. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h1153 · Cited by 199 · see citing works
Woodward, M., & Tunstall-Pedoe, H. (1999) · Journal of Epidemiology and Community Health · doi:10.1136/jech.53.8.481 · Cited by 196 · see citing works
Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta
Pieper, G. M., & Gross, G. J. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.4.h825 · Cited by 192 · see citing works
Predictors of Stroke in Middle-Aged Patients With Non–Insulin-Dependent Diabetes
SeppoLehto, TapaniRönnemaa, KaleviPyörälä, & MarkkuLaakso (1996) · Stroke · Cited by 187 · see citing works
The DECODE Study Group, & Hu, G. (2003) · Diabetologia · doi:10.1007/s00125-003-1096-6 · Cited by 184 · see citing works
Self-citationMatsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., & Matsumoto, K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0012502 · Cited by 183 · see citing works
Qiao, Q. (2002) · European Heart Journal · doi:10.1053/euhj.2001.3113 · Cited by 180 · see citing works
Self-citationCoffee Consumption and the Risk of Coronary Heart Disease and Death
Kleemola, P., Jousilahti, P., Pietinen, P., Vartiainen, E., & Tuomilehto, J. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.22.3393 · Cited by 177 · see citing works
Self-citationHu, G., Jousilahti, P., Qiao, Q., Katoh, S., & Tuomilehto, J. (2005) · Diabetologia · doi:10.1007/s00125-005-1730-6 · Cited by 176 · see citing works
Self-citationCardiovascular effects of caffeine in men and women
Hartley, T. R., Lovallo, W. R., & Whitsett, T. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.12.057 · Cited by 168 · see citing works
A meta‐analysis of coffee, myocardial infarction, and coronary death
Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199307000-00013 · Cited by 163 · see citing works
Coffee intake and risk of hypertension. The Johns Hopkins precursors study
Klag, M. J., Wang, N. H., & Meoni, L. A. (2002) · ACC Current Journal Review · doi:10.1016/s1062-1458(02)00779-1 · Cited by 156 · see citing works
Graier, W. F., Simecek, S., Kukovetz, W. R., & Kostner, G. M. (1996) · Diabetes · doi:10.2337/diab.45.10.1386 · Cited by 146 · see citing works
Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis
Kawachi, I., Colditz, G. A., & Stone, C. B. (1994) · Heart · doi:10.1136/hrt.72.3.269 · Cited by 144 · see citing works
van Dam, R. M., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Bouter, L. M., & Heine, R. J. (2004) · Diabetologia · doi:10.1007/s00125-004-1573-6 · Cited by 133 · see citing works
Coffee Drinking Is Dose-Dependently Related to the Risk of Acute Coronary Events in Middle-Aged Men
Happonen, P., Voutilainen, S., & Salonen, J. T. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.9.2381 · Cited by 120 · see citing works
Panagiotakos, D. B., Pitsavos, C. E., Chrysohoou, C. A., Kokkinos, P. F., TOUTOUZAS, P. K., & Stefanadis, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3228 · Cited by 118 · see citing works
Coffee Consumption and Coronary Heart Disease in Women
Willett, W. C. (1996) · JAMA · doi:10.1001/jama.1996.03530300042038 · Cited by 116 · see citing works
Coffee and coronary heart disease
Myers, M. G. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400210009002 · Cited by 113 · see citing works
Coffee consumption and glucose tolerance status in middle-aged Japanese men
Yamaji, T., Mizoue, T., Tabata, S., Ogawa, S., Yamaguchi, K., Shimizu, E., Mineshita, M., & Kono, S. (2004) · Diabetologia · doi:10.1007/s00125-004-1590-5 · Cited by 98 · see citing works
Myocardial Insulin Resistance and Cardiac Complications of Diabetes
Abel, E. D. (2005) · Current Drug Targets - Immune Endocrine & Metabolic Disorders · doi:10.2174/1568008054064869 · Cited by 83 · see citing works
Coffee consumption and risk of type 2 diabetes mellitus
Tan, D. S. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12582-2 · Cited by 53 · see citing works
Bidel, S., Hu, G., Sundvall, J., Kaprio, J. A., & Tuomilehto, J. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-924982 · Cited by 46 · see citing works
Self-citationDu, Y., Melchert, H.-U., Knopf, H. C., Braemer-Hauth, M., Gerding, B., & Pabel, E. (2005) · European Journal of Epidemiology · doi:10.1007/s10654-004-7536-x · Cited by 33 · see citing works
Coffee Intake and Risk of Hypertension: The Johns Hopkins Precursors Study
Klag, M. J., Wang, N.-Y., Meoni, L. A., Brancati, F. L., Cooper, L. A., Liang, K.-Y., Young, J. H., & Ford, D. E. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.6.657 · Cited by 4 · see citing works
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Sorted by citations
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763 · see citing works
Authors Task Force Members, Rydén, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht108 · Cited by 1,958 · see citing works
Self-citationCoffee and its Consumption: Benefits and Risks
Butt, M. S., & Sultan, M. T. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903586412 · Cited by 614 · see citing works
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
Ding, M., Bhupathiraju, S. N., Satija, A., van Dam, R. M., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.113.005925 · Cited by 565 · see citing works
Mesas, A. E., Leon-Muñoz, L. M., Rodriguez-Artalejo, F., & Lopez-Garcia, E. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016667 · Cited by 350 · see citing works
O’Keefe, J. H., Bhatti, S. K., Patil, H., DiNicolantonio, J. J., Lucan, S. C., & Lavie, C. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.035 · Cited by 353 · see citing works
The impact of coffee on health
Cano-Marquina, A., Tarín, J. J., & Cano, A. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.002 · Cited by 332 · see citing works
Coffee and tea consumption and the risk of Parkinson's disease
Hu, G., Bidel, S., Jousilahti, P., Antikaínen, R., & Tuomilehto, J. O. (2007) · Movement Disorders · doi:10.1002/mds.21706 · Cited by 281 · see citing works
Self-citationMineharu, Y., Koizumi, A., Wada, Y., Iso, H., Watanabe, Y., Date, C., Yamamoto, A., Kikuchi, S., Inaba, Y., Toyoshima, H., et al. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2009.097311 · Cited by 230 · see citing works
Caffeine and cardiovascular health
Turnbull, D., Rodricks, J. V., Mariano, G. F., & Chowdhury, F. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.07.025 · Cited by 216 · see citing works
Functional Foods and Nutraceuticals in the Primary Prevention of Cardiovascular Diseases
Alissa, E. M., & Ferns, G. A. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/569486 · Cited by 209 · see citing works
Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies
Larsson, S. C., & Orsini, N. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr226 · Cited by 196 · see citing works
Wu, J.-N., Ho, S. C., Zhou, C., Ling, W.-H., Chen, W.-Q., Wang, C.-L., & Chen, Y.-M. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.06.051 · Cited by 185 · see citing works
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2016) · Molecules · doi:10.3390/molecules21080974 · Cited by 189 · see citing works
Zhang, C., Qin, Y., Wei, X., Yu, F., Zhou, Y., & He, J. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9960-x · Cited by 168 · see citing works
Coffee Consumption and Risk of Stroke in Women
Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., & van Dam, R. M. (2009) · Circulation · doi:10.1161/circulationaha.108.826164 · Cited by 167 · see citing works
Effects of tea and coffee on cardiovascular disease risk
Bøhn, S. K., Ward, N. C., Hodgson, J. M., & Croft, K. D. (2012) · Food & Function · doi:10.1039/c2fo10288a · Cited by 161 · see citing works
Tea and Coffee Consumption and Cardiovascular Morbidity and Mortality
Gans, J. M. D. K., Uiterwaal, C. S. P. M., van der Schouw, Y. T., Boer, J. M. A., Grobbee, D. E., Verschuren, W. M. M., & Beulens, J. W. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201939 · Cited by 150 · see citing works
Tang, J., Zheng, J., Fang, L., Jin, Y., Cai, W., & Li, D. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002329 · Cited by 125 · see citing works
Coffee and tea consumption and risk of stroke subtypes in male smokers
Larsson, S. C., Männistö, S., Virtanen, M. J., Kontto, J., Albanes, D., & Virtamo, J. (2008) · Stroke · doi:10.1161/strokeaha.107.504183 · Cited by 122 · see citing works
The Medicinal Chemistry of Caffeine
Faudone, G., Arifi, S., & Merk, D. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00261 · Cited by 122 · see citing works
Epidemiologic Evidence on Coffee and Cancer
Arab, L. (2010) · Nutrition and Cancer · doi:10.1080/01635580903407122 · Cited by 118 · see citing works
Pharmacological potential of methylxanthines: Retrospective analysis and future expectations
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1461607 · Cited by 103 · see citing works
Role of coffee in modulation of diabetes risk
Natella, F., & Scaccini, C. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00470.x · Cited by 94 · see citing works
Coffee Consumption and Risk of Stroke in Women
Larsson, S. C., Virtamo, J., & Wolk, A. (2011) · Stroke · doi:10.1161/strokeaha.110.603787 · Cited by 93 · see citing works
Functional foods for dyslipidaemia and cardiovascular risk prevention
Sirtori, C. R., Galli, C., Anderson, J. W., Sirtori, E., & Arnoldi, A. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990187 · Cited by 79 · see citing works
Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter
Rebello, S. A., & van Dam, R. M. (2013) · Current Cardiology Reports · doi:10.1007/s11886-013-0403-1 · Cited by 78 · see citing works
Zhang, W. L., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1311-1 · Cited by 76 · see citing works
Saito, E., Inoue, M., Sawada, N., Shimazu, T., Yamaji, T., Iwasaki, M., Sasazuki, S., Noda, M., Iso, H., & Tsugane, S. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104273 · Cited by 74 · see citing works
Seal, C. J., de Mul, A., Eisenbrand, G., Haverkort, A. J., Franke, K., Lalljie, S. P. D., Mykkänen, H. M., Reimerdes, E. H., Scholz, G., Somoza, V., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508965314 · Cited by 72 · see citing works
2-Furoylglycine as a Candidate Biomarker of Coffee Consumption
Heinzmann, S. S., Holmes, E. C., Kochhar, S., Nicholson, J. K., & Schmitt‐Kopplin, P. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03040 · Cited by 71 · see citing works
Guessous, I., Dobrinas, M., Kutalik, Z., Pruijm, M., Ehret, G., Maillard, M., Bergmann, S., Beckmann, J. S., Cusi, D., Rizzi, F., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds137 · Cited by 70 · see citing works
Mukamal, K. J., Hallqvist, J., Hammar, N., Ljung, R., Gémes, K., Ahlbom, A., Ahnve, S., & Janszky, I. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.11.009 · Cited by 69 · see citing works
Carman, A. J., Dacks, P. A., Lane, R. F., Shineman, D. W., & Fillit, H. M. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0021-7 · Cited by 68 · see citing works
Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies
Shen, L., Song, L., Ma, H., Jin, C., Wang, J., & Xiang, M. (2012) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1201001 · Cited by 66 · see citing works
Coffee Consumption and Risk of Cardiovascular Events After Acute Myocardial Infarction
Silletta, M. G., Marfisi, R., Levantesi, G., Boccanelli, A., Chieffo, C., Franzosi, M., Geraci, E., Maggioni, A. P., Nicolosi, G. L., Schweiger, C., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712976 · Cited by 65 · see citing works
Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview
Saeed, M., Naveed, M., Bibi, J., Kamboh, A. A., Phil, L., & Sun, C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1489368 · Cited by 66 · see citing works
Zhang, W., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetes Care · doi:10.2337/dc08-2251 · Cited by 61 · see citing works
Shahinfar, H., Jayedi, A., Khan, T. A., & Shab‐Bidar, S. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.05.014 · Cited by 58 · see citing works
Coffee consumption and mortality in a 14-year follow-up of an elderly northern Finnish population
Happonen, P., Läärä, E., Hiltunen, L. A., & Luukinen, H. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507871650 · Cited by 55 · see citing works
Coffee consumption and the incidence of antihypertensive drug treatment in Finnish men and women
Hu, G., Jousilahti, P., Nissinen, A. M., Bidel, S., Antikaínen, R., & Tuomilehto, J. O. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.457 · Cited by 55 · see citing works
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Beaudoin, M., & Graham, T. E. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_21 · Cited by 54 · see citing works
Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study
Qian, Y., Ye, D., Huang, H., Wu, D., Zhuang, Y., Jiang, X., & Mao, Y. (2020) · Annals of Neurology · doi:10.1002/ana.25693 · Cited by 52 · see citing works
Gardener, H. E., Rundek, T., Wright, C. B., Elkind, M. S. V., & Sacco, R. L. (2013) · Journal of Nutrition · doi:10.3945/jn.112.173807 · Cited by 47 · see citing works
Caffeine Consumption and Mortality in Diabetes: An Analysis of NHANES 1999–2010
Neves, J. S., Leitão, L., Magriço, R., Vieira, M. B., Dias, C. V., Oliveira, A. B. F. D., Carvalho, D. M., & Claggett, B. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00547 · Cited by 43 · see citing works
Komorita, Y., Iwase, M., Fujii, H., Ohkuma, T., Ide, H., Jodai, T., Yoshinari, M., Oku, Y., Higashi, T., Nakamura, U., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001252 · Cited by 44 · see citing works
Shao, C., Tang, H., Wang, X., & He, J. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105452 · Cited by 43 · see citing works
The Coffee Paradox in Stroke: Increased Consumption Linked with Fewer Strokes
Liebeskind, D. S., Sanossian, N., Fu, K. A., Wang, H.-J., & Arab, L. (2016) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000035 · Cited by 30 · see citing works
Nilsson, L. M., Wennberg, M., Lindahl, B., Eliasson, M., Jansson, J.-H., & Guelpen, B. R. V. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.05.004 · Cited by 30 · see citing works
How Can Diet Influence the Risk of Stroke?
Medeiros, F., Casanova, M. D. A., Fraulob, J. C., & Trindade, M. (2012) · International Journal of Hypertension · doi:10.1155/2012/763507 · Cited by 29 · see citing works
Seng, J. J. B., Monteiro, A. Y., Kwan, Y. H., Zainudin, S. B., Tan, C. S., Thumboo, J., & Low, L. L. (2021) · BMC Medical Research Methodology · doi:10.1186/s12874-021-01209-w · Cited by 29 · see citing works
Danielsson, J., Kangastupa, P., Laatikainen, T. K., Aalto, M., & Niemelä, O. J. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt017 · Cited by 27 · see citing works
Caffeine-Containing Medicines Increase the Risk of Hemorrhagic Stroke
Lee, S.-M., Choi, N., Lee, B., Cho, K., Yoon, B., & Park, B. (2013) · Stroke · doi:10.1161/strokeaha.111.674077 · Cited by 25 · see citing works
Rustenbeck, I., Lier-Glaubitz, V., Willenborg, M., Eggert, F., Engelhardt, U. H., & Jörns, A. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.19 · Cited by 24 · see citing works
Barbaresko, J., Lang, A., Szczerba, E., Bächle, C., Beckhaus, J., Schwingshackl, L., Neuenschwander, M., & Schlesinger, S. (2023) · Diabetes Care · doi:10.2337/dc22-1018 · Cited by 20 · see citing works
A review of mortality in type 2 diabetes mellitus
Asfandiyarova, N. S. (2015) · Diabetes Mellitus · doi:10.14341/dm6846 · Cited by 21 · see citing works
Coffee consumption and type 2 diabetes — An extensive review
Bidel, S., Hu, G., & Tuomilehto, J. O. (2007) · Open Medicine · doi:10.2478/s11536-007-0059-6 · Cited by 18 · see citing works
Self-citationRydén, L., estable, G. D. T. D. L. S. E. D. C. S. D. Y. T. D. L. C. I., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H. P., et al. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2013.10.015 · Cited by 17 · see citing works
Self-citationHan, J., Shon, J., Hwang, J., & Park, Y. J. (2020) · Nutrients · doi:10.3390/nu12020493 · Cited by 16 · see citing works
Lifestyle and outcome among patients with type 2 diabetes
Hu, G., & Tuomilehto, J. O. (2007) · International Congress Series · doi:10.1016/j.ics.2007.03.022 · Cited by 11 · see citing works
Self-citationWierzejska, R. E. (2016) · Polish Journal of Food and Nutrition Sciences · doi:10.1515/pjfns-2015-0048 · Cited by 10 · see citing works
Ding, L., Wang, H.-P., Zhao, J., Zhao, X., Sha, Y., Qin, L., & Hidayat, K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1570644 · Cited by 8 · see citing works
Morakinyo, A., Adekunbi, D. A., Dada, K., & Adegoke, O. (2013) · PubMed · Cited by 8 · see citing works
Coffee and Cardiovascular Diseases
Bidel, S., & Tuomilehto, J. O. (2012) · doi:10.1002/9781119949893.ch9 · Cited by 8 · see citing works
Self-citationCoffee consumption and risk of stroke: a meta-analysis of cohort studies
Zhang, R., Wang, Y., Song, B., Stødkilde‐Jørgensen, H., & Xu, Y. (2012) · Open Medicine · doi:10.2478/s11536-011-0154-6 · Cited by 7 · see citing works
Real-time screening of melamine in coffee capsules using infrared thermography and deep learning
Luque, N. H., Pérez-Calabuig, A. M., Pradana‐López, S., Cancilla, J. C., & Torrecilla, J. S. (2025) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2025.112675 · Cited by 6 · see citing works
Kempf, K., & Martin, S. (2010) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-010-1156-x · Cited by 6 · see citing works
Tuomilehto, J. O. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00997-0 · Cited by 6 · see citing works
Self-citationAditya, S., Gnanasekaran, S., Stephen, J., & Radhakrishnan, M. (2020) · Journal of Food Process Engineering · doi:10.1111/jfpe.13450 · Cited by 5 · see citing works
Ma, T., Yang, L., Wu, M., Wang, B., Li, J., Yang, J., & Sun, X. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01807-4 · Cited by 3 · see citing works
Allan, G. M., Korownyk, C. S., & Mannarino, M. (2013) · Europe PMC (PubMed Central) · Cited by 2 · see citing works
Coffee Consumption, Myocardial Infarction and Stroke: What is the Association?
López‐García, E. (2011) · Women s Health · doi:10.2217/whe.11.23 · Cited by 2 · see citing works
Section Technologies Agro - Alimentaires, U. D. S. A., Ndong, M., Diallo, A., Ndiaye, A., Sadji, M., & Institut de Technologie Alimentaire, D. N. (2017) · African Journal of Food Agriculture Nutrition and Development · doi:10.18697/ajfand.80.15710 · Cited by 2 · see citing works
Café y enfermedades cardiovasculares
von Wichmann, M. D. L. F. (2009) · Atención Primaria · doi:10.1016/j.aprim.2009.09.002 · Cited by 2 · see citing works
Schlaganfallprävention jenseits der Apotheke
Sobesky, J. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2528-9 · Cited by 2 · see citing works
Coffee and Risk of Type 2 Diabetes
Bidel, S., & Tuomilehto, J. (2007) · Työväentutkimus Vuosikirja · Cited by 2 · see citing works
Self-citationGenetic Modifiers of Caffeine Consumption and Risk of Myocardial Infarction
Costa, L. A. D. (2011) · TSpace (University of Toronto) · Cited by 2 · see citing works
Caffeine intake and the plasma proteome
Tian, O., Josse, A. R., & El‐Sohemy, A. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.1080.3 · Cited by 1 · see citing works
Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes–Prospective Cohort Studies
Liu, B., Hu, Y., Wang, S., Wang, M., Rimm, E. B., & Sun, Q. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.01.008 · Cited by 1 · see citing works
Bae, Y., Lee, E., & Yeon, J. (2016) · The Korean Journal of Food And Nutrition · doi:10.9799/ksfan.2016.29.4.547 · Cited by 1 · see citing works
Online education model on coffee addiction on the prevention of diabetes mellitus
Halimatussakdiah, H., & Faisal, T. I. (2022) · AcTion Aceh Nutrition Journal · doi:10.30867/action.v7i2.958 · Cited by 1 · see citing works
Jawień, A., Filipiak, K. J., Doroszko, A., Dzieciątkowski, T., Krasiński, Z., Szymański, F. M., & Terlecki, P. (2023) · Acta Angiologica · doi:10.5603/aa.2023.0008 · Cited by 1 · see citing works
Martin, S., & Weiß, J. (2007) · Der Diabetologe · doi:10.1007/s11428-007-0155-x · Cited by 1 · see citing works
Danielsson, J. (2014) · Tampere University Institutional Repository (Tampere University) · Cited by 1 · see citing works
Potential Cardioprotective Effects of Functional Foods
Alissa, E. M., & Ferns, G. A. (2014) · Wiley eBooks · doi:10.1002/9781118227800.ch17 · Cited by 1 · see citing works
Alcohol and Coffee Intake, BP, and Cerebrovascular Disorders
Kelly, T. N., & He, J. (2011) · Wiley eBooks · doi:10.1002/9781444318456.ch40
Bowen, M. J. (2015) · University Library - University of Saskatchewan (University of Saskatchewan)
Coffee and Risk of Cardiovascular Disease
di Giuseppe, R., Wirth, J., & Weikert, C. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00041-3
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282c3a898
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3280d5f7e9
Current literature in diabetes
(2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.754
Nahas, R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00032-7
Pan, Y., Wu, Y., Wu, S., Li, R., Hong, J., Liu, W., & Zhu, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3402030/v1
Alba, L. H., Camacho, M. C. P., Cerquera, Y. F. V., & Rojas, A. C. R. (2024) · Revista Salud Bosque · doi:10.18270/rsb.v14i1.4537
Coffee and Cardiovascular Mortality
Bajraktari, G., & Abdyli, G. (2025) · Springer eBooks · doi:10.1007/978-3-031-93459-9_8
Rôle du café dans la prévention primaire du diabète de type 2 : Arguments épidémiologiques récents
Castetbon, K. (2015) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(15)30076-6
Seng, J. J. B., Monteiro, A. Y., Kwan, Y., Zainudin, S. B., Tan, C. S., Thumboo, J., & Low, L. L. (2021) · Figshare · doi:10.6084/m9.figshare.14205179
- Authors
- Bidel, S., Hu, G., Qiao, Q., Jousilahti, P., Antikainen, R., & Tuomilehto, J.
- Affiliations
- University of Helsinki (FI)
- Tampere University (FI)
- Corresponding author
- Bidel, S.
- Venue
- Diabetologia
- Published
- 2006-09-21
- Volume
- 49
- Issue
- 11
- Pages
- 2618-2626
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2131410623
- Cited by
- 107
- References
- 54
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 9 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 10
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for Cardiovascular Research
- Academy of Finland (46558, 204274, 205657)
- Juho Vainion Säätiö
- Sydäntutkimussäätiö
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, type 2 diabetes, cardiovascular mortality, coronary heart disease mortality, stroke mortality, all-cause mortality, cardiovascular disease, mortality risk
- MeSH terms
- Adult, Cardiovascular Diseases, Coffee, Coronary Disease, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Finland, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Body Mass Index, Risk Assessment
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