5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons
Abstract
5-HT(1A) receptors (5-HT1AR) are expressed by pyramidal and γ-aminobutyric acidergic (GABAergic) neurons in medial prefrontal cortex (mPFC). Endogenous serotonin inhibits mPFC pyramidal neurons via 5-HT1AR while 5-HT1AR agonists, given systemically, paradoxically excite ventral tegmental area-projecting pyramidal neurons. This enhances mesocortical dopamine function, a process involved in the superior efficacy of atypical antipsychotic drugs on negative and cognitive symptoms of schizophrenia. Moreover, the 5-HT1AR-induced increase of pyramidal discharge may also contribute to the maintenance of activity patterns required for working memory, impaired in schizophrenia. Given the importance of these processes, we examined the neurobiological basis of pyramidal activation through 5-HT1AR using the prototypical agent 8-OH-DPAT. (±)8-OH-DPAT (7.5 μg/kg i.v.) increased discharge rate and c-fos expression in rat mPFC pyramidal neurons. Local blockade of GABA(A) inputs with gabazine (SR-95531) avoided (±)8-OH-DPAT-induced excitations of pyramidal neurons. Moreover, (±)8-OH-DPAT administration reduced the discharge rate of mPFC fast-spiking GABAergic interneurons at doses exciting pyramidal neurons. Activation of other 5-HT1AR subpopulations (raphe nuclei or hippocampus) does not appear to contribute to pyramidal excitations. Overall, the present data suggest a preferential action of (±)8-OH-DPAT on 5-HT1AR in GABAergic interneurons. This results in pyramidal disinhibition and subsequent downstream excitations of subcortical structures reciprocally connected with PFC, such as midbrain dopaminergic neurons.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CBD rapidly increases extracellular serotonin and glutamate levels in mouse cortex.
“CBD rapidly increases extracellular serotonin and glutamate levels in mouse cortex (Llado-Pelfort et al., 2012)”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Llado-Pelfort et al., 2012
CBD amplifies 5-HT1A-R-mediated inhibition of GABAergic interneurons to disinhibit glutamatergic output in downstream structures.
“amplifies 5-HT1A-R-mediated inhibition of GABAergic interneurons (Santana et al., 2004) to disinhibit glutamatergic output in downstream structures (Llado-Pelfort et al., 2012).”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Llado-Pelfort et al., 2012
CBD's amplification of 5-HT1A-R-mediated inhibition is likely to augment activity at 5-HT neurons in the dorsal raphe nucleus, enhancing 5-HT in corticolimbic projection fields.
“This in turn is likely to augment activity at 5-HT neurons in the dorsal raphe nucleus (DRN) (Llado-Pelfort et al., 2012), enhancing 5-HT in corticolimbic projection fields to complete a system-level functional loop.”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Llado-Pelfort et al., 2012
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Fuster, J. M. (1997) · Cited by 2,095 · see citing works
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935 · see citing works
Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
Leucht, S., Corves, C., Arbter, D., Engel, R. R., Li, C., & Davis, J. M. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61764-x · Cited by 1,930 · see citing works
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440 · see citing works
The use of c-fos as a metabolic marker in neuronal pathway tracing
Dragunow, M., & Faull, R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90150-7 · Cited by 1,416 · see citing works
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine
Bymaster, F. P., Calligaro, D. O., Falcone, J. F., Marsh, R. D., Moore, N. A., Tye, N. C., Seeman, P. M., & Wong, D. T. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00129-n · Cited by 1,061 · see citing works
A network of fast-spiking cells in the neocortex connected by electrical synapses
Galarreta, M., & Hestrin, S. (1999) · Nature · doi:10.1038/47029 · Cited by 960 · see citing works
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
Robbins, T. W., & Arnsten, A. F. T. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135535 · Cited by 957 · see citing works
Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence
Arnt, J. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00112-7 · Cited by 715 · see citing works
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Ruat, M., Traiffort, É., Leurs, R., Tardivel‐Lacombe, J., Díaz, J., Arrang, J., & Schwartz, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8547 · Cited by 617 · see citing works
Studies of Cognitive Change in Patients With Schizophrenia Following Novel Antipsychotic Treatment
Harvey, P. D., & Keefe, R. S. E. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.176 · Cited by 617 · see citing works
Woodward, N. D., Purdon, S. E., Meltzer, H. Y., & Zald, D. H. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570500516x · Cited by 605 · see citing works
González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works
Andrade, R., & Nicoll, R. A. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016862 · Cited by 552 · see citing works
Ichikawa, J., Ishii, H., Bonaccorso, S., Fowler, W. L., O'Laughlin, I. A., & Meltzer, H. Y. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00154.x · Cited by 495 · see citing works
Santana, N. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh070 · Cited by 486 · see citing works
Self-citationNaunyn-Schmiedeberg's archives of pharmacology
(1975) · Journal of Molecular Medicine · doi:10.1007/bf01482719 · Cited by 447 · see citing works
Electrical synapses between Gaba-Releasing interneurons
Galarreta, M., & Hestrin, S. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077566 · Cited by 434 · see citing works
Blier, P. U., & de Montigny, C. (1987) · Synapse · doi:10.1002/syn.890010511 · Cited by 426 · see citing works
An apamin-sensitive Ca 2+ -activated K + current in hippocampal pyramidal neurons
Stocker, M., Krause, M., & Pedarzani, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4662 · Cited by 389 · see citing works
Galarreta, M., & Hestrin, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192159599 · Cited by 387 · see citing works
Immunocytochemical localization of serotonin1A receptors in the rat central nervous system
Kia, H. K., Miquel, M., Brisorgueil, M., Daval, G., Riad, M., Mestikawy, S. E., Hamon, M., & Verg�, D. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960205)365:2 · Cited by 378 · see citing works
Amargos-Bosch, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg128 · Cited by 370 · see citing works
Tepper, J. M., Martin, L., & Anderson, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-03092.1995 · Cited by 362 · see citing works
Determination of antidromic excitation by the collision test: Problems of interpretation
Fuller, J. H., & Schlag, J. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90284-5 · Cited by 341 · see citing works
Sprouse, J. S., & Aghajanian, G. K. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90079-2 · Cited by 333 · see citing works
Davidson, M., Galderisi, S., Weiser, M., Werbeloff, N., Fleischhacker, W., Keefe, R. S. E., Boter, H., Keet, I. P. M., Prelipceanu, D., RYBAKOWSKI, J. K., et al. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08060806 · Cited by 320 · see citing works
The Physiological Role of 5-HT<sub>2A</sub>Receptors in Working Memory
Williams, G. V., Rao, S. G., & Goldman-Rakic, P. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02843.2002 · Cited by 311 · see citing works
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
Selectivity of the hippocampal projection to the prelimbic area of the prefrontal cortex in the rat
Jay, T. M., Glowinski, J., & Thierry, A. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91464-9 · Cited by 295 · see citing works
Luciana, M., Collins, P., & Depue, R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.3.218 · Cited by 291 · see citing works
Díaz-Mataix, L., Scorza, M. C., Bortolozzi, A. A., Tóth, M., Celada, P., & Artigas, F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2999-05.2005 · Cited by 288 · see citing works
Self-citationElectrical synapses define networks of neocortical GABAergic neurons
Hestrin, S., & Galarreta, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.001 · Cited by 258 · see citing works
Winstanley, C. A., Chudasama, Y., Dalley, J. W., Theobald, D. E. H., Glennon, J. C., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1398-x · Cited by 234 · see citing works
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Carter, O. L., Burr, D. C., Pettigrew, J. D., Wallis, G. M., Hasler, F., & Vollenweider, F. X. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774597191 · Cited by 231 · see citing works
Puig, M. V. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.8.870 · Cited by 223 · see citing works
Hajós, M., Hajós‐Korcsok, É., & Sharp, T. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702510 · Cited by 210 · see citing works
Sumiyoshi, T., Matsui, M., Nohara, S., Yamashita, I., Kurachi, M., Sumiyoshi, C., Jayathilake, K., & Meltzer, H. Y. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1722 · Cited by 207 · see citing works
Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
Rollema, H., Lu, Y., Schmidt, A. W., & Zorn, S. H. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)81951-6 · Cited by 203 · see citing works
Influence of the hippocampus on interneurons of the rat prefrontal cortex
Tierney, P. L., Dégenètais, E., Thierry, A., Glowinski, J., & Gioanni, Y. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03501.x · Cited by 192 · see citing works
Moscrip, T. D., Terrace, H. S., Sackeïm, H. A., & Lisanby, S. H. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570500578x · Cited by 192 · see citing works
López-Gil, X., Babot, Z., Amargós-Bosch, M., Suñol, C., Artigas, F., & Adell, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301356 · Cited by 183 · see citing works
Self-citationAznar, S., Qian, Z.-X., Shah, R., Kornum, B. R., & Knudsen, G. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03727-7 · Cited by 181 · see citing works
Effect of Bicuculline on Thalamic Activity: A Direct Blockade of I AHP in Reticularis Neurons
Debarbieux, F. C., Brunton, J., & Charpak, S. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.6.2911 · Cited by 176 · see citing works
Does stimulation of 5-HT1A receptors improve cognition in schizophrenia?
Meltzer, H. Y., & Sumiyoshi, T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.016 · Cited by 169 · see citing works
Kargieman, L., Santana, N., Mengod, G., Celada, P., & Artigas, F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704848104 · Cited by 166 · see citing works
Self-citationGap-Junctional Coupling between Neurogliaform Cells and Various Interneuron Types in the Neocortex
Simon, A., Oláh, S., Molnár, G., Szabadics, J., & Tamás, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1431-05.2005 · Cited by 163 · see citing works
The effect of tandospirone, a serotonin1A agonist, on memory function in schizophrenia
Sumiyoshi, T., Matsui, M., Yamashita, I., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01025-8 · Cited by 152 · see citing works
la Cour, C. M., Mestikawy, S. E., Hanoun, N., Hamon, M., & Lanfumey, L. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022756 · Cited by 144 · see citing works
Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons
Innis, R. B., & Aghajanian, G. K. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90533-4 · Cited by 142 · see citing works
Meneses, A., & Perez-Garcia, G. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.001 · Cited by 130 · see citing works
Newman‐Tancredi, A., Martel, J.-C., Assié, M. B., Buritova, J., Lauressergues, E., Cosi, C., Heusler, P., Slot, L. A. B., Colpaert, F. C., Vacher, B., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00001.x · Cited by 128 · see citing works
Dégenètais, E. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.7.782 · Cited by 127 · see citing works
The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives.
Newman‐Tancredi, A. (2010) · PubMed · Cited by 126 · see citing works
The neurocognitive effects of aripiprazole: an open-label comparison with olanzapine
Kern, R. S., Green, M. F., Cornblatt, B. A., Owen, J. R., McQuade, R. D., Carson, W. H., Ali, M. W., & Marcus, R. N. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0428-x · Cited by 125 · see citing works
Martinez, D. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00187-1 · Cited by 122 · see citing works
Long-Term Neurocognitive Effects of Olanzapine or Low-Dose Haloperidol in First-Episode Psychosis
Keefe, R. S. E., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., Sitskoorn, M. M., Rock, S. L., Woolson, S., Tohen, M. F., Tollefson, G. D., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.022 · Cited by 120 · see citing works
Ashby, C. R., Edwards, E., & Wang, R. Y. (1994) · Synapse · doi:10.1002/syn.890170306 · Cited by 116 · see citing works
DeFelipe, J., Arellano, J. I., Gómez, A., Azmitia, E. C., & Muñoz, A. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1132 · Cited by 107 · see citing works
In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain
Bortolozzi, A., Díaz‐Mataix, L., Tóth, M., Celada, P., & Artigas, F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0698-y · Cited by 106 · see citing works
Self-citationLladó-Pelfort, L., Assié, M. B., Newman‐Tancredi, A., Artigas, F., & Celada, P. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00738.x · Cited by 104 · see citing works
Self-citationDepoortère, R., Auclair, A. L., Bardin, L., Colpaert, F. C., Vacher, B., & Newman‐Tancredi, A. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.04.005 · Cited by 93 · see citing works
Bortolozzi, A. A., Masana, M., Díaz-Mataix, L., Cortés, R., Scorza, M. C., Gingrich, J. A., Tóth, M., & Artigas, F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571000009x · Cited by 88 · see citing works
Self-citationJansson, A., Tinner, B., Bancila, M., Vergé, D., Steinbusch, H. W. M., Agnati, L. F., & Fuxé, K. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00133-8 · Cited by 83 · see citing works
Adell, A., Sarna, G. S., Hutson, P. H., & Curzon, G. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11943.x · Cited by 77 · see citing works
Steward, O., Tomasulo, R. A., & Levy, W. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)90930-a · Cited by 72 · see citing works
Gibiino, S., Marsano, A., & Serretti, A. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000746 · Cited by 68 · see citing works
Borsini, F., Ceci, A., Bietti, G., et al. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00168558 · Cited by 51 · see citing works
Regional distribution of neurotrophin receptors in the developing auditory brainstem
Hafidi, A., Moore, T., & Sanes, D. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960408)367:3 · Cited by 51 · see citing works
Valdizán, E. M., Castro, E., & Pazos, Á. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990940 · Cited by 50 · see citing works
Structural Organization of the Gap Junction Network in the Cerebral Cortex
Fukuda, T. (2007) · The Neuroscientist · doi:10.1177/1073858406296760 · Cited by 49 · see citing works
Simultaneous projections from prefrontal cortex to dopaminergic and serotonergic nuclei
Vázquez, P. M., Celada, P., Cortés, R., & Artigas, F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000349 · Cited by 46 · see citing works
Self-citationWingen, M., Kuypers, K. P. C., & Ramaekers, J. G. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106072506 · Cited by 44 · see citing works
Sumiyoshi, C., Sumiyoshi, T., Roy, A., Jayathilake, K., & Meltzer, H. Y. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006310 · Cited by 41 · see citing works
Díaz-Mataix, L., Artigas, F., & Celada, P. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.10.003 · Cited by 38 · see citing works
Self-citationUse of Buspirone in the Treatment of Schizophrenia
Sovner, R., & PARNELL-SOVNER, N. (1989) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198902000-00021 · Cited by 37 · see citing works
Romero, L. I., Celada, P., Martín‐Ruiz, R., et al. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300062 · Cited by 36 · see citing works
Self-citationTracing the Neuroanatomical Profiles of Reward Pathways with Markers of Neuronal Activation
Konkle, A. T. M., & Bielajew, C. H. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.6.383 · Cited by 31 · see citing works
The opposite effect of a low and a high dose of serotonin-1A agonist on behavior induced by MK-801
Bubeníková‐Valešová, V., Votava, M., Páleníček, T., et al. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.11.004 · Cited by 27 · see citing works
Cortés, R., Mengod, G., Celada, P., et al. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03213.x · Cited by 26 · see citing works
Self-citationSumiyoshi, T., Higuchi, Y., Matsui, M., Arai, H., Takamiya, C., Meltzer, H. Y., & Kurachi, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.017 · Cited by 24 · see citing works
Rueter, L. E., & Blier, P. U. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702344 · Cited by 21 · see citing works
An Open Study of Buspirone Augmentation of Neuroleptics in Patients With Schizophrenia
Sirota, P., Epstein, B., Benatov, R., et al. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200108000-00015 · Cited by 21 · see citing works
Beste, C., Heil, M., Domschke, K., & Konrad, C. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.025 · Cited by 19 · see citing works
Co-administration of fluoxetine and WAY100635 improves short-term memory function
Fernández-Pérez, S., Pache, D. M., & Sewell, R. D. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.039 · Cited by 13 · see citing works
Díaz-Mataix, L., Celada, P., & Artigas, F. (2005) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(05)80125-7 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders
Vollenweider, F. X., & Preller, K. H. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0367-2 · Cited by 570 · see citing works
Serotonin modulation of cortical neurons and networks
Celada, P., Puig, M. V., & Artigas, F. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00025 · Cited by 462 · see citing works
Self-citationCortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions
Fogaça, M. V., & Duman, R. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00087 · Cited by 396 · see citing works
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works
“Both of these receptors regulatemPFC and LA excitability via direct activation of pyramidal cells and/or GABAergic interneurons (Llado-Pelfort et al., 2012; Rainnie, 1999; Stutzmann & LeDoux, 1999).”
BackgroundAlbert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works
Celada, P., Bortolozzi, A., & Artigas, F. (2013) · CNS Drugs · doi:10.1007/s40263-013-0071-0 · Cited by 323 · see citing works
Self-citationThe endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
Pehrson, A. L., & Sanchez, C. (2014) · CNS Spectrums · doi:10.1017/s1092852913000540 · Cited by 161 · see citing works
Baune, B. T., & Renger, L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.013 · Cited by 115 · see citing works
Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.023 · Cited by 65 · see citing works
Scorza, M., Lladó‐Pelfort, L., Oller, S., Cortés, R., Puigdemont, D., Portella, M., Pérez‐Egea, R., Alvarez, E., Celada, P., Pérez, V, et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01770.x · Cited by 46 · see citing works
Self-citationKuniishi, H., Ichisaka, S., Matsuda, S., Futora, E., Harada, R., & Hata, Y. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00250 · Cited by 34 · see citing works
- Authors
- Llado-Pelfort, L., Santana, N., Ghisi, V., Artigas, F., & Celada, P.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-05
- Volume
- 22
- Issue
- 7
- Pages
- 1487-1497
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2129506769
- Semantic Scholar
- 48eaf08ebb8d778c01ee7bc7bed5d57264f697a8
- Cited by
- 156
- References
- 96
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 16 · 2020: 17 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 12 · 2015: 13 · 2014: 12 · 2013: 13 · 2012: 9
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- 5-HT1A receptor agonist, 8-OH-DPAT, medial prefrontal cortex, pyramidal neurons, GABAergic interneurons, fast-spiking interneurons, disinhibition, gabazine, Fos expression, schizophrenia, mesocortical dopamine, working memory
- MeSH terms
- Action Potentials, Animals, gamma-Aminobutyric Acid, Interneurons, Male, Neural Pathways, Rats, Wistar, 8-Hydroxy-2-(di-n-propylamino)tetralin, Prefrontal Cortex, Pyramidal Cells, Rats, Serotonin 5-HT1 Receptor Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
