Extensive overlap of mu-opioid and nicotinic sensitivity in cortical interneurons
Open accessAbstract
We studied mu-opioid transmission in acute slices of rat neocortex using whole-cell recordings and single-cell reverse transcription-polymerase chain reaction. The mu-opioid receptor (MOR) was found in gamma-aminobutyric acidergic (GABAergic) interneurons that were either layer I cells frequently expressing neuropeptide Y or layers II-V cells expressing vasoactive intestinal peptide and enkephalin (Enk). We found that mu-opioid agonists inhibit these interneurons that are selectively excited by nicotinic agonists. The extensive overlap of mu-opioid and nicotinic responsiveness allowed mu-opioid agonists to inhibit nicotinic excitation of responsive interneurons and of their GABAergic output onto pyramidal cells. Finally, nicotinic stimulation resulted in a dynamic sequence where GABAergic transmission was first enhanced and then depressed below its baseline. This latter disinhibitory effect was prevented by a mu-opioid antagonist, indicating that excitation of nicotinic-responsive interneurons induced the release of endogenous Enk, which in turn led to MOR activation. Our results suggest that neocortical mu-opioid transmission acts as an inhibitory feedback onto nicotinic-responsive interneurons, which may change network excitability and inhibition patterns during cholinergic excitation.
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Published physiological results on cortical neuropeptide signaling are surprisingly rare given the breadth of neuroscientific interest in cortex.
“published physiological results are surprisingly rare given the breadth of neuroscientific interest in cortex.”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Férézou et al., 2007
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- Authors
- Ferezou, I., Hill, E. L., Cauli, B., Gibelin, N., Kaneko, T., Rossier, J., & Lambolez, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Kyoto University (JP)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-26
- Volume
- 17
- Issue
- 8
- Pages
- 1948-1957
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2080190361
- Cited by
- 65
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Cerebral Cortex (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- mu-opioid receptor, nicotinic acetylcholine receptors, cortical interneurons, GABAergic interneurons, neuropeptide Y, vasoactive intestinal peptide, enkephalin, disinhibition, pyramidal neurons, cholinergic stimulation, inhibitory feedback, neocortex
- MeSH terms
- Animals, Cerebral Cortex, Electrophysiology, Enkephalins, gamma-Aminobutyric Acid, Interneurons, Nerve Net, Synaptic Transmission, Receptors, Nicotinic, Potassium Channels, Rats, Wistar, Receptors, Opioid, mu, Patch-Clamp Techniques, Nicotinic Agonists, Neocortex, Excitatory Postsynaptic Potentials, Reverse Transcriptase Polymerase Chain Reaction, Rats
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