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microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
Abstract
Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and their integration into the dentate network. Among its many targets, the transcription factor CREB activates expression of a gene locus that produces two microRNAs, miR-132 and miR-212. In cultured cortical and hippocampal neurons, miR-132 functions downstream from CREB to mediate activity-dependent dendritic growth and spine formation in response to a variety of signaling pathways. To investigate whether miR-132 and/or miR-212 contribute to the maturation of dendrites in newborn neurons in the adult hippocampus, we inserted LoxP sites surrounding the miR-212/132 locus and specifically targeted its deletion by stereotactically injecting a retrovirus expressing Cre recombinase. Deletion of the miR-212/132 locus caused a dramatic decrease in dendrite length, arborization, and spine density. The miR-212/132 locus may express up to four distinct microRNAs, miR-132 and -212 and their reverse strands miR-132* and -212*. Using ratiometric microRNA sensors, we determined that miR-132 is the predominantly active product in hippocampal neurons. We conclude that miR-132 is required for normal dendrite maturation in newborn neurons in the adult hippocampus and suggest that this microRNA also may participate in other examples of CREB-mediated signaling.
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miR-132 and miR-212 share seed sequence homology, promote dendritic outgrowth from newborn neurons, and can target MeCP2.
“Similarly, CREB-induced miR-132 and miR-212, which share seed sequence homology, promote dendritic outgrowth from newborn neurons [55] and can target methyl CpG binding protein 2 (MeCP2), a regulator of neuroplasticity [56], [57].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [55]
miR-132 can ameliorate AD pathology at multiple levels, through its involvement in TAU metabolism and hyperphosphorylation, amyloidosis, neuronal survival, adult neurogenesis and memory formation.
“miR-132 can ameliorate AD pathology at multiple levels, through its involvement in TAU metabolism and hyperphosphorylation, amyloidosis, neuronal survival, adult neurogenesis and memory formation [18, 20–34].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [25]
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“Interestingly, these decreases may be reversible, and many of the stimuli that promote neurogenesis also promote dendritic growth and increased arbor complexity (9).”
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Metadata
- Authors
- Magill, S. T., Cambronne, X. A., Luikart, B. W., Lioy, D. T., Leighton, B. H., Westbrook, G. L., Mandel, G., & Goodman, R. H.
- Affiliations
- Vollum Institute and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-11-08
- Volume
- 107
- Issue
- 47
- Pages
- 20382-20387
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 363
- References
- 8
- Language
- en
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