Cited by 95Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological DisordersNeonatal and fetal brain pathology

The Changing Number of Cells in the Human Fetal Forebrain and its Subdivisions: A Stereological Analysis

Samuelsen, G. B.·2003·Cerebral Cortex

Abstract

The total number of cells--including both neurons and glial cells - was estimated in the neocortical part of the human fetal telencephalon in 22 normal brains within four major developmental zones: the cortical plate/marginal zone, the subplate, the intermediate zone and the ventricular/subventricular zone. The fetal ages ranged from 13 to 41 weeks of gestation. The cellular growth in the human fetal forebrain appears to be two-phased: one rapid, exponential phase from 13 to 20 weeks of gestation and a second and slower phase, which increases linearly, from approximately 22 weeks of gestation to term. From 13 to 20 weeks of gestation the total number of cells increases by a factor of 4.3 from 3 x 10(9) cells to 13 x 10(9) cells at 20 weeks of gestation. From mid-gestation to term, the total cell number increases by a factor of 2.9 to 38 x 10(9) cells in the newborn infant. Studying cellular growth in the normal human fetal brain is important since it may serve as a useful parameter for the assessment of cortical growth in non-invasive and histological studies, and thus improve the analysis of fetal brain disturbances.

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Crossref · 10.1093/cercor/13.2.115

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  • The number of neurons increases rapidly and peaks between week 13 and 16 of gestation in humans, specifically in the dorsal telencephalon.

    “By the time the apical radial glial progenitors within the prefrontal subdomains start dividing asymmetrically, the number of neurons will increase rapidly and peaks between week 13 and 16 of gestation in human (E10-E15 rodents/E43-E50 primates), specifically in the dorsal telencephalon [44–47].”

    From Development of prefrontal cortex (2022) · cites this paper as [44]

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Authors
Samuelsen, G. B.
Affiliations
Bispebjerg Hospital (DK)
Corresponding author
Samuelsen, G. B.
Venue
Cerebral Cortex
Published
2003-02-01
Volume
13
Issue
2
Pages
115-122
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2103838755
Cited by
95
References
35
Citations by year
2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 7
FWCI
0.31
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
telencephalon, cell number estimation, stereology, cortical development, cortical plate, marginal zone, subplate, intermediate zone, ventricular-subventricular zone, glial cells, neurons, gestational age, fetal brain development
MeSH terms
Autopsy, Cell Count, Cell Movement, Female, Fetus, Humans, Male, Mitosis, Neuroglia, Neurons, Time Factors, Prosencephalon

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