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Cited by 149Muscle Physiology and DisordersMuscle metabolism and nutritionExercise and Physiological Responses

The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy following Resistance Training

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Bellamy, Leeann M., Joanisse, Sophie, Grubb, Amanda, Mitchell, Cameron J., McKay, Bryon R., Phillips, Stuart M., Baker, Steven, Parise, Gianni·2014·PLoS ONE
DOI 10.1371/journal.pone.0109739PMC PMC4196938
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Abstract

The extent of skeletal muscle hypertrophy in response to resistance training is highly variable in humans. The main objective of this study was to explain the nature of this variability. More specifically, we focused on the myogenic stem cell population, the satellite cell (SC) as a potential mediator of hypertrophy. Twenty-three males (aged 18-35 yrs) participated in 16 wk of progressive, whole body resistance training, resulting in changes of 7.9±1.6% (range of -1.9-24.7%) and 21.0±4.0% (range of -7.0 to 51.7%) in quadriceps volume and myofibre cross-sectional area (CSA), respectively. The SC response to a single bout of resistance exercise (80% 1RM), analyzed via immunofluorescent staining resulted in an expansion of type II fibre associated SC 72 h following exercise (pre: 11.3±0.9; 72 h: 14.8±1.4 SC/type II fibre; p<0.05). Training resulted in an expansion of the SC pool associated with type I (pre: 10.7±1.1; post: 12.1±1.2 SC/type I fibre; p<0.05) and type II fibres (pre: 11.3±0.9; post: 13.0±1.2 SC/type II fibre; p<0.05). Analysis of individual SC responses revealed a correlation between the relative change in type I associated SC 24 to 72 hours following an acute bout of resistance exercise and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.566, p = 0.012) and the relative change in type II associated SC following 16 weeks of resistance training and the percentage increase in quadriceps lean tissue mass assessed by MRI (r2 = 0.493, p = 0.027). Our results suggest that the SC response to resistance exercise is related to the extent of muscular hypertrophy induced by training.

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  • Different exercise modes appear to generate a fibre type specific satellite cell response.

    “The different exercise modes also appear to generate a fibre type specific satellite cell response which may also increase the complexity in delineating its role in the specificity of adaptation and any incompatibility with concurrent training (Babcock et al., 2012;Joanisse et al., 2013;Bellamy et al., 2014).”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Bellamy et al., 2014

    The Results section reports a fibre-type-specific satellite cell response to resistance exercise: type II-associated cells increased after an acute bout, while cells associated with both fibre types increased after 16 weeks of training. The paper does not compare different exercise modes, so it does not establish that different modes generate different fibre-type-specific responses. (LLM, conf=0.85)

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  • Resistance and aerobic exercise independently have the potential to induce satellite cell responses for skeletal muscle remodelling.

    “It should be noted that resistance and aerobic exercise independently have the potential to induce satellite cell responses for skeletal muscle remodelling”

    From Concurrent exercise training: do opposites distract? (2017) · cites this paper as Bellamy et al., 2014

    The Abstract reports a satellite-cell response after a bout of resistance exercise, supporting that part of the claim. The paper studies resistance training, and the cited passages do not establish an independent satellite-cell response to aerobic exercise. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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Authors
Bellamy, L. M., Joanisse, S., Grubb, A., Mitchell, C. J., McKay, B. R., Phillips, S. M., Baker, S., & Parise, G.
Affiliations
McMaster University (CA)
Corresponding author
Parise, Gianni
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-10-14
Volume
9
Issue
10
Pages
e109739
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0109739
PMC
PMC4196938
OpenAlex
W1984074879
Cited by
149
References
42
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 16 · 2019: 19 · 2018: 20 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 3
FWCI
6.84
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • ResearchSpace (University of Auckland) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
satellite cells, skeletal muscle hypertrophy, resistance training, myogenic stem cells, muscle fiber cross-sectional area, type I muscle fibers, fast-twitch muscle, quadriceps, lean body mass
MeSH terms
Adolescent, Adult, Cell Cycle, Humans, Hypertrophy, Male, Muscle, Skeletal, Muscle Fibers, Slow-Twitch, Satellite Cells, Skeletal Muscle, Cell Proliferation, PAX7 Transcription Factor, Resistance Training, Myostatin, Young Adult

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