Mitochondrial Dysfunction in Parkinson’s Disease

Multilineage potential of adult human mesenchymal stem cells

Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Human Adipose Tissue Is a Source of Multipotent Stem Cells

Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944 · see citing works

The many faces of α-synuclein: from structure and toxicity to therapeutic target

Lashuel, H. A., Overk, C., Oueslati, A., & Masliah, E. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3406 · Cited by 1,623 · see citing works

Association between Early-Onset Parkinson's Disease and Mutations in theParkinGene

Lücking, C. B., Dürr, A., Bonifati, V., Vaughan, J. R., Michele, G. D., Gasser, T., Harhangi, B. S., Meco, G., Denèfle, P., Wood, N. W., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005253422103 · Cited by 1,433 · see citing works

Genetics of Parkinson's DiseasePreprint

Klein, C., & Westenberger, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a008888 · Cited by 1,370 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works

Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203 · see citing works

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045 · see citing works

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401135200 · Cited by 995 · see citing works

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

Spinazzi, M., Casarin, A., Pertegato, V., Salviati, L., & Angelini, C. I. (2012) · Nature Protocols · doi:10.1038/nprot.2012.058 · Cited by 989 · see citing works

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

Dagda, R. K., Cherra, S. J., Kulich, S. M., Tandon, A., Park, D., & Chu, C. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808515200 · Cited by 954 · see citing works

Mitochondrial dynamics and mitochondrial quality control

Ni, H.-M., Williams, J. A., & Ding, W.-X. (2015) · Redox Biology · doi:10.1016/j.redox.2014.11.006 · Cited by 931 · see citing works

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

Subramaniam, S., & Chesselet, M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.004 · Cited by 925 · see citing works

Expanding insights of mitochondrial dysfunction in Parkinson's disease

Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

Liu, Y., Fallon, L., Lashuel, H. A., Liu, Z., & Lansbury, P. T. (2002) · Cell · doi:10.1016/s0092-8674(02)01012-7 · Cited by 786 · see citing works

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

Henchcliffe, C., & Beal, M. F. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0924 · Cited by 786 · see citing works

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1

Funayama, M., Hasegawa, K., Kowa, H., Saito, M., Tsuji, S., & Obata, F. (2002) · Annals of Neurology · doi:10.1002/ana.10113 · Cited by 666 · see citing works

Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons

Barsoum, M. J., Yuan, H., Gerencser, A. A., Liot, G., Kushnareva, Y., Gräber, S., Kovács, I., Lee, W. D., Waggoner, J., Cui, J., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601253 · Cited by 658 · see citing works

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

Exner, N., Lutz, A. K., Haass, C., & Winklhofer, K. F. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.170 · Cited by 652 · see citing works

PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Pridgeon, J. W., Olzmann, J. A., Chin, L.-S., & Li, L. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050172 · Cited by 596 · see citing works

Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

Stefanis, L., Larsen, K. E., Rideout, H. J., Sulzer, D. L., & Greene, L. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09549.2001 · Cited by 569 · see citing works

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

Strauss, K. M., Martins, L. M., Plun‐Favreau, H., Marx, F. P., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T. H., Bornemann, A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi215 · Cited by 569 · see citing works

Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases

Choi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314124200 · Cited by 568 · see citing works

Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat

Cochemé, H. M., & Murphy, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708597200 · Cited by 563 · see citing works

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J., Caldwell, K. A., Caldwell, G. A., Cooper, A. A., Rochet, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.300 · Cited by 535 · see citing works

Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

Exner, N., Treske, B., Paquet, D., Holmström, K. M., Schiesling, C., Gispert, S., Carballo‐Carbajal, I., Berg, D., Hoepken, H.-H., Gasser, T., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0719-07.2007 · Cited by 511 · see citing works

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

Chinta, S. J., Mallajosyula, J. K., Rane, A., & Andersen, J. K. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.061 · Cited by 451 · see citing works

Mesenchymal Stem Cells in Osteobiology and Applied Bone Regeneration

Bruder, S. P., Jaiswal, N., Ricalton, N. S., Mosca, J. D., Kraus, K. H., & Kadiyala, S. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00025 · Cited by 435 · see citing works

Ageing, neurodegeneration and Parkinson's disease

Hindle, J. V. (2010) · Age and Ageing · doi:10.1093/ageing/afp223 · Cited by 430 · see citing works

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

Bonifati, V., Rizzu, P., Squitieri, F., Krieger, E., Vanacore, N., Swieten, J. C. V., Brice, A., van Duijn, C. M., Oostra, B. A., Meco, G., et al. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0108-0 · Cited by 427 · see citing works

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works

A Population-Based Investigation of Parkinson's Disease With and Without Dementia

Mayeux, R. P. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530290076015 · Cited by 383 · see citing works

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

Grünblatt, E., Mandel, S. A., Jacob‐Hirsch, J., Zeligson, S., Amariglo, N., Rechavi, G., Li, J., Ravid, R., Roggendorf, W., Riederer, P. F., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0212-1 · Cited by 358 · see citing works

CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study

Funayama, M., Ohe, K., Amo, T., Furuya, N., Yamaguchi, J., Saiki, S., Li, Y., Ogaki, K., Ando, M., Yoshino, H., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70266-2 · Cited by 351 · see citing works

Lysosomal impairment in Parkinson's disease

Dehay, B., Martinez‐Vicente, M., Caldwell, G. A., Caldwell, K. A., Yue, Z., Cookson, M. R., Klein, C., Vila, M., & Bezard, E. (2013) · Movement Disorders · doi:10.1002/mds.25462 · Cited by 340 · see citing works

Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies

Schlossmacher, M. G., Frosch, M. P., Gai, W., Medina, M., Sharma, N., Forno, L. S., Ochiishi, T., Shimura, H., Sharon, R., Hattori, N., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61113-3 · Cited by 324 · see citing works

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

Xilouri, M., Brekk, O. R., & Stefanis, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8341-2 · Cited by 299 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

Wilson, G. R. A., Sim, J. C. H., McLean, C., Giannandrea, M., Galea, C. A., Riseley, J. R., Stephenson, S. E. M., Fitzpatrick, E., Haas, S. A., Pope, K., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.10.015 · Cited by 273 · see citing works

Protein degradation pathways in Parkinson’s disease: curse or blessing

Ebrahimi‐Fakhari, D., Wahlster, L., & McLean, P. J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1004-6 · Cited by 255 · see citing works

The Relationship of Parkinson Disease With Aging

Levy, G. (2007) · Archives of Neurology · doi:10.1001/archneur.64.9.1242 · Cited by 251 · see citing works

Novel PINK1 mutations in early‐onset parkinsonism

Hatano, Y., Li, Y., Sato, K., Asakawa, S., Yamamura, Y., Tomiyama, H., Yoshino, H., Asahina, M., Kobayashi, S. S., Hassin‐Baer, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20251 · Cited by 246 · see citing works

Manganese ethylene‐bis‐dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction

Zhang, J., Fitsanakis, V. A., Gu, G., Jing, D., Ao, M., Amarnath, V., & Montine, T. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01525.x · Cited by 238 · see citing works

The Herbicide Paraquat Induces Dopaminergic Nigral Apoptosis through Sustained Activation of the JNK Pathway

Peng, J., Mao, X. O., Stevenson, F. F., Hsu, M., & Andersen, J. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404596200 · Cited by 234 · see citing works

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works

Novel PINK1 mutations in early-onset parkinsonism

波田野, 靖. (2005) · Medical Entomology and Zoology · Cited by 227 · see citing works

Genetics of Parkinson's disease – state of the art, 2013

Bonifati, V. (2013) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70009-9 · Cited by 209 · see citing works

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin

Whitworth, A. J., Lee, J. R., Ho, V. M.-W., Flick, R., Chowdhury, R. B., & McQuibban, G. A. (2008) · Disease Models & Mechanisms · doi:10.1242/dmm.000109 · Cited by 188 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Schapira, A. H. V. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4402160 · Cited by 175 · see citing works

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

Shi, G. W., Lee, J. R., Grimes, D. A., Racacho, L., Ye, D., Yang, H. H., Ross, O. A., Farrer, M. J., McQuibban, G. A., & Bulman, D. E. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr077 · Cited by 169 · see citing works

LRRK2 pathobiology in Parkinson's disease

Martin, I., Kim, J. W., Dawson, V. L., & Dawson, T. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12949 · Cited by 168 · see citing works

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

Chaturvedi, R. K., & Beal, M. F. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.11.011 · Cited by 139 · see citing works

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

Pilsl, A., & Winklhofer, K. F. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0902-3 · Cited by 128 · see citing works

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

Lin, M. T. S., Cantuti‐Castelvetri, I., Zheng, K., Jackson, K. E., Tan, Y. B., Arzberger, T., Lees, A. J., Betensky, R. A., Beal, M. F., & Simon, D. K. (2012) · Annals of Neurology · doi:10.1002/ana.23568 · Cited by 125 · see citing works

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

Choi, K., Kim, S. ‑., Ha, J., Kim, S.-T., & Son, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06463.x · Cited by 110 · see citing works

MPP+-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport

Desai, V. G., Feuers, R. J., Hart, R. W., & Ali, S. F. (1996) · Brain Research · doi:10.1016/0006-8993(95)01255-9 · Cited by 105 · see citing works

Role of DJ-1 in parkinson’s disease

Lev, N., Roncevic, D., Ickowicz, D., Melamed, E., & Offen, D. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn:31:03:307 · Cited by 92 · see citing works

Parkinson patient fibroblasts show increased alpha-synuclein expression

Hoepken, H.-H., Gispert, S., Azizov, M., Klinkenberg, M., Ricciardi, F., Kurz, A., Morales-Gordo, B., von Bonin, M., Rieß, O., Gasser, T., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.004 · Cited by 91 · see citing works

Genetic variability at the PARK16 locus

Tucci, A., Nalls, M. A., Houlden, H., Révész, T., Singleton, A., Wood, N. W., Hardy, J., & Paisán‐Ruiz, C. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.125 · Cited by 91 · see citing works

Role of DJ-1 in Parkinson's Disease

Lev, N., Roncevich, D., Ickowicz, D., et al. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:29:3:215 · Cited by 87 · see citing works

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

Li, B., Hu, Q., Wang, H., Man, N., Ren, H., Wen, L., Nukina, N., Fei, E., & Wang, G. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.55 · Cited by 84 · see citing works

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

Bandopadhyay, R., & de Belleroche, J. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.11.004 · Cited by 84 · see citing works

Progress in the pathogenesis and genetics of Parkinson's disease

Mizuno, Y., Hattori, N., Kubo, S., Sato, S., Nishioka, K., Hatano, T., Tomiyama, H., Funayama, M., Machida, Y., & Mochizuki, H. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.2273 · Cited by 84 · see citing works

Targeting mitochondrial dysfunction in neurodegenerative disease: Part II

Burchell, V., Gandhi, S., Deas, E., Wood, N. W., Abramov, A. Y., & Plun‐Favreau, H. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728221003730434 · Cited by 82 · see citing works

Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells

Piao, Y., Kim, H. G., Oh, M. S., & Pak, Y. K. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.007 · Cited by 81 · see citing works

Long-term creatine supplementation is safe in aged patients with Parkinson disease

Bender, A., Samtleben, W., Elstner, M., & Klopstock, T. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.01.001 · Cited by 79 · see citing works

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

Zhang, X., Zhou, J.-Y., Chin, M. H., Schepmoes, A., Petyuk, V., Weitz, K., Petritis, B. O., Monroe, M. E., Camp, D., Wood, S. A., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr901024z · Cited by 78 · see citing works

Ubiquitin-dependent mitochondrial protein degradation

Heo, J.-M., & Rutter, J. P. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.06.002 · Cited by 76 · see citing works

Redox-Mediated Gene Therapies for Environmental Injury: Approaches and Concepts

Engelhardt, J. F. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.1-5 · Cited by 69 · see citing works

Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration

McInnes, J. (2013) · Translational Neurodegeneration · doi:10.1186/2047-9158-2-12 · Cited by 64 · see citing works

Targeting mitochondrial dysfunction in neurodegenerative disease: Part I

Burchell, V., Gandhi, S., Deas, E., Wood, N. W., Abramov, A. Y., & Plun‐Favreau, H. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728221003652489 · Cited by 63 · see citing works

Effect of MPTP on Brain Mitochondrial H2O2 and ATP Production and on Dopamine and DOPAC in the Striatum

Fabre, E., Monserrat, J., Herrero, A., Barja, G., & Leret, M. L. (1999) · Journal of Physiology and Biochemistry · doi:10.1007/bf03655585 · Cited by 57 · see citing works

Mitochondrial dynamics and neuronal fate in Parkinson's disease

Santos, D., & Cardoso, S. M. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.05.002 · Cited by 55 · see citing works

Alterations in the Mitochondrial Proteome of Neuroblastoma Cells in Response to Complex 1 Inhibition

Burté, F., Girolamo, L. A. D., Hargreaves, A. J., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr101211k · Cited by 53 · see citing works

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells

Shim, J. H., Yoon, S. H., Kim, K., Han, J., Ha, J., Hyun, D. H., Paek, S. H., Kang, U. J., Zhuang, X., & Son, J. H. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.013 · Cited by 52 · see citing works

Targeting Mitochondria for Neuroprotection in Parkinson's Disease

Schapira, A. H. V. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4419 · Cited by 46 · see citing works

Novel mitochondrial DNA mutations in Parkinson's disease

Richter, G., Sonnenschein, A., Grünewald, T. G. P., Reichmann, H., & Janetzky, B. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200060 · Cited by 42 · see citing works

Lack of evidence for an association between UCHL1 S18Y and Parkinson’s disease

Hutter, C. M., Samii, A., Factor, S. A., et al. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02012.x · Cited by 31 · see citing works

Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease‐associated ubiquitin C‐terminal hydrolase L1 and alters its structure and function

Contu, V. R., Kotake, Y., Toyama, T., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12762 · Cited by 30 · see citing works

Mitochondrial Dysfunction of Immortalized Human Adipose Tissue-Derived Mesenchymal Stromal Cells from Patients with Parkinson’s Disease

Moon, H. E., Yoon, S. H., Hur, Y. S., Park, H. W., Ha, J. Y., Kim, K., Shim, J. H., Yoo, S. H., Son, J. H., Paek, S. L., et al. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.4.283 · Cited by 23 · see citing works

Mitochondrial Homeostasis Molecules: Regulation by a Trio of Recessive Parkinson’s Disease Genes

Han, J., Kim, J., & Son, J. H. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.4.345 · Cited by 21 · see citing works

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

Tan, E., Lu, C.-S., Peng, R., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.008 · Cited by 17 · see citing works

Do Somatic Mitochondrial DNA Mutations Contribute to Parkinson's Disease?

Clark, J., Dai, Y., & Simon, D. K. (2011) · Parkinson s Disease · doi:10.4061/2011/659694 · Cited by 16 · see citing works

Koenzym Q10 beim Morbus Parkinson

Storch, A. (2007) · Der Nervenarzt · doi:10.1007/s00115-007-2285-1 · Cited by 13 · see citing works

Lack of association between UCHL1 S18Y gene polymorphism and Parkinson’s disease in the Asian population: a meta-analysis

Sun, S., Zhao, Y., Jin, G., et al. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1973-4 · Cited by 8 · see citing works

Genetic Profiling in Human Adipose Tissue-Derived Mesenchymal Stromal Cells from the Idiopathic and Familial Parkin-Deficient Patients of Parkinson`s Disease in Comparison with non-PD patients

Moon, H.-E., Park, H. W., Shin, H. Y., et al. (2010) · Seoul National University Open Repository (Seoul National University) · Cited by 2 · see citing works

Untitled work

(2000) · doi:10.1002/1531-8249(200011)48:5

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Brand, M. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.001 · Cited by 1,063 · see citing works

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915 · see citing works

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092293 · Cited by 529 · see citing works

Mitochondrial dysfunction in neurodegenerative disorders

Klemmensen, M. M., Borrowman, S. H., Pearce, C., Pyles, B., & Chandra, B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2023.10.002 · Cited by 396 · see citing works

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

Brandes, M. S., & Gray, N. E. (2020) · ASN Neuro · doi:10.1177/1759091419899782 · Cited by 297 · see citing works

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236 · see citing works

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

Paiva, I., Pinho, R., Pavlou, M. A., Hennion, M., Wales, P., Schütz, A.-L., Rajput, A., Szegő, É. M., Kerimoglu, C., Gerhardt, E., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx114 · Cited by 185 · see citing works

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works

Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson’s Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder

Nishiwaki, H., Hamaguchi, T., Ito, M., Ishida, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., et al. (2020) · mSystems · doi:10.1128/msystems.00797-20 · Cited by 133 · see citing works

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease

Moreira, S., Fonseca, I., Nunes, M. J., Rosa, A., Lemos, L., Rodrigues, E., Carvalho, A. N., Outeiro, T. F., Rodrigues, C. M. P., Gama, M. J., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.05.009 · Cited by 112 · see citing works

Activation of AMPK/mTORC1-mediated autophagy by metformin reverses Clk1 deficiency-sensitized dopaminergic neuronal death

Yan, Q., Han, C., Wang, G., Waddington, J. L., Zheng, L., & Zhen, X. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.109512 · Cited by 77 · see citing works

Intermingling of gut microbiota with brain: Exploring the role of probiotics in battle against depressive disorders

Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109489 · Cited by 42 · see citing works

Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37 · see citing works

Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy

Mendes, M. O., Rosa, A. I., Carvalho, A. N., Nunes, M. J., Dionísio, P., Rodrigues, E., Costa, D., Duarte-Silva, S., Maciel, P., Rodrigues, C. M. P., et al. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.01.003 · Cited by 31 · see citing works

β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38MAPK–p53 Signaling Pathway

Pan, Z., Niu, Y., Liang, Y., Zhang, X., & Dong, M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9631-7 · Cited by 21 · see citing works

Usefulness of Parkinson's KinetiGraph in a Parkinson's disease clinic – Survey of 82 patients

Klingelhoefer, L., Rizos, A., Sauerbier, A., et al. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.10.051 · Cited by 4 · see citing works

薬剤性Parkinson症候群 (7月第1土曜特集 Parkinson病) -- (Parkinson症候群)

葛原, 茂. (1998) · 医学のあゆみ

Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers

Rose, K. N., Zorlu, M. M., Fassini, A., Lee, H., Cai, W., Xue, X., Lin, S., Kivisäkk, P., Schwarzschild, M. A., Chen, X., et al. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00763-6 · Cited by 28 · see citing works

Analysis on the Effect of Heavy Metals and Genetics on the Prevalence of Parkinson’s Disease

Zhang, C. (2020) · International Conference on Public Health and Data Science (ICPHDS) · doi:10.1109/icphds51617.2020.00012 · Cited by 1 · see citing works

Parkinson’s Disease-Overview

Khaliq, F. (2021) · Journal of Regenerative Biology and Medicine · doi:10.37191/mapsci-2582-385x-3(6)-092 · Cited by 11 · see citing works