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Cited by 36Coenzyme Q10 studies and effectsExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

Age-dependent effect of every-other-day feeding and aerobic exercise in ubiquinone levels and related antioxidant activities in mice muscle

Rodríguez-Bies, Elizabeth, Navas, Plácido, López-Lluch, Guillermo·2015·The Journals of Gerontology Series A
DOI 10.1093/gerona/glu002
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Abstract

Aging affects many biochemical, cellular, and physiological processes in the organisms. Accumulation of damage based on oxidized macromolecules is found in many age-associated diseases. Coenzyme Q (Q) is one of the main molecules involved in metabolic and antioxidant activities in cells. Q-dependent antioxidant activities are importantly involved on the protection of cell membranes against oxidation. Many studies indicate that Q decay in most of the organs during aging. In our study, no changes in Q levels were found in old animals in comparison with young animals. On the other hand, the interventions, caloric restriction based on every-other-day feeding procedure, and physical exercise were able to increase Q levels in muscle, but only in old and not in young animals. Probably, this effect prevented the increase in lipid peroxidation found in aged animals and also protein carbonylation. Further, Q-dependent antioxidant activities such as NADH-cytochrome b5 reductase and NAD(P)H-quinone oxidoreductase 1 are also modulated by both exercise and every other day feeding. Taken together, we demonstrate that exercise and dietary restriction as every-other-day procedure can regulate endogenous synthesized Q levels and Q-dependent antioxidant activities in muscle, preventing oxidative damage in aged muscle.

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Crossref · 10.1093/gerona/glu002

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77 of 77 references verified0 citation errors · 0 not checkable

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  • If antioxidant enzymes decay during aging, oxidative damage accumulates.

    “if these enzymes decay during aging, as has been found in different models (Rodriguez-Bies et al., 2015; Rodriguez-Bies et al., 2016; Tung et al., 2014; Tung et al., 2015b), oxidative damage accumulates.”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Rodriguez-Bies et al., 2015

  • Ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol induce mitochondrial biogenesis in humans and other organisms.

    “ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol also induce mitochondrial biogenesis in humans and other organisms (Baur et al., 2010; Feige et al., 2008; Rodriguez-Bies et al., 2015).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Rodriguez-Bies et al., 2015

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Related

Authors
Rodríguez-Bies, E., Navas, P., & López-Lluch, G.
Affiliations
Centre for Biomedical Network Research on Rare Diseases (ES)
ORCID
Navas, Plácido
Venue
The Journals of Gerontology Series A
Publisher
Oxford University Press (OUP)
Published
2014-02-04
Volume
70
Issue
1
Pages
33-43
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/glu002
OpenAlex
W2121350042
Cited by
36
References
79
Citations by year
2023: 2 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 8 · 2014: 3
FWCI
2.05
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
  • European Commission
  • Ministerio de Ciencia e Innovación
  • European Regional Development Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
coenzyme Q10, aging, caloric restriction, aerobic exercise, skeletal muscle, lipid peroxidation, protein carbonylation, NADH-cytochrome b5 reductase, NQO1, antioxidant activity, oxidative damage, dietary restriction
MeSH terms
Aging, Animals, Antioxidants, Physical Exertion, Male, Physical Conditioning, Animal, Ubiquinone, Lipid Peroxidation, NAD(P)H Dehydrogenase (Quinone), Oxidative Stress, Muscle, Skeletal, Caloric Restriction, Cytochrome-B(5) Reductase, Protein Carbonylation, Mice

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