Cited by 195Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stressSelenium in Biological Systems

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Reduction in Glutathione Peroxidase 4 Increases Life Span Through Increased Sensitivity to Apoptosis

Ran, Q., Liang, H., Ikeno, Y., Qi, W., Prolla, T. A., Roberts, L. J., Wolf, N., VanRemmen, H., Richardson, A.·2007·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

DOI 10.1093/gerona/62.9.932

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Abstract

Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme that plays an important role in detoxification of oxidative damage to membrane lipids. Because oxidative stress is proposed to play a causal role in aging, we compared the life spans of Gpx4 heterozygous knockout mice (Gpx4(+/-) mice) and wild-type mice (WT mice). To our surprise, the median life span of Gpx4(+/-) mice (1029 days) was significantly longer than that of WT mice (963 days) even though the expression of Gpx4 was reduced approximately 50% in all tissues of Gpx4(+/-) mice. Pathological analysis revealed that Gpx4(+/-) mice showed a delayed occurrence of fatal tumor lymphoma and a reduced severity of glomerulonephritis. Compared to WT mice, Gpx4(+/-) mice showed significantly increased sensitivity to oxidative stress-induced apoptosis. Our data indicate that lifelong reduction in Gpx4 increased life span and reduced/retarded age-related pathology most likely through alterations in sensitivity of tissues to apoptosis.

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Biochemical Pathways of Caspase Activation During Apoptosis
Budihardjo, I. I., Oliver, H., Lutter, M. L., Luo, X., & Wang, X. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.269 · Cited by 2,577
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio727 · Cited by 1,256
Lipid hydroperoxide generation, turnover, and effector action in biological systems
Girotti, A. W. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32182-9 · Cited by 1,215
Mechanisms of free radical oxidation of unsaturated lipids
Porter, N. A., Caldwell, S. E., & Mills, K. A. (1995) · Lipids · doi:10.1007/bf02536034 · Cited by 1,208
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.011 · Cited by 1,176
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155
Tissue-specific functions of individual glutathione peroxidases
Brigelius-Flohé, R. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00173-2 · Cited by 1,114
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults
Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., & Prolla, T. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01360-6 · Cited by 797
Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells
Imai, H., & Nakagawa, Y. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01197-8 · Cited by 776
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734
Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510
Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*
Roberts, L., Montine, T., Markesbery, W., Tapper, A. R., Hardy, P., Chemtob, S., Dettbarn, W., & Morrow, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13605 · Cited by 430
Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress
Morrow, J. D., & Roberts, L. J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00106-8 · Cited by 409
The role of selenium peroxidases in the protection against oxidative damage of membranes
Ursini, F., & Bindoli, A. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90053-3 · Cited by 391
Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria
Petrosillo, G., Ruggiero, F. M., & Paradies, G. (2003) · The FASEB Journal · doi:10.1096/fj.03-0012com · Cited by 384
Functional Consequences of Oxidative Membrane Damage
Stark, G. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0753-8 · Cited by 380
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
Nomura, K., Imai, H., Koumura, T., Kobayashi, T., & Nakagawa, Y. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510183 · Cited by 373
Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene
Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00734-4 · Cited by 357
10N‐Nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria
Petit, J., Maftah, A. A., Ratinaud, M., & Julien, R. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17285.x · Cited by 334
Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity
Ikeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S., & Bartke, A. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.b291 · Cited by 298
Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway
Nomura, K., Imai, H., Koumura, T., Arai, M., & Nakagawa, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29294 · Cited by 285
Mechanisms of Toxicity, Clinical Features, and Management of Diquat Poisoning: A Review
Jones, G. M., & Vale, A. (2000) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-100100926 · Cited by 251
Is the Mitochondrial Free Radical Theory of Aging Intact?
Sanz, A., Pamplona, R., & Barja, G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.582 · Cited by 245
Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis*
Ran, Q.-T., Liang, H.-Y., Gu, M., Qi, W., Walter, C., Roberts, L., Herman, B., Richardson, A., & Remmen, H. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410387200 · Cited by 242
Genetic mouse models of extended lifespan
Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 239
Superoxide dismutase, aging, and degenerative disease
Warner, H. R. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90080-9 · Cited by 238
Why Do Life Spans Differ? Partitioning Mean Longevity Differences in Terms of Age-Specific Mortality Parameters
Pletcher, S. D., Khazaeli, A. A., & Curtsinger, J. W. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.8.b381 · Cited by 211
CytochromecAssociation with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice
Kirkinezos, I. G., Bacman, S. R., Hernandez, D., Oca‐Cossio, J., Arias, L. J., Pérez‐Pinzón, M. A., Bradley, W. G., & Moraes, C. T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3829-04.2005 · Cited by 200
DNA damage, mutation and fine structure DNA repair in aging
Bohr, V. A., & Anson, R. M. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00008-t · Cited by 173
Modulation of Membrane Phospholipid Fatty Acid Composition by Age and Food Restriction
Laganiere, S., & Yu, B. P. (2009) · Gerontology · doi:10.1159/000213509 · Cited by 166
Pathology of Aging B6;129 Mice
Haines, D. C., Chattopadhyay, S. K., & Ward, J. M. (2001) · Toxicologic Pathology · doi:10.1080/019262301753385988 · Cited by 141
Cell proliferation, cell death and aging
Franceschi, C. (1989) · Aging Clinical and Experimental Research · doi:10.1007/bf03323871 · Cited by 128
Untitled work
(1991) · PubMed · Cited by 123
Apoptosis and Aging: Role of p66 Shc Redox Protein
Migliaccio, E., Giorgio, M., & Pelicci, P. G. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.600 · Cited by 123
Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls
Pamplona, R., Portero‐Otín, M., Requena, J. R., Gredilla, R., & Barja, G. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00076-3 · Cited by 120
Effects of Age and Caloric Restriction on Lipid Peroxidation: Measurement of Oxidative Stress by F2-Isoprostane Levels
Ward, W. F., Qi, W., Remmen, H. V., Zackert, W. E., Roberts, L. J., & Richardson, A. G. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.7.847 · Cited by 118
Intracellular distribution of the fluorescent dye nonyl acridine orange responds to the mitochondrial membrane potential: implications for assays of cardiolipin and mitochondrial mass
Jacobson, J., Duchen, M. R., & Heales, S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00945.x · Cited by 116
Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy
Wang, H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00469-5 · Cited by 111
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFκB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells
Brigelius‐Flohé, R., Maurer, S., Lötzer, K., Böl, G., Kallionpää, H., Lehtolainen, P., Viita, H., & Ylä‐Herttuala, S. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00486-4 · Cited by 96
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity
Ran, Q., Gu, M., Remmen, H. V., Strong, R., Roberts, J. L., & Richardson, A. G. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20868 · Cited by 95
Normal Mouse and Rat Strains as Models for Age-related Cataract and the Effect of Caloric Restriction on its Development
Wolf, N. S., Li, Y., Pendergrass, W. R., Schmeider, C., & Turturro, A. (2000) · Experimental Eye Research · doi:10.1006/exer.2000.0835 · Cited by 91
Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells
Kriska, T., Korytowski, W., & Girotti, A. W. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.025 · Cited by 90
Consecutive action of phospholipase A2 and glutathione peroxidase is required for reduction of phospholipid hydroperoxides and provides a convenient method to determine peroxide values in membranes
van Kuijk, F. J. G. M., Handelman, G. J., & Dratz, E. A. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90156-4 · Cited by 87
Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different experimental models
Garcia‐Fernandez, M. I., Ceccarelli, D., & Muscatello, U. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.01.020 · Cited by 87
Housing Density Does Not Influence the Longevity Effect of Calorie Restriction
Ikeno, Y., Hubbard, G. B., Lee, S., Richardson, A., Strong, R., Diaz, V., & Nelson, J. F. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.12.1510 · Cited by 83
Isoprostanes
ROBERTS, L. J., & Morrow, J. D. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb52741.x · Cited by 81
Embryonic fibroblasts from Gpx4+/− mice: a novel model for studying the role of membrane peroxidation in biological processes
Ran, Q., Remmen, H. V., Gu, M., Qi, W., Roberts, L. J., Prolla, T. A., & Richardson, A. G. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00466-0 · Cited by 76
PHGPx and phospholipase A2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria
Antunes, F., Salvador, A., & Pinto, R. E. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00040-5 · Cited by 70
Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4
Hurst, R., Korytowski, W., Kriska, T., Esworthy, R. S., Chu, F., & Girotti, A. W. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00685-2 · Cited by 69
Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria
Lambert, A. J., Portero‐Otín, M., Pamplona, R., & Merry, B. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.002 · Cited by 69
Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease
Tanaka, M., Nakae, S., Terry, R. D., Mokhtari, G. K., Gunawan, F., Balsam, L. B., Kaneda, H., Kofidis, T., Tsao, P. S., & Robbins, R. C. (2004) · Blood · doi:10.1182/blood-2004-02-0666 · Cited by 66
Specific interaction of the new fluorescent dye 10‐N‐nonyl acridine orange with inner mitochondrial membrane
Maftah, A. A., Petit, J. M., & Julien, R. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80112-v · Cited by 57
Binding of 10-N-nonyl acridine orange to cardiolipin-deficient yeast cells: Implications for assay of cardiolipin
Gohil, V. M., Gvozdenovic‐Jeremic, J., Schlame, M., & Greenberg, M. L. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.039 · Cited by 42
Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line
Luchetti, F., Canonico, B., Mannello, F., Masoni, C., D'Emilio, A., Battistelli, M., Papa, S., & Falcieri, E. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.08.003 · Cited by 40
Senescent terminal weight loss in the male F344 rat
Black, B. J., McMahan, C. A., Masoro, E. J., Ikeno, Y., & Katz, M. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00640.2001 · Cited by 25
Apoptosis in glomerulonephritis
Hughes, J., & Savill, J. (2005) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000172728.82993.4e · Cited by 22
Ultracentrifugal analysis of the quaternary structure of the raf represser from Escherichia coli
Jaenicke, R., Muižnieks, I., Aslanidis, C., & Schmitt, R. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80111-u · Cited by 22
Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines
Viola, G., Salvador, A., Vedaldi, D., Fortunato, E., Disarò, S., Basso, G., & Queiroz, M. J. R. P. (2005) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2005.09.004 · Cited by 20
Apoptosis: a two-edged sword in aging.
Hr, W. (2000) · PubMed · Cited by 18

Research works printed but not linked: 6

1993, J NUTR SCI VITAMINOL, 39, 575
Bronson, 1991, Growth, development, and aging : GDA, 55, 169
2000, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 55A, B381
2000, 152, 307
Warner, 1999, Anticancer Research, 19, 2837
1989, Aging, 1, 3

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Authors: Ran, Q., Liang, H., Ikeno, Y., Qi, W., Prolla, T. A., Roberts, L. J., Wolf, N., VanRemmen, H., & Richardson, A.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
University of Wisconsin–Madison (US)
Vanderbilt University (US)
University of Washington (US)
South Texas Veterans Health Care System (US)
Corresponding author: Ran, Q.
ORCID: Ikeno, Y.
Qi, W.
Roberts, L. J.
Richardson, A.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2007-09-01
Volume: 62
Issue: 9
Pages: 932-942
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/62.9.932
OpenAlex: W2141897277
Cited by: 195
References: 64
Citations by year: 2026: 5 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 14 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 14 · 2013: 9 · 2012: 12
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Locations: The Journals of Gerontology Series A (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (P30AG13319, P01 AG19316, P01AG020591, P01AG019316, P30AG013319)
National Institute of General Medical Sciences (R37 GM42056, R37GM042056)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Keywords: GPX4, lifespan, aging, apoptosis sensitivity, oxidative stress, lipid peroxidation, antioxidant defense, lymphoma, glomerulonephritis, age-related diseases
MeSH terms: Phospholipid Hydroperoxide Glutathione Peroxidase, Aging, Animals, Antioxidants, Glomerulonephritis, Glutathione Peroxidase, Heterozygote, Longevity, Male, Mice, Inbred C57BL, Lipid Peroxidation, Gene Expression, Apoptosis, Mice, Knockout, Oxidative Stress, Mice

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Reduction in Glutathione Peroxidase 4 Increases Life Span Through Increased Sensitivity to Apoptosis

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