Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

Fry, Christopher S; Lee, Jonah D; Mula, Jyothi; Kirby, Tyler J; Jackson, Janna R; Liu, Fujun; Yang, Lin; Mendias, Christopher L; Dupont-Versteegden, Esther E; McCarthy, John J; Peterson, Charlotte A

doi:10.1038/nm.3710

Cited by 432Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

Open access

Fry, Christopher S, Lee, Jonah D, Mula, Jyothi, Kirby, Tyler J, Jackson, Janna R, Liu, Fujun, Yang, Lin, Mendias, Christopher L +3 more·2015·Nature Medicine

DOI 10.1038/nm.3710PMC PMC4289085

Open this paper in CoChat — free account

Abstract

A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the loss of satellite cell activity is also a cause of sarcopenia. We tested this hypothesis in male sedentary mice by experimentally depleting satellite cells in young adult animals to a degree sufficient to impair regeneration throughout the rest of their lives. A detailed analysis of multiple muscles harvested at various time points during aging in different cohorts of these mice showed that the muscles were of normal size, despite low regenerative capacity, but did have increased fibrosis. These results suggest that lifelong reduction of satellite cells neither accelerated nor exacerbated sarcopenia and that satellite cells did not contribute to the maintenance of muscle size or fiber type composition during aging, but that their loss may contribute to age-related muscle fibrosis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nm.3710

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ablating Pax7-expressing MuSCs in aged muscle does not accelerate or slow muscle wasting.
“Conditional ablation of Pax7-expressing MuSCs from aged muscles neither accelerates nor slows muscle wasting17,28.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [17]
The ablation findings are limited because Pax7CreER-DTA models do not fully eliminate MuSCs.
“However, these findings are based on Pax7CreER-DTA models which do not completely ablate the MuSC population.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [17]
Satellite cell depletion throughout adulthood does not appear to influence the onset or progression of sarcopenia in mice.
“satellite cell depletion throughout adulthood does not appear to influence the onset or progression of sarcopenia in mice”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Fry et al., 2015
Senescent satellite cells may exacerbate skeletal muscle loss or dysfunction in the context of aging, disease, or injury.
“this does not rule out the possibility that senescent satellite cells may exacerbate skeletal muscle loss or dysfunction in the context of aging, disease, or injury”
From Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions (2021) · cites this paper as Fry et al., 2015
Throughout the lifespan of satellite cell depleted mice, sarcopenia is neither exacerbated nor accelerated.
“However, throughout the lifespan of satellite cell depleted mice, sarcopenia is neither exacerbated nor accelerated [28,29].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [29]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219 · see citing works
Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605 · see citing works
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works
Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377 · see citing works
Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249 · see citing works
An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration
Lepper, C., Partridge, T. A., & Fan, C.-M. (2011) · Development · doi:10.1242/dev.067595 · Cited by 1,105 · see citing works
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A. (2011) · Development · doi:10.1242/dev.067587 · Cited by 939 · see citing works
Intrinsic Epithelial Cells Repair the Kidney after Injury
Humphreys, B. D., Valerius, M. T., Kobayashi, A., Mugford, J. W., Soeung, S., Duffield, J. S., McMahon, A. P., & Bonventre, J. V. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.014 · Cited by 868 · see citing works
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573 · see citing works
Growth and Regeneration of Adult β Cells Does Not Involve Specialized Progenitors
Teta, M., Rankin, M. M., Long, S. Y., Stein, G. M., & Kushner, J. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.011 · Cited by 551 · see citing works
A Conceptual Framework of Frailty: A Review
Bortz, W. M. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.5.m283 · Cited by 550 · see citing works
Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle
Shefer, G., de Mark, D. P. V., Richardson, J. B., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.022 · Cited by 506 · see citing works
Aging, Disability and Frailty
Topinková, E. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000115340 · Cited by 483 · see citing works
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461 · see citing works
NF-ÎºBâ€“mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia
He, W. A., Berardi, E., Cardillo, V. M., Acharyya, S., Aulino, P., Thomas-Ahner, J., Wang, J., Bloomston, M., Muscarella, P., Nau, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68523 · Cited by 357 · see citing works
A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging
Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0372 · Cited by 320 · see citing works
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
Brack, A. S., Bildsoe, H., & Hughes, S. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02602 · Cited by 308 · see citing works
Moderate Leisure-Time Physical Activity: Who Is Meeting the Public Health Recommendations? A National Cross-sectional Study
Arriaza Jones, D. (1998) · Archives of Family Medicine · doi:10.1001/archfami.7.3.285 · Cited by 277 · see citing works
Regulation of the muscle fiber micro environment by activated satellite cells during hypertrophy
Fry, C. S., Lee, J. D., Jackson, J. R., Kirby, T. J., Stasko, S. A., Liu, H., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-239426 · Cited by 273 · see citing works
Self-citation
Stem Cell Review Series: Aging of the skeletal muscle stem cell niche
Gopinath, S. D., & Rando, T. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00399.x · Cited by 262 · see citing works
Loss of stem cell regenerative capacity within aged niches
Carlson, M. E., & Conboy, I. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00286.x · Cited by 233 · see citing works
Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise
Shefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 211 · see citing works
Motor Units: Remodeling in Aged Animals
Holloszy, J. O., & Larsson, L. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.special_issue.91 · Cited by 158 · see citing works
Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy
Jackson, J. R., Mula, J., Kirby, T. J., Fry, C. S., Lee, J. D., Ubele, M. F., Campbell, K. S., McCarthy, J. J., Peterson, C. A., & Dupont‐Versteegden, E. E. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00207.2012 · Cited by 158 · see citing works
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works
Effect of Gender, Age, and Anthropometry on Axial and Appendicular Muscle Strength
Sinaki, M., Nwaogwugwu, N. C., Phillips, B. E., & Mokri, M. P. (2001) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-200105000-00002 · Cited by 133 · see citing works
Biomarker system for studying muscle, stem cells, and cancer in vivo
Nishijo, K., Hosoyama, T., Bjornson, C. R. R., Schaffer, B. S., Prajapati, S. I., Bahadur, A. N., Hansen, M. S. T., Blandford, M. C., McCleish, A. T., Rubin, B. P., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-128116 · Cited by 132 · see citing works
T-Cell-Dependent Fibrosis in the mdx Dystrophic Mouse
Morrison, J. I., Lu, Q. L., Pastoret, C., Partridge, T. A., & Bou–Gharios, G. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780092 · Cited by 124 · see citing works
Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres
Yu, F., Hedström, M., Cristea, A., Dalén, N., & Larsson, L. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01699.x · Cited by 119 · see citing works
Feasibility, Safety, and Efficacy of Myoblast Transfer Therapy on Duchenne Muscular Dystrophy Boys
Law, P. K., Goodwin, T. G., Fang, Q., Duggirala, V., Larkin, C., Florendo, J. A., Kirby, D. S., Deering, M. B., Li, H. J., Chen, M., et al. (1992) · Cell Transplantation · doi:10.1177/0963689792001002-305 · Cited by 104 · see citing works
Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
McKay, B. R., Ogborn, D. I., Baker, J. M., Toth, K., Tarnopolsky, M. A., & Parise, G. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2012 · Cited by 83 · see citing works
Decreased specific force and power production of muscle fibers from myostatin-deficient mice are associated with a suppression of protein degradation
Mendias, C. L., Kayupov, E., Bradley, J. R., Brooks, S. V., & Claflin, D. R. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00126.2011 · Cited by 76 · see citing works
Automated image analysis of skeletal muscle fiber cross-sectional area
Mula, J., Lee, J. D., Liu, F., Yang, L., & Peterson, C. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01022.2012 · Cited by 62 · see citing works
Automated fiber-type-specific cross-sectional area assessment and myonuclei counting in skeletal muscle
Liu, F., Fry, C. S., Mula, J., Jackson, J. R., Lee, J. D., Peterson, C. A., & Yang, L. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00848.2013 · Cited by 42 · see citing works
Handgrip dynamometry, Cybex measurements and lean mass as markers of the ageing of muscle function.
Shephard, R. J., Montelpare, W., Plyley, M. J., McCracken, D., & Goode, R. C. (1991) · British Journal of Sports Medicine · doi:10.1136/bjsm.25.4.204 · Cited by 42 · see citing works
Satellite cell therapy – from mice to men
Bareja, A., & Billin, A. N. (2013) · Skeletal Muscle · doi:10.1186/2044-5040-3-2 · Cited by 35 · see citing works

Flagged first, then by citations

Sorted by citations

NAD <sup>+</sup> repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works
Physical activity and exercise: Strategies to manage frailty
Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101513 · Cited by 771 · see citing works
Regulation of Muscle Growth and Regeneration by the Immune System
Tidball, J. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.150 · Cited by 740 · see citing works
Insulin resistance and sarcopenia: mechanistic links between common co-morbidities
Cleasby, M. E., Jamieson, P. M., & Atherton, P. J. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0533 · Cited by 596 · see citing works
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Zhang, Y., Kim, M. S., Jia, B., Yan, J., Zuniga-Hertz, J. P., Han, C., & Cai, D. (2017) · Nature · doi:10.1038/nature23282 · Cited by 564 · see citing works
Effects of Exercise and Aging on Skeletal MusclePreprint
Distéfano, G., & Goodpaster, B. H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029785 · Cited by 491 · see citing works
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works
Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle
Wosczyna, M. N., Konishi, C. T., Carbajal, E. E. P., Wang, T. T., Walsh, R. A., Gan, Q., Wagner, M. W., & Rando, T. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.074 · Cited by 438 · see citing works
Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training
Bowen, T. S., Schuler, G. C., & Adams, V. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12043 · Cited by 429 · see citing works
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works
The exerkine apelin reverses age-associated sarcopenia
Vinel, C., Lukjanenko, L., Batut, A., Deleruyelle, S., Pradère, J.-P., Le Gonidec, S., Dortignac, A., Geoffre, N., Pereira, O., Karaz, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0131-6 · Cited by 398 · see citing works
Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy
Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J., & Peterson, C. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.09.010 · Cited by 372 · see citing works
Satellite cells in human skeletal muscle plasticity
Snijders, T., Nederveen, J. P., McKay, B. R., Joanisse, S., Verdijk, L. B., van Loon, L. J. C., & Parise, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00283 · Cited by 359 · see citing works
A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration
Wosczyna, M. N., & Rando, T. A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.018 · Cited by 353 · see citing works
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331 · see citing works
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332 · see citing works
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease
Almada, A. E., & Wagers, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.7 · Cited by 314 · see citing works
Adult stem cells at work: regenerating skeletal muscle
Schmidt, M., Schüler, S. C., Hüttner, S. S., von Eyß, B., & von Maltzahn, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03093-6 · Cited by 313 · see citing works
Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization
Mishra, P., Varuzhanyan, G., Pham, A. H., & Chan, D. C. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.027 · Cited by 290 · see citing works
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works
Muscle stem cells contribute to myofibres in sedentary adult mice
Keefe, A. C., Lawson, J. A., Flygare, S. D., Fox, Z. D., Colasanto, M. P., Mathew, S. J., Yandell, M., & Kardon, G. (2015) · Nature Communications · doi:10.1038/ncomms8087 · Cited by 279 · see citing works
Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice
Rozo, M., Li, L., & Fan, C. (2016) · Nature Medicine · doi:10.1038/nm.4116 · Cited by 244 · see citing works
Mouse models of sarcopenia: classification and evaluation
Xie, W., He, M., Yu, D., Wu, Y., Wang, X., Lv, S., Xiao, W., & Li, Y. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12709 · Cited by 233 · see citing works
Inflammaging: Implications in Sarcopenia
Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Potes, Y., Caballero, B., Vega‐Naredo, I., Coto‐Montes, A. M., & García-González, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315039 · Cited by 223 · see citing works
Characterization of cellular senescence in aging skeletal muscle
Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00250-8 · Cited by 206 · see citing works
Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathway
Segalés, J., Perdiguero, E., & Muñoz‐Cánoves, P. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00091 · Cited by 209 · see citing works
Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle‐derived nitric oxide
Wang, Y., Wehling‐Henricks, M., Samengo, G., & Tidball, J. G. (2015) · Aging Cell · doi:10.1111/acel.12350 · Cited by 205 · see citing works
Age-related changes in skeletal muscle: changes to life-style as a therapy
McCormick, R., & Vasilaki, A. (2018) · Biogerontology · doi:10.1007/s10522-018-9775-3 · Cited by 210 · see citing works
Regulation of skeletal muscle stem cells by fibroblast growth factors
Pawlikowski, B. T., Vogler, T. O., Gadek, K. E., & Olwin, B. B. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24495 · Cited by 204 · see citing works
Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases
Molina, T., Fabre, P., & Dumont, N. A. (2021) · Open Biology · doi:10.1098/rsob.210110 · Cited by 193 · see citing works
Pervasive satellite cell contribution to uninjured adult muscle fibers
Pawlikowski, B. T., Pulliam, C., Betta, N. D., Kardon, G., & Olwin, B. B. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0067-1 · Cited by 182 · see citing works
Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
Angulo, J., Assar, M. E., & Rodríguez‐Mañas, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.06.001 · Cited by 185 · see citing works
The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation
Bilodeau, P., Coyne, E. S., & Wing, S. S. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00125.2016 · Cited by 180 · see citing works
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
Ham, D. J., Börsch, A., Lin, S., Thürkauf, M., Weihrauch, M., Reinhard, J. R., Delezie, J., Battilana, F., Wang, X., Kaiser, M. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18140-1 · Cited by 178 · see citing works
Estrogen Regulates the Satellite Cell Compartment in Females
Collins, B. C., Arpke, R. W., Larson, A. A., Baumann, C. W., Xie, N., Cabelka, C. A., Nash, N. L., Juppi, H., Laakkonen, E. K., Sipilä, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.025 · Cited by 177 · see citing works
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Yamakawa, H., Kusumoto, D., Hashimoto, H., & Yuasa, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051830 · Cited by 178 · see citing works
The ins and outs of muscle stem cell aging
Brack, A. S., & Muñoz-Cánoves, P. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0072-z · Cited by 166 · see citing works
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia
Uezumi, A., Ikemoto‐Uezumi, M., Zhou, H., Kurosawa, T., Yoshimoto, Y., Nakatani, M., Hitachi, K., Yamaguchi, H., Wakatsuki, S., Araki, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci139617 · Cited by 166 · see citing works
Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis
Bennett, J. L., Pratt, A. G., Dodds, R. M., Sayer, A. A., & Isaacs, J. D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-00921-9 · Cited by 166 · see citing works
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163 · see citing works
Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Vargas-Mendoza, N., Morales‐González, Á., Madrigal‐Santillán, E., Madrigal‐Bujaidar, E., Álvarez‐González, I., García-Melo, L. F., Anguiano‐Robledo, L., Fregoso-Aguilar, T. A., & Morales‐González, J. A. (2019) · Antioxidants · doi:10.3390/antiox8060196 · Cited by 163 · see citing works
Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease
Farup, J., Madaro, L., Puri, P., & Mikkelsen, U. R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.198 · Cited by 156 · see citing works
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice
Murach, K. A., White, S. H., Wen, Y., Ho, A., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0132-z · Cited by 156 · see citing works
Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
Yucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M., & Blau, H. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.092 · Cited by 159 · see citing works
Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy
Goh, Q., & Millay, D. P. (2017) · eLife · doi:10.7554/elife.20007 · Cited by 157 · see citing works
Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen
Lu, L., & Tian, L. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0116 · Cited by 154 · see citing works
Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions
Liu, W., Wei‐LaPierre, L., Klose, A. M., Dirksen, R. T., & Chakkalakal, J. V. (2015) · eLife · doi:10.7554/elife.09221 · Cited by 152 · see citing works
Muscle-bone interactions: From experimental models to the clinic? A critical update
Laurent, M. R., Dubois, V., Claessens, F., Verschueren, S., Vanderschueren, D., Gielen, E., & Jardí, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.017 · Cited by 152 · see citing works
Regenerative decline of stem cells in sarcopenia
Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147 · see citing works
Intrinsic muscle clock is necessary for musculoskeletal health
Schroder, E. A., Harfmann, B. D., Zhang, X., Srikuea, R., England, J. H., Hodge, B. A., Wen, Y., Riley, L. A., Yu, Q., Christie, A., et al. (2015) · The Journal of Physiology · doi:10.1113/jp271436 · Cited by 145 · see citing works
A Twist2-dependent progenitor cell contributes to adult skeletal muscle
Liu, N., Garry, G. A., Li, S., Bezprozvannaya, S., Sanchez‐Ortiz, E., Chen, B., Shelton, J. M., Jaichander, P., Bassel‐Duby, R., & Olson, E. N. (2017) · Nature Cell Biology · doi:10.1038/ncb3477 · Cited by 144 · see citing works
Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 143 · see citing works
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy
Mankhong, S., Kim, S., Moon, S., Kwak, H., Park, D., & Kang, J. (2020) · Cells · doi:10.3390/cells9061385 · Cited by 143 · see citing works
Characterization and isolation of highly purified porcine satellite cells
Ding, S., Wang, F., Liu, Y., Li, S., Zhou, G., & Hu, P. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.3 · Cited by 140 · see citing works
Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging
Théret, M., Rossi, F. M. V., & Contreras, O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673404 · Cited by 144 · see citing works
Klotho, stem cells, and aging
Hu, M. C., Bian, A., Neyra, J. A., & Zhan, M. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s84978 · Cited by 139 · see citing works
Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Murach, K. A., Fry, C. S., Kirby, T. J., Jackson, J. R., Lee, J. D., White, S. H., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Physiology · doi:10.1152/physiol.00019.2017 · Cited by 137 · see citing works
Self-citation
Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury
Aguilar, C. A., Greising, S. M., Watts, A., Goldman, S. M., Peragallo, C., Zook, C., Larouche, J. A., & Corona, B. T. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0027-8 · Cited by 133 · see citing works
The Muscle Stem Cell Niche in Health and Disease
Mashinchian, O., Pisconti, A., Moal, E. L., & Bentzinger, C. F. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.003 · Cited by 127 · see citing works
Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution
Bachman, J. F., Klose, A. M., Liu, W., Paris, N. D., Blanc, R. S., Schmalz, M., Knapp, E. K., & Chakkalakal, J. V. (2018) · Development · doi:10.1242/dev.167197 · Cited by 133 · see citing works
Regenerative function of immune system: Modulation of muscle stem cells
Saini, J., McPhee, J. S., Al-Dabbagh, S., Stewart, C. E., & Al‐Shanti, N. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.03.006 · Cited by 129 · see citing works
Cellular and Morphological Alterations in the Vastus Lateralis Muscle as the Result of ACL Injury and Reconstruction
Noehren, B. W., Andersen, A. H., Hardy, P., Johnson, D. L., Ireland, M. L., Thompson, K. L., & Damon, B. M. (2016) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.00035 · Cited by 127 · see citing works
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
Franco, I., Johansson, A., Olsson, K., Vrtačnik, P., Lundin, P., Helgadottir, H. T., Larsson, M., Revêchon, G., Bosia, C., Pagnani, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03244-6 · Cited by 126 · see citing works
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
Owen, A. M., Patel, S. P., Smith, J. D., Balasuriya, B. K., Mori, S. F., Hawk, G. S., Stromberg, A. J., Kuriyama, N., Kaneki, M., Rabchevsky, A. G., et al. (2019) · eLife · doi:10.7554/elife.49920 · Cited by 126 · see citing works
Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization
Joanisse, S., Nederveen, J. P., Snijders, T., McKay, B. R., & Parise, G. (2016) · Gerontology · doi:10.1159/000450922 · Cited by 124 · see citing works
Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2021) · The FASEB Journal · doi:10.1096/fj.202101096r · Cited by 120 · see citing works
Self-citation
Biological basis and treatment of frailty and sarcopenia
Sato, R., Vatic, M., da Fonseca, G. W. P., Anker, S. D., & von Haehling, S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae073 · Cited by 128 · see citing works
Muscle contracture and passive mechanics in cerebral palsy
Lieber, R. L., & Fridén, J. O. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00278.2018 · Cited by 119 · see citing works
Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells
Muñoz‐Cánoves, P., Neves, J., & Sousa‐Victor, P. (2019) · FEBS Journal · doi:10.1111/febs.15182 · Cited by 111 · see citing works
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men
Granic, A., Suetterlin, K., Shavlakadze, T., Grounds, M. D., & Sayer, A. A. (2023) · Clinical Science · doi:10.1042/cs20230319 · Cited by 118 · see citing works
Cellular and molecular mechanisms of sarcopenia: The S100B perspective
Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12363 · Cited by 114 · see citing works
Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline
Xiao, Y.-Z., Yang, M., Xiao, Y., Guo, Q., Huang, Y., Li, C., Cai, D., & Luo, X. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.002 · Cited by 112 · see citing works
Immune system and sarcopenia: Presented relationship and future perspective
Zhang, X., Li, H., He, M., Wang, J., Wu, Y., & Li, Y. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111823 · Cited by 112 · see citing works
Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle
Goh, Q., Song, T., Petrany, M. J., Cramer, A., Sun, C., Sadayappan, S., Lee, S., & Millay, D. P. (2019) · eLife · doi:10.7554/elife.44876 · Cited by 110 · see citing works
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104 · see citing works
Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration
Tachtsis, B., Camera, D., & Lacham-Kaplan, O. (2018) · Nutrients · doi:10.3390/nu10030309 · Cited by 104 · see citing works
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
Dungan, C. M., Murach, K. A., Zdunek, C. J., Tang, Z. J., Nolt, G. L., Brightwell, C. R., Hettinger, Z. R., Englund, D. A., Liu, Z., Fry, C. S., et al. (2021) · Aging Cell · doi:10.1111/acel.13528 · Cited by 105 · see citing works
Adiponectin promotes muscle regeneration through binding to T-cadherin
Tanaka, Y., Kita, S., Nishizawa, H., Fukuda, S., Fujishima, Y., Obata, Y., Nagao, H., Masuda, S., Nakamura, Y., Shimizu, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37115-3 · Cited by 103 · see citing works
The clinical impact and biological mechanisms of skeletal muscle aging
Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R., & LeBrasseur, N. K. (2019) · Bone · doi:10.1016/j.bone.2019.05.021 · Cited by 104 · see citing works
Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation
Pérez-Baos, S., Prieto‐Potín, I., Roman‐Blas, J. A., Sánchez‐Pernaute, O., Largo, R., & Herrero‐Beaumont, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00409 · Cited by 99 · see citing works
PRMT7 Preserves Satellite Cell Regenerative Capacity
Blanc, R. S., Vogel, G., Chen, T., Crist, C., & Richard, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.022 · Cited by 97 · see citing works
Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions
Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94 · see citing works
Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice
Murach, K. A., Mobley, C. B., Zdunek, C. J., Frick, K. K., Jones, S. R., McCarthy, J. J., Peterson, C. A., & Dungan, C. M. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12617 · Cited by 93 · see citing works
Fusion-independent satellite cell communication to muscle fibers during load-induced hypertrophy
Murach, K. A., Vechetti, I. J., Van Pelt, D. W., Crow, S. E., Dungan, C. M., Figueiredo, V. C., Kosmac, K., Fu, X., Richards, C. I., Fry, C. S., et al. (2020) · Function · doi:10.1093/function/zqaa009 · Cited by 94 · see citing works
p21 induces a senescence program and skeletal muscle dysfunction
Englund, D. A., Jolliffe, A., Aversa, Z., Zhang, X., Sturmlechner, I., Sakamoto, A. E., Zeidler, J. D., Warner, G. M., McNinch, C., White, T. A., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101652 · Cited by 90 · see citing works
Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity
Englund, D. A., Murach, K. A., Dungan, C. M., Figueiredo, V. C., Vechetti, I. J., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00090.2020 · Cited by 90 · see citing works
Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia
Wang, Y., Wehling‐Henricks, M., Welc, S. S., Fisher, A. L., Qun, Z., & Tidball, J. G. (2018) · The FASEB Journal · doi:10.1096/fj.201800973r · Cited by 87 · see citing works
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
Neelakantan, H., Brightwell, C. R., Graber, T. G., Maroto, R., Wang, H.-Y. L., McHardy, S. F., Papaconstantinou, J., Fry, C. S., & Watowich, S. J. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.008 · Cited by 88 · see citing works
PAI-1, the Plasminogen System, and Skeletal Muscle
Rahman, F. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197066 · Cited by 87 · see citing works
Musculoskeletal senescence: a moving target ready to be eliminated
Baar, M. P., Perdiguero, E., Muñoz-Cánoves, P., & de Keizer, P. L. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.05.007 · Cited by 83 · see citing works
Mitochondria and cellular senescence: Implications for musculoskeletal ageing
Habiballa, L., Salmonowicz, H., & Passos, J. F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.417 · Cited by 82 · see citing works
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target
Zuo, X., Zhao, R., Wu, M., Wang, Y., Wang, S., Tang, K., Wang, Y., Chen, J., Yan, X., Cao, Y., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00797-8 · Cited by 82 · see citing works
Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise
Englund, D. A., Figueiredo, V. C., Dungan, C. M., Murach, K. A., Peck, B. D., Petrosino, J. M., Brightwell, C. R., Dupont, A., Neal, A. C., Fry, C. S., et al. (2020) · Function · doi:10.1093/function/zqaa033 · Cited by 81 · see citing works
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia
Delbono, O., Rodrigues, A. C. Z., Bonilla, H. J., & Messi, M. L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101305 · Cited by 81 · see citing works
Myeloid Cell-Derived Tumor Necrosis Factor-Alpha Promotes Sarcopenia and Regulates Muscle Cell Fusion with Aging Muscle Fibers
Wang, Y., Welc, S. S., Wehling‐Henricks, M., & Tidball, J. G. (2018) · Aging Cell · doi:10.1111/acel.12828 · Cited by 80 · see citing works
Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma
Han, W. M., Anderson, S. E., Mohiuddin, M., Barros, D., Nakhai, S. A., Shin, E.-J., Amaral, I. F., Pêgo, A. P., Garcı́a, A. J., & Jang, Y. C. (2018) · Science Advances · doi:10.1126/sciadv.aar4008 · Cited by 80 · see citing works
microRNAs: Modulators of the underlying pathophysiology of sarcopenia?
Brown, D. M., & Goljanek‐Whysall, K. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.007 · Cited by 75 · see citing works
Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances
Najm, A., Niculescu, A.-G., Grumezescu, A. M., & Beuran, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084300 · Cited by 78 · see citing works
Muscle Stem Cells and Aging
Hwang, A. B., & Brack, A. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.008 · Cited by 80 · see citing works

P74. Age-related changes in prospectively isolated muscle satellite cells
Ikemoto‐Uezumi, M., Uezumi, A., Tsuchida, K., Fukada, S., & Hashimoto, N. (2010) · Differentiation · doi:10.1016/j.diff.2010.09.080
Regenerative decline of stem cells in sarcopenia
Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147 · see citing works
Role of muscle stem cells in sarcopenia
Snijders, T., & Parise, G. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000360 · Cited by 54 · see citing works
Depletion of resident muscle stem cells inhibits muscle fiber hypertrophy induced by lifelong physical activityPreprint
Englund, D. A., Murach, K. A., Dungan, C. M., Figueiredo, V. C., Vechetti, I. J., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/588731 · Cited by 1 · see citing works
Muscle stem cells contribute to myofibres in sedentary adult mice
Keefe, A. C., Lawson, J. A., Flygare, S. D., Fox, Z. D., Colasanto, M. P., Mathew, S. J., Yandell, M., & Kardon, G. (2015) · Nature Communications · doi:10.1038/ncomms8087 · Cited by 279 · see citing works

Authors: Fry, C. S., Lee, J. D., Mula, J., Kirby, T. J., Jackson, J. R., Liu, F., Yang, L., Mendias, C. L., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A.
Affiliations: University of Kentucky (US)
University of Michigan (US)
Corresponding author: Peterson, Charlotte A
ORCID: Fry, Christopher S
Kirby, Tyler J
Liu, Fujun
Yang, Lin
Mendias, Christopher L
McCarthy, John J
Peterson, Charlotte A
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2014-12-15
Volume: 21
Issue: 1
Pages: 76-80
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm.3710
PMC: PMC4289085
OpenAlex: W2072493014
Cited by: 432
References: 43
Citations by year: 2026: 26 · 2025: 20 · 2024: 27 · 2023: 40 · 2022: 35 · 2021: 45 · 2020: 45 · 2019: 37 · 2018: 40 · 2017: 41 · 2016: 37 · 2015: 39
FWCI: 15.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
PubMed Central (acceptedVersion)
UKnowledge (University of Kentucky) (submittedVersion)
Pure Amsterdam UMC (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Ellison Medical Foundation (EPD 12102)
National Institutes of Health (1f32ar065337-01a1, UL1TR000117)
National Institute on Aging (R21AG043721, R21AG034453, AG043721, AG-34453)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR065479, F32 AR065337, AR065337, R01AR060701, AR60701)
National Institute of Dental and Craniofacial Research (K12DE023574)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: satellite cells, sarcopenia, muscle regeneration, muscle stem cells, skeletal muscle aging, sedentary behavior, muscle fibrosis, muscle mass, muscle fiber composition, geriatric frailty
MeSH terms: Aging, Animals, Humans, Regeneration, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Mice, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks