Altered processing of corollary discharge in thalamic lesion patients
Abstract
Accumulating evidence suggests that thalamic nuclei relay corollary discharge information of saccadic eye movements, enabling the visual system to update the representation of visual space. The present study aimed to explore the effect of thalamic lesions in humans on updating‐related cortical processing. Event‐related potentials were recorded while four patients with impairments in using corollary discharge information and 12 healthy control subjects performed a saccadic double‐step task. In the experimental condition, which required the use of corollary discharge information, control subjects showed a pronounced positivity over the parietal cortex starting about 150 ms after first saccade onset, reflecting the updating process. In the patients, parietal processing related to updating was altered. Three patients showed evidence of reduced updating event‐related potential effects, consistent with a unilateral deficit in using corollary discharge information. In two patients, the event‐related potential topography differed significantly from the topography pattern observed in controls. Thalamic damage affects updating‐related processing, presumably due to insufficient transfer of saccade‐related information to parietal areas. This study thus provides further evidence for thalamic involvement in relaying corollary discharge information related to saccadic eye movements. Our data suggest that integration of corollary discharge and motor information occurs directly before the second saccade in a double‐step task.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Corollary discharge has repeatedly been implicated in the process of updating the internal record of the current saccade to facilitate planning the next.
“CD has repeatedly been implicated in this process59–64.”
From Corollary discharge across the animal kingdom (2008) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new method for off-line removal of ocular artifact
Gratton, G., Coles, M. G. H., & Donchin, E. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90135-9 · Cited by 5,055 · see citing works
Das Reafferenzprinzip: Wechselwirkungen zwischen Zentralnervensystem und Peripherie
von Holst, E., & Mittelstaedt, H. (1950) · Naturwissenschaften · doi:10.1007/bf00622503 · Cited by 2,655 · see citing works
The updating of the representation of visual space in parietal cortex by intended eye movements
Duhamel, J.-R., Colby, C. L., & Goldberg, M. E. (1992) · Science · doi:10.1126/science.1553535 · Cited by 1,966 · see citing works
Neural basis of the spontaneous optokinetic response produced by visual inversion
Sperry, R. W. (1950) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0055479 · Cited by 1,789 · see citing works
SPACE AND ATTENTION IN PARIETAL CORTEX
Colby, C. L., & Goldberg, M. E. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.319 · Cited by 1,710 · see citing works
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403 · see citing works
Coding of intention in the posterior parietal cortex
Snyder, L. H., Batista, A. P., & Andersen, R. A. (1997) · Nature · doi:10.1038/386167a0 · Cited by 1,103 · see citing works
Mapping of Contralateral Space in Retinotopic Coordinates by a Parietal Cortical Area in Humans
Sereno, M. I., Pitzalis, S., & Martinez, A. (2001) · Science · doi:10.1126/science.1063695 · Cited by 682 · see citing works
Huerta, M. F., Krubitzer, L. A., & Kaas, J. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902650304 · Cited by 594 · see citing works
A Pathway in Primate Brain for Internal Monitoring of Movements
Sommer, M. A., & Wurtz, R. H. (2002) · Science · doi:10.1126/science.1069590 · Cited by 565 · see citing works
The ascending projections of the superior colliculus in the rhesus monkey (Macaca mulatta)
Benevento, L. A., & Fallon, J. H. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901600306 · Cited by 460 · see citing works
Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal
Goldberg, M. E., & Bruce, C. J. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.2.489 · Cited by 409 · see citing works
Gaze-Centered Updating of Visual Space in Human Parietal Cortex
Medendorp, W. P., Goltz, H. C., Vilis, T., & Crawford, J. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06209.2003 · Cited by 407 · see citing works
Topography of projections to posterior cortical areas from the macaque frontal eye fields
Stanton, G. B., Bruce, C. J., & Goldberg, M. E. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903530210 · Cited by 370 · see citing works
Intention-related activity in the posterior parietal cortex: a review
Snyder, L. H., Batista, A. P., & Andersen, R. A. (2000) · Vision Research · doi:10.1016/s0042-6989(00)00052-3 · Cited by 352 · see citing works
Saccadic eye movements to flashed targets
Hallett, P. E., & Lightstone, A. D. (1976) · Vision Research · doi:10.1016/0042-6989(76)90084-5 · Cited by 344 · see citing works
Sommer, M. A., & Wurtz, R. H. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00738.2003 · Cited by 339 · see citing works
Sommer, M. A., & Wurtz, R. H. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00740.2003 · Cited by 254 · see citing works
Kusunoki, M., & Goldberg, M. E. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00519.2002 · Cited by 211 · see citing works
SACCADIC DYSMETRIA IN A PATIENT WITH A RIGHT FRONTOPARIETAL LESION
Duhamel, J., Goldberg, M. E., FitzGibbon, E. J., Angela Sirigu, B., & Grafman, J. H. (1992) · Brain · doi:10.1093/brain/115.5.1387 · Cited by 204 · see citing works
Mazzoni, P., Bracewell, R. M., Barash, S., & Andersen, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1439 · Cited by 197 · see citing works
Heide, W., Binkofski, F., Seitz, R. J., Posse, S., Nitschke, M. F., Freund, H. ‐., & Kömpf, D. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01472.x · Cited by 182 · see citing works
Afferent connections of the thalamic intralaminar nuclei in the cat
Kaufman, E. F. S., & Rosenquist, A. C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90479-2 · Cited by 163 · see citing works
Spatial Processing in the Monkey Frontal Eye Field. II. Memory Responses
Umeno, M. M., & Goldberg, M. E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.5.2344 · Cited by 148 · see citing works
Combined deficits of saccades and visuo-spatial orientation after cortical lesions
Heide, W., & Kömpf, D. (1998) · Experimental Brain Research · doi:10.1007/s002210050558 · Cited by 141 · see citing works
False perception of motion in a patient who cannot compensate for eye movements
Haarmeier, T., Thier, P., Repnow, M., & Petersen, D. (1997) · Nature · doi:10.1038/39872 · Cited by 131 · see citing works
Efferent projections of the thalamic intralaminar nuclei in the cat
Kaufman, E. F. S., & Rosenquist, A. C. (1985) · Brain Research · doi:10.1016/0006-8993(85)90478-0 · Cited by 128 · see citing works
A review of the role of efference copy in sensory and oculomotor control systems
Bridgeman, B. (1995) · Annals of Biomedical Engineering · doi:10.1007/bf02584441 · Cited by 126 · see citing works
Word and Nonword Repetition Within- and Across-Modality: An Event-Related Potential Study
Rugg, M. D., Doyle, M. C., & Wells, T. (1995) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1995.7.2.209 · Cited by 125 · see citing works
The role of the human thalamus in processing corollary discharge
Bellebaum, C., Daum, I., Koch, B., Schwarz, M., & Hoffmann, K.-P. (2005) · Brain · doi:10.1093/brain/awh474 · Cited by 105 · see citing works
Self-citationMotor intention activity in the macaque's lateral intraparietal area. II. Changes of motor plan
Bracewell, R. M., Mazzoni, P., Barash, S., & Andersen, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1457 · Cited by 102 · see citing works
Parietal Lobe Lesions Disrupt Saccadic Remapping of Inhibitory Location Tagging
Sapir, A., Hayes, A. E., Henik, A., Danziger, S., & Rafal, R. D. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/089892904323057245 · Cited by 97 · see citing works
Thickbroom, G. W., & Mastaglia, F. L. (1985) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(85)90005-x · Cited by 78 · see citing works
Impairment of extraretinal eye position signals after central thalamic lesions in humans
Gaymard, B. M., Rivaud-Péchoux, S., & Pierrot‐Deseilligny, C. (1994) · Experimental Brain Research · doi:10.1007/bf00232433 · Cited by 61 · see citing works
Post-saccadic updating of visual space in the posterior parietal cortex in humans
Bellebaum, C., Hoffmann, K., & Daum, I. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.05.007 · Cited by 46 · see citing works
Self-citationCraniotopic updating of visual space across saccades in the human posterior parietal cortex
van Donkelaar, P., & Müri, R. M. (2002) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2001.1935 · Cited by 46 · see citing works
Heiser, L. M., Berman, R. A., Saunders, R. C., & Colby, C. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00029.2005 · Cited by 37 · see citing works
Berman, R. A., Heiser, L. M., Saunders, R. C., & Colby, C. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00028.2005 · Cited by 35 · see citing works
Time course of cross-hemispheric spatial updating in the human parietal cortex
Bellebaum, C., & Daum, I. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.001 · Cited by 31 · see citing works
Self-citationSkrandies, W., & Laschke, K. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00749-6 · Cited by 30 · see citing works
Functional organisation of the saccadic reference system processing extraretinal signals in humans
Tobler, P. N., Felblinger, J., Buerki, M., Nirkko, A. C., Ozdoba, C., & Müri, R. M. (2001) · Vision Research · doi:10.1016/s0042-6989(00)00316-3 · Cited by 24 · see citing works
Spatial localisation: does extraocular muscle proprioception play a role?
Weir, C. R. (2000) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170000166 · Cited by 18 · see citing works
Electrophysiological correlates of human intrasaccadic processing
Anagnostou, E., Kleiser, R., & Skrandies, W. (2000) · Experimental Brain Research · doi:10.1007/s002219900245 · Cited by 13 · see citing works
Auditory saccade impairment after central thalamus lesions
Versino, M. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.2.234 · Cited by 11 · see citing works
Kleiser, R., & Skrandies, W. (2000) · Experimental Brain Research · doi:10.1007/s002210000383 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Corollary discharge across the animal kingdom
Crapse, T. B., & Sommer, M. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2457 · Cited by 789 · see citing works
Corollary discharge circuits in the primate brain
Crapse, T. B., & Sommer, M. A. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.017 · Cited by 147 · see citing works
Corollary Discharge Contributions to Perceptual Continuity Across Saccades
Wurtz, R. H. (2018) · Annual Review of Vision Science · doi:10.1146/annurev-vision-102016-061207 · Cited by 126 · see citing works
Saccadic Corollary Discharge Underlies Stable Visual Perception
Cavanaugh, J. R., Berman, R. A., Joiner, W. M., & Wurtz, R. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2054-15.2016 · Cited by 120 · see citing works
Spatial updating and the maintenance of visual constancy
Klier, E. M., & Angelaki, D. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.079 · Cited by 94 · see citing works
Pergola, G., Ranft, A., Mathias, K., & Boris Suchan, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.017 · Cited by 77 · see citing works
Amplitudes and directions of individual saccades can be adjusted by corollary discharge
Joiner, W. M. (2010) · Journal of Vision · doi:10.1167/10.2.22 · Cited by 61 · see citing works
Altered Error Processing following Vascular Thalamic Damage: Evidence from an Antisaccade Task
Peterburs, J., Pergola, G., Koch, B., Schwarz, M., Hoffmann, K., Daum, I., & Bellebaum, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021517 · Cited by 58 · see citing works
Self-citationElectrophysiological correlates of presaccadic remapping in humans
Parks, N. A., & Corballis, P. M. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00669.x · Cited by 49 · see citing works
Prevosto, V., Graf, W. M., & Ugolini, G. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06885.x · Cited by 42 · see citing works
Stenner, M., Bauer, M., Haggard, P., Heinze, H., & Dolan, R. J. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00658 · Cited by 34 · see citing works
The Involvement of the Thalamus in Semantic Retrieval: A Clinical Group Study
Pergola, G., Bellebaum, C., Gehlhaar, B., Koch, B., Schwarz, M., Daum, I., & Boris Suchan, A. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00364 · Cited by 32 · see citing works
Self-citationMelief, E. J., McKinley, J. W., Lam, J. Y., Whiteley, N. M., Gibson, A. W., Neumaier, J. F., Henschen, C. W., Palmiter, R. D., Bamford, N. S., & Darvas, M. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0060-6 · Cited by 30 · see citing works
Involvement of the human thalamus in relational and non‐relational memory
Soei, E., Koch, B., Schwarz, M., & Daum, I. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06536.x · Cited by 19 · see citing works
Self-citationBansal, S., Bray, L. C. J., Schwartz, B. L., & Joiner, W. M. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.06.004 · Cited by 15 · see citing works
Separate and overlapping functional roles for efference copies in the human thalamus
Zimmermann, E., Ghio, M., Pergola, G., Koch, B., Schwarz, M., & Bellebaum, C. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107558 · Cited by 14 · see citing works
Self-citationUpdating of Visual Space Across Horizontal Saccades in Cerebellar and Thalamic Lesion Patients
Peterburs, J., Koch, B., Schwarz, M., Hoffmann, K.-P., Daum, I., & Bellebaum, C. (2012) · The Cerebellum · doi:10.1007/s12311-012-0386-2 · Cited by 13 · see citing works
Self-citationCortical processing of saccade‐related efference copy signals in patients with cerebellar lesion
Peterburs, J., Koch, B., Schwarz, M., Hoffmann, K., Daum, I., & Bellebaum, C. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12081 · Cited by 13 · see citing works
Self-citationPeterburs, J., Gajda, K., Hoffmann, K.-P., Daum, I., & Bellebaum, C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.025 · Cited by 12 · see citing works
Self-citationThe effect of saccade metrics on the corollary discharge contribution to perceived eye location
Bansal, S., Bray, L. C. J., Peterson, M. S., & Joiner, W. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00771.2014 · Cited by 11 · see citing works
Thalamic roles in eye movements
Tanaka, M., & Kunimatsu, J. (2011) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199539789.013.0013 · Cited by 10 · see citing works
Cheviet, A., Laure Pisella, A., & Pélisson, D. (2021) · Cortex · doi:10.1016/j.cortex.2021.02.026 · Cited by 9 · see citing works
Cheviet, A., Masselink, J., Koun, É., Salemme, R., Lappe, M., Tilikete, C., & Pélisson, D. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab455 · Cited by 6 · see citing works
Eye proprioception may provide real time eye position information
Wang, J., & Pan, Y. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1172-0 · Cited by 5 · see citing works
Visuo-motor updating in individuals with heightened autistic traits
Pomè, A., & Zimmermann, E. (2024) · eLife · doi:10.7554/elife.94946 · Cited by 1 · see citing works
Visuo-motor updating in individuals with heightened autistic traits
Pomè, A., & Zimmermann, E. (2024) · eLife · doi:10.7554/elife.94946.3 · Cited by 2 · see citing works
Lehet, M. I., Yao, B., Tso, I. F., Diwadkar, V. A., Fattal, J., Bao, J. Y., & Thakkar, K. N. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae232 · Cited by 1 · see citing works
Harrison, W. J. (2014) · ORCA Online Research @Cardiff (Cardiff University)
Eye proprioception may provide real time eye position information
Pan, J. W. (2013)
Transsaccadic visual perception of foveal compared to peripheral environmental changes
Bansal, S., & Joiner, W. M. (2021) · Journal of Vision · doi:10.1167/jov.21.6.12
Oculomotor Thalamus and Efference Copy
Sommer, M. A. (2023) · doi:10.1093/med/9780197676158.003.0036
Visuo-motor updating in individuals with heightened autistic traitsPreprint
Pomè, A., & Zimmermann, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.19.572419
Visuo-motor updating in autism symptomatologyPreprint
Pomè, A., & Zimmermann, E. (2024) · eLife · doi:10.7554/elife.94946.1
Visuo-motor updating in individuals with heightened autistic traitsPreprint
Pomè, A., & Zimmermann, E. (2024) · eLife · doi:10.7554/elife.94946.2
- Authors
- Bellebaum, C., Hoffmann, K., Koch, B., Schwarz, M., & Daum, I.
- Affiliations
- Ruhr University Bochum (DE)
- Klinikum Dortmund (DE)
- Corresponding author
- Bellebaum, Christian
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-10
- Volume
- 24
- Issue
- 8
- Pages
- 2375-2388
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2090710464
- Cited by
- 35
- References
- 45
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2021: 4 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- corollary discharge, thalamic lesions, saccades, parietal cortex, event-related potentials, thalamocortical relay
- MeSH terms
- Adult, Aged, Brain Mapping, Data Interpretation, Statistical, Electroencephalography, Evoked Potentials, Visual, Female, Fixation, Ocular, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Nervous System Diseases, Photic Stimulation, Psychomotor Performance, Space Perception, Thalamic Nuclei, Visual Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
