The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cognitive sequelae of head injury: involvement of basal forebrain and associated structures
Abstract
Traumatic brain injury is the most common cause of death and disability in young people and survivors often suffer from chronic cognitive deficits. From animal, post-mortem and cognitive studies, there is now increased evidence that abnormalities in the cholinergic system may be underlying some of these deficits. This study investigated this hypothesis in a group of survivors of moderate-severe head injury (n = 31). Patients completed a comprehensive neuropsychological assessment and an MRI scan. Compared with a group of controls (matched on age, sex and premorbid intelligence quotient), the patients showed deficits in sustained attention, paired associate learning and reaction time, but comparative preservation of spatial working memory. Voxel-based morphometry revealed reduced grey matter density in the head injured group in the basal forebrain, the hippocampal formation and regions of the neocortex. These cognitive and structural results are consistent with cholinergic dysfunction. These preliminary findings suggest that cholinergic enhancers may be an effective treatment of cognitive deficits post head injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Neuromodulation: acetylcholine and memory consolidation
Hasselmo, M. E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01365-0 · Cited by 809
SAHAKIAN, B. J., MORRIS, R. G., EVENDEN, J. L., HEALD, A., LEVY, R., PHILPOT, M., & ROBBINS, T. W. (1988) · Brain · doi:10.1093/brain/111.3.695 · Cited by 666
Self-citationSwainson, R., Hodges, J. R., Galton, C. J., Semple, J., Michael, A., Dunn, B. D., Iddon, J. L., Robbins, T. W., & Sahakian, B. J. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051269 · Cited by 375
Tryptophan depletion in normal volunteers produces selective impairments in learning and memory
Park, S. B., Coull, J. T., McShane, R. H., Young, A. H., Sahakian, B. J., Robbins, T. W., & Cowen, P. J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90089-2 · Cited by 310
ELLIOTT, R., BAKER, S. C., ROGERS, R. D., O'LEARY, D. A., PAYKEL, E. S., FRITH, C. D., DOLAN, R. J., & SAHAKIAN, B. J. (1997) · Psychological Medicine · doi:10.1017/s0033291797005187 · Cited by 307
Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study
Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., & Kurland, L. T. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009724 · Cited by 295
Increases in cortical acetylcholine release during sustained attention performance in rats
Himmelheber, A. M., Sarter, M., & Bruno, J. P. (2000) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00012-4 · Cited by 261
Gill, T. M., Sarter, M., & Givens, B. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04745.2000 · Cited by 228
Cited by
The cholinergic system in aging and neuronal degeneration
Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047
The role of the medial prefrontal cortex in cognition, ageing and dementia
Jobson, D. D., Hase, Y., Clarkson, A. N., & Kalaria, R. N. (2021) · Brain Communications · doi:10.1093/braincomms/fcab125 · Cited by 338
Basal forebrain control of wakefulness and cortical rhythms
Anaclet, C., Pedersen, N. P., Ferrari, L. L., Venner, A., Bass, C. E., Arrigoni, E., & Fuller, P. M. (2015) · Nature Communications · doi:10.1038/ncomms9744 · Cited by 273
Imaging in sepsis-associated encephalopathy—insights and opportunities
Stubbs, D. J., Yamamoto, A. K., & Menon, D. K. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.177 · Cited by 118
Blast TBI models, neuropathology, and implications for seizure risk.
Kovacs, S. K., Leonessa, F., & Ling, G. S. F. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00047 · Cited by 71
The septo-hippocampal system, learning and recovery of function
Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.03.039 · Cited by 67
Morand-Beaulieu, S., O'Connor, K. P., Sauvé, G., Blanchet, P. J., & Lavoie, M. E. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.024 · Cited by 42
Metadata
- Authors
- Salmond, C. H.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-17
- Volume
- 128
- Issue
- 1
- Pages
- 189-200
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2064036287
- Cited by
- 196
- References
- 13
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
