Selective Cholinergic Modulation of Cortical GABAergic Cell Subtypes
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Kawaguchi, Yasuo. Selective cholinergic modulation of cortical GABAergic cell subtypes. J. Neurophysiol. 78: 1743–1747, 1997. Acetylcholine from the basal forebrain and γ-aminobutyric acid (GABA) from intracortical inhibitory interneurons exert strong influence on the cortical activity and may interact with each other. Cholinergic or muscarinic agonists indeed induced GABAergic postsynaptic currents in pyramidal cells by exciting inhibitory interneurons that have recently been classified into several distinct subtypes on the basis of the physiological, chemical, and morphological criteria. Cholinergic effects on GABAergic cell subtypes were investigated of rat frontal cortex by in vitro whole cell recording with intracellular staining in frontal cortex of young rats. GABAergic cell subtypes were identified physiologically by firing responses to depolarizing current pulses and immunohistochemically as containing parvalbumin, somatostatin, vasoactive intestinal polypeptide (VIP), or cholecystokinin (CCK). Carbachol (10 μM) or (+)-muscarine (3 μM) affected the activities of peptide-containing GABAergic cells with regular- or burst-spiking characteristics, but not of GABAergic cells with fast-spiking characteristics containing the calcium-binding protein parvalbumin orGABAergic cells with late-spiking characteristics. Somatostatin- or VIP-immunoreactive cells were depolarized with spike firing. CCK-immunoreactive cells were affected heterogeneously by cholinergic agonists. Larger CCK cells were hyperpolarized, followed by a slow depolarization, whereas smaller CCK cells were only depolarized. These results suggest that the excitability of cortical GABAergic cell subtypes is differentially regulated by acetylcholine. Differences in cholinergic responses suggest a distinct functional role of each GABAergic cell subtype.
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In response to bath-applied agonists, the muscarinic depolarization of Sst interneurons is strong enough to produce prolonged spiking.
“In response to bath applied agonists, the depolarization is strong enough that it is capable of producing prolonged spiking”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kawaguchi, 1997
The Results passage describing Fig. 3A says carbachol depolarized somatostatin-immunoreactive cells and was accompanied by spike firing in all five tested cells; the Fig. 3 caption also describes spikes during carbachol application. Our copy does not establish that the spiking was prolonged, so it supports agonist-induced firing but not that duration. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSst interneurons exhibit muscarinic-mediated depolarization.
“Another feature of Sst INs is a muscarinic mediated depolarization.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kawaguchi, 1997
Vip-expressing bipolar neurons are also depolarized by muscarinic agonists.
“It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists (Kawaguchi, 1997)”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kawaguchi, 1997
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“It has also been shown that PV neurons do not respond to ACh (Kawaguchi, 1997) and are not directly activated by stimulating basal forebrain cholinergic neurons (Alitto and Dan, 2012; Arroyo et al.”
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“Previous work has demonstrated cholinergic facilitation of cortical inhibitory neurons (Kawaguchi, 1997; Xiang et al., 1998; Arroyo et al., 2012; Alitto and Dan, 2012), including SST neurons (Kawaguchi, 1997; Fanselow et al.”
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- Authors
- Kawaguchi, Y.
- Affiliations
- RIKEN (JP)
- Corresponding author
- Kawaguchi, Yasuo
- ORCID
- Kawaguchi, Yasuo
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1997-09-01
- Volume
- 78
- Issue
- 3
- Pages
- 1743-1747
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1890686428
- Cited by
- 250
- References
- 1
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 12 · 2018: 13 · 2017: 12 · 2016: 13 · 2015: 3 · 2014: 17 · 2013: 12 · 2012: 10
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- cholinergic modulation, GABAergic interneurons, parvalbumin, somatostatin, vasoactive intestinal peptide, cholecystokinin, acetylcholine, muscarinic agonists, carbachol, muscarine, frontal cortex, neuronal excitability, fast spiking
- MeSH terms
- Animals, Cerebral Cortex, Electrophysiology, Frontal Lobe, gamma-Aminobutyric Acid, Immunohistochemistry, Ion Channels, Parasympathetic Nervous System, Pyramidal Cells, Cholinergic Agonists, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Rats, In Vitro Techniques
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