Acquisition of spatial search strategies and reversal learning in the Morris water maze depend on disparate brain functional connectivity in mice
Open accessAbstract
Learning has been proposed to coincide with changes in connections between brain regions. In the present study, we used resting-state fMRI (rsfMRI) to map brain-wide functional connectivity (FC) in mice that were trained in the hidden-platform version of the Morris water maze. C57BL6 mice were investigated in a small animal MRI scanner following 2, 10, or 15 days of acquisition learning, or 5 days of reversal learning. Spatial learning coincided with progressive and changing FC between telencephalic regions that have been implemented in spatial learning (such as hippocampus, cingulate, visual, and motor cortex). Search strategy assessment demonstrated that the use of cognitively advanced spatial strategies correlated positively with extensive telencephalic connectivity, whereas non-spatial strategies correlated negatively with connectivity. FC patterns were different and more extensive after reversal learning compared with after extended acquisition learning, which could explain why reversal learning has been shown to be more sensitive to subtle functional defects.
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Acquisition of spatial search strategies and reversal learning in the MWM depend on functional connectivity of the hippocampus.
“A study combining neuroimaging and behavior found that acquisition of spatial search strategies and reversal learning in the MWM depend on functional connectivity of the hippocampus (Shah et al., 2019).”
From Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain (2026) · cites this paper as Shah et al., 2019
The Discussion (page unavailable) describes hippocampal connections as important during acquisition and reports hippocampal connectivity after reversal learning. The results also link hippocampal connectivity with spatial strategies after reversal. However, the study reports associations across broader brain networks, not a demonstrated dependence of both learning processes specifically on hippocampal connectivity. (LLM, conf=0.84)
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Self-citation
- Authors
- Shah, D., Verhoye, M., Van der Linden, A., & D’Hooge, R.
- Affiliations
- University of Antwerp (BE)
- Bio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
- KU Leuven (BE)
- Corresponding author
- Shah, Disha
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-22
- Volume
- 29
- Issue
- 11
- Pages
- 4519-4529
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2906174022
- Cited by
- 25
- References
- 55
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 3
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- EU Seventh Framework Programme Imaging of Neuroinflammation in Neurodegenerative Diseases INMiND (278850)
- Molecular Imaging of Brain Pathophysiology BRAINPATH (612360)
- Marie Curie Actions-Industry-Academia Partnerships and Pathways
- Ultrafast Functional Ultrasound
- Imaging for Highly-Resolved Targeted Mapping of Functional Connectivity (G.0D7615N)
- University Research Fund of Antwerp University BOF DOCPRO (FFB150340)
- Institute for the Promotion of Innovation by Science and Technology (13160)
- Research Foundation Flanders (G.0D76.14, G.0587.14, 12R1119N)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- spatial learning, reversal learning, functional connectivity, Morris water maze, search strategies, hippocampus, telencephalon, resting-state functional connectivity, mice
- MeSH terms
- Animals, Brain, Brain Mapping, Female, Magnetic Resonance Imaging, Mice, Inbred C57BL, Reversal Learning, Maze Learning, Spatial Processing
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