Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study
Abstract
Controversy continues as to whether traumatic brain injury is a risk factor for Alzheimer's disease. The authors examined a related hypothesis that among persons with traumatic brain injury who develop Alzheimer's disease, time to onset of the disease is reduced. They used data on all documented episodes of traumatic brain injury that occurred from 1935 to 1984 among Olmsted County, Minnesota, residents. Community-based medical records were used to follow traumatic brain injury cases who were aged 40 years or older at last contact prior to June 1, 1988, for Alzheimer's disease until last contact, death, or June 1, 1988. The test of the hypothesis was restricted to those cases who developed Alzheimer's disease. The expected time to onset of Alzheimer's disease was derived from a life table constructed by using age-of-onset distributions within sex groups for a previously identified cohort of Rochester, Minnesota, Alzheimer's disease incidence cases without a history of head trauma. The authors found that of the 1,283 traumatic brain injury cases followed, 31 developed Alzheimer's disease, a number similar to that expected (standardized incidence ratio = 1.2, 95% confidence interval 0.8-1.7). However, the observed time from traumatic brain injury to Alzheimer's disease was less than the expected time to onset of Alzheimer's disease (median = 10 vs. 18 years, p = 0.015). The results suggest that traumatic brain injury reduces the time to onset of Alzheimer's disease among person…
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Head injury during adulthood reduces the time to onset of AD.
“and reduces the time to onset of AD (20).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [20]
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- Authors
- Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., & Kurland, L. T.
- Affiliations
- Mayo Clinic (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 149
- Issue
- 1
- Pages
- 32-40
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2132397828
- Cited by
- 295
- References
- 3
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 16 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 18 · 2016: 13 · 2015: 18 · 2014: 17 · 2013: 12 · 2012: 6
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- traumatic brain injury, Alzheimer's disease, time to onset, head trauma, risk factors, incidence, Olmsted County, Minnesota, life tables, standardized incidence ratio
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Brain Injuries, Female, Humans, Male, Middle Aged, Risk Factors, Time Factors, Cohort Studies, Age of Onset
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