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Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
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“Again, however, controversy obfuscates the picture because both pro-aging and anti-aging roles have been reported in disparate mouse models that express elevated levels of p53 (Arum and Johnson, 2007; Bauer et al., 2005; Matheu et al., 2008).”
From p53 at a glance (2010) · cites this paper as Arum and Johnson, 2007
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Citations
Cites
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Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 3×
“Quite intriguingly, CEP-1 overexpression leads to widespread caspaseindependent cell death, which is lethal to the organism at any stage of life (8), as p53 overexpression leads to embryonic lethality in Mus musculus (2).”
BackgroundDNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
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p53: traffic cop at the crossroads of DNA repair and recombination
Sengupta, S., & Harris, C. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1546 · Cited by 544 · cited 2×
“In mammalian cells, p53 can be phosphorylated by DNA damage– responsive kinases ataxia telangectasia mutated (ATM), ataxia telangiectasia and Rad3-related protein (ATR), DNAdependent protein kinase (DNA-PK), checkpoint kinase 1 (Chk1), and checkpoint kinase 2 (Chk2), among others (44,45).”
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Cited by
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Brady, C. A., & Attardi, L. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.064501 · Cited by 403
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387
Farnebo, M., Bykov, V. J. N., & Wiman, K. G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.152 · Cited by 268
Relevance of the p53–MDM2 axis to aging
Wu, D., & Prives, C. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.187 · Cited by 215
Metadata
- Authors
- Arum, O., & Johnson, T. E.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-01
- Volume
- 62
- Issue
- 9
- Pages
- 951-959
- ISSN
- 1079-5006
- 1758-535X
- Cited by
- 64
- References
- 7
- Language
- en
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- CoChat. (2026). Citation check: Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity. https://app.cochat.ai/papers/10.1093/gerona/62.9.951
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- Arum, O., & Johnson, T. E. (2007). Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. https://doi.org/10.1093/gerona/62.9.951
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
