Contribution of Socioeconomic Status at 3 Life-Course Periods to Late-Life Memory Function and Decline: Early and Late Predictors of Dementia Risk
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Both early life and adult socioeconomic status (SES) predict late-life level of memory; however, evidence is mixed on the relationship between SES and rate of memory decline. Further, the relative importance of different life-course periods for rate of late-life memory decline has not been evaluated. We examined associations between life-course SES and late-life memory function and decline. Health and Retirement Study participants (n = 10,781) were interviewed biennially from 1998-2012 (United States). SES measurements for childhood (composite score including parents' educational attainment), early adulthood (high-school or college completion), and older adulthood (income, mean age 66 years) were all dichotomized. Word-list memory was modeled via inverse-probability weighted longitudinal models accounting for differential attrition, survival, and time-varying confounding, with nonrespondents retained via proxy assessments. Compared to low SES at all 3 points (referent), stable, high SES predicted the best memory function and slowest decline. High-school completion had the largest estimated effect on memory (β = 0.19; 95% confidence interval: 0.15, 0.22), but high late-life income had the largest estimated benefit for slowing declines (for 10-year memory change, β = 0.35; 95% confidence interval: 0.24, 0.46). Both early and late-life interventions are potentially relevant for reducing dementia risk by improving memory function or slowing decline.
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Research shows dementia risk to be associated with lower socio-economic status, independently of education status.
“research shows dementia risk to be associated with lower socio-economic status, independently of education status118,119.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [119]
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- Authors
- Marden, J. R., Tchetgen Tchetgen, E. J., Kawachi, I., & Glymour, M. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Marden, Jessica R.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-24
- Volume
- 186
- Issue
- 7
- Pages
- 805-814
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC5859987
- OpenAlex
- W2618542456
- Cited by
- 284
- References
- 79
- Citations by year
- 2026: 33 · 2025: 45 · 2024: 52 · 2023: 27 · 2022: 25 · 2021: 41 · 2020: 28 · 2019: 23 · 2018: 9 · 2017: 1
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Epidemiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (NINDS T32 NS048005, NIAID R01 AI104459)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- socioeconomic status, memory decline, dementia risk, word list memory, childhood socioeconomic status, high school graduation, income, educational attainment, Health and Retirement Study
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Educational Status, Female, Humans, Income, Male, Memory, Memory Disorders, Risk Factors, Social Class, United States
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