Cited by 105Motor Control and AdaptationVisual perception and processing mechanismsVestibular and auditory disorders

The role of the human thalamus in processing corollary discharge

Bellebaum, C., Daum, I., Koch, B., Schwarz, M., Hoffmann, K.-P.·2005·Brain

Abstract

Corollary discharge signals play an important role in monitoring self-generated movements to guarantee spatial constancy. Recent work in macaques suggests that the thalamus conveys corollary discharge information of upcoming saccades passing from the superior colliculus to the frontal eye field. The present study aimed to investigate the involvement of the thalamus in humans by assessing the effect of thalamic lesions on the processing of corollary discharge information. Thirteen patients with selective thalamic lesions and 13 healthy age-matched control subjects performed a saccadic double-step task in which retino-spatial dissonance was induced, i.e. the retinal vector of the second target and the movement vector of the second saccade were different. Thus, the subjects could not rely on retinal information alone, but had to use corollary discharge information to correctly perform the second saccade. The amplitudes of first and second saccades were significantly smaller in patients than in controls. Five thalamic lesion patients showed unilateral deficits in using corollary discharge information, as revealed by asymmetries compared with the other patients and controls. Three patients with lateral thalamic lesions including the ventrolateral nucleus (VL) were impaired contralaterally to the side of damage and one patient with a lesion in the mediodorsal thalamus (MD) was impaired ipsilaterally to the lesion. The largest asymmetry was found in a patient with a bilateral thalamic lesion. The results provide evidence for a thalamic involvement in the processing of corollary discharge information in humans, with a potential role of both the VL and MD nuclei.

Integrity signals

Registry

Crossref · 10.1093/brain/awh474

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Corollary discharge has repeatedly been implicated in the process of updating the internal record of the current saccade to facilitate planning the next.

    “CD has repeatedly been implicated in this process59–64.”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [59]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bellebaum, C., Daum, I., Koch, B., Schwarz, M., & Hoffmann, K.-P.
Affiliations
Ruhr University Bochum (DE)
Corresponding author
Bellebaum, C.
Venue
Brain
Published
2005-03-09
Volume
128
Issue
5
Pages
1139-1154
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2116970850
Cited by
105
References
55
Citations by year
2025: 1 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 6
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
corollary discharge, thalamus, thalamic lesions, saccades, ventrolateral thalamic nucleus, mediodorsal thalamus, spatial constancy, self-generated movement, hemispheric lateralization, saccade amplitude
MeSH terms
Adult, Aged, Brain Ischemia, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Saccades, Thalamus, Visual Pathways, Mediodorsal Thalamic Nucleus, Ventral Thalamic Nuclei

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review