The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
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Sirt1 has been shown to be atheroprotective in Apoe−/− mice.
“Sirt1 has been shown to be atheroprotective in apolipoprotein E-deficient (Apoe−/−) mice2–4 whereas genetic overexpression of Sirt1 in LDL-receptor-deficient (Ldlr−/−) mice enhanced atherosclerosis.5”
From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [3]
Intracellular activation of SIRT1 protects against atherosclerosis.
“Mounting evidence has demonstrated that intracellular activation of SIRT1 protects against atherosclerosis.30–33”
From Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation (2025) · cites this paper as [31]
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Cites
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1×
“Sir2 is an NAD-dependent class III deacetylase that was found to increase lifespan in yeast.(2) Its mammalian orthologue SIRT1 senses”
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707
Minireview: Adiposity, Inflammation, and Atherogenesis
Lyon, C. J., Law, R. E., & Hsueh, W. A. (2003) · Endocrinology · doi:10.1210/en.2003-0285 · Cited by 761
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040031 · Cited by 715
Self-citationThe macrophage foam cell as a target for therapeutic intervention
Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
Moore, K. J., & Freeman, M. W. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000229218.97976.43 · Cited by 562
Increase in Activity During Calorie Restriction Requires Sirt1
Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science · doi:10.1126/science.1118357 · Cited by 419
Flagged first, then by citations
Research works printed but not linked: 33
- 2002, Inflammation in atherosclerosis, Nature, 420, 868, 10.1038/nature01323 · DOI · Paper page
- 2004, Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma, Nature, 429, 771, 10.1038/nature02583 · DOI
- 2001, hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase, Cell, 107, 149, 10.1016/S0092-8674(01)00527-X · DOI
- 2004, Mammalian SIRT1 represses forkhead transcription factors, Cell, 116, 551, 10.1016/S0092-8674(04)00126-6 · DOI
- 2007, SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase, Proc Natl Acad Sci USA, 104, 14855, 10.1073/pnas.0704329104 · DOI · Paper page
- 2001, Negative control of p53 by Sir2alpha promotes cell survival under stress, Cell, 107, 137, 10.1016/S0092-8674(01)00524-4 · DOI · Paper page
- 2007, Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells, Antioxid Redox Signal, 9, 301, 10.1089/ars.2006.1456 · DOI
- 1996, Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion, J Clin Invest, 97, 1715, 10.1172/JCI118598 · DOI
- 2000, Enhanced atherosclerosis and kidney dysfunction in eNOS(−/−)Apoe(−/−) mice are ameliorated by enalapril treatment, J Clin Invest, 105, 451, 10.1172/JCI8376 · DOI
- 1999, The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo, Nat Med, 5, 335, 10.1038/6585 · DOI
- 2004, Dysfunction of endothelial nitric oxide synthase and atherosclerosis, Arterioscler Thromb Vasc Biol, 24, 998, 10.1161/01.ATV.0000125114.88079.96 · DOI
- 2008, Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice, Cardiovasc Res, 80, 191, 10.1093/cvr/cvn224 · DOI · Paper page
- 2008, Sirt1-null mice develop an autoimmune-like condition, Exp Cell Res, 314, 3069, 10.1016/j.yexcr.2008.07.011 · DOI
- 2003, The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis, Mol Cell Biol, 23, 38, 10.1128/MCB.23.1.38-54.2003 · DOI · Paper page
- 2001, The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system, J Exp Med, 193, 967, 10.1084/jem.193.8.967 · DOI
- 2005, Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress, Cell Metab, 2, 67, 10.1016/j.cmet.2005.06.007 · DOI
- 2008, Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65, Nucleic Acids Res, 36, 1665, 10.1093/nar/gkn003 · DOI
- 1995, Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet, J Clin Invest, 95, 2246, 10.1172/JCI117915 · DOI
- 2008, Macrophages: an elusive yet emerging therapeutic target of atherosclerosis, Med Res Rev, 28, 483, 10.1002/med.20118 · DOI
- 2007, Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet, Circ Res, 100, 1634, 10.1161/CIRCRESAHA.107.149724 · DOI
- 1998, Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene, J Biol Chem, 273, 33702, 10.1074/jbc.273.50.33702 · DOI
- 2009, Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF{alpha} production in cultured macrophage cell lines, Am J Physiol Gastrointest Liver Physiol, 296, G1047, 10.1152/ajpgi.00016.2009 · DOI
- 2009, LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells, Cardiovasc Res, 84, 127, 10.1093/cvr/cvp177 · DOI · Paper page
- 2004, Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage, Arthritis Rheum, 50, 3495, 10.1002/art.20581 · DOI
- 2003, LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells, Circulation, 107, 612, 10.1161/01.CIR.0000047276.52039.FB · DOI
- 2002, LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation, Am J Physiol Heart Circ Physiol, 283, H1795, 10.1152/ajpheart.00382.2002 · DOI
- 2003, Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice, J Clin Invest, 112, 1176, 10.1172/JCI200318580 · DOI
- 2007, Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation, Atherosclerosis, 192, 283, 10.1016/j.atherosclerosis.2006.07.018 · DOI
- 2004, Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype, Blood, 103, 934, 10.1182/blood-2003-05-1450 · DOI
- 2008, Understanding NF-kappaB signaling via mathematical modeling, Mol Syst Biol, 4, 192, 10.1038/msb.2008.30 · DOI
- 2006, Introduction to NF-kappaB: players, pathways, perspectives, Oncogene, 25, 6680, 10.1038/sj.onc.1209954 · DOI
- 2007, Nuclear factor-kappa B: from clone to clinic, Curr Mol Med, 7, 619, 10.2174/156652407782564363 · DOI
- 2007, SIRT1 deacetylates and positively regulates the nuclear receptor LXR, Mol Cell, 28, 91, 10.1016/j.molcel.2007.07.032 · DOI
Cited by
Sorted by citations
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618
Self-citationChen, H.-Z., Wang, F., Gao, P., Pei, J.-F., Liu, Y., Xu, T.-T., Tang, X., Fu, W.-Y., Lu, J., Yan, Y.-F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308895 · Cited by 265
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases
Lu, C., Zhao, H., Liu, Y., Yang, Z., Yao, H., Liu, T., Gou, T., Wang, L., Zhang, J., Tian, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.78654 · Cited by 160
Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu095 · Cited by 153
Self-citationHung, C.-H., Chan, S.-H., Chu, P.-M., & Tsai, K.-L. (2015) · Clinical Science · doi:10.1042/cs20150127 · Cited by 25
Velagapudi, S., Miranda, M. X., Adla, P., Kraler, S., Mohammed, S. A., Baki, S., Robert, J., Rohrer, L., Lee, H., Jang, H.-D., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf087 · Cited by 4
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Metadata
- Authors
- Stein, S., Lohmann, C., Schäfer, N., Hofmann, J., Rohrer, L., Besler, C., Rothgiesser, K. M., Becher, B., Hottiger, M. O., Borén, J., McBurney, M. W., Landmesser, U., Lüscher, T. F., & Matter, C. M.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-23
- Volume
- 31
- Issue
- 18
- Pages
- 2301-2309
- ISSN
- 0195-668X
- 1522-9645
- PMC
- PMC2938465
- Cited by
- 188
- References
- 14
- Language
- en
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