Circulating adhesion molecules in obstructive sleep apnea and cardiovascular disease
Open accessAbstract
Over 20 years of evidence indicates a strong association between obstructive sleep apnea (OSA) and cardiovascular disease. Although inflammatory processes have been heavily implicated as an important link between the two, the mechanism for this has not been conclusively established. Atherosclerosis may be one of the mechanisms linking OSA to cardiovascular morbidity. This review addresses the role of circulating adhesion molecules in patients with OSA, and how these may be part of the link between cardiovascular disease and OSA. There is evidence for the role of adhesion molecules in cardiovascular disease risk. Some studies, albeit with small sample sizes, also show higher levels of adhesion molecules in patients with OSA compared to controls. There are also studies that show that levels of adhesion molecules diminish with continuous positive airway pressure therapy. Limitations of these studies include small sample sizes, cross-sectional sampling, and inconsistent control for confounding variables known to influence adhesion molecule levels. There are potential novel therapies to reduce circulating adhesion molecules in patients with OSA to diminish cardiovascular disease. Understanding the role of cell adhesion molecules generated in OSA will help elucidate one mechanistic link to cardiovascular disease in patients with OSA.
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The risks of sleep apnoea are probably largely due to intermittent hypoxia and co-morbid obesity.
“though the risks are probably largely due to the intermittent hypoxia and co-morbid obesity (Pak et al., 2014).”
From Addressing sleep disturbances: an opportunity to prevent cardiometabolic disease? (2014) · cites this paper as Pak et al., 2014
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Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173 · see citing works
Self-citationAddressing sleep disturbances: an opportunity to prevent cardiometabolic disease?
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“Sleep apnoea is associated with signifi - cant sleep fragmentation (Bianchi et al., 2012) which may be one of the causal pathways linking this disorder to poor sleep, though the risks are probably largely due to the intermittent hypoxia and co-morbid obesity (Pak et al., 2014).”
BackgroundSelf-citation
- Authors
- Pak, V. M., Grandner, M. A., & Pack, A. I.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Pak, Victoria M.
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 18
- Issue
- 1
- Pages
- 25-34
- ISSN
- 1087-0792 (ISSN-L)
- PMC
- PMC3864978
- OpenAlex
- W2162524327
- Cited by
- 43
- References
- 130
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (T32 HL07713, K23 HL110216, P01 HL094307)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obstructive sleep apnea, cardiovascular disease, circulating adhesion molecules, inflammation, atherosclerosis, continuous positive airway pressure, cardiovascular risk
- MeSH terms
- Hypoxia, Cardiovascular Diseases, Humans, Cell Adhesion Molecules, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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