Cited by 284Dementia and Cognitive Impairment ResearchHealth disparities and outcomesCognitive Abilities and Testing

Contribution of Socioeconomic Status at 3 Life-Course Periods to Late-Life Memory Function and Decline: Early and Late Predictors of Dementia Risk

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Marden, Jessica R., Tchetgen Tchetgen, Eric J., Kawachi, Ichiro, Glymour, M. Maria·2017·American Journal of Epidemiology

Abstract

Both early life and adult socioeconomic status (SES) predict late-life level of memory; however, evidence is mixed on the relationship between SES and rate of memory decline. Further, the relative importance of different life-course periods for rate of late-life memory decline has not been evaluated. We examined associations between life-course SES and late-life memory function and decline. Health and Retirement Study participants (n = 10,781) were interviewed biennially from 1998-2012 (United States). SES measurements for childhood (composite score including parents' educational attainment), early adulthood (high-school or college completion), and older adulthood (income, mean age 66 years) were all dichotomized. Word-list memory was modeled via inverse-probability weighted longitudinal models accounting for differential attrition, survival, and time-varying confounding, with nonrespondents retained via proxy assessments. Compared to low SES at all 3 points (referent), stable, high SES predicted the best memory function and slowest decline. High-school completion had the largest estimated effect on memory (β = 0.19; 95% confidence interval: 0.15, 0.22), but high late-life income had the largest estimated benefit for slowing declines (for 10-year memory change, β = 0.35; 95% confidence interval: 0.24, 0.46). Both early and late-life interventions are potentially relevant for reducing dementia risk by improving memory function or slowing decline.

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Authors
Marden, J. R., Tchetgen Tchetgen, E. J., Kawachi, I., & Glymour, M. M.
Affiliations
Harvard University (US)
Corresponding author
Marden, Jessica R.
Venue
American Journal of Epidemiology
Published
2017-05-24
Volume
186
Issue
7
Pages
805-814
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
OpenAlex
W2618542456
Cited by
284
References
79
Citations by year
2026: 33 · 2025: 45 · 2024: 52 · 2023: 27 · 2022: 25 · 2021: 41 · 2020: 28 · 2019: 23 · 2018: 9 · 2017: 1
FWCI
13.69
Type
journal article
Language
en
Open access
Locations
  • American Journal of Epidemiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institutes of Health (NINDS T32 NS048005, NIAID R01 AI104459)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Health › Health disparities and outcomes
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
socioeconomic status, memory decline, dementia risk, word list memory, childhood socioeconomic status, high school graduation, income, educational attainment, Health and Retirement Study
MeSH terms
Aged, Aged, 80 and over, Dementia, Educational Status, Female, Humans, Income, Male, Memory, Memory Disorders, Risk Factors, Social Class, United States

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