Selective Coexpression of Multiple Chemical Markers Defines Discrete Populations of Neocortical GABAergic Neurons
Abstract
Whether neocortical γ-aminobutyric acid (GABA) cells are composed of a limited number of distinct classes of neuron, or whether they are continuously differentiated with much higher diversity, remains a contentious issue for the field. Most GABA cells of rat frontal cortex have at least 1 of 6 chemical markers (parvalbumin, calretinin, alpha-actinin-2, somatostatin, vasoactive intestinal polypeptide, and cholecystokinin), with each chemical class comprising several distinct neuronal subtypes having specific physiological and morphological characteristics. To better clarify GABAergic neuron diversity, we assessed the colocalization of these 6 chemical markers with corticotropin-releasing factor (CRF), neuropeptide Y (NPY), the substance P receptor (SPR), and nitric oxide synthase (NOS); these 4 additional chemical markers suggested to be expressed diversely or specifically among cortical GABA cells. We further correlated morphological and physiological characteristics of identified some chemical subclasses of inhibitory neurons. Our results reveal expression specificity of CRF, NPY, SPR, and NOS in morphologically and physiologically distinct interneuron classes. These observations support the existence of a limited number of functionally distinct subtypes of GABA cells in the neocortex.
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Additional molecular markers commonly associated with hippocampal and neocortical CCK-expressing dendrite targeting interneurons are calbindin (CB) (hippocampus and neocortex), calretinin (CR) (neocortex), and VIP (neocortex), though none of these markers is specific for or ubiquitously expressed by CCK-expressing dendrite targeting interneurons.
“Additional molecular markers commonly associated with hippocampal and neocortical CCK-expressing dendrite targeting interneurons are calbindin (CB) (hippocampus and neocortex), calretinin (CR) (neocortex), and VIP (neocortex), though none of these markers is specific for or ubiquitously expressed by CCK-expressing dendrite targeting interneurons (224, 556, 569, 584, 611, 612).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [612]
While limited evidence supports NPY expression in morphologically identified Martinotti and HIPP cells, anatomically identified O-LMs repeatedly fail to immunostain for NPY.
“However, while limited evidence supports NPY expression in morphologically identified Martinotti and HIPP cells (352, 549, 612, 716, 1192), anatomically identified O-LMs repeatedly fail to immunostain for NPY (561, 862, 344).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [612]
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Neurogliaform cells of amygdala: a source of slow phasic inhibition in the basolateral complex
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- Authors
- Kubota, Y., Shigematsu, N., Karube, F., Sekigawa, A., Kato, S., Yamaguchi, N., Hirai, Y., Morishima, M., & Kawaguchi, Y.
- Affiliations
- National Institute for Physiological Sciences (JP)
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-10
- Volume
- 21
- Issue
- 8
- Pages
- 1803-1817
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2127618814
- Cited by
- 235
- References
- 75
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 9 · 2017: 23 · 2016: 24 · 2015: 18 · 2014: 18 · 2013: 22 · 2012: 23
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (21240030)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABAergic interneurons, neuronal cell types, chemical markers, parvalbumin, calretinin, ACTN2, somatostatin, vasoactive intestinal peptide, cholecystokinin, corticotropin-releasing factor, neuropeptide Y, neurokinin-1 receptor, nitric oxide synthase, frontal cortex, inhibitory neurons
- MeSH terms
- Animals, Cell Differentiation, Frontal Lobe, gamma-Aminobutyric Acid, Interneurons, Male, Nerve Tissue Proteins, Phenotype, Biomarkers, Rats, Wistar, Neocortex, Rats, Neurogenesis, Rats, Transgenic, GABAergic Neurons
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