Cited by 171Lipoproteins and Cardiovascular HealthLipid metabolism and disordersCholesterol and Lipid Metabolism

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The dawn of a new era of targeted lipid-lowering therapies

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Tokgözoğlu, Lale, Libby, Peter·2022·European Heart Journal

DOI 10.1093/eurheartj/ehab841PMC PMC9448630

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Abstract

Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless contributes causally to atherosclerosis. Recent human genetic findings have substantiated a number of novel targets for lipid-lowering therapy including apolipoprotein C-III, angiopoietin-like protein 3 and 4, apolipoprotein V, and ATP citrate lyase. These discoveries coupled with advances in biotechnology development afford new avenues for management of LDL and other aspects of lipid risk. Beyond LDL, new treatments targeting triglyceride-rich lipoproteins and lipoprotein(a) have become available and have entered clinical development. Biological and RNA-directed agents have joined traditional small-molecule approaches, which themselves have undergone considerable refinement. Innovative targeting strategies have increased efficacy of some of these novel interventions and markedly improved their tolerability. Gene-editing approaches have appeared on the horizon of lipid management. This article reviews this progress offering insight into novel biological and therapeutic discoveries, and places them into a practical patient care perspective.

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See all 171

Authors: Tokgözoğlu, L., & Libby, P.
Affiliations: Hacettepe University (TR)
Brigham and Women's Hospital (US)
Corresponding author: Libby, Peter
ORCID: Tokgözoğlu, Lale
Libby, Peter
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2022-01-20
Volume: 43
Issue: 34
Pages: 3198-3208
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehab841
PMC: PMC9448630
OpenAlex: W4205823791
Cited by: 171
References: 116
Citations by year: 2026: 20 · 2025: 49 · 2024: 59 · 2023: 31 · 2022: 12
FWCI: 6.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: European Heart Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (1R01HL134892)
American Heart Association
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: lipid-lowering therapy, LDL cholesterol, cardiovascular risk, apolipoprotein C-III, ANGPTL3, ANGPTL4, ATP citrate lyase, triglyceride-rich lipoproteins, lipoprotein(a), PCSK9 inhibitors, genome editing, genetic risk factors, atherosclerosis
MeSH terms: Hypolipidemic Agents, Cardiovascular Diseases, Humans, Triglycerides, Lipoprotein(a), Dyslipidemias, Atherosclerosis

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The dawn of a new era of targeted lipid-lowering therapies

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